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Stephan Huusmann, Mathias Wolters, David Schilling, Stephan Kruck, Markus Bader, Theodoros Tokas, Thomas Rw Herrmann, Udo Nagele
Over the last decade, several devices for percutaneous nephrolithotomy with smaller diameters have been introduced in order to reduce renal trauma. Recent studies have found comparable stone free rates but also exhibit the same rate of postoperative fever and septicaemia. One possible cause is the influence of irrigation fluid during stone treatment procedures. The purpose of this ex vivo study was to compare two new miniaturised PNL nephroscopy sheaths with an outer sheath diameter of 9.5 F and 12 F to the well-established MIP M Set (17...
December 5, 2018: Aktuelle Urologie
Nada Ahmed, Mohamed Ismail Nounou, Alaa Abouelfetouh, Amal El-Kamel
OBJECTIVES: Nutraceuticals are advertised and sold with the label claim of being natural and safe herbal products. Due to the absence of clear regulations and guidelines for safety assessments of these products, nutraceuticals are commonly adulterated in order to increase sales. The objective of the current study was to design a comprehensive evaluation system to assess the safety, efficacy, authenticity according to label claim and pharmaceutical quality, of herbal slimming products in between 2015 and 2017...
December 5, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Eileen R Chasens, Charles W Atwood, Lora E Burke, Mary Korytkowski, Robert Stansbury, Patrick J Strollo, Susan M Sereika
The Diabetes Sleep Treatment Trial (DSTT) is a multi-site, double-blinded, randomized, sham-controlled trial. The study objective is to test whether treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) treatment results in improved glycemic control and diabetes self-management behavior compared to participants on a sham-CPAP (sub-therapeutic) device in participants with type 2 diabetes mellitus (T2DM) and co-morbid OSA. The purpose of this paper is to describe the premise for the DSTT, the study design, and the methodology used in this on-going trial...
December 2, 2018: Contemporary Clinical Trials
Alan Cervantes Farrell, Xiao Meng, Dingkun Ren, Hyunseok Kim, Pradeep Senanayake, Nick Y Hsieh, Zixuan Rong, Ting-Yuan Chang, Khalifa Mohammad Azizur-Rahman, Diana L Huffaker
Single photon detection at near-infrared (NIR) wavelengths is critical for light detection and ranging (LiDAR) systems used in imaging technologies such as autonomous vehicle trackers and atmospheric remote sensing. Portable, high-performance LiDAR relies on silicon-based single-photon avalanche diodes (SPADs) due to their extremely low dark count rate (DCR) and afterpulsing probability, but their operation wavelengths are typically limited up to 905 nm. Although InGaAs-InP SPADs offer an alternative platform to extend the operation wavelengths to eye-safe ranges, their high DCR and afterpulsing severely limit their commercial applications...
December 5, 2018: Nano Letters
Weina Ke, Enping Hong, Renata F Saito, Maria Cristina Rangel, Jian Wang, Mathias Viard, Melina Richardson, Emil F Khisamutdinov, Martin Panigaj, Nikolay V Dokholyan, Roger Chammas, Marina A Dobrovolskaia, Kirill A Afonin
Nucleic acid-based assemblies that interact with each other and further communicate with the cellular machinery in a controlled manner represent a new class of reconfigurable materials that can overcome limitations of traditional biochemical approaches and improve the potential therapeutic utility of nucleic acids. This notion enables the development of novel biocompatible 'smart' devices and biosensors with precisely controlled physicochemical and biological properties. We extend this novel concept by designing RNA-DNA fibers and polygons that are able to cooperate in different human cell lines and that have defined immunostimulatory properties confirmed by ex vivo experiments...
December 4, 2018: Nucleic Acids Research
Carolyn H Still, Nicholas M Pajewski, Gordon J Chelune, Stephen R Rapp, Kaycee M Sink, Virginia G Wadley, Jeff D Williamson, Alan J Lerner
Objective: To examine the association of global cognitive function assessed via the Montreal Cognitive Assessment (MoCA) and deficiencies in instrumental activities of daily living (IADL) on the Functional Activity Questionnaire (FAQ) in hypertensive older adults in the Systolic Blood Pressure Intervention Trial (SPRINT). Methods: In cross-sectional analysis, 9,296 SPRINT participants completed the MoCA at baseline. The FAQ was obtained from 2,705 informants for SPRINT participants scoring <21 or <22 on the MoCA, depending on education...
December 5, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Angélica M Vera, Omar A Casadiego, Julio C Mantilla, Patricia Escobar
The effectiveness of various pharmaceutical formulations of ketoconazole was evaluated in experimental models of cutaneous leishmaniasis (LC) in BALB C mice. Topical gel, lipogel, and cream formulations containing permeation enhancers and different concentrations of ketoconazole were prepared. Stability, toxicity and anti-Leishmania activity were determined in vitro. In addition, the effectiveness of topically applied formulations in LC-infected mice infected with Leishmania (Viannia) braziliensis was evaluated in vivo...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Breno Cayeiro Cruz, Lucas Vinicius Costa Gomes, Willian Giquelin Maciel, Gustavo Felippelli, Isabella Barbosa Dos Santos, Leonardo Bueno Cruvinel, Luiz Fellipe Monteiro Couto, Thiago Souza Azeredo Bastos, Alliny Souza de Assis Cavalcante, João Eduardo Nicaretta, Vando Edésio Soares, Alvimar José da Costa, Welber Daniel Zanetti Lopes
This study involved two field trials with the aim of evaluating the efficacy of diflubenzuron, via mineral supplementation, against Haematobia irritans parasitizing cattle. Concomitantly with the main trial, a stall test was conducted to ascertain the effects of a different formulation with the same active ingredient against Rhipicephalus microplus, along with the action of diflubenzuron on the reproductive parameters of R. microplusfemales that had naturally detached from cattle. Against H. irritans, it was observed that the efficacy indexes fordiflubenzuron were low (≤ 31...
October 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
Rennan H R Moreira, Rodrigo F DE Oliveira, Jorge Y P Palencia, Marina A G Lemes, Marilane D Silva, Cesar A P Garbossa, Márvio L T DE Abreu, Giselle B DE Moura, Rony A Ferreira
The objective of this trial was to evaluate the behavioral patterns and performance of lactating sows and their litters under the effect of artificial vocalization. Twenty-eight sows and their litters were distributed in a completely randomized design in a 2x2 factorial scheme (artificial vocalization x lactation week). The behavior of the animals was monitored during 24 hours on the 7th and 15th days of lactation, analyzing the number, interval, and frequency of nursings. The body condition and performance of the sows were also evaluated...
October 2018: Anais da Academia Brasileira de Ciências
Shahid Hussain, Sonal Saxena, Sameer Shrivastava, Ashok Kumar Mohanty, Sudarshan Kumar, Rajkumar James Singh, Abhinav Kumar, Sajad Ahmad Wani, Ravi Kumar Gandham, Naveen Kumar, Anil Kumar Sharma, Ashok Kumar Tiwari, Raj Kumar Singh
Spontaneously occurring canine mammary tumours (CMTs) are the most common neoplasms of unspayed female dogs leading to thrice higher mortality rates than human breast cancer. These are also attractive models for human breast cancer studies owing to clinical and molecular similarities. Thus, they are important candidates for biomarker studies and understanding cancer pathobiology. The study was designed to explore underlying molecular networks and pathways in CMTs for deciphering new prognostic factors and therapeutic targets...
2018: PloS One
David Barbado, Belen Irles-Vidal, Amaya Prat-Luri, María Pilar García-Vaquero, Francisco J Vera-Garcia
Although core stability (CS) training is largely used to enhance motor performance and prevent musculoskeletal injuries, the lack of methods to quantify CS training intensity hinders the design of CS programs and the comparison and generalization of their effects. The aim of this study was to analyze the reliability of accelerometers integrated into smartphones to quantify the intensity of several CS isometric exercises. Additionally, this study analyzed to what extent the pelvic acceleration data represent the local stability of the core structures or the whole-body postural control...
2018: PloS One
Steven A Cohen, Mary L Greaney, Natalie J Sabik
BACKGROUND: Obesity is a critical public health issue, affecting over one-third of all Americans, and is an underlying cause of numerous health issues across the lifespan. For older adults, obesity is linked to premature declines in physical and mental health and cognitive functioning. The occurrence of obesity and related health behaviors and chronic diseases are higher in rural areas than in urban areas. Furthermore, rural areas of the United States have a higher proportion of older adults than urban areas...
2018: PloS One
Maria Yousuf, Nimra Naveed Shaikh, Zaheer Ul-Haq, M Iqbal Choudhary
Identification of hotspot drug-receptor interactions through in-silico prediction methods (Pharmacophore mapping, virtual screening, 3DQSAR, etc), is considered as a key approach in drug designing and development process. In the current design study, advanced in-silico based computational techniques were used for the identification of lead-like molecules against the targeted receptor β-glucuronidase. The binding pattern of a potent inhibitor in the ligand-receptor X-ray co-crystallize complex was used to identify and extract the structure-base Pharmacophore features...
2018: PloS One
Arne Skerra, Mikhail Barkovskiy, Elena Ilyukhina, Martin Dauner, Andreas Eichinger
Colchicine is a toxic alkaloid prevalent in autumn crocus (Colchicum autumnale) that binds to tubulin and inhibits polymerization of microtubules. Using combinatorial and rational protein design, we have developed an artificial binding protein based on the human lipocalin 2 that binds colchicine with a dissociation constant of 120 pM, i.e. 10 000-fold stronger than tubulin. Crystallographic analysis of the engineered lipocalin, dubbed Colchicalin, revealed major structural changes in the flexible loop region that forms the ligand pocket at one end of the eight-stranded β-barrel, resulting in a lid-like structure over the deeply buried colchicine...
December 1, 2018: Biological Chemistry
A Liebermann, J Detzer, B Stawarczyk
OBJECTIVES: The aim of this investigation was to test the tensile bond strength (TBS) between different computer-aided-design/manufacturing (CAD/CAM) ceramics after conditioning using different universal adhesive systems and resin composite cement. METHODS AND MATERIALS: Substrates of four CAD/CAM ceramics-1) VITABLOCS Mark II, 2) Initial LRF, 3) Celtra Duo, and 4) IPS e.max CAD (N=648, n=162)-were fabricated. VITABLOCS Mark II and Initial LRF were etched using 9% hydrofluoric acid for 60 seconds, Celtra Duo for 30 seconds, and IPS e...
December 5, 2018: Operative Dentistry
Michael Duss, Jijo J Vallooran, Livia Salvati Manni, Nicole Kieliger, Stephan Handschin, Raffaele Mezzenga, Henning J Jessen, Ehud M Landau
Lipidic cubic phases (LCPs) can reduce Pd2+-salts to palladium nanoparticles (PdNPs) of ~ 5 nm size in their confined water channels under mild conditions. The resulting PdNP-containing LCPs were used as nanoreactor scaffolds to catalyze Suzuki-Miyaura cross coupling reactions in the aqueous channels of the mesophase. To turn on catalysis, PdNP-containing LCPs are activated by swelling the aqueous channels of the lipidic framework, thereby enabling diffusion of the water-soluble substrates to the catalysts...
December 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ishita Mukherjee, Anwesha Ghosh, Punyasloke Bhadury, Priyadarsi De
Design of new drug material through modification of some well known antibiotics to combat pathogenic bacteria must include a complete understanding of matrix regulation, since the human body consists of majorly three types of matrices; solid, semisolid and liquid which has a tendency to regulate antibacterial efficacy along with bactericidal mechanism of several antimicrobial agents. Herein, matrix dependent action of ciprofloxacin based polymeric hydrogel scaffold was explored against a new species of Vibrio, namely Vibrio chemaguriensis Iso1 (V...
December 5, 2018: Bioconjugate Chemistry
Keyi Chen, Ye Zhang, Chilin Li
Metal-polysulfide batteries are attracting broad attentions as conversion reaction systems of high theoretical energy density and low cost. However, their further applications are hindered by low loading of active species, excess conductive additive and loose (nanostructured) electrode network. Herein, we propose that compact grain stacking and surface fluorination are two crucial factors for achieving high-rate and long-life pyrite (FeS2) cathode enabled by sulfurating ionic liquid wrapped open framework fluorides...
December 5, 2018: ACS Nano
Zhengyan Guo, Pengwei Li, Guozhu Chen, Chao Li, Zhenju Cao, Yuwei Zhang, Jinwei Ren, Hua Xiang, Shuangjun Lin, Jianhua Ju, Yihua Chen
Alboflavusins (AFNs) are a group of cyclohexapeptides with moderate antibacterial and antitumor activities from Streptomyces alboflavus sp. 313. In vivo and in vitro studies proposed that AFNs are biosynthesized by a non-ribosomal peptide synthetase machinery, and the 6-Cl-L-Trp precursor is supplied by a tryptophan halogenase gene locating outside the afn gene cluster. Guided by the structure-activity relationship knowledge about the AFN-like cyclohexapeptides, two Dimeric AFNs (Di-AFNs) with regiospecific biaryl linkages were designed and generated biotechnologically by expressing the P450 gene hmtS or clpS in S...
December 5, 2018: Journal of the American Chemical Society
Lekha Paramanik, K Hemalata Reddy, Sabiha Sultana, Kulamani Parida
Erection of a resourceful p-n heterojunction is a state-of-the-art tactic to flourish the charge anti-recombination process at the heterojunction interface and boost the photocatalytic activities under visible light irradiation. In the present work, we have engineered a new series of PbTiO3 /LaCrO3 (PT/LC) p-n heterojunction through a facile two-step combustion process. The structural, interface, and optical analysis distinctly revealed a strong intact between p-type LaCrO3 and n-type PbTiO3 , elucidating their electronic channelization and substantial reduction of electron-hole recombination at the PbTiO3 /LaCrO3 interface, which extend the lifetime and population of photogenerated charges in the p-n heterojunction material...
December 5, 2018: Inorganic Chemistry
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