Read by QxMD icon Read

Active design

Stuart Linley, Andrew Holmes, Timothy Leshuk, Wanis Nafo, Neil R Thomson, Adil Al-Mayah, Kevin McVey, Kanwartej Sra, Frank X Gu
Targeted nanoparticle binding has become a core feature of experimental pharmaceutical product design which enables more efficient payload delivery and enhances medical imaging by accumulating nanoparticles in specific tissues. Environmental remediation and geophysical monitoring encounter similar challenges which may be addressed in part by the adoption of targeted nanoparticle binding strategies. This study illustrates that engineered nanoparticles can bind to crude oil-impacted silica sand, a selective adsorption driven by active targeting based on an amphiphilic polymer coating...
October 8, 2018: Chemosphere
Tim Van Winckel, Xiaocen Liu, Siegfried E Vlaeminck, Imre Takács, Ahmed Al-Omari, Belinda Sturm, Birthe V Kjellerup, Sudhir N Murthy, Haydée De Clippeleir
High-rate activated sludge (HRAS) is an essential cornerstone of the pursuit towards energy positive sewage treatment through maximizing capture of organics. The capture efficiency heavily relies on the degree of solid separation achieved in the clarifiers. Limitations in the floc formation process commonly emerge in HRAS systems, with detrimental consequences for the capture of organics. This study pinpointed and overcame floc formation limitations present in full-scale HRAS reactors. Orthokinetic flocculation tests were performed with varying shear, sludge concentration, and coagulant or flocculant addition...
October 1, 2018: Chemosphere
Sushant K Shrivastava, Saurabh K Sinha, Pavan Srivastava, Prabhash N Tripathi, Piyoosh Sharma, Manish K Tripathi, Avanish Tripathi, Priyanka K Choubey, Digambar K Waiker, Lalit M Aggarwal, Manish Dixit, Subhash C Kheruka, Sanjay Gambhir, Sharmila Shankar, Rakesh K Srivastava
Based on the quantitative structure-activity relationship (QSAR), some novel p-aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were designed, synthesized, characterized and evaluated to enhance learning and memory. The in vitro enzyme kinetic study of the synthesized compounds revealed the type of inhibition on the respective acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The in vivo studies of the synthesized compounds exhibited significant reversal of cognitive deficits in the animal models of amnesia as compared to standard drug donepezil...
October 9, 2018: Bioorganic Chemistry
Venkanna Muripiti, Lohchania Brijesh, Hari Krishnareddy Rachamalla, Srujan Kumar Marepally, Rajkumar Banerjee, Srilakshmi V Patri
Natural antioxidants and vitamins have potential to protect biological systems from peroxidative damage induced by peroxyl radicals, α-tocopherol (Vitamin E, lipid soluble) and ascorbic acid (vitamin C, water soluble), well known natural antioxidant molecules. In the present study we described the synthesis and biological evaluation of hybrid of these two natural antioxidants with each other via ammonium di-ethylether linker, Toc-As in gene delivery. Two control cationic lipids N14-As and Toc-NOH are designed in such a way that one is with ascorbic acid moiety and no tocopherol moiety; another is with tocopherol moiety and no ascorbic acid moiety respectively...
April 17, 2018: Bioorganic Chemistry
Qinqin Xia, Xiaodong Bao, Chuchu Sun, Di Wu, Xiaona Rong, Zhiguo Liu, Yugui Gu, Jianmin Zhou, Guang Liang
Acute lung injury (ALI) is primarily driven by inflammation that severely impacts lung function. Novel 2-sulfonylindoles were recently shown to exhibit anti-inflammatory activity through the inhibition of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production. Here, we synthesized 31 compounds which contained 2-sulfonylindole structure. The compounds 8a, 9g, 9h and 9k exhibited dose-dependent anti-inflammatory activity in vitro. Structural-activity relationship analysis revealed that the introduction of sulfonyl group in indole nucleus may be successful to obtain new anti-inflammatory structures and leads...
October 9, 2018: European Journal of Medicinal Chemistry
Shin-Woo Ha, Manjula Viggeswarapu, Mark M Habib, George R Beck
Silica based nanoparticles have been demonstrated to have intrinsic biologic activity towards the skeleton and to function by promoting the differentiation of bone forming osteoblasts while inhibiting the differentiation of bone resorbing osteoclasts. The excitement surrounding nanomedicine in part revolves around the almost unlimited possibilities for varying the physicochemical properties including size, composition, and surface charge. To date few studies have attempted to manipulate these characteristics in concert to optimize a complex biologic outcome...
October 13, 2018: Acta Biomaterialia
Piotr Poznański, Anna Lesniak, Magdalena Bujalska-Zadrozny, Mariusz Sacharczuk
Mice selected for high (HA) and low (LA) swim stress-induced analgesia (SSIA) are a unique model for studying the genetic background of this phenomenon. HA and LA mice show substantial differences in the magnitude of the antinociceptive response to stress and when treated with exogenous opioids. However, the direct cause underplaying this distinctive feature has not yet been identified. The current study was designed to investigate the possibility that disturbances in G-protein signaling could explain the divergent response to opioid agonists...
October 13, 2018: Neuropharmacology
Huigang Hu, Qiaoli Zhao, Jianghui Xie, Dequan Sun
This study determined the optimal extraction conditions for ultrasonic-cellulase synergistic extraction of polysaccharides from pineapple pomace (PPP) using Plackett-Burman design and response surface methodology. The optimal hydrolysis temperature, ratio of material to water, pH value, hydrolysis time, ultrasonic power and the additive quantity of cellulase were 50 °C, 1:45 g/mL, 6.0, 100 min, 160 W and 2.0%, respectively, giving a extraction yield of 1.10 ± 0.03%. PPP was further isolated and purified by DEAE-52 cellulose and Sephadex G-100 chromatography columns, revealing four main elution peaks, named PPF0, PPF1, PPP2 and PPF3, were obtained...
October 13, 2018: International Journal of Biological Macromolecules
Brian H Kushner, Irene Y Cheung, Shakeel Modak, Ellen M Basu, Stephen S Roberts, Nai-Kong Cheung
Importance: Chimeric and murine anti-GD2 antibodies are active against neuroblastoma, but the development of neutralizing antibodies can compromise efficacy. To decrease immunogenicity, hu3F8, a humanized anti-GD2 antibody, was constructed. Objective: To find the maximum-tolerated dose of hu3F8 with granulocyte-macrophage colony-stimulating factor. Design, Setting, and Participants: This phase 1 clinical trial used a 3 + 3 dose-escalation design in a single referral center (Memorial Sloan Kettering Cancer Center, New York, New York)...
September 20, 2018: JAMA Oncology
Heng Ning Wu, Yukiko Nakura, Michinobu Yoshimura, Ourlad Alzeus Gaddi Tantengco, Makoto Nomiyama, Toshimitsu Takayanagi, Tomio Fujita, Kiyoshi Yasukawa, Itaru Yanagihara
Ureaplasma parvum serovar 3 strain, OMC-P162, was isolated from the human placenta of a preterm delivery at 26 weeks' gestation. In this study, we sequenced the complete genome of OMC-P162 and compared it with other serovar 3 strains isolated from patients with different clinical conditions. Ten unique genes in OMC-P162, five of which encoded for hypothetical proteins, were identified. Of these, genes UPV_229 and UPV_230 formed an operon whose open reading frames were predicted to code for a DNA methyltransferase and a hypothetical protein, respectively...
2018: PloS One
Naja Hulvej Rod, Agnete Skovlund Dissing, Alice Clark, Thomas Alexander Gerds, Rikke Lund
BACKGROUND: Round-the-clock use of smartphones holds a potential for awakenings and/or shorter sleep duration, which may have adverse health consequences. We aim to describe overnight smartphone activity among young adults and to characterize those with smartphone interrupted sleep in terms of sleep impairment and mental and physical health indicators. METHODS: We use unique objective high-resolution information on timing of smartphone activity (based on >250,000 phone actions) continuously monitored over a four-week period among 815 young adults combined with indicators of mental and physical health...
2018: PloS One
Neil P Sheth, Joshua C Rozell, Wayne G Paprosky
As the demand for total hip arthroplasty (THA) continues to increase, the burden of revision THA is also expected to increase. Although the quality of polyethylene has improved markedly, osteolysis continues to be a risk for older designs and younger, active patients. Although progressive but typically asymptomatic in early stages, osteolysis can result in component failure and complicate revision surgery. Serial radiographs are paramount for monitoring progression. Although select cases may be treated with observation, surgery should be considered based on age, activity level, and projected life span...
October 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
Charlene H Chu, Martine Puts, Dina Brooks, Monica Parry, Katherine S McGilton
PURPOSE: The aim of the study was to evaluate the feasibility, acceptability, and efficacy of a multifaceted walking intervention (MWI) aimed to maintain the functional mobility, activities of daily living function, and quality of life of long-term care home residents with dementia. DESIGN/METHODS: A quasiexperimental time-series design was used. The 4-month intervention provided one-on-one walking 2-4 days a week, guided by an individualized communication care plan and interviews with collaterals and staff...
October 12, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Tian-Xiao Wang, Bo Xiong, Wei Xu, Hao-Hua Wei, Wei-Min Qu, Zong-Yuan Hong, Zhi-Li Huang
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: The parabrachial nucleus (PBN), which is a brainstem region containing glutamatergic neurons, is a key arousal nucleus. Injuries to the area often prevent patient reanimation. Some studies suggest that brain regions that control arousal and reanimation are a key part of the anesthesia recovery. Therefore, we hypothesize that the PBN may be involved in regulating emergence from anesthesia. METHODS: We investigated the effects of specific activation or inhibition of PBN glutamatergic neurons on sevoflurane general anesthesia using the chemogenetic "designer receptors exclusively activated by designer drugs" approach...
October 16, 2018: Anesthesiology
Andrea Polli, Jessica Van Oosterwijck, Mira Meeus, Luc Lambrecht, Jo Nijs, Kelly Ickmans
Background and aims The interaction between the immune system and pain has been thoroughly explored in the recent decades. The release of inflammatory mediators from immune cells has the capability of activating neurons and glial cells, in turn sensitizing the nervous system. Both immune system alterations and pain modulation dysfunctions have been shown in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) following exercise. However, no studies tried to explore whether these two phenomena are linked and can explain exercise-induced symptoms worsening in people with ME/CFS...
October 16, 2018: Scandinavian Journal of Pain
Leonardo Vazquez, Andre Teixeira da Silva Ferreira, Fernanda Sampaio Cavalcante, Israel José P Garcia, Katia Regina Netto Dos Santos, Leandro Augusto de Oliveira Barbosa, Marcius da Silva Almeida, Julio Alberto Mignaco, Carlos Frederico Leite Fontes
Eight molecules, four peptides (SPs) and four lipopeptides (LPs) derived by rational design from surfactin, a well-known secreted biosurfactant from Bacillus subtilis, were produced employing Fmoc-based solid-phase synthesis. These new peptides were tested to evaluate their potential biosurfactant and biological activities, aiming at possible applications in industrial, biological, pharmaceutical, and medical use. Five molecules (SP1, SP2, SP4, LP5, and LP8) presented potential for medical uses, mainly due to their drug delivery properties as suggested by their synergistic activity with the antibiotic vancomycin against Staphylococcus aureus...
October 16, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
Robin Bofinger, May Zaw-Thin, Nicholas J Mitchell, P Stephen Patrick, Cassandra Stowe, Ana Gomez-Ramirez, Helen C Hailes, Tammy L Kalber, Alethea B Tabor
The design, synthesis and formulation of non-viral gene delivery vectors is an area of renewed research interest. Amongst the most efficient non-viral gene delivery systems are lipopolyplexes, in which cationic peptides are co-formulated with plasmid DNA and lipids. One advantage of lipopolyplex vectors is that they have the potential to be targeted to specific cell types by attaching peptide targeting ligands on the surface, thus increasing both the transfection efficiency and selectivity for disease targets such as cancer cells...
October 16, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
Sarah Bertoli, Etienne Paubelle, Emilie Bérard, Estelle Saland, Xavier Thomas, Suzanne Tavitian, Marie-Virginie Larcher, François Vergez, Audrey Sarry, Françoise Huguet, Clément Larrue, Claudie Bosc, Thomas Farge, Jean Emmanuel Sarry, Mauricette Michallet, Christian Récher
OBJECTIVES: We previously reported the prognostic value of serum ferritin in younger patients with intermediate-risk acute myeloid leukemia (AML). The aims of this study were to confirm this finding in a larger cohort regardless of age and prognostic subgroups, to explore the expression and functional role of ferritin in AML cells as well as the regulation of serum ferritin levels in AML patients. PATIENTS/MATERIALS/METHODS: Serum ferritin levels at diagnosis were collected in a cohort of 527 patients treated by intensive chemotherapy...
October 16, 2018: European Journal of Haematology
R Melo, L Sanhueza, L Mendoza, M Cotoras
The fungitoxic effect of aristolochic acids I and II on mycelial growth and conidial germination of Botrytis cinerea was analyzed. Aristolochic acid I had a higher effect on mycelial growth of B. cinerea than aristolochic acid II with IC50 value of 18·7 and 57·0μg mL-1 , respectively. These compounds did not affect the conidia germination. Also, the effect of both compounds on DNA and plasmatic membrane integrity of B. cinerea was studied. Only aristolochic acid II was able to cause damage to the integrity of the plasmatic membrane...
October 16, 2018: Letters in Applied Microbiology
Aoife M Harbison, Lorna P Brosnan, Keith Fenlon, Elisa Fadda
Fc glycosylation of human immunoglobulins G (IgGs) is essential for their structural integrity and activity. Interestingly, the specific nature of the Fc glycoforms is known to modulate the IgG effector function and inflammatory properties. Indeed, while core-fucosylation of IgG Fc-glycans greatly affects the antibody-dependent cell-mediated cytotoxicity (ADCC) function, with obvious repercussions in the design of therapeutic antibodies, sialylation can reverse the antibody inflammatory response, and galactosylation levels have been linked to aging, to the onset of inflammation, and to the predisposition to rheumatoid arthritis...
October 16, 2018: Glycobiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"