keyword
https://read.qxmd.com/read/38452865/influence-of-lead-induced-toxicity-on-the-inflammatory-cytokines
#21
REVIEW
P Harshitha, Kalpita Bose, Herman Sunil Dsouza
Lead (Pb2+ ) is a hazardous heavy metal that is pervasive in the human environment as a result of anthropogenic activity, and poses serious health risks, particularly in children. Due to its innumerable unique physical and chemical properties, it has various applications; therefore, it has become a common environmental pollutant. Lead may cause oxidative stress, and accumulating evidence indicates that oxidative stress influences the pathophysiology of lead poisoning, also called plumbism. The immune system is continually exposed to various environmental pathogens and xenobiotics, including heavy metals such as lead, and appears to be one of the most vulnerable targets...
March 5, 2024: Toxicology
https://read.qxmd.com/read/38452656/oxyimperatorin-attenuates-lps-induced-microglial-activation-in-vitro-and-in-vivo-via-suppressing-nf-%C3%AE%C2%BAb-p65-signaling
#22
JOURNAL ARTICLE
Changcheng Lu, Chen Huang, Shuhui Qu, Huiyuan Lin, Hai-Jing Zhong, Cheong-Meng Chong
BACKGROUND: Microglia-mediated neuroinflammation is an important pathological feature in many neurological diseases; thus, suppressing microglial activation is considered a possible therapeutic strategy for reducing neuronal damage. Oxyimperatorin (OIMP) is a member of furanocoumarin, isolated from the medicinal herb Glehnia littoralis. However, it is unknown whether OIMP can suppress the neuroinflammation. PURPOSE: To investigate the neuroprotective activity of oxyimperatorin (OIMP) in LPS-induced neuroinflammation in vitro and in vivo models...
March 6, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38449809/capsaicin-ameliorate-pulmonary-fibrosis-via-antioxidant-nrf-2-ppar-%C3%AE-pathway-activation-and-inflammatory-tgf-%C3%AE-1-nf-%C3%AE%C2%BAb-cox-ii-pathway-inhibition
#23
JOURNAL ARTICLE
Wesam H Abdulaal, Hani Z Asfour, Nawal Helmi, Hadeel Al Sadoun, Basmah Eldakhakhny, Nabil A Alhakamy, Hani Mohammed Alqarni, Saeed Ali Mohammed Alzahrani, Mohamed A El-Moselhy, Sara S Sharkawi, Esam Mohamed Aboubakr
Bleomycin is an effective antibiotic with a significant anticancer properties, but its use is limited due to its potential to induce dose-dependent pulmonary fibrosis. Therefore, this study aimed to assess the therapeutic potential of Capsaicin as an additional treatment to enhance patient tolerance to Bleomycin compared to the antifibrotic drug Pirfenidone. Pulmonary fibrosis was induced in rats through by a single intratracheal Bleomycin administration in day zero, followed by either Capsaicin or Pirfenidone treatment for 7 days...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38449457/cannabidiol-alleviates-chronic-prostatitis-and-chronic-pelvic-pain-syndrome-via-cb2-receptor-activation-and-trpv1-desensitization
#24
JOURNAL ARTICLE
Jun Jie Piao, Soomin Kim, Dongho Shin, Hwa Jong Lee, Kyung-Hwa Jeon, Wen Jie Tian, Kyung Jae Hur, Jong Soo Kang, Hyun-Je Park, Joo Young Cha, Aeri Song, Sang-Hyuck Park, Mahadevan Rajasekaran, Woong Jin Bae, Sungjoo Kim Yoon, Sae Woong Kim
PURPOSE: This study elucidates the mechanism of the physiological effect of cannabidiol (CBD) by assessing its impact on lipopolysaccharide (LPS)-induced inflammation in RWPE-1 cells and prostatitis-induced by 17β-estradiol and dihydrotestosterone in a rat model, focusing on its therapeutic potential for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). MATERIALS AND METHODS: RWPE-1 cells were stratified in vitro into three groups: (1) controls, (2) cells with LPS-induced inflammation, and (3) cells with LPS-induced inflammation and treated with CBD...
February 29, 2024: World Journal of Men's Health
https://read.qxmd.com/read/38447847/screening-and-characterization-of-an-anti-inflammatory-pectic-polysaccharide-from-cucurbita-moschata-duch
#25
JOURNAL ARTICLE
Linlin Huang, Qi Sun, Quanhong Li, Xin Li
Pectin polysaccharides have demonstrated diverse biological activities, however, the inflammatory potential of pectin polysaccharides extracted from Cucurbita moschata Duch remains unexplored. This study aims to extract, characterize and evaluate the effects of pumpkin pectin polysaccharide on lipopolysaccharide (LPS)-induced inflammatory response in RAW264.7 cells and dextran sulfate sodium (DSS)-induced colitis in mice, along with its underlying mechanism of action. Initially, we extracted three fractions of pectin polysaccharides from pumpkin and screened them for anti-inflammatory activity in LPS-induced macrophages, identifying CMDP-3a as the most potent anti-inflammatory fraction...
March 4, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38447296/precise-cuts-for-tailoring-chromene-phenyl-cox-inhibitors-with-ligand-designer
#26
JOURNAL ARTICLE
Huy Hoang Nguyen Vo, Thu Huong Thi Phung, Khanh Linh Chung, Thien Y Vu
Cyclooxygenases 1 and 2 (COX-1/2) are enzymes renowned for inducing inflammatory responses through the production of prostaglandins. Thus, the development of COX inhibitors has been a promising approach for identifying compounds with anti-inflammatory potential. In this study, we designed 27 new compounds (1-27) based on the structure of a previously known COX inhibitor, using the Ligand Designer tool. Our aim was to improve the affinity of the compounds with COX enzymes by inducing interactions with residue Arg120 while retaining the good π-π stacking interactions of the chromene-phenyl scaffold...
March 1, 2024: Journal of Molecular Graphics & Modelling
https://read.qxmd.com/read/38446637/-in-utero-exposure-to-maternal-diabetes-exacerbates-dietary-sodium-intake-induced-endothelial-dysfunction-by-activating-cyclooxygenase-2-derived-proteinoids
#27
JOURNAL ARTICLE
Rafael M da Costa, Debora Malta Cerqueira, Lydia Francis, Ariane Bruder-Nascimento, Juliano V Alves, Sunder Sims-Lucas, Jacqueline Ho, Thiago Bruder-Nascimento
Prenatal exposure to maternal diabetes has been identified as a cardiovascular risk factor. It is unclear if offspring exposed to diabetes in utero manifest a worse vascular outcome to a high salt (HS) diet. To test the hypothesis that in utero exposure to maternal diabetes facilitates salt-induced vascular dysfunction, we treated adult male wild-type offspring (DM_Exp, 6-months-old) of diabetic Ins2+/C96Y mice ( Akita mice) with HS (8% sodium chloride, 10-days) and analyzed endothelial function via wire myograph and cyclooxygenase (COX)-derived prostanoids pathway by ELISA, qPCR, and immunochemistry...
March 6, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38443372/brain-regulates-weight-bearing-bone-through-pge2-skeletal-interoception-implication-of-ankle-osteoarthritis-and-pain
#28
JOURNAL ARTICLE
Feng Gao, Qimiao Hu, Wenwei Chen, Jilong Li, Cheng Qi, Yiwen Yan, Cheng Qian, Mei Wan, James Ficke, Junying Zheng, Xu Cao
Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. However, it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the brain. In this study, we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone prostaglandin E2 (PGE2) concentration in response to mechanical loading. Bone PGE2 levels are in proportion to their weight bearing. When weight bearing changes in the tail-suspension mice, the PGE2 concentrations in bones change in line with their weight bearing changes...
March 5, 2024: Bone Research
https://read.qxmd.com/read/38440794/relation-between-reactive-oxygen-species-production-and-transient-receptor-potential-vanilloid1-expression-in-human-skin-during-aging
#29
JOURNAL ARTICLE
Gaia Favero, Marzia Gianò, Caterina Franco, Daniela Pinto, Cornelis J F van Noorden, Fabio Rinaldi, Rita Rezzani
Skin sensitivity and impaired epidermal barrier function are associated with aging and are at least partly due to increased production of reactive oxygen species (ROS). Transient receptor potential vanilloid1 (TRPV1) is expressed in keratinocytes, fibroblasts, mast cells, and endothelial cells in skin. We investigated in skin biopsies of adult and elderly donors whether TRPV1 expression is involved in the skin aging process. We found that aging skin showed a strongly reduced epidermal thickness, strongly increased oxidative stress, protease expression, and mast cell degranulation and strongly increased TRPV1 expression both in epidermis and dermis...
March 5, 2024: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://read.qxmd.com/read/38439814/loss-of-cdx2-and-high-cox2-ptgs2-expression-in-metastatic-colorectal-cancer
#30
JOURNAL ARTICLE
Álvaro M C Caldas, Warley A Nunes, Rodrigo Taboada, Marcelle G Cesca, Janaína N Germano, Rachel P Riechelmann
Lack of expression of the tumour suppressor gene caudal-type homeobox 2 ( CDX2 ) associates with poor outcomes in early stage colorectal cancer (CRC). Yet its prognostic value in the context of other prognostic biomarkers in metastatic CRC (mCRC) is unknown. Overexpressed cyclooxygenase-2 (COX2) has been reported in advanced CRC. However, CDX2 and COX2 relationship in mCRC remains undetermined. We aimed to assess their expression in mCRC tumours from a clinically characterised cohort and their influence on overall survival (OS) and progression-free survival (PFS) in first line...
2024: Ecancermedicalscience
https://read.qxmd.com/read/38439200/the-glucocorticoid-dexamethasone-alleviates-allergic-inflammation-through-a-mitogen-activated-protein-kinase-phosphatase-1-dependent-mechanism-in-mice
#31
JOURNAL ARTICLE
Tiina Lehtola, Elina Nummenmaa, Riina Nieminen, Mari Hämäläinen, Katriina Vuolteenaho, Eeva Moilanen
Glucocorticoids are widely used in the treatment of allergic and inflammatory diseases. Glucocorticoids have a widespread action on gene expression resulting in their pharmacological actions and also an array of adverse effects which limit their clinical use. It remains, however, to be studied which target gene effects are essential for the anti-allergic activity of glucocorticoids. Mitogen-activated protein kinase phosphatase-1 (MKP-1) inhibits proinflammatory signalling by suppressing the activity of mitogen activated protein kinase (MAP kinase) pathways...
March 4, 2024: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/38439036/large-scale-phosphoproteomics-reveals-activation-of-the-mapk-gadd45%C3%AE-p38-axis-and-cell-cycle-inhibition-in-response-to-bmp9-and-bmp10-stimulation-in-endothelial-cells
#32
JOURNAL ARTICLE
Mohammad Al Tarrass, Lucid Belmudes, Dzenis Koça, Valentin Azemard, Hequn Liu, Tala Al Tabosh, Delphine Ciais, Agnès Desroches-Castan, Christophe Battail, Yohann Couté, Claire Bouvard, Sabine Bailly
BACKGROUND: BMP9 and BMP10 are two major regulators of vascular homeostasis. These two ligands bind with high affinity to the endothelial type I kinase receptor ALK1, together with a type II receptor, leading to the direct phosphorylation of the SMAD transcription factors. Apart from this canonical pathway, little is known. Interestingly, mutations in this signaling pathway have been identified in two rare cardiovascular diseases, hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension...
March 4, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38437956/resveratrol-alleviates-inflammatory-bowel-disease-by-inhibiting-jak2-stat3-pathway-activity-via-the-reduction-of-o-glcnacylation-of-stat3-in-intestinal-epithelial-cells
#33
JOURNAL ARTICLE
Zhang Yaqin, Wu Kehan, Zhu Yi, Wang Naijian, Qiu Wei, Mao Fei
The role of O-linked N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) in the pathogenesis of inflammatory bowel disease (IBD) has been increasingly highlighted in recent studies. It's been reported that signal transducer and activator of transcription 3 (STAT3) O-GlcNAcylation can affect the activity of the Janus kinase2 (JAK2)/STAT3 pathway.Our recent study showed that resveratrol repairsIBDin mice.On this basis,the present study aimed to explore whether the mechanism of IBD repair by resveratrol is associated with STAT3 O-GlcNAcylation...
March 2, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38435992/use-of-callistemon-citrinus-as-a-gastroprotective-and-anti-inflammatory-agent-on-indomethacin-induced-gastric-ulcers-in-obese-rats
#34
JOURNAL ARTICLE
Jonathan Saúl Piñón-Simental, Luis Alberto Ayala-Ruiz, Luis Gerardo Ortega-Pérez, Oliver Rafid Magaña-Rodríguez, Esperanza Meléndez-Herrera, Asdrubal Aguilera-Méndez, Patricia Rios-Chavez
BACKGROUND: Obesity leads to an elevated risk of developing gastrointestinal disease such as gastric ulcers. Callistemon citrinus leaf extract has shown antioxidant, antimicrobial, hepatoprotective, and chemoprotective effects against colon cancer. The aim of this study is to evaluate the gastroprotective effect of C. citrinus leaf extract on indomethacin-induced gastric ulcers in obese rats. METHODS: Gastric ulcers were induced in female obese Wistar rats using a single oral dose of indomethacin (IND)...
2024: PeerJ
https://read.qxmd.com/read/38430971/design-synthesis-and-molecular-docking-of-novel-d-ring-substituted-steroidal-4-5-dihydropyrazole-thiazole-derivatives-that-act-as-inos-cox-2-inhibitors-with-potent-anti-inflammatory-activity-against-lps-induced-raw264-7-macrophage-cells
#35
JOURNAL ARTICLE
Shuopo Fang, Xiaodan Huang, Fen Cai, Guodong Qiu, Fei Lin, Xiaorui Cai
Inflammation, an important biological protective response to tissue damage or microbial invasion, is considered to be an alarming signal for the progress of varied biological complications. Based on the previous reports in the literature that proved the noticeable efficacy of pyrazole and thiazole scaffold as well as nitrogen heterocyclic based compounds against acute and chronic inflammatory disease, a new set of novel D-ring substituted steroidal 4,5-dihydropyrazole thiazole derivatives were synthesized and evaluated their anti-inflammatory activities in vitro...
February 29, 2024: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/38430788/3-4-methylenedioxymethamphetamine-mdma-impairs-cognitive-function-during-withdrawal-via-activation-of-the-arachidonic-acid-cascade-in-the-hippocampus
#36
JOURNAL ARTICLE
Yoko Nawata, Tsuyoshi Nishioku, Tsuneyuki Yamamoto, Taku Yamaguchi
BACKGROUND: The recreational drug ±3,4-methylenedioxymethamphetamine (MDMA; also known as "ecstasy") has unusual subjective prosocial and empathogenic effects, and has exhibited potential as an adjunct to psychotherapy in recent years. However, there has been some concern regarding possible neuropsychiatric symptoms, such as cognitive impairment and dependence, emerging after abstinence. Therefore, this study aimed to evaluate the mechanism underlying cognitive impairment during MDMA withdrawal...
February 24, 2024: Drug and Alcohol Dependence
https://read.qxmd.com/read/38429312/insight-into-antioxidant-and-anti-inflammatory-effects-of-marine-bacterial-natural-exopolysaccharide-epssm-using-carrageenan-induced-paw-edema-in-rats
#37
JOURNAL ARTICLE
Mohamed E El Awady, Sahar S Mohamed, Mostafa M Abo Elsoud, Manal G Mahmoud, Mai M Anwar, Mahgoub M Ahmed, Ashraf Eltaher, Sameh Magdeldin, Ashraf Attallah, Ali E Elhagry, Sayeda A Abdelhamid
Inflammation is a part of the body's intricate biological reaction to noxious stimuli and defensive reactions. So, the aim of this investigation was to study the anti-inflammatory activity of exopolysaccharide (EPSSM) using carrageenan-induced paw edema in rats. A halophilic bacterial strain was isolated from marine sediments in the Red Sea in Egypt. The isolate has been visually and physiologically recognized, as well as by analyzing its 16S rRNA gene, which confirms Kocuria sp. clone Asker4. This particular isolate can be referenced using the accession number OL798051...
March 1, 2024: Scientific Reports
https://read.qxmd.com/read/38426619/expression-of-ptgs2-along-with-genes-regulating-vegf-signalling-pathway-and-association-with-high-risk-factors-in-locally-advanced-oral-squamous-cell-carcinoma
#38
JOURNAL ARTICLE
Mehta Vedant Kamal, Rama Rao Damerla, Preetiparna Parida, Mahadev Rao, Vijetha Shenoy Belle, Punit Singh Dikhit, Akhil Palod, Rinsha Gireesh, Naveena An Kumar
BACKGROUND: PTGS2 encodes cyclooxygenase-2 (COX-2), which catalyses the committed step in prostaglandin synthesis. Various in vivo and in vitro data suggest that COX-2 mediates the VEGF signalling pathway. In silico analysis performed in TCGA, PanCancer Atlas for head and neck cancers, demonstrated significant expression and co-expression of PTGS2 and genes that regulate VEGF signalling. This study was designed to elucidate the expression pattern of PTGS2 and genes regulating VEGF signalling in patients with locally advanced oral squamous cell carcinoma (OSCC)...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38421984/protective-effects-of-ectoine-on-articular-chondrocytes-and-cartilage-in-rats-for-treating-osteoarthritis
#39
JOURNAL ARTICLE
Peng Li, Yong Huang, Lishuai Miao, Zhiqi Zhu, Zhanjun Shi
Osteoarthritis (OA) is a chronic degenerative disease that primarily includes articular cartilage destruction and inflammatory reactions, and effective treatments for this disease are still lacking. The present study aimed to explore the protective effects of ectoine, a compatible solute found in nature, on chondrocytes in rats and its possible application in OA treatment. In the in vitro studies, the morphology of the chondrocytes after trypsin digestion for 2 min and the viability of the chondrocytes at 50°C were observed after ectoine treatment...
2024: PloS One
https://read.qxmd.com/read/38420770/epoxidase-inhibitor-aspirin-resistance-and-the-relationship-with-genetic-polymorphisms-a-review
#40
REVIEW
Xiaolin Hou
Strokes are the leading cause of death in most regions of the world. Epoxidase inhibitors include the drug aspirin (acetylsalicylic acid). Aspirin is widely used as first-line treatment for the prevention of cardiovascular and cerebrovascular diseases in at-risk patients. However, patients using conventional doses of aspirin can still develop ischaemic cardiovascular and cerebrovascular diseases, a phenomenon known as aspirin resistance. The occurrence of aspirin resistance hinders the prevention and treatment of ischaemic cardiovascular and cerebrovascular diseases...
February 2024: Journal of International Medical Research
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