keyword
https://read.qxmd.com/read/38492181/resveratrol-ameliorates-dss-induced-ulcerative-colitis-by-acting-on-mouse-gut-microbiota
#1
JOURNAL ARTICLE
Bing Yu, Ying Wang, Zekai Tan, Zhengyi Hong, Lewen Yao, Shiyuan Huang, Zexi Li, Lanyue Zhang, Hui Li
OBJECTIVE AND DESIGN: Ulcerative colitis (UC) is a multi-faceted, recurrent immune disorder caused by dextran sulfate sodium (DSS). The intestinal microbiota has multiple functions in the host, so UC requires long-term potent medication. The effect of resveratrol (RSV) has seldom been reported, and this study researched that. Herein, the effect of RSV and Grape seed oil that anti-inflammatory ability in experimental mice was explored, also why RSV altered Gut Microbiota has been researched...
March 16, 2024: Inflammopharmacology
https://read.qxmd.com/read/38490272/cobalt-protoporphyrin-promotes-heme-oxygenase-1-expression-and-ameliorates-cardiac-dysfunction-in-long-term-fasting-mice
#2
JOURNAL ARTICLE
Masayuki Shiba, Takao Kato, Yuta Seko, Eri Minamino-Muta, Yohei Tanada, Takeshi Kimura, Koh Ono
BACKGROUND: The association between malnutrition and cardiac dysfunction has been reported. Heme oxygenase (HO)-1 played protective roles in the animals functioning as a myocardial infarction, heart failure, or cardiomyopathy model. We hypothesized that the administration of HO-1 inducer, cobalt protoporphyrin (CoPP) reduces oxidative stress and ameliorates cardiac systolic dysfunction in long-term fasting mice. METHODS: C57BL/6 J mice were classified into three groups: fed mice (fed group), 48-h fasting mice with a single intraperitoneal injection of the corresponding vehicle (fasting group), and 48-h fasting mice with a single intraperitoneal injection of 5 mg/kg CoPP (CoPP group)...
March 13, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38487174/modification-of-4-4-chlorothiophen-2-yl-thiazol-2-amine-derivatives-for-the-treatment-of-analgesia-and-inflammation-synthesis-and-in-vitro-in-vivo-and-in-silico-studies
#3
JOURNAL ARTICLE
Mater H Mahnashi, Umer Rashid, Hassan Hussain Almasoudi, Mohammed H Nahari, Imran Ahmad, Abdulkarim S Binshaya, Osama Abdulaziz, Meshari A Alsuwat, Muhammad Saeed Jan, Abdul Sadiq
Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives ( 5a - 5g ). Initially, we examined the in vitro anti-inflammatory potentials of our compounds using COX-1, COX-2, and 5-LOX enzyme assays. After in vitro confirmation, the potential compounds were subjected to in vivo analgesic and anti-inflammatory studies...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38486777/modification-of-ibuprofen-to-improve-the-medicinal-effect-structural-biological-and-toxicological-study
#4
JOURNAL ARTICLE
Mst Mahfuza Rahman, Mst Farhana Afrin, Cai Zong, Gaku Ichihara, Yusuke Kimura, Md Anamul Haque, Mir Imam Ibne Wahed
Ibuprofen is classified as a non-steroidal anti-inflammatory drug (NSAID) that is employed as an initial treatment option for its non-steroidal anti-inflammatory, pain-relieving, and antipyretic properties. However, Ibuprofen is linked to specific well-known gastrointestinal adverse effects like ulceration and gastrointestinal bleeding. It has been linked to harmful effects on the liver, kidney, and heart. The purpose of the study is to create novel and potential IBU analogue with reduced side effects with the enhancement of their medicinal effects, so as to advance the overall safety profile of the drug...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38485340/lps-priming-induced-immune-tolerance-mitigates-lps-stimulated-microglial-activation-and-social-avoidance-behaviors-in-mice
#5
JOURNAL ARTICLE
Vichuda Charoensaensuk, Bor-Ren Huang, Sian-Ting Huang, Chingju Lin, Sheng-Yun Xie, Chao-Wei Chen, Yen-Chang Chen, Han-Tsung Cheng, Yu-Shu Liu, Sheng-Wei Lai, Ching-Kai Shen, Hui-Jung Lin, Liang-Yo Yang, Dah-Yuu Lu
In this study, we investigated the regulatory mechanisms underlying the effects of LPS tolerance on the inflammatory homeostasis of immune cells. LPS priming-induced immune tolerance downregulated cyclooxygenase-2, and lowered the production of prostaglandin-E2 in microglial cells. In addition, LPS tolerance downregulated the expression of suppressor of cytokine signaling 3, and inducible nitric oxide synthase/nitric oxide; suppressed the LPS-mediated induction of tumor necrosis factor-α, interleukin (IL)-6, and IL-1; and reduced reactive oxygen species production in microglial cells...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38480622/a-comprehensive-review-on-potential-drug-drug-interactions-of-proton-pump-inhibitors-with-antidiabetic-drugs-metformin-and-dpp-4-inhibitors
#6
REVIEW
Jarin Tasnim, Najihah Mohd Hashim, Heh Choon Han
A drug interaction is a condition in which two or more drugs are taken at the same time. Type 2 diabetes mellitus is a significant contributor to polypharmacy. Proton pump inhibitors (PPIs) are often prescribed in combination with metformin or DPP-4 inhibitors (sitagliptin, saxagliptin, linagliptin, and alogliptin) or a combined dose of metformin and DPP-4 inhibitor to treat gastritis in diabetic patients. This review article mainly focused on evaluating the potential drug-drug interactions (DDIs) between PPIs (i...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38478882/development-of-cytotoxic-gw7604-zeise-s-salt-conjugates-as-multitarget-compounds-with-selectivity-for-estrogen-receptor-positive-tumor-cells
#7
JOURNAL ARTICLE
Patricia Grabher, Paul Kapitza, Nikolas Hörmann, Amelie Scherfler, Martin Hermann, Michael Zwerger, Hristo P Varbanov, Brigitte Kircher, Daniel Baecker, Ronald Gust
( E/Z )-3-(4-(( E )-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylic acid ( GW7604 ) as a carrier was esterified with alkenols of various lengths and coordinated through the ethylene moiety to PtCl3 , similar to Zeise's salt (K[PtCl3 (C2 H4 )]). The resulting GW7604-Alk-PtCl 3 complexes (Alk = Prop, But, Pent, Hex) degraded in aqueous solution only by exchange of the chlorido ligands. For example, GW7604-Pent-PtCl 3 coordinated the amino acid alanine in the cell culture medium, bound the isolated nucleotide 5'-GMP, and interacted with the DNA (empty plasmid pSport1)...
March 13, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38476652/anti-ulcerative-colitis-effects-of-chemically-characterized-extracts-from-c-alliandra-haematocephala-in-acetic-acid-induced-ulcerative-colitis
#8
JOURNAL ARTICLE
Inaam Ur Rehman, Mohammad Saleem, Syed Atif Raza, Saher Bashir, Taha Muhammad, Shahzad Asghar, Muhammad Usman Qamar, Tawaf Ali Shah, Yousef A Bin Jardan, Amare Bitew Mekonnen, Mohammed Bourhia
Background: Ulcerative colitis is a chronic immune-mediated inflammatory bowel disease that involves inflammation and ulcers of the colon and rectum. To date, no definite cure for this disease is available. Objective: The objective of the current study was to assess the effect of Calliandra haematocephala on inflammatory mediators and oxidative stress markers for the exploration of its anti-ulcerative colitis activity in rat models of acetic acid-induced ulcerative colitis. Methods: Methanolic and n-hexane extracts of areal parts of the plant were prepared by cold extraction method...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38474420/nicotinamide-riboside-augments-human-macrophage-migration-via-sirt3-mediated-prostaglandin-e2-signaling
#9
JOURNAL ARTICLE
Jing Wu, Maximilian Bley, Russell S Steans, Allison M Meadows, Rebecca D Huffstutler, Rong Tian, Julian L Griffin, Michael N Sack
NAD+ boosting via nicotinamide riboside (NR) confers anti-inflammatory effects. However, its underlying mechanisms and therapeutic potential remain incompletely defined. Here, we showed that NR increased the expression of CC-chemokine receptor 7 (CCR7) in human M1 macrophages by flow cytometric analysis of cell surface receptors. Consequently, chemokine ligand 19 (CCL19, ligand for CCR7)-induced macrophage migration was enhanced following NR administration. Metabolomics analysis revealed that prostaglandin E2 (PGE2) was increased by NR in human monocytes and in human serum following in vivo NR supplementation...
March 5, 2024: Cells
https://read.qxmd.com/read/38474052/is-there-a-link-between-the-molecular-basis-of-juvenile-idiopathic-arthritis-and-autoimmune-diseases-systematic-review
#10
REVIEW
Ignacio Ventura, Gemma Clara Meira-Blanco, María Ester Legidos-García, Marcelino Pérez-Bermejo, María Teresa Murillo-Llorente
UNLABELLED: Juvenile Idiopathic Arthritis (JIA) is currently the most common chronic rheumatic disease in children. It is known to have no single identity, but a variety of diagnoses. Under-diagnosis is a barrier to early treatment and reduced complications of the disease. Other immune-mediated diseases may coexist in the same patient, making research in this area relevant. The main objective was to analyse whether links could be established between the molecular basis of JIA and other immune-mediated diseases...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472560/pebp4-deficiency-aggravates-lps-induced-acute-lung-injury-and-alveolar-fluid-clearance-impairment-via-modulating-pi3k-akt-signaling-pathway
#11
JOURNAL ARTICLE
Qiao-Qing Shi, Yong-Hong Huang, Yu-Fei Li, Shuang-Yan Zhen, Yan-Hong Li, Jia-Yi Huang, Jia-Yang Wang, Xiao-Yan Zhou
Acute lung injury (ALI) is a common clinical syndrome, which often results in pulmonary edema and respiratory distress. It has been recently reported that phosphatidylethanolamine binding protein 4 (PEBP4), a basic cytoplasmic protein, has anti-inflammatory and hepatoprotective effects, but its relationship with ALI remains undefined so far. In this study, we generated PEBP4 knockout (KO) mice to investigate the potential function of PEBP4, as well as to evaluate the capacity of alveolar fluid clearance (AFC) and the activity of phosphatidylinositide 3-kinases (PI3K)/serine-theronine protein kinase B (PKB, also known as AKT) signaling pathway in lipopolysaccharide (LPS)-induced ALI mice models...
March 13, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38468376/renoprotective-effect-of-hyperin-against-cdcl-2-prompted-renal-damage-by-activation-of-nrf-2-keap-1-are-pathway-in-male-mice
#12
JOURNAL ARTICLE
O Lucky Iserhienrhien, I Iyoha Aisuhuehien, Memudu A Adejoke
Objectives: This study explored the mitigating properties of hyperin on renotoxicity induced by cadmium chloride (CdCl2 ). Methods: Four groups of seven male albino mice each were used in this experiment. Group 1 served as the control, receiving no treatment. Group 2 received daily oral gavage of cadmium chloride (CdCl2 ) at 0.3 mg/kg body weight for 28 days. Group 3 received both CdCl2 (0.3 mg/kg) and hyperin (100 mg/kg) daily using the same administration method. Finally, Group 4 received only hyperin (100 mg/kg) daily...
March 11, 2024: Toxicology Mechanisms and Methods
https://read.qxmd.com/read/38464781/gut-microbiome-based-thiamine-metabolism-contributes-to-the-protective-effect-of-one-acidic-polysaccharide-from-selaginella-uncinata-desv-spring-against-inflammatory-bowel-disease
#13
JOURNAL ARTICLE
Haochen Hui, Zhuoya Wang, Xuerong Zhao, Lina Xu, Lianhong Yin, Feifei Wang, Liping Qu, Jinyong Peng
Inflammatory bowel disease (IBD) is a serious disorder, and exploration of active compounds to treat it is necessary. An acidic polysaccharide named SUSP-4 was purified from Selaginella uncinata (Desv.) Spring, which contained galacturonic acid, galactose, xylose, arabinose, and rhamnose with the main chain structure of →4)-α-d-GalAp-(1→ and →6)-β-d-Galp-(1→ and the branched structure of →5)-α-l-Araf-(1→ . Animal experiments showed that compared with Model group, SUSP-4 significantly improved body weight status, disease activity index (DAI), colonic shortening, and histopathological damage, and elevated occludin and zonula occludens protein 1 (ZO-1) expression in mice induced by dextran sulfate sodium salt (DSS)...
February 2024: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/38463391/a-phase-1-trial-of-human-telomerase-reverse-transcriptase-htert-vaccination-combined-with-therapeutic-strategies-to-control-immune-suppressor-mechanisms
#14
JOURNAL ARTICLE
Nahid Zareian, Oleg Eremin, Hardev Pandha, Richard Baird, Vineet Kwatra, Gabriel Funingana, Chandan Verma, Desmond Choy, Steven Hargreaves, Pejvak Moghimi, Adrian Shepherd, Dileep N Lobo, Jennifer Eremin, Farzin Farzaneh, Shahram Kordasti, James Spicer
The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) peptides with concomitant therapies targeting regulatory T cells (Tregs) and cyclooxygenase-2 (COX2)-mediated immunosuppression. This Phase 1 trial combined an hTERT-derived 7-peptide library, selected to ensure presentation by both HLA class-I and class-II in 90% of patients, with oral low-dose cyclophosphamide (to modulate Tregs) and the COX2 inhibitor celecoxib...
2024: Experimental Biology and Medicine
https://read.qxmd.com/read/38462044/engineered-nanomicelles-inhibit-the-tumour-progression-via-abrogating-the-prostaglandin-mediated-immunosuppression
#15
JOURNAL ARTICLE
Poonam Yadav, Kajal Rana, Viviani Nardini, Ali Khan, Trishna Pani, Animesh Kar, Dolly Jain, Ruchira Chakraborty, Ragini Singh, Somesh K Jha, Devashish Mehta, Harsh Sharma, Ravi Datta Sharma, S V S Deo, Sagar Sengupta, Veena S Patil, Lúcia Helena Faccioli, Ujjaini Dasgupta, Avinash Bajaj
Cancer treatment is challenged due to immunosuppressive inflammatory tumour microenvironment (TME) caused by infiltration of tumour-promoting and inhibition of tumour-inhibiting immune cells. Here, we report the engineering of chimeric nanomicelles (NMs) targeting the cell proliferation using docetaxel (DTX) and inflammation using dexamethasone (DEX) that alters the immunosuppressive TME. We show that a combination of phospholipid-DTX conjugate and PEGylated-lipid-DEX conjugate can self-assemble to form sub-100 nm chimeric NMs (DTX-DEX NMs)...
March 8, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38460574/chemometric-profiling-and-anti-arthritic-activity-of-aerial-parts-of-glinus-oppositifolius-l-aug-dc
#16
JOURNAL ARTICLE
Chandan Das, Goutam Ghosh, Goutam Rath, Debajyoti Das, Biswakanth Kar, Deepak Pradhan, Vineet Kumar Rai, Tushar Kanti Rajwar, Jitu Halder, Priyanka Dash
ETHNOPHARMACOLOGICAL RELEVANCE: Glinus oppositifolius (L.) Aug. DC. belongs to the family Molluginaceae, an annual prostrate herb traditionally used to treat inflammations, arthritis, malarial, wounds, fevers, diarrhoea, cancer, stomach discomfort, jaundice, and intestinal parasites. However, the anti-arthritic activity of the aerial part has still not been reported. AIM OF THE STUDY: To investigate the antioxidant and anti-arthritic activity of G. oppositifolius in Complete Freund's Adjuvant (CFA) induced rats...
March 7, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38459935/a-network-pharmacological-approach-for-the-identification-of-potential-therapeutic-targets-of-brahmi-nei-a-complex-traditional-siddha-formulation
#17
JOURNAL ARTICLE
Agnes Preethy H, Yanamandram Balasubramanian Venkatakrishnan, Vigneshwar Ramakrishnan, Uma Maheswari Krishnan
Brahmi Nei (BN), a traditional Indian polyherbal formulation has been described in classical texts for the treatment of anxiety and depression, as well as to fortify the immune system. The individual herbs of BN have been used for treatment of wide range of disorders including cognition, inflammation, skin ailments and cancer etc., This diverse basket of therapeutic activity suggests that BN may possess therapeutic benefits to other disorders. So, the present study aims to identify the potential therapeutic targets of BN using a network pharmacological approach to comprehend the multi target action of its multiple phytoconstituents...
March 9, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38455216/unveiling-the-pharmacological-potential-of-coelogyne-suaveolens-an-investigation-of-its-diverse-pharmacological-activities-by-in%C3%A2-vivo-and-computational-studies
#18
JOURNAL ARTICLE
Taslima Akter Eva, Husnum Mamurat, Md Habibul Hasan Rahat, S M Moazzem Hossen
The medicinal potential of Coelogyne suaveolens , a traditional medicinal plant, was investigated through in vivo and molecular docking studies. The ethyl acetate fraction of the plant's acetonic extract was subjected to various bioactivity tests to assess its analgesic, anxiolytic, and sedative effects on Swiss albino mice. Furthermore, we used GCMS to identify the bioactive chemicals in the extract's ethyl acetate fraction. The root and bulb extracts demonstrated significant analgesic activity in acetic acid-induced writhing, hot plate, and tail immersion tests in a dose-dependent manner when compared to the control...
March 2024: Food Science & Nutrition
https://read.qxmd.com/read/38454146/synthetic-polyploidization-induces-enhanced-phytochemical-profile-and-biological-activities-in-thymus-vulgaris-l-essential-oil
#19
JOURNAL ARTICLE
Neha Gupta, Soham Bhattacharya, Adrish Dutta, Jan Tauchen, Přemysl Landa, Klára Urbanová, Markéta Houdková, Eloy Fernández-Cusimamani, Olga Leuner
Essential oil from Thymus vulgaris L. has valuable therapeutic potential that is highly desired in pharmaceutical, food, and cosmetic industries. Considering these advantages and the rising market demand, induced polyploids were obtained using oryzalin to enhance essential oil yield. However, their therapeutic values were unexplored. So, this study aims to assess the phytochemical content, and antimicrobial, antioxidant, and anti-inflammatory activities of tetraploid and diploid thyme essential oils. Induced tetraploids had 41...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38453637/endoplasmic-reticulum-stress-induced-nlrp3-inflammasome-activation-as-a-novel-mechanism-of-polystyrene-microplastics-ps-mps-induced-pulmonary-inflammation-in-chickens
#20
JOURNAL ARTICLE
Hongmin Lu, Tiantian Guo, Yue Zhang, Dewang Liu, Lulu Hou, Chengxue Ma, Mingwei Xing
Microplastics (MPs) have attracted growing attention worldwide as an increasingly prevalent environmental pollutant. In addition, chicken meat is currently the most widely consumed kind of poultry in the global market. Consumer demand for chicken is on the rise both at home and abroad. As a result, the safety of chicken raising has also received significant attention. The lungs play an essential role in the physiological activities of chickens, and they are also the most vulnerable organs. Lung injury is difficult to repair after the accumulation of contaminants, and the mortality rate is high, which brings huge economic losses to farmers...
March 15, 2024: Journal of Zhejiang University. Science. B
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