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Shikai Deng, Songwei Che, Rousan Debbarma, Vikas Berry
Since 2D transition metal dichalcogenides (TMDs) exhibit strain-tunable bandgaps, locally confining strain can allow lateral manipulation of their band structure, in-plane carrier transport and optical transitions. Herein, we show that a single wrinkle (width = 10 nm-10 μm) on an MoS2 flake can induce confined uniaxial strain to reduce the local bandgap (40-60 meV per % deformation), producing a microscopic exciton funnel with an enhancement in photocurrent over flat MoS2 devices. This study also shows that wrinkles can spatially reconfigure the distribution of dopants and enhance the light absorption in the MoS2 layer via Fabry-Perot interference in its nanocavity...
December 13, 2018: Nanoscale
Panmela Soares, Suellen Secchi Martinelli, Rafaela Karen Fabri, Marcela Boro Veiros, Mari Carmen Davó-Blanes, Suzi Barletto Cavalli
This study aimed to analyze the financial investment used for the procurement of food for the Brazilian National School Food Program (PNAE) in a city in the South of Brazil. The bidding process, the public calls and accountability reports of the PNAE were analyzed in the following variables: I) municipal financial complementation values; II) percentage of resources used to purchase foods from Family Farmer (FF), and Recommended, Restricted, Prohibited and others foods. The comparison of proportions was employed as a test to identify differences between investments...
December 2018: Ciência & Saúde Coletiva
Leandro José de Assis, Adriana Manfiolli, Eliciane Mattos, João H T Marilhano Fabri, Iran Malavazi, Ilse D Jacobsen, Matthias Brock, Robert A Cramer, Arsa Thammahong, Daisuke Hagiwara, Laure Nicolas Annick Ries, Gustavo Henrique Goldman
Aspergillus fumigatus mitogen-activated protein kinases (MAPKs) are involved in maintaining the normal morphology of the cell wall and providing resistance against cell wall-damaging agents. Upon cell wall stress, cell wall-related sugars need to be synthesized from carbohydrate storage compounds. Here we show that this process is dependent on cAMP-dependent protein kinase A (PKA) activity and regulated by the high-osmolarity glycerol response (HOG) MAPKs SakA and MpkC. These protein kinases are necessary for normal accumulation/degradation of trehalose and glycogen, and the lack of these genes reduces glucose uptake and glycogen synthesis...
December 11, 2018: MBio
Christoffer V Madsen, Henrik Granqvist, Jørgen H Petersen, Åse K Rasmussen, Allan M Lund, Peter Oturai, Søren S Sørensen, Ulla Feldt-Rasmussen
Background: Nephropathy is common in Fabry disease (FD). Prior studies of renal function during enzyme replacement therapy (ERT) have primarily used estimated glomerular filtration rate (eGFR). We studied the attrition of renal function in FD by measured GFR (mGFR) and urine protein excretion, and explored the influence of age. Methods: This was a long-term observational study of a nationwide, family-screened cohort of FD patients. All Danish genetically verified FD patients on ERT, without end-stage renal disease at baseline and with three or more mGFR values were included...
December 10, 2018: Nephrology, Dialysis, Transplantation
Jitupam Baishya, Praveen Kesav, Sheela Nampoothiri, Sapna Erat Sreedharan, P N Sylaja
No abstract text is available yet for this article.
October 2018: Annals of Indian Academy of Neurology
Kiyean Kim, Chung Il Park, Hyuk Lee, Yoon Young Kim
In spite of the extensive studies of zero-index metamaterials, the realization of zero impedance with finite phase velocity has not been explored. Here, we show that this extreme case, realized by elaborately-tuned paired resonators, can effectively enhance sensing and actuation. To explain the formation mechanism of the near-zero effective impedance with finite phase velocity by paired resonators at a target frequency, a theory using an equivalent model based on mechanical longitudinal waves is developed. If the frequency of the extreme property is further tuned at a Fabry-Pérot resonance frequency, highly efficient enhancement is possible...
December 10, 2018: Nature Communications
Priyanka Dey, Nuria Fabri-Faja, Olalla Calvo-Lozano, Roland Terborg, Alexander Belushkin, Filiz Yesilköy, Anna Fàbrega, Juan Carlos Ruiz-Rodriguez, Ricard Ferrer, Juan José González-López, Maria Carmen Estévez, Hatice Altug, Valerio Pruneri, Laura M Lechuga
Existing clinical methods for bacteria detection lack in speed, sensitivity and importantly in Point-of-Care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Aiming that, we here report a portable PoC device based on Lens-free Interferometric Microscopy (LIM). The device employs high performance nanoplasmonics and custom bioprinted microarrays and is capable of direct label-free bacteria (E. coli) quantification. With only one-step sample handling we offer a sampletodata turnaround time of 40 minutes...
December 7, 2018: ACS Sensors
I-Lin Ho, Watson Kuo
Electromagnetic waves propagating in open Cooper-Pair Boxes (CPBs) system is studied by using Maxwell-Bloch equations and Lindblad master equation. The results demonstrate an ensemble of CPBs as highly non-linear meta-material for electromagnetic waves. Incorporating the CPBs in a ring resonator or a Fabry-Perot cavity, one finds that: (1) With weak environmental couplings and CPBs in superconducting phase dominant regime, the non-linearity is enhanced and the system exhibits regular optical hysteresis. (2) With finite environmental couplings and CPBs in charge dominant regime, the Josephson effect and environmental effect can constructively interplay to produce a gain...
November 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Dibya Kanti Mukherjee, Sumathi Rao, Sourin Das
We show that the electrical transport across a minimal model for a time-reversal symmetry(TRS) breaking Weyl semi-metal (WSM) involving two Weyl nodes can be interpreted as an interferometer in momentum space. The interference phase depends on the distance between the Weyl nodes ($\vec{\delta k}$) and is
 {\it anisotropic}. It is further shown that a minimal inversion symmetry broken model for a WSM with four Weyl nodes effectively mimics a situation corresponding to having two copies of the interferometer due to the presence of an orbital pseudo-spin domain wall in momentum space...
November 14, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Jáder Buzati Rebelato, Caroline Ferreira da Silva Mazeto Pupo da Silveira, Tainá Fabri Carneiro Valadão, Fabrício Moreira Reis, Rodrigo Bazan, Silméia Garcia Zanati Bazan
No abstract text is available yet for this article.
December 2018: Arquivos Brasileiros de Cardiologia
Lucy A Eddowes, Kinda Al-Hourani, Narayan Ramamurthy, Jamie Frankish, Hannah T Baddock, Cynthia Sandor, John D Ryan, Dahlene N Fusco, João Arezes, Eleni Giannoulatou, Sara Boninsegna, Stephane Chevaliez, Benjamin M J Owens, Chia Chi Sun, Paolo Fabris, Maria Teresa Giordani, Diego Martines, Slobodan Vukicevic, John Crowe, Herbert Y Lin, Jan Rehwinkel, Peter J McHugh, Marco Binder, Jodie L Babitt, Raymond T Chung, Matthew W Lawless, Andrew E Armitage, Caleb Webber, Paul Klenerman, Hal Drakesmith
Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling. We found that HCV infection and the BMP/SMAD pathway are mutually antagonistic. HCV blunted induction of hepcidin expression by BMP6, probably via tumour necrosis factor (TNF)-mediated downregulation of the BMP co-receptor haemojuvelin. In HCV-infected patients, disruption of the BMP6/hepcidin axis and genetic variation associated with the BMP/SMAD pathway predicted the outcome of infection, suggesting that BMP/SMAD activity influences antiviral immunity...
December 3, 2018: Nature Microbiology
David John Werring, Aine Merwick, Indran Davagnanam, Po Phyu, Fay Bolsover, Fatima Jichi, Claudia Wheeler-Kingshott, Xavier Golay, Derralynn Hughes, Lisa Cipolotti, Elaine Murphy, Robin H Lachmann
No abstract text is available yet for this article.
December 4, 2018: Neurology
Sirio Cocozza, Mario Quarantelli
No abstract text is available yet for this article.
December 4, 2018: Neurology
Ariane Lewis, Steven Galetta
No abstract text is available yet for this article.
December 4, 2018: Neurology
Jonas Müntze, Daniel Gensler, Octavian Maniuc, Dan Liu, Tereza Cairns, Daniel Oder, Kai Hu, Kristina Lorenz, Stefan Frantz, Christoph Wanner, Peter Nordbeck
Long-term effects of migalastat therapy in clinical practice are currently unknown. We evaluated migalastat efficacy and biomarker changes in a prospective, single-center study on 14 patients with Fabry disease (55±14 years, 11 male). After one year of open-label migalastat therapy, patients showed significant changes in alpha-galactosidase-A activity (0.06 to 0.2 nmol/min/mg protein;p=0.001), left ventricular myocardial mass index (137 to 130 g/m²;p=0.037), and serum creatinine (0.94 to 1.0 mg/dL;p=0.021), accounting for deterioration in estimated glomerular filtration rate (87 to 78 mL/min/1...
December 3, 2018: Clinical Pharmacology and Therapeutics
Tzu Lin Huang, Shu Ching Li, Chia Han Tsou, Hsing Chih Liang, K F Huang, Yung Fu Chen
A novel scheme to realize a mode-locked laser with a narrow spectral linewidth is demonstrated by exploiting a reflected Fabry-Perot (FP) cavity to introduce an intense FP effect. Stable continuous-wave mode-locked operation is achieved with the repetition rate of 48 MHz and the maximum average output power of 2.6 W under an incident pump power of 11.9 W. The mode-locked pulse width is systematically investigated by varying the optical thickness of the reflected FP cavity. The pulse duration is experimentally found to be in a range of 0...
December 1, 2018: Optics Letters
Supannee Learkthanakhachon, Suejit Pechprasarn, Michael G Somekh
A lateral shearing interferometric technique combined with an 11.6 μm polydimethylsiloxane (PDMS) transparent thin film is proposed and demonstrated for optical detection of ultrasound. We experimentally report the device change of reflectivity with pressure of 5.1×10-7   Pa-1 , 9.5 times more sensitive than the critical-angle-based sensor, 31 times more sensitive than the surface-plasmon-based sensor, and comparable to the Fabry-Perot sensor. The objective-lens-based angle scanning characterization setup inspired from a laser scanning system allows direct comparison between the PDMS sensor and critical-angle-based sensor by adjusting the incident angle with a scanning mirror, thereby eliminating optical and electronics system dependence...
December 1, 2018: Optics Letters
Chiara Cimmaruta, Valentina Citro, Giuseppina Andreotti, Ludovica Liguori, Maria Vittoria Cubellis, Bruno Hay Mele
BACKGROUND: Severity gradation of missense mutations is a big challenge for exome annotation. Predictors of deleteriousness that are most frequently used to filter variants found by next generation sequencing, produce qualitative predictions, but also numerical scores. It has never been tested if these scores correlate with disease severity. RESULTS: wANNOVAR, a popular tool that can generate several different types of deleteriousness-prediction scores, was tested on Fabry disease...
November 30, 2018: BMC Bioinformatics
Mehmet Akgul, Alper Ozgurluk, Clark T-C Nguyen
This part II of a two-paper sequence presents fabri-cation and measurement results for a micromechanical disk-based RF channel-select filter designed using the theory and procedure of Part I. Successful demonstration of an actual filter required sev-eral practical additions to an ideal design, including the introduc-tion of a 39nm-gap capacitive transducer, voltage-controlled fre-quency tuning electrodes, and a stress relieving coupled array de-sign, all of which combine to enable a 0.1%-bandwidth 223.4-MHz channel-select filter with only 2...
November 26, 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Robert Pola, Vlastimil Král, Sergey K Filippov, Leonid Kaberov, Tomáš Etrych, Irena Sieglova, Juraj Sedlacek, Milan Fábry, Michal Pechar
A water-soluble polymer cancerostatic actively targeted against cancer cells expressing a disialoganglioside antigen GD2 was designed, synthesized and characterized. A polymer conjugate of an anti-tumor drug doxorubicin with a N-(2-hydroxypropyl)methacrylamide-based copolymer was specifically targeted against GD2 antigen-positive tumor cells using a recombinant single chain fragment (scFv) of an anti-GD2 monoclonal antibody. The targeting protein ligand was attached to the polymer-drug conjugate either via a covalent bond between the amino groups of the protein using a traditional non-specific aminolytic reaction with a reactive polymer precursor or via a non-covalent but highly specific interaction between bungarotoxin covalently linked to the polymer and the recombinant scFv modified with a C-terminal bungarotoxin-binding peptide...
November 28, 2018: Biomacromolecules
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