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https://www.readbyqxmd.com/read/29453409/a-potential-prognostic-long-noncoding-rna-signature-to-predict-recurrence-among-er-positive-breast-cancer-patients-treated-with-tamoxifen
#1
Kang Wang, Jie Li, Yong-Fu Xiong, Zhen Zeng, Xiang Zhang, Hong-Yuan Li
Limited predictable long noncoding RNA (lncRNA) signature was reported in tamoxifen resistance among estrogen receptor (ER)-positive breast cancer (BC) patients. The aim of this study was to identify and assess prognostic lncRNA signature to predict recurrence among ER-positive BC patients treated with tamoxifen. Cohorts from Gene Expression Omnibus (GEO) (n = 298) and The Cancer Genome Atlas (TCGA) (n = 160) were defined as training and validation cohort, respectively. BC relapse associated lnRNAs was identify within training cohort, and the predictable value of recurrence was assessed in both cohorts...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453046/molecular-chemoprevention-by-morin-a-plant-flavonoid-that-targets-nuclear-factor-kappa-b-in-experimental-colon-cancer
#2
Sharada H Sharma, Jayasurya Suresh Kumar, David Raj Chellappan, Sangeetha Nagarajan
Colorectal cancer is the third most common cancer worldwide. The development of effective, inexpensive and safe chemopreventive agents would be of great benefit as it involves use of natural products to prevent or suppress the progression of precursor lesions. Morin a flavonoid found in figs (Ficus carica) and other plants is shown to inhibit 1,2-dimethylhydrazine (DMH) induced colon cancer progression in a short term and long term model of colon cancer rats; however, the molecular target for the colon cancer chemoprotective efficacy of morin is yet to be discovered...
February 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29451015/chemical-constituents-from-the-rhizomes-of-polygonatum-sibiricum-red-and-anti-inflammatory-activity-in-raw264-7-macrophage-cells
#3
Huan Zhao, Qiao-Lian Wang, Shu-Bing Hou, Guang Chen
Chemical investigation of the rhizomes of Polygonatum sibiricum Red. led to the identification of 27 constituents. Among them, a total of 16 compounds were obtained from Polygonatum for the first time, in which, 3 and 4 were also firstly isolated as natural products. Anti-inflammatory activity studies on 13 isolated compounds showed that β-carboline constituents, especially compounds 1 and 2, significantly inhibited the expression of NO, TNF-α, IL-6 and IL-1β in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells...
February 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29448206/regulation-of-jak2-stat3-and-nf-%C3%AE%C2%BAb-signal-transduction-pathways-veronica-polita-alleviates-dextran-sulfate-sodium-induced-murine-colitis
#4
Md Rashedunnabi Akanda, Hyeon-Hwa Nam, Weishun Tian, Anowarul Islam, Byung-Kil Choo, Byung-Yong Park
Ulcerative colitis (UC) is a major inflammatory bowel disease (IBD) has become a worldwide emergent disease. Veronica polita (VP) is a medicinal herb that has strong antioxidant and anti-inflammatory properties. In the present study, we studied the protective effect of VP on dextran sulfate sodium (DSS)-induced experimental colitis in mice. Phytochemical screening of VP extract demonstrated the presence of high total phenolic and flavonoid contents. Compared with the DSS group, VP significantly reduced clinical symptoms with less weight loss, bloody stool, shortening of the colon, and the severity of colitis was considerably inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in the colon and spleen...
February 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29445914/interaction-between-dietary-acrylamide-intake-and-genetic-variants-for-estrogen-receptor-positive-breast-cancer-risk
#5
Janneke G F Hogervorst, Piet A van den Brandt, Roger W L Godschalk, Frederik-Jan van Schooten, Leo J Schouten
PURPOSE: The association between dietary acrylamide intake and estrogen receptor-positive (ER+) breast cancer risk in epidemiological studies is inconsistent. By analyzing gene-acrylamide interactions for ER+ breast cancer risk, we aimed to clarify the role of acrylamide intake in ER+ breast cancer etiology. METHODS: The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline, a random subcohort of 2589 women was sampled from the total cohort for a case-cohort analysis approach...
February 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29442025/sinomenine-inhibits-the-inflammatory-responses-of-human-fibroblast-like-synoviocytes-via-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway-in-rheumatoid-arthritis
#6
Ru-Bing Yao, Zhi-Ming Zhao, Ling-Jie Zhao, Hui Cai
Rheumatoid arthritis (RA) is a systemic autoimmune disorder mainly characterized by inflammation of the synovial tissue that can lead to destruction of bone and cartilage. Sinomenine is an alkaloid extracted from the stem of the Chinese medicinal plant Sinomenium acutum. It has been reported that sinomenine has immunosuppressive and anti-inflammatory properties. However, the molecular mechanism underlying the effect of sinominine on IL-1β-induced human RA fibroblast-like synoviocytes (RAFLS) is poorly understood...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441228/a-gene-expression-based-risk-model-reveals-prognosis-of-gastric-cancer
#7
Xiaorong Deng, Qun Xiao, Feng Liu, Cihua Zheng
Background: The prognosis of gastric cancer is difficult to determine, although clinical indicators provide valuable evidence. Methods: In this study, using screened biomarkers of gastric cancer in combination with random forest variable hunting and multivariable Cox regression, a risk score model was developed to predict the survival of gastric cancer. Survival difference between high/low-risk groups were compared. The relationship between risk score and other clinicopathological indicators was evaluated...
2018: PeerJ
https://www.readbyqxmd.com/read/29440293/a-correlative-analysis-of-pd-l1-pd-1-pd-l2-egfr-her2-and-her3-expression-in-oropharyngeal-squamous-cell-carcinoma
#8
Conor E Steuer, Christopher C Griffith, Sreenivas Nannapaneni, Mihir R Patel, Yuan Liu, Kelly R Magliocca, Mark W El-Deiry, Cynthia Cohen, Taofeek K Owonikoko, Dong M Shin, Zhuo Georgia Chen, Nabil F Saba
We explored potential associations of the PD-1/PD-L1/PD-L2 pathway with clinical characteristics, outcome, and expression of EGFR, HER2, HER3 in oropharyngeal squamous cell carcinoma (OPSCC) using an institutional database. Protein expression was assessed by immunohistochemistry on tissue microarray sections (EGFR, HER2, HER3) or whole tissue sections (PD-1/PD-L1/PD-L2). Expression of EGFR, HER2, HER3, PD-L1, and PD-L2 was quantified on tumor cells. Maximum density of PD-1 positive lymphocytes was measured on a scale of 0-4 within the tumor mass and peritumoral stroma...
February 13, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29439255/co-upregulation-of-14-3-3%C3%AE-and-p-akt-is-associated-with-oncogenesis-and-recurrence-of-hepatocellular-carcinoma
#9
Yufu Tang, Ruoyu Wang, Yibing Zhang, Shenhui Lin, Na Qiao, Zhongyi Sun, Shuqun Cheng, Wenping Zhou
BACKGROUND/AIMS: 14-3-3ζ is involved in the regulation of PI3K/Akt pathway which is closely associated with carcinogenesis. However, the clinical significance of combined detection of 14-3-3ζ and p-Akt in hepatocellular carcinoma (HCC) remains unclear. METHODS: Two-hundred pairs of HCC and adjacent liver specimens were subjected to tissue microarray. The association of 14-3-3ζ and p-Akt levels with the postoperative survival and recurrence in HCC patients was analyzed with univariate and multivariate methods...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29438996/global-identification-of-sumo-substrates-reveals-crosstalk-between-sumoylation-and-phosphorylation-promotes-cell-migration
#10
Ijeoma Uzoma, Jianfei Hu, Eric Cox, Shuli Xia, Jianying Zhou, Hee-Sool Rho, Catherine Guzzo, Corry Paul, Olutobi Ajala, C Rory Goodwin, Junseop Jeong, Cedric Moore, Hui Zhang, Pamela Meluh, Seth Blackshaw, Michael Matunis, Jiang Qian, Heng Zhu
Proteomics studies have revealed that SUMOylation is widely used posttranslational modification (PTM) in eukaryotes. However, how SUMO E1/2/3 complexes use different SUMO isoforms and recognize substrates remains largely unknown.  Using a human proteome microarray-based activity screen, we identified over 2,500 proteins that undergo SUMO E3-dependent SUMOylation.  We next constructed a SUMO isoform- and E3 ligase-dependent enzyme-substrate relationship network. Protein kinases were significantly enriched among SUMOylation substrates, suggesting crosstalk between tyrosine phosphorylation and SUMOylation...
February 8, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29438491/new-insights-on-a-ngf-mediated-pathway-to-induce-ovulation-in-rabbits-oryctolagus-cuniculus
#11
Margherita Maranesi, Linda Petrucci, Leonardo Leonardi, Federica Piro, Pilar García Rebollar, Pilar Millán, Paolo Cocci, Cecilia Vullo, Francesco Parillo, Arlindo Moura, Gabriela Gonzalez Mariscal, Cristiano Boiti, Massimo Zerani
To investigate the ovulatory mechanisms triggered by raw semen in rabbits, we examined the expression of nerve growth factor (NGF)-a supposed ovulation-inducing factor (OIF)-and cognate receptors in anterior pituitary, ovary, and cervix as well as plasma NGF and LH concentrations. Six does/group were: sham-inseminated with sterile saline (PBS), naturally mated (NM), inseminated with raw semen alone (RS) or after lumbar anesthesia (ARS) or treatment with COX inhibitors (CIRS). Immunohistochemistry revealed positive signals for NGF and receptors in all tissues...
February 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29438162/serum-glucose-and-insulin-and-risk-of-cancers-of-the-breast-endometrium-and-ovary-in-postmenopausal-women
#12
Geoffrey C Kabat, Mimi Y Kim, Dorothy S Lane, Oleg Zaslavsky, Gloria Y F Ho, Juhua Luo, Wanda K Nicholson, Rowan T Chlebowski, Wendy E Barrington, Mara Z Vitolins, Xiaochen Lin, Simin Liu, Thomas E Rohan
Limited evidence suggests that hyperinsulinemia may contribute to the risk of breast, endometrial, and, possibly, ovarian cancer. The aim of this study was to assess the association of serum glucose and insulin with risk of these cancers in postmenopausal women, while taking into account potential confounding and modifying factors. We studied 21 103 women with fasting baseline insulin and glucose measurements in a subsample of the Women's Health Initiative. The subsample was composed of four studies within Women's Health Initiative with different selection and sampling strategies...
February 12, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29437866/how-to-use-sequence-analysis-for-life-course-epidemiology-an-example-on-hiv-positive-sub-saharan-migrants-in-france
#13
Anne Gosselin, Annabel Desgrées du Loû, Eva Lelièvre
BACKGROUND: Life course epidemiology is now an established field in social epidemiology; in sociodemography, the quantitative analysis of biographies recently experienced significant trend from event history analysis to sequence analysis. The purpose of this article is to introduce and adapt this methodology to a social epidemiology question, taking the example of the impact of HIV diagnosis on Sub-Saharan migrants' residential trajectories in the Paris region. METHODS: The sample consists of 640 migrants born in Sub-Saharan Africa receiving HIV care...
February 2, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29436586/amelioration-of-inflammatory-responses-by-socheongryong-tang-a-traditional-herbal-medicine-in-raw-264-7%C3%A2-cells-and-rats
#14
Sang Mi Park, Tae Hoon Lee, Rongjie Zhao, Youn Sook Kim, Ji Yun Jung, Chung A Park, Kyung Hwan Jegal, Sae Kwang Ku, Jae Kwang Kim, Chul Won Lee, Young Woo Kim, Il Je Cho, Won G An, Sang Chan Kim
Socheongryong-Tang (SCRT) is a natural medicine prescription that has been mainly used in East Asia for the treatment of inflammatory disorders, including asthma and allergic rhinitis. The present study evaluated the anti-inflammatory effects of SCRT on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in a rat model of carrageenan (CA)-induced paw edema. Levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in the culture supernatant were quantified and nitric oxide (NO) production was monitored...
February 6, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29435104/niclosamide-suppresses-acute-myeloid-leukemia-cell-proliferation-through-inhibition-of-creb-dependent-signaling-pathways
#15
Hee-Don Chae, Nick Cox, Gary V Dahl, Norman J Lacayo, Kara L Davis, Samanta Capolicchio, Mark Smith, Kathleen M Sakamoto
CREB (cAMP Response Element Binding protein) is a transcription factor that is overexpressed in primary acute myeloid leukemia (AML) cells and associated with a decreased event-free survival and increased risk of relapse. We recently reported a small molecule inhibitor of CREB, XX-650-23, which inhibits CREB activity in AML cells. Structure-activity relationship analysis for chemical compounds with structures similar to XX-650-23 led to the identification of the anthelminthic drug niclosamide as a potent anti-leukemic agent that suppresses cell viability of AML cell lines and primary AML cells without a significant decrease in colony forming activity of normal bone marrow cells...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435043/wnt3a-expression-is-associated-with-poor-prognosis-of-esophageal-squamous-cell-carcinoma
#16
Junya Oguma, Soji Ozawa, Akihito Kazuno, Miho Nitta, Yamato Ninomiya, Hiroshi Kajiwara
The Wnt signaling pathway is widely implicated in various types of cancer. Canonical Wnt signaling, including Wnt3a, may be a key component of cancer progression or chemoresistance. Consequently, it was hypothesized that Wnt3a expression may be a prognostic factor of esophageal squamous cell carcinoma (ESCC) due to its roles in chemoresistance and tumor progression. The aim of the present study was to investigate the association between Wnt3a expression and prognosis in patients with ESCC. Wnt3a expression was evaluated in resected specimens from 139 patients with thoracic ESCC who were subjected to curative surgery without neoadjuvant therapy in Tokai University Hospital between 2007 and 2009...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434748/mapk-pathway-mediates-the-anti-oxidative-effect-of-chicoric-acid-against-cerebral-ischemia-reperfusion-injury-in-vivo
#17
Linwei Jia, Yonghan Chen, Yao-Hui Tian, Gang Zhang
The aim of the present study was to investigate the protective effect of chicoric acid on oxidative stress and inflammation in rats with cerebral ischemia-reperfusion injury. A cerebral ischemia-reperfusion injury rat model was created via transient middle cerebral artery occlusion (MCAO) and rats were treated with various doses of chicoric acid (0, 1, 10 and 100 mg/kg). Neurological deficits and infarct volume were used to estimate the protective effects of chicoric acid treatment. Levels of reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, nitric oxide (NO) and prostaglandin E2 (PGE2) were assessed...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434705/identification-of-a-progression-associated-long-non-coding-rna-signature-for-predicting-the-prognosis-of-lung-squamous-cell-carcinoma
#18
Yanyan Wang, Fang Yang, Yongzhi Zhuang
Long non-coding RNAs (lncRNAs) have been indicated to have prognostic roles in various cancer types. However, the association between lncRNAs and lung squamous cell carcinoma (LSCC) progression, and the prognostic value of lncRNAs as a marker for early detection of LSCC have not been systematically investigated. The present study performed a genome-wide comparative analysis in order to determine the expression profiles of 10,207 lncRNAs to investigate the expression patterns between patients with early stages of LSCC (stage I-II) and those with late-stage disease (stage III-IV)...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29431904/atrial-fibrillation-and-venous-thromboembolism-evidence-of-bidirectionality-in-the-atherosclerosis-risk-in-communities-study
#19
P L Lutsey, F L Norby, A Alonso, M Cushman, L Y Chen, E D Michos, A R Folsom
BACKGROUND: Atrial fibrillation (AF) and venous thromboembolism (VTE) frequently co-occur. These conditions have shared risk factors and are accompanied by coagulation abnormalities. Furthermore, mechanistic pathways may directly link the disorders. OBJECTIVES: To test the hypothesis that individuals with incident AF are at greater risk of developing VTE, and those with VTE are at elevated risk of AF. We also tested whether associations were stronger in the first 6 months after the initial diagnosis, and explored race differences...
February 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29429524/nintedanib-effects-on-delaying-cancer-progression-and-decreasing-cox-2-and-il-17-in-the-prostate-anterior-lobe-in-tramp-mice
#20
Letícia Ferreira Alves, Raquel Frenedoso da Silva, Valéria Helena Alves Cagnon
Prostate cancer is the most prevalent type of cancer in men around the world. Due to its high incidence, new therapies have been evaluated, including drugs capable of inhibiting the FGF/VEGF pathways, as Nintedanib. The aim herein was to evaluate the Nintedanib therapeutic effects on morphology and COX-2 and IL-17 levels in the prostate anterior lobe in different grades of the tumor progression in TRAMP mice. Animals were treated with Nintedanib at a dose of 10 mg/kg/day in initial and intermediate grades of tumor development...
February 2018: Tissue & Cell
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