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https://www.readbyqxmd.com/read/28641369/markers-of-inflammation-and-incident-breast-cancer-risk-in-the-women-s-health-study
#1
Deirdre K Tobias, Akintunde O Akinkuolie, Paulette D Chandler, Patrick R Lawler, JoAnn E Manson, Julie E Buring, Paul M Ridker, Lu Wang, I-Min Lee, Samia Mora
Chronic inflammation may be a risk factor for breast cancer development and progression, yet which inflammatory biomarkers and pathways are relevant is unknown. The study included 27,071 Women's Health Study participants (mean, 54.5 years old) free of cancer and cardiovascular disease at enrollment (1992 to 1995) with baseline measures of four inflammatory biomarkers: high sensitivity C-reactive protein (hsCRP), fibrinogen, N-acetyl side-chains of acute phase proteins (GlycA), and soluble intercellular adhesion molecule-1 (sICAM-1)...
June 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28636993/polymorphisms-and-expression-pattern-of-circular-rna-circ-itch-contributes-to-the-carcinogenesis-of-hepatocellular-carcinoma
#2
Wenzhi Guo, Jiakai Zhang, Dongyu Zhang, Shengli Cao, Gongquan Li, Shuijun Zhang, Zhihui Wang, Peihao Wen, Han Yang, Xiaoyi Shi, Jie Pan, Hua Ye
Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and the third cause of cancer-related mortality worldwide. Recent studies identified that circ-ITCH Suppresses mutiple cancers proliferation via inhibiting the Wnt/beta-Catenin pathway. In current study, conducted a genetic association study together with epidemiological follow-up study to delineate the role of circ-ITCH in the development and progression of HCC. we found rs10485505 (adjusted OR =1.18; 95% CI=1.06-1.31; P value =3.1×10-3) and rs4911154 (adjusted OR =1...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28634425/a-transcriptional-regulatory-role-for-the-membrane-type-1-matrix-metalloproteinase-in-carcinogen-induced-inflammasome-gene-expression
#3
Samuel Sheehy, Borhane Annabi
Signal-transducing functions driven by the cytoplasmic domain of membrane type-1 matrix metalloproteinase (MT1-MMP) are believed to regulate many inflammation-associated cancer cell functions including migration, proliferation, and survival. Aside from upregulation of the inflammation biomarker cyclooxygenase-2 (COX-2) expression, MT1-MMP's role in relaying intracellular signals triggered by extracellular pro-inflammatory cues remains poorly understood. Here, we triggered inflammation in HT1080 fibrosarcoma cells with phorbol-12-myristate-13-acetate (PMA), an inducer of COX-2 and of MT1-MMP...
2017: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/28634076/lncrna-hulc-promotes-the-growth-of-hepatocellular-carcinoma-cells-via-stabilizing-cox-2-protein
#4
Haojun Xiong, Bo Li, Jintao He, Yijun Zeng, Yan Zhang, Fengtian He
Highly upregulated in liver cancer (HULC), a lncRNA overexpressed in hepatocellular carcinoma (HCC), has been demonstrated to be involved in the carcinogenesis and progression of HCC. However, the mechanisms of HULC promoting the abnormal growth of HCC cells are still not well elucidated. In the present study, we for the first time demonstrated that HULC promoted the growth of HCC cells through elevating COX-2 protein. Moreover, the study of the corresponding mechanism by which HULC upregulated COX-2 showed that HULC enhanced the level of ubiquitin-specific peptidase 22 (USP22), which decreased ubiquitin-mediated degradation of COX-2 protein by removing the conjugated polyubiquitin chains from COX-2 and finally stabilized COX2 protein...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28632747/selective-cyclooxygenase-inhibition-by-sc-560-improves-hepatopulmonary-syndrome-in-cirrhotic-rats
#5
Ching-Chih Chang, Wen-Shin Lee, Hsian-Guey Hsieh, Chiao-Lin Chuang, Hui-Chun Huang, Fa-Yauh Lee, Shou-Dong Lee
OBJECTIVE: Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary vasodilatation, inflammation, and angiogenesis. Prostaglandins synthesized by cyclooxygenases (COX) participate in vascular responsiveness, inflammation and angiogenesis, which can be modulated by COX inhibitors. We therefore evaluated the impact of COX inhibition in rats with common bile duct ligation (CBDL)-induced liver cirrhosis and HPS...
2017: PloS One
https://www.readbyqxmd.com/read/28629629/association-between-lithium-use-and-melanoma-risk-and-mortality-a-population-based-study
#6
Maryam M Asgari, Andy J Chien, Ai Lin Tsai, Bruce Fireman, Charles P Quesenberry
Laboratory studies show lithium, an activator of the Wnt/ß-catenin signaling pathway, slows melanoma progression, but no published epidemiologic studies have explored this association. We conducted a retrospective cohort study of adult white Kaiser Permanente Northern California members (n=2,213,848) from 1997-2012 to examine the association between lithium use and melanoma risk. Lithium exposure (n=11,317) was assessed from pharmacy databases, serum lithium levels were obtained from electronic laboratory databases, and incident cutaneous melanomas (n= 14,056) were identified from an established cancer registry...
June 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28628921/activation-of-cox-2-mpges-1-pge2-cascade-via-nlrp3-inflammasome-contributes-to-albumin-induced-proximal-tubule-cell-injury
#7
Yibo Zhuang, Fei Zhao, Jing Liang, Xu Deng, Yue Zhang, Guixia Ding, Aihua Zhang, Zhanjun Jia, Songming Huang
BACKGROUND/AIMS: The activation of NOD-like receptor family, pyrin domain containing3 (NLRP3) inflammasome has been shown to be positively correlated with the severity of proteinuria in chronic kidney disease (CKD) patients. Prostaglandin E2 (PGE2), an important inflammatory mediator, is also involved in various kidney injuries. The aim of the present study was to investigate the involvement of NLRP3 inflammasome and PGE2 synthetic pathway in albumin-induced renal tubular injury. METHODS: Murine proximal tubular cells (mPTCs) were treated with albumin to induce cell injury...
June 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28627266/anti-inflammatory-effect-of-a-powder-formulation-of-coconut-inflorescence-sap-against-ox-ldl-induced-inflammatory-responses-in-human-peripheral-blood-mononuclear-cells-by-modulating-tlr-nf-%C3%B2-b-signaling-pathway
#8
Ratheesh M, Svenia P Jose, Asha S, Sandya S, Girish Kumar B, Krishnakumar Im
An inflammatory response induced by oxidized low density lipoprotein (ox-LDL) was reported to play an important role in the pathogenesis of atherosclerosis. The purpose of this study was to explore the anti-inflammatory effect of a novel powder formulation of coconut inflorescence sap (CSP) against ox-LDL induced inflammatory responses in human peripheral blood mononuclear cells (hPBMCs). The hPBMCs were isolated from healthy human volunteers and cultured in collagen coated plates at 37°C. The cells were grouped as Group I (Control), Group II (ox-LDL treated) and Group III (ox-LDL+CSP treated)...
June 19, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28625237/-study-on-mechanisms-and-myocardial-protective-effect-of-qishen-yiqi-dropping-pills-on-rats-with-myocardial-infarction
#9
Quan Yang, Yunshan Cao
OBJECTIVE: To approach the mechanisms and myocardial protective effect of Qishen Yiqi dropping pills on rats with myocardial infarction. METHODS: Sixty clean healthy male Sprague-Dawley (SD) rats were randomly divided into sham operation group, model group and observation group (each n = 20). The rat model of acute myocardial infarction (AMI) was established by ligation of left anterior descent (LAD) branch of coronary artery. After modeling, the rats in observation group were given 0...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28624808/yb-1-regulates-tumor-growth-by-promoting-macc1-c-met-pathway-in-human-lung-adenocarcinoma
#10
Tao Guo, Shilei Zhao, Peng Wang, Xiaoyuan Xue, Yan Zhang, Mengying Yang, Nan Li, Zhuoshi Li, Lingzhi Xu, Lei Jiang, Lei Zhao, Patrick C Ma, Rafael Rosell, Jinxiu Li, Chundong Gu
Aberrant overexpression of the transcription/translation factor Y-box-binding protein (YB-1) is associated with poor prognosis of lung adenocarcinoma, however the underlying mechanism by which YB-1 acts has not been fully elucidated. Here, we reported that inhibition of YB-1 diminished proliferation, migration and invasion of lung adenocarcinoma cells. Interestingly, we identified metastasis associated in colon cancer-1 (MACC1) as a target of YB-1. Depletion of YB-1 markedly decreased MACC1 promoter activity and suppressed the MACC1/c-Met signaling pathway in lung adenocarcinoma cells...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28624598/inhibition-of-lps-induced-pro-inflammatory-responses-in-raw-264-7-macrophage-cells-by-pvp-coated-naringenin-nanoparticle-via-down-regulation-of-nf-%C3%AE%C2%BAb-p38mapk-mediated-stress-signaling
#11
Pradeep Kumar R, Annie Abraham
BACKGROUND: Naringenin (NAR) was found to display strong pharmacological properties. Since the clinical relevance of NAR is limited by its low bioavailability, we effectively synthesized and characterized a novel PVP-coated NAR nanoparticle (NAR NP) to enhance the therapeutic efficacy of NAR. The present study was designed to investigate the effects of NAR NP on lipopolysaccharide (LPS) induced inflammatory response in RAW 264.7 macrophage cells. METHODS: In vitro cell culture studies of LPS stimulated RAW 264...
April 6, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28624453/folic-acid-attenuates-cobalt-chloride-induced-pge2-production-in-huvecs-via-the-no-hif-1alpha-cox-2-pathway
#12
Yuming Liang, Xiaozhou Zhen, Kaiwen Wang, Jing Ma
Prostaglandin E2 (PGE2), an important lipid inflammatory mediator involved in the progression of vascular diseases, can be induced by hypoxia in many cell types. While folic acid has been shown to protect against inflammation in THP-1 cells duringpo hypoxia and hypoxia-induced endothelial cell injury, whether it might do so by attenuating PGE2 production remains unclear. To investigate this we constructed a hypoxia-induced injury model by treating human umbilical vein endothelial cells (HUVECs) with cobalt chloride (CoCl2), which mimics the effects of hypoxia...
June 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28624320/prognostic-value-of-the-vhl-hif-1%C3%AE-and-vegf-signaling-pathway-and-associated-mapk-erk1-2-and-erk5-pathways-in-clear-cell-renal-cell-carcinoma-a-long-term-study
#13
Antonio S Salinas-Sánchez, Leticia Serrano-Oviedo, Syongh Y Nam-Cha, Olga Roche-Losada, Ricardo Sánchez-Prieto, José M Giménez-Bachs
BACKGROUND: The prognostic value of molecular markers in renal cell carcinoma has been investigated in several studies. Although their value is still not confirmed, various proteins are important. We describe the effect on long-term survival of the status of the von Hippel-Lindau (VHL) hypoxia-inducible factor 1-α (HIF1-α) signaling pathway as well as associated mitogen-activated protein kinase (extracellular signal-regulated kinase [ERK]1/2 and ERK5). PATIENTS AND METHODS: A prospective, longitudinal cohort study was conducted with 50 patients diagnosed with clear-cell renal cell carcinoma to analyze VHL mutations and hypermethylation as well as VHL, HIF1-α, vascular endothelial growth factor (VEGF), ERK1/2, and ERK5 protein expression...
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28620147/prostaglandin-i2-is-responsible-for-ameliorating-prostaglandin-e2-stress-in-stimulating-the-expression-of-tumor-necrosis-factor-%C3%AE-in-a-%C3%AE-amyloid-protein-dependent-mechanism
#14
Shao-Qin Zheng, Zi-Yi Gong, Chen-Di Lu, Pu Wang
Cyclooxygenase-2 (COX-2) has been found to be induced during the early stage of Alzheimer's disease (AD). Using mouse-derived astrocyte and APP/PS1 transgenic (Tg) mice as model systems, we firstly elucidated the mechanisms underlying COX-2 metabolic production including prostaglandin (PG)E2- and PGI2-mediated tumor necrosis factor α (TNF-α) regulation. Specifically, PGE2 accumulation in astrocyte activated the p38 and JNK/c-Jun signaling pathways via phosphorylation, resulting in TNF-α expression. In contrast, the administration of PGI2 attenuated the effects of PGE2 in stimulating the production of TNF-α by inhibiting the activity of TNF-α promoter and the binding activity of AP1 on the promoter of TNF-α...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619001/icariin-attenuates-interleukin-1%C3%AE-induced-inflammatory-response-in-human-nucleus-pulposus-cells
#15
Wen-Bin Hua, Yu-Kun Zhang, Xing-Huo Wu, Liang Kang, Ji Tu, Kang-Cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-Jin Luo, Zeng-Wu Shao, Cao Yang
BACKGROUND: Low back pain is a common problem, mainly caused by intervertebral disc degeneration (IDD). An important pathophysiological characteristic of IDD is the loss of homeostatic balance of the extracellular matrix metabolism. Interleukin-1β (IL-1β) is one of the inflammatory mediators stimulating the degradation of extracellular matrix in the nucleus pulposus (NP) and contributing to IDD pathogenesis. Icariin, which is isolated from Epimedium brevicornum, acts as an anti-inflammatory drug...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28618389/involvement-of-p38-mapk-and-atf-2-signaling-pathway-in-anti-inflammatory-effect-of-a-novel-compound-bis-5-methyl-2-furyl-4-nitrophenyl-methane-on-lipopolysaccharide-stimulated-macrophages
#16
Sarinporn Udompong, Sakulrat Mankhong, Jaray Jaratjaroonphong, Klaokwan Srisook
Activated macrophages produce various pro-inflammatory mediators such as inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) and cyclooxygenase (COX)-2-derived prostaglandin E2 (PGE2) during inflammatory response. However, overproduction of NO and PGE2 appears to be involved in pathogenesis of various inflammatory diseases. Therefore, inhibition of NO and PGE2 production might be useful for the treatment of inflammatory-related diseases. In this study, the bis[(5-methyl)2-furyl](4-nitrophenyl)methane or BFNM was evaluated for the anti-inflammatory activity and mechanism of action in lipopolysaccharide (LPS)-stimulated RAW 264...
June 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28618119/kh-type-splicing-regulatory-protein-mediate-inflammatory-response-in-gastric-epithelial-cells-induced-by-lipopolysaccharide
#17
Chong Chen, Mei Cao, Daoyan Wu, Ningzhe Li, Jingshan Peng, Liju Song, Panpan Qi, Mao Zhang, Jian Zhao
To study differential expressions of KH-type splicing regulatory protein (KSRP) and inflammatory factors and to explore the relationship between them in Lipopolysaccharide (LPS)-induced gastric epithelial cells (GES-1), cells were exposed to LPS for 24 h in the presence or absence of SC-514. Western blot and real-time PCR (RT-PCR) were used to analysis the contents of KSRP, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). The results showed that LPS decreased the expression of KSRP protein in GES-1 cells, but not KSRP mRNA, while increasing the levels of iNOS and COX-2 proteins and mRNAs in GES-1cells...
June 15, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28616865/isoacteoside-a-dihydroxyphenylethyl-glycoside-exhibits-anti-inflammatory-effects-through-blocking-tlr4-dimerization
#18
Hongwei Gao, Yankun Cui, Naixin Kang, Xin Liu, Yanli Liu, Yue Zou, Ziyu Zhang, Xiaoran Li, Shilin Yang, Ji Li, Chunming Wang, Qiong-Ming Xu, Xiuping Chen
BACKGROUND AND PURPOSE: Isoacteoside (ISO) is a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., which is an anti-inflammatory herb widely used in traditional Chinese medicine. However, the exact mechanism of the anti-inflammatory activity of ISO is not completely understood. In this study, its anti-inflammatory mechanism in mouse macrophages was elucidated. EXPERIMENTAL APPROACH: The expression of the NF-κB pathway, MAPK pathway, iNOS, TNF-α, IL-6 and IL-1β was evaluated using western blotting, qRT-PCR or ELISA...
June 14, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28615991/mir-34a-and-mir-206-act-as-novel-prognostic-and-therapy-biomarkers-in-cervical-cancer
#19
Ai-Hua Chen, Yu-E Qin, Wen-Fan Tang, Jing Tao, Hua-Mei Song, Manzhen Zuo
BACKGROUND: Recent evidence indicated that the aberrant expression of microRNA plays a crucial role in the development of cervical cancer. The overall shorter survival was strongly related to the abnormal expression of microRNA-34a (miR-34a) and microRNA-206 (miR-206), which target B cell lymphoma-2(Bcl2) and c-Met. Hepatocyte growth factor (HGF)/c-Met pathway is related to the occurrence, development and prognosis of cervical cancer, and c-Met is significantly overexpressed in cervical squamous cell carcinoma...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28615294/pituitary-stem-cell-regulation-who-is-pulling-the-strings
#20
Benoit Cox, Heleen Roose, Annelies Vennekens, Hugo Vankelecom
The pituitary gland plays a pivotal role in the endocrine system, steering fundamental processes of growth, metabolism, reproduction and coping with stress. The adult pituitary contains resident stem cells which are highly quiescent in homeostatic conditions. However, the cells show marked signs of activation during processes of increased cell remodeling in the gland, including maturation at neonatal age, adaptation to physiological demands, regeneration upon injury, and growth of local tumors. Although functions of pituitary stem cells are slowly but gradually uncovered, their regulation largely remains virgin territory...
June 14, 2017: Journal of Endocrinology
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