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Subclinical hyperthyroidism and heart

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https://www.readbyqxmd.com/read/29796905/-thyroid-gland-and-the-heart-pathophysiological-background-diagnostic-and-therapeutic-consequences
#1
REVIEW
U Dischinger, M Fassnacht
BACKGROUND: Irregularities in thyroid-specific laboratory parameters are frequent in the general population. Observational studies have shown associations between dysfunction of the thyroid gland and cardiovascular morbidity and mortality. OBJECTIVE: The aim of this review is to give a critical overview of the relationship and treatment recommendations for the simultaneous occurrence of functional disorders of the thyroid gland and the heart. MATERIAL AND METHODS: Literature searches were conducted in PubMed and Medline...
July 2018: Der Internist
https://www.readbyqxmd.com/read/29132170/thyroid-dysfunction-states-and-incident-cardiovascular-events-the-tehran-thyroid-study
#2
Maryam Tohidi, Arash Derakhshan, Samaneh Akbarpour, Atieh Amouzegar, Ladan Mehran, Aidin Baghbani-Oskouei, Fereidoun Azizi, Farzad Hadaegh
The objective of the study was to investigate the relation of different thyroid function states with the incidence of cardiovascular disease (CVD)/coronary heart disease (CHD) among a Middle-Eastern population with a high incidence of CVD/CHD. A total of 3975 participants entered the study (43.6% men). According to their thyroid stimulating hormone (TSH) and free thyroxin (FT4) levels, the participants were categorized into 5 groups: euthyroid, subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism...
January 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29081800/relationship-between-subclinical-thyroid-dysfunction-and-the-risk-of-cardiovascular-outcomes-a-systematic-review-and-meta-analysis-of-prospective-cohort-studies
#3
REVIEW
Jing Sun, Liang Yao, Yuan Fang, Ruifei Yang, Yaolong Chen, Kehu Yang, Limin Tian
BACKGROUND: Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS: PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies were included for meta-analysis. We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29061566/thyroid-function-within-the-normal-range-subclinical-hypothyroidism-and-the-risk-of-atrial-fibrillation
#4
REVIEW
Christine Baumgartner, Bruno R da Costa, Tinh-Hai Collet, Martin Feller, Carmen Floriani, Douglas C Bauer, Anne R Cappola, Susan R Heckbert, Graziano Ceresini, Jacobijn Gussekloo, Wendy P J den Elzen, Robin P Peeters, Robert Luben, Henry Völzke, Marcus Dörr, John P Walsh, Alexandra Bremner, Massimo Iacoviello, Peter Macfarlane, Jan Heeringa, David J Stott, Rudi G J Westendorp, Kay-Tee Khaw, Jared W Magnani, Drahomir Aujesky, Nicolas Rodondi
BACKGROUND: Atrial fibrillation (AF) is a highly prevalent disorder leading to heart failure, stroke, and death. Enhanced understanding of modifiable risk factors may yield opportunities for prevention. The risk of AF is increased in subclinical hyperthyroidism, but it is uncertain whether variations in thyroid function within the normal range or subclinical hypothyroidism are also associated with AF. METHODS: We conducted a systematic review and obtained individual participant data from prospective cohort studies that measured thyroid function at baseline and assessed incident AF...
November 28, 2017: Circulation
https://www.readbyqxmd.com/read/29023926/hyperthyroidism-in-patients-with-ischaemic-heart-disease-after-iodine-load-induced-by-coronary-angiography-long-term-follow-up-and-influence-of-baseline-thyroid-functional-status
#5
Nadia Bonelli, Ruth Rossetto, Davide Castagno, Matteo Anselmino, Francesca Vignolo, Mirko Parasiliti Caprino, Fiorenzo Gaita, Ezio Ghigo, Roberto Garberoglio, Roberto Grimaldi, Mauro Maccario
OBJECTIVE: To study the effect of a iodine load on thyroid function of patients with ischaemic heart disease (IHD) and the long-term influence of unknown subclinical hyperthyroidism. CONTEXT: Subclinical hyperthyroidism is considered an independent risk factors for cardiovascular morbidity of patients with IHD. They routinely undergo coronary angiography with iodine contrast media (ICM) which may induce or even worsen hyperthyroidism. DESIGN: A cross-sectional study followed by a longitudinal study on patients with subclinical hyperthyroidism...
February 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/28915531/subclinical-hyperthyroidism-and-the-cardiovascular-disease
#6
REVIEW
Alessandro P Delitala
Thyroid hormone excess has complex metabolic effects, particularly on the cardiovascular system. Treatment of these conditions is universally suggested by international guidelines. Subclinical hyperthyroidism, defined by reduced or suppressed TSH levels in the presence of normal free thyroxine and free triiodothyronine values, is common in the general population and progressively increases with aging, being as high as 15.4% in subjects more than 75 years old and more frequent in subjects with nodular goiter...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28867263/effects-of-hyperthyroidism-on-coronary-artery-disease-a-computed-tomography-angiography-study
#7
Christoph Beyer, Fabian Plank, Guy Friedrich, Matthias Wildauer, Gudrun Feuchtner
BACKGROUND: Changes in thyroid hormone concentration can negatively affect the cardiovascular system. Subclinical hyperthyroidism has been linked to an increase of cardiovascular heart disease, however, clinical effects and significance are still uncertain. Therefore, we analyzed coronary computed tomography angiographies of patients with overt and subclinical hyperthyroidism for quantitative parameters and plaque morphology. METHODS: Seven hundred forty-four (47...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28671443/subclinical-hyperthyroidism-when-to-consider-treatment
#8
REVIEW
Ines Donangelo, Se Young Suh
Subclinical hyperthyroidism is defined by a low or undetectable serum thyroid-stimulating hormone level, with normal free thyroxine and total or free triiodothyronine levels. It can be caused by increased endogenous production of thyroid hormone (e.g., in Graves disease, toxic nodular goiter, or transient thyroiditis), by administration of thyroid hormone to treat malignant thyroid disease, or by unintentional excessive replacement therapy. The prevalence of subclinical hyperthyroidism in the general population is about 1% to 2%; however, it may be higher in iodinedeficient areas...
June 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28329380/subclinical-thyroid-dysfunction-and-cardiovascular-diseases-2016-update
#9
Carmen Floriani, Baris Gencer, Tinh-Hai Collet, Nicolas Rodondi
Subclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4. Up to 10% of the elderly have SHypo, which is usually asymptomatic. Individual participant data (IPD) analyses of prospective cohort studies from the international Thyroid Studies Collaboration show that SHypo is associated with increased coronary heart disease (CHD) mortality [hazard ratio (HR) 1,58 for TSH ≥ 10 mIU/L, 95% CI 1...
February 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/27857052/permanent-atrial-fibrillation-in-heart-failure-patients-as-another-condition-with-increased-reverse-triiodothyronine-concentration
#10
Maciej Jakowczuk, Dominika Zalas, Maciej Owecki
OBJECTIVE: To fully investigate the thyroid hormonal function in patients with the most common arrhythmia - atrial fibrillation. MATERIALS AND METHODS: 120 patients (aged 55-85 yrs) with symptoms of congestive heart failure exacerbation and no other concomitant disorders (inclusion criteria: normal cardiac troponin T at admission and 12 hours after, normal renal, hepatic and respiratory function; exclusion criteria: inflammatory state, history of myocardial infarction)...
September 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27818781/subclinical-hypothyroidism-is-an-independent-predictor-of-adverse-cardiovascular-outcomes-in-patients-with-acute-decompensated-heart-failure
#11
Tomohiro Hayashi, Takuya Hasegawa, Hideaki Kanzaki, Akira Funada, Makoto Amaki, Hiroyuki Takahama, Takahiro Ohara, Yasuo Sugano, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
AIMS: Altered thyroid hormone metabolism characterized by a low triiodothyronine (T3), so-called low-T3 syndrome, is a common finding in patients with severe systemic diseases. Additionally, subclinical thyroid dysfunction, defined as abnormal thyroid stimulating hormone (TSH) and normal thyroxine (T4), causes left ventricular dysfunction. Our objective was to identify the prevalence and prognostic impact of low-T3 syndrome and subclinical thyroid dysfunction in patients with acute decompensated heart failure (ADHF)...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27811932/thyroid-hormones-and-cardiovascular-disease
#12
REVIEW
Avais Jabbar, Alessandro Pingitore, Simon H S Pearce, Azfar Zaman, Giorgio Iervasi, Salman Razvi
Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are sensitive to changes in the concentrations of circulating thyroid hormones. The importance of thyroid hormones in maintaining cardiovascular homeostasis can be deduced from clinical and experimental data showing that even subtle changes in thyroid hormone concentrations - such as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome - adversely influence the cardiovascular system...
January 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27734699/-thyroid-hormones-and-cardiovascular-system
#13
Zdeňka Límanová, Jan Jiskra
Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27651121/total-thyroidectomy-a-clue-to-understanding-the-metabolic-changes-induced-by-subclinical-hyperthyroidism
#14
Pierre Bel Lassen, Aglaia Kyrilli, Maria Lytrivi, Maria Ruiz Patino, Bernard Corvilain
OBJECTIVE: The effects of endogenous subclinical hyperthyroidism (eSCH) on heart and bone have been well documented. There are only limited data available regarding the impact of eSCH on weight regulation and lipid metabolism. Our aim was to evaluate the changes in body weight and metabolic parameters after total thyroidectomy in patients with pre-operative eSCH compared with pre-operative patients with euthyroid (EUT). DESIGN: A retrospective study of 505 patients who underwent total thyroidectomy for benign multinodular goitre in an academic hospital in Brussels (Belgium) was performed...
February 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/26860516/electrocardiographic-and-scintigraphic-evaluation-of-patients-with-subclinical-hyperthyroidism-during-workout
#15
Grzegorz Kaminski, Mirosław Dziuk, Ewelina Szczepanek-Parulska, Ariadna Zybek-Kocik, Marek Ruchala
Subclinical hyperthyroidism (sHT) was found to be associated with elevated heart rate, blood pressure and increased risk of extrasystoles. However, the full clinical relevance of morphological and functional implications of sHT on the cardiovascular system is still a matter of debate. The aim of the study was to prospectively assess the influence of endogenous sHT on exercise capacity and cardiac function during workout with the use of exercise electrocardiography (ExECG) and perfusion scintigraphy. The studied group consisted of 44 consecutively recruited patients diagnosed with sHT...
August 2016: Endocrine
https://www.readbyqxmd.com/read/26770196/thyroid-function-prevalent-coronary-heart-disease-and-severity-of-coronary-atherosclerosis-in-patients-undergoing-coronary-angiography
#16
Yan Ling, Jingjing Jiang, Minghui Gui, Lin Liu, Qiqige Aleteng, Bingjie Wu, Shanshan Wang, Xiaojing Liu, Xin Gao
This study investigated if free T4 and TSH concentrations or thyroid function categories were associated with prevalent CHD and the severity of coronary atherosclerosis in a population undergoing coronary angiography. This was a cross-sectional study including 1799 patients who were consecutively admitted and underwent coronary angiography. We evaluated the severity of coronary atherosclerosis using Gensini score. In the entire study population, free T4 level was inversely associated with prevalent CHD (OR = 0...
2015: International Journal of Endocrinology
https://www.readbyqxmd.com/read/26715657/how-does-subclinical-hyperthyroidism-affect-right-heart-function-and-mechanics
#17
Marijana Tadic, Vera Celic, Cesare Cuspidi, Sanja Ilic, Vladimir Zivanovic, Tamara Marjanovic
OBJECTIVES: Right heart function and mechanics have not been investigated in patients with subclinical hyperthyroidism. Our aim was to investigate right ventricular (RV) and right atrial (RA) function and deformation as evaluated by 3-dimensional echocardiography (3DE) and speckle-tracking 2-dimensional echocardiography (2DE) in these individuals. METHODS: We included 39 untreated women with endogenous subclinical hyperthyroidism and 39 healthy women matched by age...
February 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/26558232/the-2015-european-thyroid-association-guidelines-on-diagnosis-and-treatment-of-endogenous-subclinical-hyperthyroidism
#18
Bernadette Biondi, Luigi Bartalena, David S Cooper, Laszlo Hegedüs, Peter Laurberg, George J Kahaly
Endogenous subclinical hyperthyroidism (SHyper) is caused by Graves' disease, autonomously functioning thyroid nodules and multinodular goitre. Its diagnosis is based on a persistently subnormal serum thyroid-stimulating hormone (TSH) level with free thyroid hormone levels within their respective reference intervals. In 2014 the European Thyroid Association Executive Committee, given the controversies regarding the treatment of Endo SHyper, formed a task force to develop clinical practice guidelines based on the principles of evidence-based medicine...
September 2015: European Thyroid Journal
https://www.readbyqxmd.com/read/26421178/thyroid-hormone-profile-in-patients-with-acute-coronary-syndrome
#19
Faiza Abdulaziz Qari
BACKGROUND: Thyroid hormone has the a major role in the cardiovascular system function and cardiac a As well as to maintain the cardiovascular homeostasis A slightly change ind thyroid status actually affects cardiovascular mortality hemodynamic. The background of this study was to define the prevalence of thyroid dysfunction in acute coronary syndrome (ACS). OBJECTIVES: The primary objective was to define the prevalence of thyroid dysfunction in acute coronary syndrome, including Non-ST Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI), and unstable angina groups...
July 2015: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/26305196/cardiothyreosis-pathogenic-conjectures-clinical-aspects-and-surgical-approach
#20
M R Diaconescu, I Costea, M Glod, S Diaconescu
INTRODUCTION: The presence of striking cardiovascular manifestations were noted in the first descriptions of hyperthyroidism owing to Parry (1825) and Basedow (1840) in his famous Merseburg triad. Hyperthyroidism may either cause cardiac complications in individuals with a normal myocardium (genuine form of disorder) or complicate preexisting cardiac troubles. MATERIAL AND METHOD: An homogenous series of 49 cardiothyreosis, 11 males and 38 females, aged 12 - 78 (mean 45) years selected between 138 thyrotoxic patients operated on in a period of two decades is herein presented...
July 2015: Chirurgia
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