Yuji Hayashi, Shoko Miyoshi, Itaru Watanabe, Nagomi Yano, Kodai Nagashio, Mihiro Kaneko, Teppei Kaminota, Tomoyoshi Sanada, Yuki Hosokawa, Takashi Kitani, Sohei Mitani, Mohammed E Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato
OBJECTIVE: Although there have been brilliant advancements in the practical application of therapies targeting immune checkpoints, achieving success in targeting the microenvironment remains elusive. In this study, we aimed to address this gap by focusing on Na+ / H+ exchanger 1 (NHE1) and Lysyl Oxidase Like 2 (LOXL2), which are upregulated in head and neck squamous cell carcinoma (HNSCC) cells. METHODS: The malignancy of a metastatic human HNSCC cell line was assessed in a mouse tongue cancer xenograft model by knocking down (KD) NHE1, responsible for regulating intracellular pH, and LOXL2, responsible for extracellular matrix (ECM) reorganization via cross-linking of ECM proteins...
March 22, 2024: Auris, Nasus, Larynx