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"Advanced Glycation End Products"

Francesca Riuzzi, Guglielmo Sorci, Roberta Sagheddu, Sara Chiappalupi, Laura Salvadori, Rosario Donato
Emerging evidence suggests that the signalling of the Receptor for Advanced Glycation End products (RAGE) is critical for skeletal muscle physiology controlling both the activity of muscle precursors during skeletal muscle development and the correct time of muscle regeneration after acute injury. On the other hand, the aberrant re-expression/activity of RAGE in adult skeletal muscle is a hallmark of muscle wasting that occurs in response to ageing, genetic disorders, inflammatory conditions, cancer, and metabolic alterations...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
Maria Papadaki, Ronald J Holewinski, Samantha Beck Previs, Thomas G Martin, Marisa J Stachowski, Amy Li, Cheavar A Blair, Christine S Moravec, Jennifer E Van Eyk, Kenneth S Campbell, David M Warshaw, Jonathan A Kirk
Patients with diabetes are at significantly higher risk of developing heart failure. Increases in advanced glycation end products are a proposed pathophysiological link, but their impact and mechanism remain incompletely understood. Methylglyoxal (MG) is a glycolysis byproduct, elevated in diabetes, and modifies arginine and lysine residues. We show that left ventricular myofilament from patients with diabetes and heart failure (dbHF) exhibited increased MG modifications compared with nonfailing controls (NF) or heart failure patients without diabetes...
October 18, 2018: JCI Insight
Yasuharu Tabara, Tome Ikezoe, Mikihiro Yamanaka, Kazuya Setoh, Hiroaki Segawa, Takahisa Kawaguchi, Shinji Kosugi, Takeo Nakayama, Noriaki Ichihashi, Tadao Tsuboyama, Fumihiko Matsuda
Background: The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods: This study investigated a general population of 9,203 patients (mean age, 57.8 years). Skeletal muscle mass was measured by bioelectrical impedance analysis, whereas accumulation of AGEs was assessed by skin autofluorescence (SAF-AGE). The muscle strength of upper and lower limbs and usual gait speed were measured in a portion of older (≥60 years of age) participants (n = 1,934)...
October 11, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Zhao-Hui Jin, Pu Gao, Zheng-Tang Liu, Bing Jin, Guang-Yi Song, Tian-Yuan Xiang
OBJECTIVE: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids (CONR) on myocardial apoptosis of diabetic atherosclerosis (DA) rabbits METHODS: Sixty male New Zealand white rabbits were randomly divided into 6 groups [control group, model group, CONR high-dose group (450 mg/kg), CONR medium-dose group (150 mg/kg), CONR low-dose group (50 mg/kg), and simvastatin group] by using a completely random method, 10 in each group...
October 17, 2018: Chinese Journal of Integrative Medicine
Debora Collotta, Laura Lucarini, Fausto Chiazza, Alessia Sofia Cento, Mariaconcetta Durante, Silvia Sgambellone, Jacopo Chini, Francesca Baratta, Manuela Aragno, Raffaella Mastrocola, Emanuela Masini, Massimo Collino
Background: D-tagatose is an isomer of fructose and is ~90% as sweet as sucrose with less caloric value. Nowadays, D-tagatose is used as a nutritive or low-calorie sweetener. Despite clinical findings suggesting that D-tagatose could be beneficial in subjects with type 2 diabetes, there are no experimental data comparing D-tagatose with fructose, in terms of metabolic derangements and related molecular mechanisms evoked by chronic exposure to these two monosaccharides. Materials and methods: C57Bl/6j mice were fed with a control diet plus water (CD), a control diet plus 30% fructose syrup (L-Fr), a 30% fructose solid diet plus water (S-Fr), a control diet plus 30% D-tagatose syrup (L-Tg), or a 30% D-tagatose solid diet plus water (S-Tg), during 24 weeks...
2018: Oxidative Medicine and Cellular Longevity
Sarah C Skinner, Mor Diaw, Vincent Pialoux, Maïmouna Ndour Mbaye, Pauline Mury, Philomène Lopez, Delphine Bousquet, Fatou Gueye, Demba Diedhiou, Philippe Joly, Céline Renoux, Djiby Sow, Saliou Diop, Brigitte Ranque, Agnès Vinet, Abdoulaye Samb, Nicolas Guillot, Philippe Connes
OBJECTIVE: The prevalence of type 2 diabetes (T2D) is rapidly increasing in Sub-Saharan Africa, where sickle-cell trait (SCT) is also frequent. Although SCT is generally considered a benign condition, evidence suggests that SCT could exaggerate vascular dysfunction in T2D. However, it remains unclear whether SCT could increase the risk of the development of T2D complications. Therefore, this study was conducted to determine whether T2D complications were more prevalent among Senegalese individuals with SCT and T2D than among those with T2D only...
October 16, 2018: Diabetes Care
Ravichandran Ramasamy, Richard A Friedman, Alexander Shekhtman, Ann Marie Schmidt
No abstract text is available yet for this article.
October 16, 2018: Expert Review of Proteomics
Xiao-Jun Chen, Wen-Jun Wu, Qi Zhou, Jin-Ping Jie, Xiong Chen, Fang Wang, Xiao-Hua Gong
Despite the administration of exogenous insulin and other medications used to control many aspects of diabetes mellitus (DM), increased oxidative stress has been increasingly acknowledged in DM development and complications. Therefore, this study aims to investigate the role of advanced glycation end-products (AGEs) in oxidative stress (OS) of thyroid cells in patients with DM. Patients with DM with or without thyroid dysfunction (TD) were enrolled. Thyroid toxic damage was induced by adding AGE-modified bovine serum albumin (AGE-BSA) to normal human thyroid follicular epithelial cells...
October 15, 2018: Journal of Cellular Biochemistry
Xiao-Jun Chen, Xiao-Hua Gong, Jin-Ping Jie, Wei-Hui Yu, Xiong Chen, Xuan Du, Qi Zhou, Wen-Jun Wu
Advanced glycation end products (AGEs) play a causative role in the complications involved with diabetes mellitus (DM). Nowadays, DM with hypothyroidism (DM-hypothyroidism) is indicative of an ascended tendency in the combined morbidity. In this study, we examine the role of the receptor (RAGE) played for AGEs in thyroid hormone (TH) secretion via the silent information regulator 1 (SIRT1)/nuclear factor erythroid-derived factor 2-related factor 2 (Nrf2) pathway. Blood samples were collected from patients with type 2 DM (T2DM)-hypothyroidism and from patients with T2DM, followed by detection of serum AGEs level...
October 15, 2018: Journal of Cellular Biochemistry
Nordin M J Hanssen, Coen D A Stehouwer, Casper G Schalkwijk
PURPOSE OF REVIEW: Chronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments. Accumulation of methylglyoxal, a highly reactive glucose metabolite and a major precursor in the formation of advanced glycation end products, may link the hemodynamic, inflammatory, metabolic, and structural changes that drive diabetic CKD. Therefore, methylglyoxal may serve as a potential therapeutic target to prevent diabetic CKD...
October 12, 2018: Current Opinion in Nephrology and Hypertension
Haiyan Zhang, Xiang Lu, Zhengxia Liu, Kang Du
Rosuvastatin has cardiac protective effects through its anti‑inflammatory effects. The nuclear protein high‑mobility group box 1 (HMGB1) can activate inflammatory pathways when released from dying cells. The present study aimed to investigate the effects of rosuvastatin in adriamycin (ADR)‑treated rats. Adult male rats were randomized to three groups: i) Control group, ii) ADR group, and iii) ADR+rosuvastatin group. Serum biochemical indices were measured using an enzyme‑linked immunosorbent assay...
October 11, 2018: International Journal of Molecular Medicine
Wenbin Gao, Zheng Zhou, Birong Liang, Yusheng Huang, Zhongqi Yang, Yang Chen, Lu Zhang, Cui Yan, Jiajia Wang, Lu Lu, Zhaorui Wen, Shaoxiang Xian, Lingjun Wang
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy. However, the role of RAGE in pressure overload-induced HF is not well understood. We found that stimulation of RAGE triggered the death of neonatal rat ventricular myocytes (NRVMs), while cell death was alleviated by ATG5 knockdown. Using transverse aortic constriction (TAC) in mice as a model of pressure overload-induced HF, we demonstrated that RAGE knockout or RAGE blockade attenuated cardiac hypertrophy and fibrosis as well as cardiac dysfunction at 8 weeks after TAC...
2018: Frontiers in Physiology
Anna V Kamynina, Noemi Esteras, Dmitriy O Koroev, Natalia V Bobkova, Samson M Balasanyants, Ruben A Simonyan, Armine V Avetisyan, Andrey Y Abramov, Olga M Volpina
Receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of Alzheimer's disease. We have previously revealed that RAGE fragment sequence (60-76) and its shortened analogs sequence (60-70) and (60-65) under intranasal insertion were able to restore memory and improve morphological and biochemical state of neurons in the brain of bulbectomized mice developing major AD features. In the current study, we have investigated the ability of RAGE peptide (60-76) and five shortened analogs to bind beta-amyloid (Aβ) 1-40 in an fluorescent titration test and show that all the RAGE fragments apart from one [sequence (65-76)] were able to bind Aβ in vitro ...
2018: Frontiers in Neuroscience
Bahar Gürlek Demirci, Emre Tutal, Irem O Eminsoy, Eyup Kulah, Siren Sezer
OBJECTIVE: We aimed to analyze the relationship between the effect of total dietary fiber intake on C-reactive protein (CRP) and on oxidative stress parameters such as serum advanced glycation end products (AGEs), superoxide dysmutase (SOD), malondialdehyde, and arterial stiffness by pulse wave velocity (PWv) in maintanace hemodialysis (MHD) patients. METHODS: Among 650 MHD patients, 128 were selected according to inclusion criteria. The dietary survey was performed with a 3-day dietary history...
October 9, 2018: Journal of Renal Nutrition
Meihong Deng, Yiting Tang, Wenbo Li, Xiangyu Wang, Rui Zhang, Xianying Zhang, Xin Zhao, Jian Liu, Cheng Tang, Zhonghua Liu, Yongzhuo Huang, Huige Peng, Lehui Xiao, Daolin Tang, Melanie J Scott, Qingde Wang, Jing Liu, Xianzhong Xiao, Simon Watkins, Jianhua Li, Huan Yang, Haichao Wang, Fangping Chen, Kevin J Tracey, Timothy R Billiar, Ben Lu
Caspase-11, a cytosolic endotoxin (lipopolysaccharide: LPS) receptor, mediates pyroptosis, a lytic form of cell death. Caspase-11-dependent pyroptosis mediates lethality in endotoxemia, but it is unclear how LPS is delivered into the cytosol for the activation of caspase-11. Here we discovered that hepatocyte-released high mobility group box 1 (HMGB1) was required for caspase-11-dependent pyroptosis and lethality in endotoxemia and bacterial sepsis. Mechanistically, hepatocyte-released HMGB1 bound LPS and targeted its internalization into the lysosomes of macrophages and endothelial cells via the receptor for advanced glycation end-products (RAGE)...
October 16, 2018: Immunity
Yi Li, Mohd Shahnawaz Khan, Firoz Akhter, Fohad Mabood Husain, Saheem Ahmad, Lihui Chen
Advanced glycation end-products (AGEs) can aggregate amid incessant inflammation, as may be available in patients with rheumatoid arthritis. d-Ribose reacts more promptly than glucose monosaccharide to the proteins and forms heterogeneous group of products known as AGEs. Obesity includes persons with provocative joint inflammation with increased lipid profile. Immunogenic evidences recommend a cross-sectional relationship between glycated LDL-Apo B100 and inflammation. The point of this examination was to look at the connection between d-ribose glycated ApoB100 (ApoB100-AGE) with obesity and rheumatoid arthritis...
October 9, 2018: International Journal of Biological Macromolecules
Anna Adamska, Aleksandra Araszkiewicz, Stanislaw Pilacinski, Agnieszka Gandecka, Agata Grzelka, Katarzyna Kowalska, Agnieszka Malinska, Michal Nowicki, Dorota Zozulinska-Ziolkiewicz
In patients with diabetes, functional changes in microcirculation and subclinical vascular pathology precede clinical manifestation of microangiopathic complications. The objective of this study was to evaluate the association between established vascular risk factors and density, maturity, and reactivity of dermal blood vessels in adults with type 1 diabetes (DM1). We included 148 DM1 patients (87 men) with a median (IQR) age of 40.5 (30.5-49) years and a median diabetes duration of 21 (17-29.5) years. The control group consisted of 13 healthy volunteers (6 men) with a median (IQR) age of 36 (31-43)...
October 9, 2018: Microvascular Research
Mingwang Yang, Jiangli Fan, Junwei Zhang, Jianjun Du, Xiaojun Peng
Methylglyoxal (MGO), a dicarbonyl metabolite, is the most studied precursor of advanced glycation end-products (AGEs) and its elevated levels have also been associated with various pathologies. Hence, the development of effective methods for monitoring MGO in live cells and in vivo is of great importance for ascertaining the onset and progress of related diseases. Herein, we designed and synthesized an endoplasmic reticulum-targeting two-photon fluorescent probe called NI-OPD for the detection of MGO with high selectivity, sensitivity, and hypotoxicity...
September 7, 2018: Chemical Science
Daniela Viramontes Hörner, Nicholas M Selby, Maarten W Taal
OBJECTIVE: Advanced glycation end products (AGEs) are uremic toxins that result from hyperglycemia, oxidative stress, and systemic inflammation. AGEs are also formed in food during cooking. On the other hand, malnutrition may contribute to AGE formation through its association with oxidative stress and inflammation. AGE accumulation can be measured by skin autofluorescence (SAF) and elevated SAF is independently associated with higher mortality on hemodialysis (HD). We aimed to investigate associations between SAF, dietary AGE intake, and markers of malnutrition in persons receiving HD...
October 8, 2018: Journal of Renal Nutrition
Yuanyuan Chen, Shimiao Tang, Yashu Chen, Roujie Zhang, Mengzhou Zhou, Chao Wang, Nianjie Feng, Qian Wu
Nonenzymatic glycosylation (NEG) can generate advanced glycation end products (AGEs) and its intermediates α-dicarbonyl compounds, which contribute to the risk of diabetes. This study investigated the anti-glycation mechanisms and structure-activity relationship of (+)-catechin (CC) and (-)-epicatechin (EC). The results showed that the effect of CC on inhibiting AGEs was significantly better than that of EC (p < 0.05). By exploring the mechanism, we found that there was no significant difference in the ability of CC and EC to capture α-dicarbonyl compounds...
January 30, 2019: Food Chemistry
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