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Solid phase extraction

Wei Yang, Xia Wu, Tingting Liu, Ting Wang, Xiaohong Hou
An attractive triazine-based conjugated microporous polymer (TCMP) was fabricated via the Friedel-Crafts reaction and magnetized by a simple reduction co-precipitation method for the first time. The morphology and textural properties of the as-synthesized materials were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, N2 adsorption measurements, elemental analysis, and magnetic measurements. The resulting magnetic triazine-based conjugated microporous polymer (MTCMP) was introduced as an efficient adsorbent for vortex-assisted magnetic solid phase extraction (MSPE) coupled with ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the determination of trace 5-nitroimidazoles (5-NDZs) in environmental water samples...
October 16, 2018: Analyst
Yashpal S Chhonker, Liping Ma, Constant Edi, Daryl J Murry
AIM: A sensitive and selective LC-MS/MS method was validated for quantitation of ivermectin (IVM) in plasma. METHOD: The IVM was extracted from plasma using solid-phase extraction with C-18 cartridges. Separation of analytes was achieved on an ACE C18 column with isocratic elution using 0.1% acetic acid and methanol: acetonitrile (1:1, v/v) as mobile phase. The IVM was quantitated using electrospray ionization operating in negative multiple reaction monitoring mode...
October 16, 2018: Bioanalysis
María de la Luz Cádiz-Gurrea, Ignacio Fernández de Las Nieves, Luis Manuel Aguilera Saez, Salvador Fernández-Arroyo, Laurence Legeai-Mallet, Mohamed Bouaziz, Antonio Segura-Carretero
Plants, including most food and feed plants, produce a broad range of bioactive chemical compounds. Among these compounds, polyphenols are reported to provide beneficial effects as anti-carcinogenic, anti-atherogenic, anti-inflammatory, immune modulating, anti-microbial, vasodilatory and analgesic. Cocoa (Theobroma cacao), a major, economically important, international crop, has been related to several nutritional benefits, which have been associated with the phenolic fraction. The main subclass of flavonoids found in cocoa is flavanols, particularly (epi)catechins monomers, and their oligomers, also known as procyanidins...
October 15, 2018: Plant Foods for Human Nutrition
Federica Pellati, Virginia Brighenti, Johanna Sperlea, Lucia Marchetti, Davide Bertelli, Stefania Benvenuti
Cannabis sativa L. is a dioecious plant belonging to the Cannabaceae family. The main phytochemicals that are found in this plant are represented by cannabinoids, flavones, and terpenes. Some biological activities of cannabinoids are known to be enhanced by the presence of terpenes and flavonoids in the extracts, due to a synergistic action. In the light of all the above, the present study was aimed at the multi-component analysis of the bioactive compounds present in fibre-type C. sativa (hemp) inflorescences of different varieties by means of innovative HPLC and GC methods...
October 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kashinath Chiluwal, Junheon Kim, Soon Do Bae, Gwang Hyun Roh, Hae Jun Park, Chung Gyoo Park
Azuki bean beetle, Callosobruchus chinensis (L.) (Coleoptera: Bruchidae), is a field-to-storage pest of legumes and its females produce sex pheromone components with two isomers: (2Z,6E)-7-ethyl-3,11-dimethyl-2,6,10-dodecatrienal (2Z-homofarnesal) and (2E,6E)-7-ethyl-3,11-dimethyl-2,6,10-dodecatrienal (2E-homofarnesal). Two-day-old virgin adults were treated with different doses (0, 200, 300, 400, 500, and 600 Gy) of gamma radiation and the effects on adult survivorship, fecundity, sterility, and pheromone production were studied...
October 15, 2018: Journal of Economic Entomology
Weilin Wu, Wenqi Qian, Haitian Hao, Yun Kang, Yaqin Wang, Yuanrong Deng, Chengjie Ni, Jianming Huang, Weiyu Weng
Five main components of Azolla imbricata were isolated and identified as caffeoylquinic acid derivatives, four of which were isolated from this species for the first time. The five compounds exhibited strong antioxidant activities and were used as chemical markers for quantitative analysis. A chitosan-based matrix solid-phase dispersion (MSPD) extraction coupled with high-performance liquid chromatography (HPLC) was developed for the determination of the five analytes in A. imbricata. The optimal conditions for the chitosan-based MSPD extraction were as follows: low viscosity chitosan HL-1 as the dispersant, sample-to-dispersant mass ratio of 1:1, 10 mL of a methanol-sulfuric acid aqueous solution (0...
October 4, 2018: Journal of Pharmaceutical and Biomedical Analysis
Cristina Sottani, Elena Grignani, Laura Zaratin, Donatella Santorelli, Emanuele Studioso, Davide Lonati, Carlo A Locatelli, Ornella Pastoris, Sara Negri, Danilo Cottica
A method for the quantitation of α-fluoro-β-alanine (AFBA), the main metabolite of capecitabine (Cape) and 5-fluoruracil (5-FU), is described. Among antineoplastic drugs (ADs), 5-FU and Cape (the new oral prodrug) are the most commonly applied drugs in cancer therapy. The main objective of this study was to develop a reliable method that would be easy to run on a reversed-phase UHPLC system coupled to tandem mass spectrometry. AFBA was derivatized with Sanger's reagent to ensure complete yield of a stable 2,4 dinitrophenil-α-fluoro-β-alanine derivative...
October 10, 2018: Toxicology Letters
Arnon Grafit, Dan Muller, Sarit Kimchi, Yaniv Y Avissar
Solid-phase microextraction (SPME) has been established as a very powerful alternative to traditional extraction methods since its introduction in the early 1990s. The heart of the SPME device is an expensive thin and very delicate fused-silica fiber, coated with a thin polymer film. When extracted, the fiber may bend and break. Due to the fragility of the SPME fiber, a fiber protector device is proposed. The protector is easily assembled on the SPME device and can easily be removed by unscrewing for sampling to the injector...
September 17, 2018: Forensic Science International
Bahia Abbas Moussa, Marianne Alphonse Mahrouse, Michael Gamal Fawzy
Combination therapy has a pivotal role in type II diabetes mellitus management in patients unable to maintain normal glycemic level using metformin alone. Addition of linagliptin, dipeptidyl peptidase-IV inhibitor, to metformin improves glycemic control. This study is concerned with the development of an HPLC-MS/MS method for simultaneous quantification of linagliptin and metformin in spiked human plasma. The method was applied to evaluate the potential pharmacokinetic interactions between the cited drugs in healthy volunteers...
October 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
Mohammad Behbahani, Saman Bagheri, Fariborz Omidi, Mostafa Mohammadpour Amini
The authors described a new application of amino-functionalized KIT-6 for dispersive ultrasonication-assisted micro solid phase extraction of hippuric acid (HA) and methyl hippuric acid (MHA) from human urine and water samples. In the first step, an amino-functionalized mesoporous silica of type KIT-6 was synthesized. It was characterized by field emission scanning electron microscopy, Fourier transform infrared spectrometry, nitrogen adsorption-desorption analysis, thermogravimetry and X-ray diffraction. Following sorption and desorption with 1...
October 11, 2018: Mikrochimica Acta
Lin Wang, Xizhi Shi, Qiaoling Zhao, Aili Sun, Dexiang Li, Jian Zhao
A simple QuEChERS method coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed to improve the extraction efficiency of lipophilic marine toxins (yessotoxins, dinophysistoxins, okadaic acid, azazspiracids, and spirolides) in fresh and processed shellfish products. The proposed method included freezing and dispersive solid-phase extraction with graphene oxide as the sorbent to clean complex matrices containing lipids (e.g., free fatty acids) and pigments...
January 30, 2019: Food Chemistry
María Teresa García-Valverde, Theodoros Chatzimitakos, Rafael Lucena, Soledad Cárdenas, Constantine D Stalikas
A new procedure for the functionalization of melamine sponge (MeS) with urea-formaldehyde (UF) co-oligomers is put forward. The procedure differs from the typical synthesis of the UF co-polymer, as it employs a base-catalyzed condensation step at certain concentrations of urea and formaldehyde. The produced melamine-urea-formaldehyde (MUF) sponge cubes are hydrophobic, despite the presence of hydrophilic groups in the oligomers. The MUF sponge developed herein is used as a sorbent for the solid-phase extraction of 10 analytes, from 6 different classes (i...
October 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Dongmei Jiang, Dizhe Wei, Liuqing Wang, Shuai Ma, Yuanfang Du, Meng Wang
One-step solid-phase extraction (SPE) using a multiwalled carbon nanotube (MWCNT) for simultaneous analysis of 21 mycotoxins, including nine trichothecenes, zearalenone (ZEN) and its derivatives, four aflatoxins, and two ochratoxins, in corn and wheat was developed. Several key parameters affecting the performance of the one-step SPE procedure-types of MWCNT, combinations with five sorbents (octadecylsilyl (C18 ), hydrophilic⁻lipophilic balance (HLB), mixed-mode cationic exchange (MCX), silica gel, and amino-propyl (NH₂)), and filling amounts of the MWCNTs-were thoroughly investigated...
October 10, 2018: Toxins
Leilei Chen, Huiju Lin, Haipu Li, Mengmeng Wang, Bo Qiu, Zhaoguang Yang
Owing to the ease and effectiveness of removing suspended substances (SSs), filtration has become a universal pretreatment step during water sample preparation. However, it can lead to the underestimation of contaminants if the targets easily associate with the SSs or filters. For the first time, this study comprehensively assessed issues related to filtration for the accurate quantification of 35 typical pharmaceuticals, including 28 antibiotics and seven non-steroidal anti-inflammatory drugs (NSAIDs), in water samples by comparing the effects of different filter materials, preservatives, and water matrices on the recoveries...
February 10, 2019: Science of the Total Environment
Liqin Hu, Tingting Zhou, Dan Luo, Jingwen Feng, Yun Tao, Yusun Zhou, Surong Mei
Recently, magnetic solid-phase extraction (MSPE) using magnetic molecularly imprinted polymers (MMIPs), which is a simple process with excellent selectivity, has attracted much attention for the determination of environmental pollutants. In this study, MMIPs were used as an adsorbent to establish a selective MSPE method coupled with high-performance liquid chromatography using ultraviolet detection (HPLC-UV) for the determination of tetrabromobisphenol A (TBBPA) levels in water and fish samples. The samples were collected from a laboratory-based fish-water system after 0, 2, 5, 8, 11, 20, 30, and 50 days...
February 10, 2019: Science of the Total Environment
Fuyang Huang, Shengzhang Zou, Dongdong Deng, Hang Lang, Fei Liu
Karst aquifers are highly susceptible to contamination because compounds in water from the land surface are able to enter aquifers directly through sinkholes and travel rapidly through conduits. To investigate the occurrence and profiles of antibiotics in the typical karst river system in Kaiyang, southwest China, 34 aqueous samples were collected periodically to delineate seasonal trends in antibiotic levels. Thirty-five antibiotics, including nine sulfonamides, four tetracyclines, five macrolides, 16 quinolones and chloramphenicol, were analysed via solid phase extraction combined with ultra-performance liquid chromatography-tandem mass spectrometry...
February 10, 2019: Science of the Total Environment
Zengwei Li, Chan Lei, Na Wang, Xiongli Jiang, Yue Zeng, Zhenzhen Fu, Likou Zou, Li He, Shuliang Liu, Xiaolin Ao, Kang Zhou, Shujuan Chen
In this study, an efficient, selective, and simple analytical method for the extraction of chloramphenicol (CAP) from food using magnetic molecularly imprinted polymers (MMIPs) as the solid-phase extraction (SPE) sorbent was successfully developed. MMIPs with varying ratios of methacrylic acid to acrylamide were prepared by suspension polymerization on the surface of double-bond-modified Fe3 O4 magnetic nanoparticles. Further, these MMIPs were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy, as well as using a vibrating sample magnetometer...
October 3, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ningge Jian, Liangliang Qian, Chunmin Wang, Ruixian Li, Qian Xu, Jian Li
Core-shell polyaniline/polyacrylonitrile nanofibers mat (PANI/Pan NFsM) was prepared for extraction of hydrophilic non-steroidal anti-inflammatory drugs (NSAIDs) in environmental water. Superior adsorption and desorption performance of PANI/Pan NFsM was confirmed by both static and dynamic adsorption/desorption experiments. These properties proved PANI/Pan NFsM was a potentially efficient and fast solid phase extraction (SPE) adsorbent for NSAIDs. Under the optimized conditions, only 3 mg of PANI/Pan NFsM could easily extract eight target analytes in 10 mL of water sample without any pre-treatment, and the analytes retained on NFsM could be easily eluted by 500 μL of 1% acetic acid methanol for direct UPLC-MS/MS analysis...
September 26, 2018: Journal of Hazardous Materials
Xiangping Ji, Juanjuan Feng, Xiuqin Wang, Yu Tian, Chunying Li, Chuannan Luo, Min Sun
Diamond nanoparticles were coated onto stainless steel wires as a extraction material, then it was filled into a poly(ether ether ketone) tube for in-tube solid-phase microextraction. Coupled with high performance liquid chromatography, the extraction tube was evaluated with different types of analytes including polycyclic aromatic hydrocarbons, estrogens and plasticizers. As the coating, diamond nanoparticles exhibited greater extraction capacity for hydrophobic analytes. Several polycyclic aromatic hydrocarbons were used as model analytes, four main extraction and desorption factors were optimized, including sampling volume, sampling rate, methanol content in sample and desorption time...
October 11, 2018: Journal of Separation Science
Jörg Schlotterbeck, Agnes Kolb, Michael Lämmerhofer
Undaria pinnatifida (Wakame) alga contains high amounts of hexadeca-4Z,7Z,10Z,13Z-tetraenoic acid which was reported to decrease the efficiency of cisplatin chemotherapeutics. To obtain a fatty acid enriched extract of this ω-3 poly-unsaturated fatty acid as an analytical standard, Wakame was used as source material for its extraction. A 2-step extraction protocol consisting of a liquid-liquid extraction followed by solid-phase extraction with 3-aminopropyl silica in accordance to a normal-phase elution mode was developed...
October 11, 2018: Journal of Separation Science
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