Florence Naillat, Ganga Deshar, Anni Hankkila, Aleksandra Rak-Raszewska, Abhishek Sharma, Renata Prunskaite-Hyyrylainen, Antti Railo, Jingdong Shan, Seppo J Vainio
The renal tubular epithelial cells (TEC) have a strong capacity for repair after acute injury, but when this mechanism becomes uncontrollable, it leads to chronic kidney diseases (CKD). Indeed, in progress toward CKDs, the TECs may dedifferentiate, undergo epithelial-to-mesenchyme transition (EMT), and promote inflammation and fibrosis. Given the critical role of Wnt4 signaling in kidney ontogenesis, we addressed whether changes in this signaling are connected to renal inflammation and fibrosis by taking advantage of a knock-in Wnt4mCh/mCh mouse...
April 21, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease