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Practice Transformation

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https://www.readbyqxmd.com/read/30121641/il-1%C3%AE-mediated-up-regulation-of-wt1d-via-mir-144-3p-and-their-synergistic-effect-with-nf-%C3%AE%C2%BAb-cox-2-hif-1%C3%AE-pathway-on-cell-proliferation-in-luad
#1
Chen Wu, Xiaodong Li, Dachuan Zhang, Bin Xu, Wenwei Hu, Xiao Zheng, Danxia Zhu, Qi Zhou, Jingting Jiang, Changping Wu
BACKGROUND/AIMS: IL-1β is an important mediator of "inflammation-cancer" transformation through IL-1β/NF-κB/COX-2/HIF-1α signaling pathway, whereas certain portion of patients with lung adenocarcinoma (LUAD) still suffer from rapid tumor progression in clinical practice, indicating the occurrence of potential bypass. METHODS: Real-time polymerase chain reaction was applied to examine the expressions of mir-144-3p, WT1, NF-κB, COX2 and HIF-1α at the mRNA level in 127 LUAD samples and corresponding adjacent tissues...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30119731/a-class-specific-artificial-receptor-based-on-molecularly-imprinted-polymer-coated-quantum-dot-centers-for-the-detection-of-signaling-molecules-n-acyl-homoserine-lactones-present-in-gram-negative-bacteria
#2
Jean de Dieu Habimana, Jian Ji, Fuwei Pi, Eric Karangwa, Jiadi Sun, Wei Guo, Fangchao Cui, Jingdong Shao, Claudine Ntakirutimana, Xiulan Sun
Herein, a novel class-specific artificial receptor-based on molecularly imprinted polymer (MIP)-coated quantum dots (QDs@MIP) was synthesized, characterized, and used for the detection and quantification of the bacterial quorum signaling molecules N-acyl-homoserine lactones (AHLs), a class of autoinducers from Gram-negative bacteria. The QDs@MIP was prepared by surface imprinting technique under controlled conditions using CdSe/ZnS QDs as the signal transducing material. The synthesis of the QDs@MIP was characterized by transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction analysis, and fluorescence spectroscopy...
November 15, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30119548/polarization-multiplexed-nonlinear-inverse-synthesis-with-standard-and-reduced-complexity-nft-processing
#3
S Civelli, S K Turitsyn, M Secondini, J E Prilepsky
In this work, we study the performance of polarization division multiplexing nonlinear inverse synthesis transmission schemes for fiber-optic communications, expected to have reduced nonlinearity impact. Our technique exploits the integrability of the Manakov equation-the master model for dual-polarization signal propagation in a single mode fiber-and employs nonlinear Fourier transform (NFT) based signal processing. First, we generalize some algorithms for the NFT computation to the two- and multicomponent case...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119328/wide-angle-optical-half-wave-plate-from-the-field-transformation-approach-and-form-birefringence-theory
#4
Hongyu Shi, Yang Hao
In this paper, we theoretically design and analyse a wide-angle optical half-wave plate by combining the field transformation (FT) approach with the form-birefringence theory. The FT method is a general approach to manipulate electromagnetic wave propagations from pre-defined boundary conditions and artificial media by design. In theory, the approach is valid for both parallel and perpendicular polarizations. In practice, the resulting medium can be mimicked by a form-birefringent structure which has the same dispersion properties for a wide range of incident angles...
August 6, 2018: Optics Express
https://www.readbyqxmd.com/read/30116234/eighteen-year-farming-management-moderately-shapes-the-soil-microbial-community-structure-but-promotes-habitat-specific-taxa
#5
Huaihai Chen, Qing Xia, Tianyou Yang, Wei Shi
Soil microbes have critical influence on the productivity and sustainability of agricultural ecosystems, yet the magnitude and direction to which management practices affect the soil microbial community remain unclear. This work aimed to examine the impacts of three farming systems, conventional grain cropping (CON), organic grain cropping (ORG), and grain cropping-pasture rotation (ICL), on the soil microbial community structure and putative gene abundances of N transformations using high-throughput 16S rRNA gene and ITS sequencing approaches...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30116190/antibacterial-properties-of-medicinal-plants-from-pakistan-against-multidrug-resistant-eskape-pathogens
#6
Muhammad Faraz Khan, Huaqiao Tang, James T Lyles, Rozenn Pineau, Zia-Ur-Rahman Mashwani, Cassandra L Quave
Local people in the Sudhnoti district of Pakistan share a rich practice of traditional medicine for the treatment of a variety of ailments. We selected nine plants from the Sudhnoti ethnopharmacological tradition used for the treatment of infectious and inflammatory disease. Our aim was to evaluate the in vitro anti-infective potential of extracts from these species against multidrug-resistant (MDR) ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa , and Enterobacter species) pathogens...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30116169/cytotoxic-profiling-of-endogenous-metabolites-relevant-to-chronic-fatigue-immune-dysfunction-syndrome-cfids-on-p53-variant-human-colon-carcinoma-cell-lines
#7
Dusan Vukmirovic, Colin Seymour, Dave Rollo, Carmel Mothersill
Chemoprophylatic strategies against development of multifactorial diseases utilize compounds to block the multistep events in chronic inflammation and carcinogenesis. The successful chemopreventative candidate must therefore selectively inhibit growth of transformed cells and be administered frequently to confer maximal protection with minimal side effects. In addition to synthetic and exogenous natural compounds, endogenous metabolites represent another class of compounds that exhibit anticarcinogenic and anti-inflammatory properties contributing to proper cell function...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30114938/effective-diversity-equity-and-inclusion-practices
#8
Gurwinder Kaur Gill, Mary Jane McNally, Vin Berman
Demographics in Canada, and the workplace, are changing. These include population changes due to race, ethnicity, religion/faith, immigration status, gender, sexual identity and orientation, disability, income, educational background, socioeconomic status, and literacy. While this rich diversity can present challenges for patient experiences/outcomes and working environments, it can also present opportunities for positive transformation. For successful transformation to take place, strategies should focus on "Diversity, Equity, and Inclusion" (DEI) versus "diversity" alone and on creating inclusive team environments for positive staff experiences/engagement...
August 16, 2018: Healthcare Management Forum
https://www.readbyqxmd.com/read/30114221/family-history-based-colorectal-cancer-screening-in-australia-a-modelling-study-of-the-costs-benefits-and-harms-of-different-participation-scenarios
#9
Mary Dillon, Louisa Flander, Daniel D Buchanan, Finlay A Macrae, Jon D Emery, Ingrid M Winship, Alex Boussioutas, Graham G Giles, John L Hopper, Mark A Jenkins, Driss Ait Ouakrim
BACKGROUND: The Australian National Bowel Cancer Screening Programme (NBCSP) was introduced in 2006. When fully implemented, the programme will invite people aged 50 to 74 to complete an immunochemical faecal occult blood test (iFOBT) every 2 years. METHODS AND FINDINGS: To investigate colorectal cancer (CRC) screening occurring outside of the NBCSP, we classified participants (n = 2,480) in the Australasian Colorectal Cancer Family Registry (ACCFR) into 3 risk categories (average, moderately increased, and potentially high) based on CRC family history and assessed their screening practices according to national guidelines...
August 2018: PLoS Medicine
https://www.readbyqxmd.com/read/30114078/high-resolution-continuous-wave-terahertz-spectroscopy-on-solid-state-samples-with-coherent-detection
#10
De-Yin Kong, Xiao-Jun Wu, Bo Wang, Yang Gao, Jun Dai, Li Wang, Cun-Jun Ruan, Jun-Gang Miao
We systematically investigate the data analysis methods in terahertz frequency domain spectroscopy (THz-FDS) with coherent detection. We demonstrate that the Hilbert transform method is one of the most appropriate for data processing in THz-FDS. By converting frequency-domain signal into time domain with further data processing, the system noise due to Fabry-Pérot (FP) interference is greatly restrained. Accurate permittivity of lactose monohydrate is successfully extracted under the condition of the existence of atmospheric water vapor...
July 9, 2018: Optics Express
https://www.readbyqxmd.com/read/30114037/dynamic-morphing-of-3d-curved-laser-traps-for-all-optical-manipulation-of-particles
#11
José A Rodrigo, Mercedes Angulo, Tatiana Alieva
The development of optical manipulation techniques focused on the confinement and transport of micro/nano-particles has attracted increased interest in the last decades. In particular the combination of all-optical confinement and propelling forces, respectively arising from high intensity and phase gradients of a strongly focused laser beam, is promising for optical transport. The recently developed freestyle laser trap exploits this manipulation mechanism to achieve optical transport along arbitrary 3D curves...
July 9, 2018: Optics Express
https://www.readbyqxmd.com/read/30113916/practical-considerations-for-assessing-pulmonary-gas-exchange-and-ventilation-during-flume-swimming-using-the-metaswim-metabolic-cart
#12
Mitch Lomax, Billy Mayger, Zoe L Saynor, Christopher Vine, Heather C Massey
Lomax, M, Mayger, B, Saynor, ZL, Vine, C, and Massey, HC. Practical considerations for assessing pulmonary gas exchange and ventilation during flume swimming using the MetaSwim metabolic cart. J Strength Cond Res XX(X): 000-000, 2018-The MetaSwim (MS) metabolic cart can assess pulmonary gas exchange and ventilation in aquatic environments. The aims of this study were: (a) to determine the agreement between minute ventilation (V[Combining Dot Above]E), pulmonary oxygen uptake (V[Combining Dot Above]O2), and carbon dioxide output (V[Combining Dot Above]CO2) using the MS and Douglas bag (DB) methods during flume swimming; and (b) to assess the repeatability of these and other MS-derived parameters...
August 15, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/30113358/global-health-education-at-home-canadian-medical-students-perspectives-after-learning-alongside-haitian-peers
#13
Samantha Siu Lian Liauw, Ayelet Kuper, Geoffroy Noël, Lisa Richardson
PURPOSE: To explore how host medical students learn from visiting foreign students, by reporting on a global health program that has invited 2 or 3 Haitian medical students each year since 2013 to a Canadian medical school for a summer anatomy program. METHOD: In 2017, the authors conducted a qualitative descriptive study that collected data through one-on-one, semistructured interviews with 10 Canadian students, who participated in the Université Quisqueya-McGill University collaborative, a bidirectional global health education initiative, between 2013 and 2016...
August 14, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/30110831/fast-inverse-nonlinear-fourier-transform
#14
V Vaibhav
This paper considers the non-Hermitian Zakharov-Shabat scattering problem which forms the basis for defining the SU(2)-nonlinear Fourier transform (NFT). The theoretical underpinnings of this generalization of the conventional Fourier transform is quite well established in the Ablowitz-Kaup-Newell-Segur formalism; however, efficient numerical algorithms that could be employed in practical applications are still unavailable. In this paper, we present two fast inverse NFT algorithms with O(KN+Nlog^{2}N) complexity and a convergence rate of O(N^{-2}), where N is the number of samples of the signal and K is the number of eigenvalues...
July 2018: Physical Review. E
https://www.readbyqxmd.com/read/30110429/optimized-modelling-and-application-of-exhaust-gas-recirculation-performance-evaluation-of-turbocharged-diesel-engine
#15
Chuan-Lei Yang, Xiang-Huan Zu, He-Chun Wang, Yin-Yan Wang
Aimed at the problem of exhaust gas recirculation (EGR) performance evaluation and optimal EGR rate determination of turbocharged diesel engines, an optimized decision-making method, based on grey theory and entropy weight, was proposed. The internal combustion pressure, fuel consumption rate, NOX , CO and smoke were selected as the decision-making targets and the initial decision-making model was established based on the traditional grey decision-making theory. According to the characteristics and optimization requirements of EGR, the optimal compromise between combustion and emission performance is proposed to transform into decision-making target weighting problem, then an optimized subjective weighting method based on expert scoring and grey relational analysis is proposed...
June 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30109902/comparing-costs-of-a-senior-wellness-care-redesign-in-group-and-independent-physician-practices-of-an-accountable-care-organization
#16
Arturo Vargas Bustamante, Ana Martinez, Jeremy Rich, Xiao Chen, Hector P Rodriguez
Primary care redesign for older adult patients is currently ongoing in countries with aging populations. One of the main challenges of this type of transformations is how to estimate implementation costs in different types of health care delivery organizations. This study compares start-up and incremental expenses of implementing a primary care redesign across 2 organization types: integrated group (n = 31) practices and independent practice association (IPA) sites (n = 213). Administrators involved with implementing the redesign completed a cost capture template to quantifying expenses...
August 15, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/30109521/synchronization-and-alignment-of-follow-up-examinations-a-practical-and-educational-approach-using-the-dicom-reference-coordinate-system
#17
Sebastian Nowak, Alois M Sprinkart
This work presents an approach for synchronization and alignment of Digital Imaging and Communications in Medicine (DICOM) series from different studies that allows, e.g., easier reading of follow-up examinations. The proposed concept developed within the DICOM's patient-based reference coordinate system allows to synchronize all image data of two different studies/examinations based on a single registration. The most suitable DICOM series for registration could be set as default per protocol. Necessary basics regarding the DICOM standard and the used mathematical transformations are presented in an educative way to allow straightforward implementation in Picture Archiving And Communications Systems (PACS) and other DICOM tools...
August 14, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/30108209/fast-and-powerful-genome-wide-association-of-dense-genetic-data-with-high-dimensional-imaging-phenotypes
#18
Habib Ganjgahi, Anderson M Winkler, David C Glahn, John Blangero, Brian Donohue, Peter Kochunov, Thomas E Nichols
Genome wide association (GWA) analysis of brain imaging phenotypes can advance our understanding of the genetic basis of normal and disorder-related variation in the brain. GWA approaches typically use linear mixed effect models to account for non-independence amongst subjects due to factors, such as family relatedness and population structure. The use of these models with high-dimensional imaging phenotypes presents enormous challenges in terms of computational intensity and the need to account multiple testing in both the imaging and genetic domain...
August 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/30107562/breed-specific-differences-in-the-immune-response-to-lipopolysaccharide-in-ewes
#19
Jessalyn M Hadfield, Elizabeth C Bowdridge, Ida Holásková, Ted H Elsasser, Robert A Dailey
Innate immune response to a lipopolysaccharide (LPS) challenge varies among sheep breeds. How different breeds respond to bacterial infections impacts management practices of sheep producers. Hence, clinical response, acute-phase response, and gene expression of pro- and anti-inflammatory markers in peripheral white blood cells (WBCs) were examined after an LPS challenge in Dorset and Suffolk ewes. Ewes received either PBS or 2.5 µg/kg LPS (i.v.) 4 to 5 d after onset of synchronized estrus. Blood was collected via jugular venipuncture intermittently for 24 h to determine WBC counts...
August 9, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30106468/meta-analysis-and-individual-participant-data-synthesis-in-child-development-introduction-to-the-special-section
#20
Glenn I Roisman, Marinus H van IJzendoorn
This paper serves as an Introduction by the co-editors to a Special Section of Child Development entitled "Meta-analysis and Individual Participant Data Synthesis in Child Development." First, the co-editors emphasize that the work contained in the Special Section was selected to highlight the value of meta-analysis not only for synthesizing study-level published and unpublished data but also as regards its ability to support programmatic, replicable, and cumulative developmental science. Second, the co-editors identify some of the cross-cutting themes of the papers featured in the Special Section, including the value of meta-analysis for summarizing and interrogating the full range of developmental science and in potentially transforming conventional wisdom in given domains along with the importance of recent innovations for improving standard meta-analytic practice-particularly in the context of developmental questions...
August 14, 2018: Child Development
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