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https://www.readbyqxmd.com/read/28905186/antidepressants-inhibit-nav1-3-nav1-7-and-nav1-8-neuronal-voltage-gated-sodium-channels-more-potently-than-nav1-2-and-nav1-6-channels-expressed-in-xenopus-oocytes
#1
Takafumi Horishita, Nobuyuki Yanagihara, Susumu Ueno, Dan Okura, Reiko Horishita, Tomoko Minami, Yuichi Ogata, Yuka Sudo, Yasuhito Uezono, Takeyoshi Sata, Takashi Kawasaki
Tricyclic antidepressants (TCAs) and duloxetine are used to treat neuropathic pain. However, the mechanisms underlying their analgesic effects remain unclear. Although many investigators have shown inhibitory effects of antidepressants on voltage-gated sodium channels (Nav) as a possible mechanism of analgesia, to our knowledge, no one has compared effects on the diverse variety of sodium channel α subunits. We investigated the effects of antidepressants on sodium currents in Xenopus oocytes expressing Nav1...
September 14, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28900824/external-nasal-neuralgia-an-update
#2
REVIEW
Hida Nierenburg, Morgane Swift Morris
PURPOSE OF REVIEW: External nasal neuralgia is a rare syndrome of atypical facial pain for which there is limited reports in the scientific literature. We aim to review diagnosis and provide an update on treatments for this rare condition. RECENT FINDINGS: Etiology has been documented as post-traumatic due to direct trauma to the nose area and in few case reports, idiopathic. Sensory innervation of the nose arises from the ophthalmic and maxillary divisions of the trigeminal nerve...
September 13, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28887616/amitriptyline-plays-important-roles-in-modifying-the-ovarian-morphology-and-improving-its-functions-in-rats-with-estradiol-valerate-induced-polycystic-ovary
#3
Xinqiang Li, Shufen Wang, Li Zhang, Lei Zhang, Jiali Liu, Haoshu Luo, Kemian Gou, Sheng Cui
Previous studies demonstrated that depression is more prevalent in women with polycystic ovary syndrome (PCOS). In this study, we aimed to determine whether amitriptyline (AMT), an antidepressant drug, plays a role in preventing PCOS. The results showed that AMT modified ovarian morphology improved the ovarian functions and estrus cycle in estradiol valerate (EV)-induced polycystic ovary (PCO). AMT restored the levels of estradiol (E2), testosterone (T) and progesterone (P4) to normal, and elevated the level of luteinizing hormone (LH) in EV-induced PCO...
September 8, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28885085/targeting-the-central-projection-of-the-dural-trigeminovascular-system-for-migraine-prophylaxis
#4
Simon Akerman, Marcela Romero-Reyes
Migraine abortives likely target both peripheral-dural and central trigeminovascular mechanisms in mediating their therapeutic effects. However, in preclinical assays, many migraine preventives have little success at inhibiting similar trigeminovascular-mediated peripheral changes within the dural microenvironment. In addition, their effects on central trigeminovascular neuronal responses are largely unknown. Using a validated preclinical model of acute dural-intracranial (migraine-like) head pain, using Sprague Dawley rats, we tested whether migraine preventives suppress ongoing firing of central trigeminocervical neurons, and evoked responses to cranial neurovascular activation...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28853697/analysis-of-inappropriate-medication-use-and-drug-interactions-in-older-people-in-south-korea%C3%A2
#5
Hyunah Kim, Hun-Sung Kim, Hyerang Ko, Jia Choi, Nam Cho
OBJECTIVES: Medication use in older people has been increasing as the incidence of chronic diseases increases worldwide. The objective of this study was to assess potentially inappropriate medications (PIMs) and potential drug-drug interactions (pDDIs) to improve the rational use of medications in this population. MATERIALS AND METHODS: In this large, cross-sectional study, data on older people from a regional community obtained during health examinations in 2013 - 2014 were analyzed...
August 30, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28837263/magnetic-micro-solid-phase-extraction-based-on-magnetite-mcm-41-with-gc-ms-for-the-determination-of-anti-depressant-drugs-in-biological-fluids
#6
Sazlinda Kamaruzaman, Mohd Marsin Sanagi, Noorfatimah Yahaya, Wan Aini Wan Ibrahim, Salasiah Endud, Wan Nazihah Wan Ibrahim
A new facile magnetic micro-solid-phase extraction coupled to gas chromatography and mass spectrometry detection was developed for extraction and determination of selected anti-depressant drugs in biological fluids using magnetite-MCM-41 as adsorbent. The synthesized sorbent was characterized by several spectroscopic techniques. The maximum extraction efficiency for extraction of 500 μg/L anti-depressant drugs from aqueous solution was obtained with 15 mg of magnetite-MCM-41 at pH 12. The analyte was desorbed using 100 μL of acetonitrile prior to gas chromatography determination...
August 24, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28837087/ginseng-extract-g115-attenuates-ethanol-induced-depression-in-mice-by-increasing-brain-bdnf-levels
#7
Weerawan Boonlert, Hattaya Benya-Aphikul, Jariya Umka Welbat, Ratchanee Rodsiri
The decrease of brain-derived neurotrophic factor (BDNF) has been reported in alcohol use disorder and major depression. The effective treatment of these comorbid diseases remains undiscovered. Nutraceutical products are therefore proposed as an alternative approach to overcome this challenge. Ginseng extract G115, the standardized extract of Panax ginseng, is a widely-used nutraceutical that is beneficial for various central nervous system disorders. This study aimed to determine the antidepressant effect of ginseng extract G115 in ethanol-treated mice models...
August 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28836365/use-of-antidepressants-in-dentistry-a-systematic-review
#8
REVIEW
Patrícia Azevedo Lino, Carolina de Castro Martins, Gabriel Ferreira Pessoa Carvalho Miranda, Maria Elisa de Souza E Silva, Mauro Henrique Nogueira Guimarães de Abreu
OBJECTIVE: Previous research has suggested that antidepressants can be used in oral health care. The aim of this systematic review was to search for scientific evidence of the efficacy of the use of antidepressants in dentistry. MATERIALS AND METHODS: The clinical question was as follows (PICO Question): dentistry patients (Patients); antidepressants (Intervention); no use or placebo or other drug (Comparison); efficacy in oral health problems (Outcome). An electronic search was conducted in seven databases, as well as a manual search without restriction regarding language and date of publication...
August 24, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28831272/pain-reporting-and-analgesia-management-in-270-children-with-a-progressive-neurologic-metabolic-or-chromosomally-based-condition-with-impairment-of-the-central-nervous-system-cross-sectional-baseline-results-from-an-observational-longitudinal-study
#9
Stefan J Friedrichsdorf, Andrea C Postier, Gail S Andrews, Karen Es Hamre, Rose Steele, Harold Siden
Little is known about the prevalence, characterization and treatment of pain in children with progressive neurologic, metabolic or chromosomal conditions with impairment of the central nervous system. The primary aims of this study were to explore the differences between parental and clinical pain reporting in children with life-limiting conditions at the time of enrollment into an observational, longitudinal study and to determine if differences in pain experiences were associated with patient- or treatment-related factors...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28828613/glutamate-transport-system-as-a-novel-therapeutic-target-in-chronic-pain-molecular-mechanisms-and-pharmacology
#10
Georgi Gegelashvili, Ole Jannik Bjerrum
The vast majority of peripheral neurons sensing noxious stimuli and conducting pain signals to the dorsal horn of the spinal cord utilize glutamate as a chemical transmitter of excitation. High-affinity glutamate transporter subtypes GLAST/EAAT1, GLT1/EAAT2, EAAC1/EAAT3, and EAAT4, differentially expressed on sensory neurons, postsynaptic spinal interneurons, and neighboring glia, ensure fine modulation of glutamate neurotransmission in the spinal cord. The glutamate transport system seems to play important roles in molecular mechanisms underlying chronic pain and analgesia...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28827861/the-prospective-24-week-assessment-of-cost-efficacy-of-and-compliance-to-antidepressant-medications-in-a-rural-setting-pacecar-study
#11
T S Sathyanarayana Rao, J Shivanand Manohar, Rajesh Raman, M S Darshan, Abhinav Tandon, K N Karthik, N Saraswathi, Keya Das, G T Harsha, Swetha Patil Kunkeri, Chittaranjan Andrade
BACKGROUND: Anxiety and depression are common mental health disorders that are responsible for considerable societal burden. There are no data on cost-efficacy and medication compliance related to the treatment of these disorders in rural India. MATERIALS AND METHODS: All consenting adults (n = 455) diagnosed with generalized anxiety or (unipolar) depressive disorders in Suttur village, Karnataka, were treated with open-label fluoxetine (20-60 mg/day), sertraline (50-150 mg/day), escitalopram (10-20 mg/day), desvenlafaxine (50-150 mg/day), duloxetine (30-90 mg/day), amitriptyline (75-150 mg/day), or clomipramine (75-150 mg/day) in a structured, monotherapy dosing plan...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28826256/amitriptyline-poisoning-at-34-weeks-of-pregnancy
#12
Ka Yuen Tang
No abstract text is available yet for this article.
August 21, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28822709/the-influence-of-antidepressants-on-restless-legs-syndrome-and-periodic-limb-movements-a-systematic-review
#13
REVIEW
Bhanu Prakash Kolla, Meghna P Mansukhani, J Michael Bostwick
Restless legs syndrome is commonly co-morbid with medical conditions that are treated with antidepressant medications, such as depression, anxiety, fibromyalgia, and chronic insomnia disorder. Evidence from case reports and cross-sectional studies suggests that antidepressants may induce or worsen restless legs syndrome and increase periodic limb movements. We undertook a systematic review of the literature to identify and collate all prospective studies that measured restless legs syndrome symptoms and/or periodic limb movements following the introduction of an antidepressant...
June 15, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28803208/n-glucuronidation-catalyzed-by-ugt1a4-and-ugt2b10-in-human-liver-microsomes-assay-optimization-and-substrate-identification
#14
Danyi Lu, Qian Xie, Baojian Wu
N-glucuronidation is an important pathway for metabolism and disposition of tertiary amines in humans. This reaction is mainly catalyzed by the enzymes UGT1A4 and UGT2B10. However, the metabolic patterns of UGT1A4- and UGT2B10-mediated N-glucuronidation are not fully clear. In this study, we first optimized in vitro reaction conditions for N-glucuronidation by using specific substrates (i.e., trifluoperazine for UGT1A4, cotinine and amitriptyline for UGT2B10). Furthermore, we found that hepatic N-glucuronidation showed significant species differences...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28769859/adverse-effects-of-antidepressants-for-chronic-pain-a-systematic-review-and-meta-analysis
#15
Carina Riediger, Tibor Schuster, Kristian Barlinn, Sarah Maier, Jürgen Weitz, Timo Siepmann
BACKGROUND: Antidepressants are widely used in the treatment of chronic pain. Applied doses are lower than those needed to unfold an antidepressive effect. While efficacy of antidepressants for chronic pain has been reported in large randomized-controlled trials (RCT), there is inconsistent data on adverse effects and tolerability. We aimed at synthesizing data from RCT to explore adverse effect profiles and tolerability of antidepressants for treatment of chronic pain. METHODS: Systematic literature research and meta-analyses were performed regarding side effects and safety of different antidepressants in the treatment of chronic pain according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28764131/effects-of-selected-tricyclic-antidepressants-on-early-life-stages-of-common-carp-cyprinus-carpio
#16
Pavla Sehonova, Lucie Plhalova, Jana Blahova, Veronika Doubkova, Petr Marsalek, Miroslav Prokes, Frantisek Tichy, Michaela Skladana, Emma Fiorino, Premysl Mikula, Vladimir Vecerek, Caterina Faggio, Zdenka Svobodova
Despite the fact that pharmaceuticals occur in surface water in low concentrations, they can still have adverse effect on aquatic biota, because these substances are designed to have a specific mode of action even at low concentrations. To our knowledge, only little is known about the long-term effect of tricyclic antidepressant residues on non-target animals, especially fish. Hence, the aim of this study was to assess the effect of subchronic exposure to selected tricyclic antidepressants - namely, amitriptyline, nortriptyline, and clomipramine and their mixture - on early-life stages of common carp (Cyprinus carpio)...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28760537/randomized-double-blind-trial-of-amitriptyline-versus-placebo-in-treatment-of-chronic-laryngopharyngeal-neuropathy
#17
Minyoung Jang, Samuel J Rubin, Daniel J Stein, Jacob Pieter Noordzij
OBJECTIVE: A neuropathic etiology has been suggested for patients with chronic laryngopharyngitis symptoms without visible structural pathology. Prior studies have shown that treatment with neuro-modulating medications is beneficial, but it is unknown if this was due to placebo effect. Our objective was to compare the efficacy of amitriptyline versus placebo in treating chronic laryngopharyngeal neuropathy. STUDY DESIGN: Prospective, randomized placebo-controlled trial...
July 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28758432/psychotropic-medication-use-in-australia-2007-to-2015-changes-in-annual-incidence-prevalence-and-treatment-exposure
#18
Jonathan Brett, Emily A Karanges, Benjamin Daniels, Nicholas A Buckley, Carl Schneider, Atheer Nassir, Helga Zoega, Andrew J McLachlan, Sallie-Anne Pearson
OBJECTIVE: To examine changes in annual patterns of psychotropic medication use in Australia from 2007 to 2015. METHODS: We used a 10% sample of individual-level nationwide dispensing claims for concessional beneficiaries dispensed psychotropic medications (stratified by class, subclass) to investigate annual trends and changes in the incidence and prevalence of use, median annual duration of exposure, proportion of people with single psychotropic dispensing and median defined daily doses per person dispensed each medicine per year...
July 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28757918/low-doses-of-amitriptyline-pregabalin-and-gabapentin-are-preferred-for-management-of-neuropathic-pain-in-india-is-there-a-need-for-revisiting-dosing-recommendations
#19
Sanjay Vasant Kamble, Salman Abdulrehman Motlekar, Lyndon Lincoln D'souza, Vinay Nanda Kudrigikar, Sameer Eknath Rao
BACKGROUND: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent Indian market data suggested that the utilization (sale) of drugs such as amitriptyline, pregabalin, and gabapentin was more for low-dose unit packs than that of the high-dose unit packs, raising the belief that these drugs are prescribed at a lower dose than is actually recommended in the guidelines...
July 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28752512/medical-treatment-guidelines-for-preventive-treatment-of-migraine
#20
Tzu-Chou Huang, Tzu-Hsien Lai, Treatment Guideline Subcommittee Of Taiwan Headache Society Taiwan Headache Society
The Treatment Guideline Subcommittee of the Taiwan Headache Society evaluated the medications currently used for migraine prevention in Taiwan. We assessed the results of new published drug trials, information from medical database and referred to the latest guidelines published. After comprehensive discussion, we proposed Taiwanese consensus about the preventive treatment for migraine including recommendation levels, strength of evidences, and related prescription information regarding dosage and adverse effects...
March 15, 2017: Acta Neurologica Taiwanica
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