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https://www.readbyqxmd.com/read/28108386/trajectory-of-improvement-in-children-and-adolescents-with-chronic-migraine-results-from-the-cognitive-behavioral-therapy-and-amitriptyline-trial
#1
John W Kroner, James Peugh, Susmita M Kashikar-Zuck, Susan L LeCates, Janelle R Allen, Shalonda K Slater, Marium Zafar, Marielle A Kabbouche, Hope L O'Brien, Chad E Shenk, Ashley M Kroon Van Diest, Andrew D Hershey, Scott W Powers
: We compared headache frequency trajectories between clinical trial participants who received cognitive behavioral therapy plus amitriptyline (CBT+A) or headache education plus amitriptyline (HE+A) to determine if there was differential time course of treatment response between the groups. 135 patients (age 10-17) diagnosed with chronic migraine participated, attending 8 one-hour one-on-one CBT or HE sessions with a trained psychologist for 8 weekly sessions, 2 sessions at weeks 12 and 16, and a post-treatment visit at week 20...
January 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28106990/bioconcentration-and-biotransformation-of-amitriptyline-in-gilt-head-bream
#2
Haizea Ziarrusta, Leire Mijangos, Urtzi Izagirre, Merle M Plassmann, Jonathan P Benskin, Eneritz Anakabe, Maitane Olivares, Olatz Zuloaga
Extensive global use of the serotonin-norepinephrine reuptake inhibitor Amitriptyline (AMI) for treatment of depression has led to its ubiquitous occurrence in the aquatic environment. To assess AMI bioconcentration factors, tissue distribution, and metabolite formation in fish, we exposed gilt-head bream (Spaurus aurata) to AMI in seawater for 7 days at two concentrations (0.2 µg/L and 10 µg/L). Day 7 proportional bioconcentration factors (BCFs) ranged from 6 (10 µg/L dose, muscle) to 127 (0.2 µg/L dose, brain) and were consistently larger at the low dose level...
January 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28099869/amitriptyline-down-regulates-coenzyme-q10-biosynthesis-in-lung-cancer-cells
#3
Tamara Ortiz, Marina Villanueva-Paz, Eduardo Díaz-Parrado, Matilde Illanes, Ana Fernández-Rodríguez, José A Sánchez-Alcázar, Manuel de Miguel
Amitriptyline, a tricyclic antidepressant, has been proposed as an antitumoral drug in oxidative therapy. Its pro-apoptotic effects, mediated by high reactive oxygen species generation, have been already described. In this study we analysed the effect of amitriptyline on the biosynthesis of coenzyme Q10 (CoQ), an essential component for electron transport and a potent membrane antioxidant involved in redox signaling. We treated H460 cells, a non-small-cell lung cancer cell line, with amitriptyline and we analyzed CoQ levels by HPLC and CoQ biosynthesis rate, as well as the enzymes involved in CoQ biosynthesis by real-time PCR and Western blot...
January 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28093374/predictors-of-pharmacological-intervention-in-adolescents-with-protracted-symptoms-after-sports-related-concussion
#4
Shanti M Pinto, Maria F Twichell, Luke C Henry
BACKGROUND: Though recovery after concussion is spontaneous and typically occurs within two to three weeks, a subset of adolescents develop persistent symptoms after a sports-related concussion. Medications are frequently prescribed as part of a comprehensive treatment approach to alleviate these symptoms; however, there are no guidelines for prescription of pharmacologic therapy after concussion. OBJECTIVE: To investigate common factors that are associated with the use of medications (anti-epileptic, anti-depressant, neurostimulant, or sleeping medication) during recovery from a sports-related concussion...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28075425/management-of-fibromyalgia-practical-guides-from-recent-evidence-based-guidelines
#5
Winfried Häuser, Jacob Ablin, Serge Perrot, Mary-Ann Fitzcharles
Fibromyalgia (FM) is a prevalent and costly condition worldwide, affecting approximately 2% of the general population. Recent evidence- and consensus-based guidelines from Canada, Germany, Israel and the European League Against Rheumatism aim to support physicians in achieving a comprehensive diagnostic work-up of patients with chronic widespread pain (CWP) and to assist patients and physicians in shared decision making on treament options. Every patient with CWP requires at the first medical evaluation a complete history, medical examination and some laboratory tests (complete blood count, C-reactive protein, serum calcium, creatine phosphokinase, thyroid stimulating hormone, 25-OH vitamin D) to screen for metabolic or inflammatory causes of CWP...
January 4, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28056704/a-double-blind-randomized-and-placebo-controlled-clinical-trial-with-omega-3-polyunsaturated-fatty-acids-opfa-%C3%A9-3-for-the-prevention-of-migraine-in-chronic-migraine-patients-using-amitriptyline
#6
Adriana de Almeida Soares, Polyanna Mendes Camarço Louçana, Ema Pereira Nasi, Kamila Maria de Holanda Sousa, Odara Maria de Sousa Sá, Raimundo Pereira Silva-Néto
OBJECTIVE: To determine the prophylactic effect of OPFAϖ-3 in migraine. SUBJECTS AND METHODS: This was a prospective, experimental, controlled, double-blind, and with comparison groups study. Sixty patients diagnosed with chronic migraine, according to the criteria of the International Classification of Headache Disorders, Third Edition (beta version) (ICHD-3β), were prophylactically treated with amitriptyline. They were divided into two equal groups: in group 1, prophylaxis was associated with OPFAϖ-3 and in group 2 with placebo...
January 5, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28051093/a-four-compartment-pbpk-heart-model-accounting-for-cardiac-metabolism-model-development-and-application
#7
Zofia Tylutki, Sebastian Polak
In the field of cardiac drug efficacy and safety assessment, information on drug concentration in heart tissue is desirable. Because measuring drug concentrations in human cardiac tissue is challenging in healthy volunteers, mathematical models are used to cope with such limitations. With a goal of predicting drug concentration in cardiac tissue, we have developed a whole-body PBPK model consisting of seventeen perfusion-limited compartments. The proposed PBPK heart model consisted of four compartments: the epicardium, midmyocardium, endocardium, and pericardial fluid, and accounted for cardiac metabolism using CYP450...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045892/cyclobenzaprine-raises-ros-levels-in-leishmania-infantum-and-reduces-parasite-burden-in-infected-mice
#8
Edézio Ferreira Cunha-Júnior, Valter Viana Andrade-Neto, Marta Lopes Lima, Thais Alves da Costa-Silva, Andres J Galisteo Junior, Maria A Abengózar, Coral Barbas, Luis Rivas, Elmo Eduardo Almeida-Amaral, Andre Gustavo Tempone, Eduardo Caio Torres-Santos
BACKGROUND: The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the antidepressant amitriptyline, differing only by the presence of a double bond in the central ring. This paper describes the effect of CBP in experimental visceral leishmaniasis, its inhibitory effect in trypanothione reductase and the potential immunomodulatory activity...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28040196/aquatic-concentrations-of-chemical-analytes-compared-to-ecotoxicity-estimates
#9
Mitchell S Kostich, Robert W Flick, Angela L Batt, Heath E Mash, J Scott Boone, Edward T Furlong, Dana W Kolpin, Susan T Glassmeyer
We describe screening level estimates of potential aquatic toxicity posed by 227 chemical analytes that were measured in 25 ambient water samples collected as part of a joint USGS/USEPA drinking water plant study. Measured concentrations were compared to biological effect concentration (EC) estimates, including USEPA aquatic life criteria, effective plasma concentrations of pharmaceuticals, published toxicity data summarized in the USEPA ECOTOX database, and chemical structure-based predictions. Potential dietary exposures were estimated using a generic 3-tiered food web accumulation scenario...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28034861/dtb-select-1-january-2017
#10
(no author information available yet)
Brimonidine gel: risk of exacerbation of rosacea ● Metformin for patients with moderately reduced kidney function ● Effect of an optimal cranberry dose on bacteriuria ● Amitriptyline and topiramate ineffective for paediatric migraine prophylaxis ● Etoricoxib: 60mg dose for RA and ankylosing spondylitis ● CRP and diagnosis of CAP ● International travel and antimicrobial resistance ● Effect of telemedicine on diabetes control.
December 29, 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28034828/evidenced-based-guidelines-on-the-treatment-of-fibromyalgia-patients-are-they-consistent-and-if-not-why-not-have-effective-psychological-treatments-been-overlooked
#11
Kati Thieme, Marc Mathys, Dennis C Turk
: We compared the recommendations and methodology of several recent evidence-based guidelines for the management of patients with fibromyalgia (FM) published by professional organizations: 1. American Pain Society (APS) (2005) 2. Association of the Scientific Medical Societies in Germany (AWMF) (2012) 3. Canadian Pain Society (CPS, 2013), - Also used in United Kingdom and 4. European League Against Rheumatism (EULAR) (2016) Each guideline used systematic reviews and meta-analyses as highest level of evidence, APS, CPS, and AWMF also included individual randomized clinical trials (RCT)...
December 26, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28028812/a-systematic-review-and-meta-analysis-of-the-efficacy-of-cognitive-behavioral-therapy-for-the-management-of-pediatric-migraine
#12
REVIEW
Qin Xiang Ng, Nandini Venkatanarayanan, Lakshmi Kumar
INTRODUCTION: Migraine headaches are common in children and adolescents. Current pharmacologic treatment options are limited despite the prevalence and debilitating effects of pediatric migraine. Cognitive behavioral therapy (CBT) is an evidence-based practice that focuses on the development of coping strategies and cognitive restructuring to alter the pain experience. Till date, no meta-analysis has been done to examine the use of CBT in pediatric migraine. METHODS: Using the keywords (cognitive behavioral therapy OR cognitive behavior therapy OR cognitive behavioral therapy OR cognitive behavior therapy OR CBT) AND (headache OR migraine), a preliminary search on the PubMed and Ovid database yielded 3841 articles published in English between 1 Jan 1980 and 1 May 2016...
December 28, 2016: Headache
https://www.readbyqxmd.com/read/28009749/acid-sphingomyelinase-inhibition-in-stored-erythrocytes-reduces-transfusion-associated-lung-inflammation
#13
Richard S Hoehn, Peter L Jernigan, Lukasz Japtok, Alex L Chang, Emily F Midura, Charles C Caldwell, Burkhard Kleuser, Alex B Lentsch, Michael J Edwards, Erich Gulbins, Timothy A Pritts
OBJECTIVE: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion. SUMMARY BACKGROUND DATA: Large volume pRBC transfusions are associated with multiple adverse clinical sequelae, including lung inflammation. Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion. METHODS: Human and murine pRBCs were stored with or without amitriptyline, a functional inhibitor of acid sphingomyelinase, or obtained from acid sphingomyelinase-deficient mice, and lung inflammation was studied in mice receiving transfusions of pRBCs and microparticles isolated from these units...
January 2017: Annals of Surgery
https://www.readbyqxmd.com/read/27997040/clinical-pharmacogenetics-implementation-consortium-guideline-cpic%C3%A2-for-cyp2d6-and-cyp2c19-genotypes-and-dosing-of-tricyclic-antidepressants-2016-update
#14
J Kevin Hicks, Katrin Sangkuhl, Jesse J Swen, Vicki L Ellingrod, Daniel J Müller, Kazutaka Shimoda, Jeffrey R Bishop, Evan D Kharasch, Todd C Skaar, Andrea Gaedigk, Henry M Dunnenberger, Teri E Klein, Kelly E Caudle, Julia C Stingl
CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy and safety of tricyclic antidepressants (TCAs), with some drugs being affected by CYP2D6 only (e.g., nortriptyline and desipramine) and others by both polymorphic enzymes (e.g., amitriptyline, clomipramine, doxepin, imipramine, and trimipramine). Evidence is presented for CYP2D6 and CYP2C19 genotype-directed dosing of TCAs. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants...
December 20, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27994924/correlation-between-amitriptyline-induced-cardiotoxic-effects-and-cardiac-s100b-protein-in-isolated-rat-hearts
#15
Nil Hocaoğlu, Nergis Murat, Serap Cilaker Mıcılı, Burç Aydın, Bekir Uğur Ergür, Şule Kalkan
BACKGROUND: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. AIMS: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between amitriptyline-induced cardiotoxic effects and cardiac S100b protein in an isolated rat heart model. STUDY DESIGN: Animal experimentation, isolated heart model. METHODS: After a stabilization period, isolated hearts were randomized to two groups (n=5 and n=7)...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27993427/reconsideration-of-the-diagnosis-and-treatment-of-childhood-migraine-a-practical-review-of-clinical-experiences
#16
Yoshiaki Saito, Gaku Yamanaka, Hideki Shimomura, Kazuhiro Shiraishi, Tomoyuki Nakazawa, Fumihide Kato, Yuko Shimizu-Motohashi, Masayuki Sasaki, Yoshihiro Maegaki
OBJECTIVE: To provide insight into the wide spectrum of migraine during childhood to establish practical and comprehensive treatment strategies. BACKGROUND: Although recent studies have confirmed the effect of anti-migraine agents in childhood headaches fulfilling the criteria of migraine without aura, there have been no studies regarding the efficacy of these drugs in childhood migraine without aura not filling the diagnostic criteria. METHODS: In total, 154 patients with a clinical diagnosis of migraine, with onset of repetitive headaches at the age of ⩽15years, were retrospectively included from clinics in seven tertiary medical centers...
December 16, 2016: Brain & Development
https://www.readbyqxmd.com/read/27988285/cardamonin-attenuates-hyperalgesia-and-allodynia-in-a-mouse-model-of-chronic-constriction-injury-induced-neuropathic-pain-possible-involvement-of-the-opioid-system
#17
Yogesvari Sambasevam, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, B Hemabarathy Bharatham, Enoch Kumar Perimal
Neuropathic pain arises from the injury of nervous system. The condition is extremely difficult to be treated due to the ineffectiveness and presence of various adverse effects of the currently available drugs. In the present study, we investigated the antiallodynic and antihyperlagesic properties of cardamonin, a naturally occurring chalcone in chronic constriction injury (CCI)-induced neuropathic pain mice model. Our findings showed that single and repeated dose of intra-peritoneal administration of cardamonin (3, 10, 30mg/kg) significantly inhibited (P<0...
December 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27974346/nominal-isomers-incorrect-spellings-of-medicines-eluding-researchers-variants-in-the-spellings-of-drug-names-in-pubmed-a-database-review
#18
Robin E Ferner, Jeffrey K Aronson
OBJECTIVE:  To examine how misspellings of drug names could impede searches for published literature. DESIGN:  Database review. DATA SOURCE:  PubMed. REVIEW METHODS:  The study included 30 drug names that are commonly misspelt on prescription charts in hospitals in Birmingham, UK (test set), and 30 control names randomly chosen from a hospital formulary (control set). The following definitions were used: standard names-the international non-proprietary names, variant names-deviations in spelling from standard names that are not themselves standard names in English language nomenclature, and hidden reference variants-variant spellings that identified publications in textword (tw) searches of PubMed or other databases, and which were not identified by textword searches for the standard names...
December 14, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27941941/potentiation-of-amitriptyline-anti-hyperalgesic-like-action-by-astroglial-connexin-43-inhibition-in-neuropathic-rats
#19
Tiffany Jeanson, Adeline Duchêne, Damien Richard, Sylvie Bourgoin, Christèle Picoli, Pascal Ezan, Franck Mouthon, Christian Giaume, Michel Hamon, Mathieu Charvériat
Antidepressants, prescribed as first line treatment of neuropathic pain, have a limited efficacy and poorly tolerated side effects. Because recent studies pointed out the implication of astroglial connexins (Cx) in both neuropathic pain and antidepressive treatment, we investigated whether their blockade by mefloquine could modulate the action of the tricyclic antidepressant amitriptyline. Using primary cultures, we found that both mefloquine and amitriptyline inhibited Cx43-containing gap junctions, and that the drug combination acted synergically...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934123/aspects-of-quantitation-in-mass-spectrometry-imaging-investigated-on-cryo-sections-of-spiked-tissue-homogenates
#20
Heidi Toft Hansen, Christian Janfelt
Internal standards have been introduced in quantitative mass spectrometry imaging in order to compensate for differences in intensities throughout an image caused by, for example, difference in ion suppression or analyte extraction efficiency. To test how well the internal standards compensate for differences in tissue types in, for example, whole-body imaging, a set of tissue homogenates of different tissue types (lung, liver, kidney, heart, and brain) from rabbit was spiked to the same concentration with the drug amitriptyline and imaged in the same experiment using isotope labeled amitriptyline as internal standard...
December 6, 2016: Analytical Chemistry
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