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https://www.readbyqxmd.com/read/27886774/analysis-of-tricyclic-antidepressants-in-human-plasma-using-online-restricted-access-molecularly-imprinted-solid-phase-extraction-followed-by-direct-mass-spectrometry-identification-quantification
#1
Mariane Gonçalves Santos, Isabela Maria Campos Tavares, Adriano Francisco Barbosa, Jefferson Bettini, Eduardo Costa Figueiredo
The use of a new class of hybrid materials, called restricted access molecularly imprinted polymers (RAMIPs) seems to present a good strategy for the sample preparation of complex matrices, since these materials combine good protein elimination capacity with high degree selectivity. Mass spectrometers (MS) have been successfully used for polar drug identification and quantification. In order to combine the advantages of both RAMIPs and mass spectrometry, we proposed a study that joins these properties in a single system, where we could analyse tricyclic antidepressants from human plasma, without offline extraction or chromatographic separation...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27870551/poor-feeding-and-severe-sedation-in-a-newborn-nursed-by-a-mother-on-a-low-dose-of-amitriptyline
#2
Faruk Uguz
Sleep problems are frequently seen during the postpartum period. Some mothers need to use sedative agents for insomnia. Amitriptyline is a tricyclic antidepressant that has sedative effects. Despite no adverse reports, data on safety for the maternal use of this medication on breastfed infants are limited. This case report presents severe sedation and poor feeding in the breastfed baby of a woman using amitriptyline at 10 mg/day.
November 21, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27867572/the-efficacy-of-specific-neuromodulators-on-human-refractory-chronic-cough-a-systematic-review-and-meta-analysis
#3
REVIEW
Weili Wei, Ruilin Liu, Yangzi ZhangTong, Zhongmin Qiu
BACKGROUND: There have been several published reports on the use of orally administered, specific centrally acting medicines for the treatment of idiopathic cough; however, there is no extant systematic review of randomized controlled trials (RCTs) that evaluated their efficacy and safety for the treatment of idiopathic cough in human beings. METHODS: We conducted a series of definitive systematic reviews and meta-analyses of RCTs. Claims data from the MEDLINE, EMBASE, LILACS, CBM, CNKI, VIP, Wan Fang, and Cochrane Library databases were used...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27866243/monitoring-of-adherence-to-headache-treatments-by-means-of-hair-analysis
#4
Anna Ferrari, Manuela Licata, Cecilia Rustichelli, Carlo Baraldi, Daniele Vandelli, Filippo Marchesi, Federica Palazzoli, Patrizia Verri, Enrico Silingardi
PURPOSE: The aim of this study was to evaluate the potential of hair analysis to monitor medication adherence in headache patients undergoing chronic therapy. For this purpose, the following parameters were analyzed: the detection rate of 23 therapeutic drugs in headache patients' hair, the degree of agreement between the self-reported drug and the drug found in hair, and whether the levels found in hair reflected the drug intake reported by the patients. METHODS: The study included 93 patients suffering from primary headaches declaring their daily intake of at least one of the following drugs during the 3 months before the hair sampling: alprazolam, amitriptyline, citalopram, clomipramine, clonazepam, delorazepam, diazepam, duloxetine, fluoxetine, flurazepam, levomepromazine, levosulpiride, lorazepam, lormetazepam, mirtazapine, paroxetine, quetiapine, sertraline, topiramate, trazodone, triazolam, venlafaxine, and zolpidem...
November 20, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27864362/identification-of-lysophosphatidic-acid-receptor-1-in-astroglial-cells-as-a-target-for-glial-cell-line-derived-neurotrophic-factor-expression-induced-by-antidepressants
#5
Naoto Kajitani, Kanako Miyano, Mami Okada-Tsuchioka, Hiromi Abe, Kei Itagaki, Kazue Hisaoka-Nakashima, Norimitsu Morioka, Yasuhito Uezono, Minoru Takebayashi
Preclinical and clinical evidence suggests that glial cell line-derived neurotrophic factor (GDNF) is important in the therapeutic effect of antidepressants. A previous study demonstrated that the tricyclic antidepressant amitriptyline induces Gαi/o activation, which leads to GDNF expression in astrocytes. However, the specific target expressed in astrocytes that mediates antidepressant-evoked Gαi/o activation has yet to be identified. Thus, the current study explored the possibility that antidepressant-induced Gαi/o activation depends on lysophosphatidic acid receptor 1 (LPAR1), a Gαi/o-coupled receptor...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27863000/activated-charcoal-hemoperfusion-in-the-treatment-of-experimental-amitriptyline-poisoning-in-pigs-the-effect-on-amitriptyline-plasma-concentration-and-hemodynamic-parameters
#6
Tejs Jansen, Henrik Petersen, Cecilie M Malskaer, Charlotte Gabel-Jensen, Kim Dalhoff, Thomas Eriksen, Bo Belhage, Lotte C G Hoegberg
Coated activated charcoal hemoperfusion (CAC-HP) is a well-known treatment modality. Case reports have revealed conflicting results about the efficacy of CAC-HP in the treatment of amitriptyline (AT) poisoning, and no randomised clinical trials have been identified in the literature. This study aimed at quantifying the efficacy of modern CAC-HP as an adjunctive treatment of AT intoxication compared to standard care alone. Fourteen female Danish landrace pigs were randomized to either standard care or standard care plus 4 hr of CAC-HP...
November 14, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27859528/the-effects-of-pharmaceuticals-on-a-unionid-mussel-lampsilis-siliquoidea-an-examination-of-acute-and-chronic-endpoints-of-toxicity-across-life-stages
#7
Ève A M Gilroy, Patricia L Gillis, Laura E King, Nicholas A Bendo, Joseph Salerno, Marina Giacomin, Shane R de Solla
The toxicity and bioconcentration of three pharmaceuticals (amitriptyline, iopamidol and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage, but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Iopamidol was not toxic at concentrations up to 101 mg/L. Sertraline was the most toxic chemical (LC/EC50 = 0.02-0.04 mg/L), but exposure did not induce oxidative stress...
November 10, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27851687/determination-of-antidepressants-in-hair-via-uhplc-ms-ms-as-a-complementary-informative-tool-for-clinical-and-forensic-toxicological-assessments
#8
María Del Mar Ramírez Fernández, Sarah M R Wille, Virginia Hill, Nele Samyn
BACKGROUND: Hair analysis is a complementary approach for the detection of antidepressants (ADs) in clinical and forensic schemes because it yields a picture of long-term exposure over a time window depending on the length of the hair. METHODS: A fast and sensitive ultra-high performance liquid chromatography tandem mass spectrometry method using a BEH C18 column with a mobile phase consisting of ammonium acetate/acetonitrile was developed and validated according to international guidelines for the simultaneous analysis of 24 ADs in hair...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27837173/persistence-and-switching-patterns-of-oral-migraine-prophylactic-medications-among-patients-with-chronic-migraine-a-retrospective-claims-analysis
#9
Zsolt Hepp, David W Dodick, Sepideh F Varon, Jenny Chia, Nitya Matthew, Patrick Gillard, Ryan N Hansen, Emily Beth Devine
BACKGROUND: Migraine prevention guidelines recommend oral prophylactic medications for patients with frequent headache. This study examined oral migraine preventive medication (OMPM) treatment patterns by evaluating medication persistence, switching, and re-initiation in patients with chronic migraine (CM). METHODS: A retrospective US claims analysis (Truven Health MarketScan® Databases) evaluated patients ≥18 years old diagnosed with CM who had initiated an OMPM between 1 January, 2008 and 30 September, 2012...
November 10, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27836227/polythiophene-graphene-oxide-nanostructured-electrodeposited-coating-for-on-line-electrochemically-controlled-in-tube-solid-phase-microextraction
#10
Maryam Shamsayei, Yadollah Yamini, Hamid Asiabi
In this work, a novel polythiophene/graphene oxide (PTh/GO) nanostructured coating was introduced for on-line electrochemically-controlled in-tube solid phase microextraction of amitriptyline (AMI) and doxepin (DOX) as antidepressant drugs. The PTh/GO coating was prepared on the inner surface of a stainless steel tube by a facile in-situ electro-deposition method and it was used as a working electrode for electrochemically control in-tube solid phase microextraction. In the PTh/GO coating, GO acts as an anion dopant and sorbent...
December 2, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27821197/the-association-between-pro-arrhythmic-agents-and-aortic-stenosis-in-young-adults-is-it-sufficient-to-clarify-the-sudden-unexpected-deaths
#11
Bojana Radnic, Nemanja Radojevic, Jelena Vucinic, Natasa Duborija-Kovacevic
Most young patients with mild-to-moderate aortic stenosis show no symptoms, and sudden death appears only occasionally. We hypothesised that malignant ventricular arrhythmias could be responsible for the high incidence of sudden death in such patients. If multiple factors such as asymptomatic aortic stenosis in association with arrhythmia-provoking agents are involved, could it be sufficient to account for sudden unexpected death? In this study, eight cases of sudden death in young adults, with ages ranging from 22 to 36 years, who had never reported any symptoms that could be related to aortic stenosis, were investigated...
November 8, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27818278/effect-of-amitriptyline-treatment-on-neurofilament-h-protein-in-an-experimental-model-of-depression
#12
Maria Domenica Sanna, Carla Ghelardini, Nicoletta Galeotti
It has been proposed that depression is associated with dysfunction of hippocampal plasticity. Novel hypotheses suggest that antidepressants induce neuronal structural plasticity, although the underlying mechanisms still remain unclear. Therefore, the aim of this study was to investigate the effects of amitriptyline on levels of phosphorylated heavy neurofilament subunit (NF-H) in the hippocampus of mice exposed to acute and chronic behavioral despair paradigms. Immunoblotting experiments showed that animals exposed to the tail suspension test (TST) displayed diminished levels of pNF-H 24h after testing...
November 3, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27814849/multimodal-compared-to-pharmacologic-treatments-for-chronic-tension-type-headache-in-adolescents
#13
Peter Przekop, Allison Przekop, Mark G Haviland
Chronic tension-type headache (CTTH) in children and adolescents is a serious medical condition, with considerable morbidity and few effective, evidence-based treatments. We performed a chart review of 83 adolescents (age range = 13-18 years; 67 girls and 16 boys) diagnosed with CTTH. Two treatment protocols were compared: multimodal (osteopathic manipulative treatments, mindfulness, and qi gong) and pharmacologic (amitriptyline or gabapentin). Four outcomes (headache frequency, pain intensity, general health, and health interference) were assessed at three time points (baseline, 3 months, and 6 months)...
October 2016: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/27807736/-analgesic-drugs-during-pregnancy
#14
S Hultzsch, C Schaefer
Some important limitations must be taken into consideration for analgesic therapy during pregnancy. Paracetamol is the agent of choice for mild to moderate pain in any stage of pregnancy. Ibuprofen is the non-steroidal anti-inflammatory drug (NSAID) of choice; however, these substances are contraindicated after 28 weeks of gestation due to the increasing risk of premature closure of the ductus arteriosus and impairment of fetal kidney function. Even opioids can be used for severe pain but peripartum administration can lead to neonatal respiratory depression and adaptation disorders and long-term therapy up to the end of pregnancy can lead to neonatal withdrawal symptoms...
November 2, 2016: Der Schmerz
https://www.readbyqxmd.com/read/27807605/learning-to-experience-side-effects-after-antidepressant-intake-results-from-a-randomized-controlled-double-blind-study
#15
Julia Rheker, Alexander Winkler, Bettina K Doering, Winfried Rief
BACKGROUND: Side effects play a key role in patients' failure to take antidepressants. There is evidence that verbal suggestions and informed consent elicit expectations that can in turn trigger the occurrence of side effects. Prior experience or learning mechanisms are also assumed to contribute to the development of side effects, although their role has not been thoroughly investigated. In this study, we examined whether an antidepressant's side effects can be learned via Pavlovian conditioning...
November 2, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27788026/trial-of-amitriptyline-topiramate-and-placebo-for-pediatric-migraine
#16
Scott W Powers, Christopher S Coffey, Leigh A Chamberlin, Dixie J Ecklund, Elizabeth A Klingner, Jon W Yankey, Leslie L Korbee, Linda L Porter, Andrew D Hershey
Background Which, medication, if any, to use to prevent the headache of pediatric migraine has not been established. Methods We conducted a randomized, double-blind, placebo-controlled trial of amitriptyline (1 mg per kilogram of body weight per day), topiramate (2 mg per kilogram per day), and placebo in children and adolescents 8 to 17 years of age with migraine. Patients were randomly assigned in a 2:2:1 ratio to receive one of the medications or placebo. The primary outcome was a relative reduction of 50% or more in the number of headache days in the comparison of the 28-day baseline period with the last 28 days of a 24-week trial...
October 27, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27775149/amitriptyline-dose-and-treatment-outcomes-in-specialty-headache-practice-a-retrospective-cohort-study
#17
Lauren Doyle Strauss, Emma Weizenbaum, Elizabeth W Loder, Paul B Rizzoli
OBJECTIVE: To characterize treatment patterns and real world outcomes in headache patients treated with amitriptyline in an academic headache center. DESIGN AND METHODS: A retrospective chart review identified 178 patients in our center who were given a new prescription for amitriptyline in treatment of headache, and who were seen in follow-up within one year. Charts were reviewed to identify dosing patterns (initial and maximum dose) and persistence, patient-reported headache benefit, and reported side effects...
November 2016: Headache
https://www.readbyqxmd.com/read/27771722/inhibitory-effects-of-antidepressants-on-acetylcholine-induced-contractions-in-isolated-guinea-pig-urinary-bladder-smooth-muscle
#18
Junji Uno, Keisuke Obara, Hiroko Suzuki, Satomi Miyatani, Daisuke Chino, Takashi Yoshio, Yoshio Tanaka
BACKGROUND/AIMS: To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. METHODS: Concentration-response curves for ACh-induced contractions in guinea pig UBSM strips were obtained in the absence or presence of selected antidepressants. When inhibitory effects indicated competitive antagonism, pA2 values against ACh were calculated and compared to plausible antidepressant blood concentrations...
October 22, 2016: Pharmacology
https://www.readbyqxmd.com/read/27770809/is-low-dose-amitriptyline-effective-in-the-management-of-chronic-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#19
Donna M Urquhart, Anita E Wluka, Malcolm R Sim, Maurits van Tulder, Andrew Forbes, Stephen J Gibson, Carolyn Arnold, Chris Fong, Shane N Anthony, Flavia M Cicuttini
BACKGROUND: Low back pain is a major clinical and public health problem, with limited evidence-based treatments. Low-dose antidepressants are commonly used to treat pain in chronic low back pain. However, their efficacy is unproven. The aim of this pragmatic, double-blind, randomised, placebo-controlled trial is to determine whether low-dose amitriptyline (an antidepressant) is more effective than placebo in reducing pain in individuals with chronic low back pain. METHODS/DESIGN: One hundred and fifty individuals with chronic low back pain will be recruited through hospital and private medical and allied health clinics, advertising in local media and posting of flyers in community locations...
October 22, 2016: Trials
https://www.readbyqxmd.com/read/27757817/novel-treatments-for-cyclic-vomiting-syndrome-beyond-ondansetron-and-amitriptyline
#20
Sanjay Bhandari, Thangam Venkatesan
Cyclic vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder that is characterized by episodic nausea and vomiting. Initially thought to only affect children, CVS in adults was often misdiagnosed with significant delays in therapy. Over the last decade, there has been a considerable increase in recognition of CVS in adults but there continues to be a lack of knowledge about management of this disorder. This paper seeks to provide best practices in the treatment of CVS and also highlight some novel therapies that have the potential in better treating this disorder in the future...
October 18, 2016: Current Treatment Options in Gastroenterology
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