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https://www.readbyqxmd.com/read/29141481/liposome-supported-peritoneal-dialysis-in-rat-amitriptyline-exposure-with-and-without-intravenous-lipid-emulsion
#1
Robin Chapman, Martyn Harvey, Paul Davies, Zimei Wu, Grant Cave
INTRODUCTION: Liposome supported peritoneal dialysis is a recently described technique which may eventually be applicacle in the clinical scenario of the intoxicated patient. We evaluated the hypothesis that intravenous injection lipid emulsion (ILE) would augment acidic pH gradient liposome supported peritoneal dialysis (LSPD). METHODS: Orogastrically amitriptyline dosed rats were treated with either NaHCO3 intravenously and standard intraperitoneal dialysate (A); NaHCO3 intravenously and LSPD (B); or ILE and LSPD (C)...
November 15, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/29138563/squarticles-as-the-nanoantidotes-to-sequester-the-overdosed-antidepressant-for-detoxification
#2
Chun-Han Chen, Tse-Hung Huang, Ahmed O Elzoghby, Pei-Wen Wang, Chia-Wen Chang, Jia-You Fang
The increasing death rate caused by drug overdose points to an urgent demand for the development of novel detoxification therapy. In an attempt to detoxify tricyclic antidepressant overdose, we prepared a lipid nanoemulsion, called squarticles, as the nanoantidote. Squalene was the major lipid matrix of the squarticles. Here, we present the animal study to investigate both the pharmacokinetic and pharmacodynamic effects of squarticles on amitriptyline intoxication. The anionic and cationic squarticles had average diameters of 97 and 122 nm, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29137046/multiple-adverse-drug-reactions-and-genetic-polymorphism-testing-a-case-report-with-negative-result
#3
Ana Lucía Arellano, Marta Martin-Subero, Mar Monerris, Adrián LLerena, Magí Farré, Eva Montané
RATIONALE: Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6. PATIENT CONCERNS: We report a patient with psychosis and hypertension related to amitriptyline, tramadol, and duloxetine within a 2-year period. INTERVENTIONS AND OUTCOMES: A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29121034/the-impact-of-advanced-opioid-drugs-and-analgesic-adjuvants-on-murine-macrophage-oxygen-burst
#4
Michael Kozlowski, Katarzyna Nazimek, Magdalena Wąsik, Iwona Filipczak-Bryniarska, Krzysztof Bryniarski
Macrophages (Mf) are a versatile group of phagocytic cells responsible for fulfilling a variety of immune functions, most notably for mounting the initial anti-microbial response and for the clearance of cellular debris and apoptotic bodies. The key processes for fulfilling these functions include the production of reactive oxygen intermediates (ROIs) and nitric oxide (NO). Mf also express a variety of receptors, including opioid, serotonin, and norepinephrine receptors, and thus can react to various substances...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29118871/gastroesophageal-reflux-disease-associated-with-anxiety-efficacy-and-safety-of-fixed-dose-combination-of-amitriptyline-and-pantoprazole
#5
Arif A Faruqui
Background: The aim of the study was to evaluate the efficacy and tolerability of fixed dose combination of amitriptyline and pantoprazole in gastroesophageal reflux disease (GERD) associated with anxiety. Methods: A non-randomized, open-labeled, non-comparative, multi-center study was conducted in a total of 99 patients (77 men and 22 women, mean age 44.16 ± 11.53 years). Each patient was administered a fixed dose combination of amitriptyline 10 mg and pantoprazole 40 mg once a day, for 4 weeks...
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29117643/advanced-electrocardiogram-ecg-analysis-in-the-amitriptyline-poisoned-pig-treated-with-activated-charcoal-hemoperfusion-cac-hp
#6
Tejs Jansen, Lotte C G Hoegberg, Thomas Eriksen, Christian Haarmark, Kim Dalhoff, Bo Belhage
Coated Activated Charcoal Hemoperfusion (CAC-HP) does not reduce the plasma concentration in amitriptyline (AT)-poisoned pigs. The aim of this non-blinded, randomised, controlled animal trial was to determine if CAC-HP reduces the pathological ECG changes caused by AT poisoning. Fourteen female Danish Land Race pigs (mean weight 27.7 kg, range 20-35 kg (CAC-HP) and 24.4 kg, range 18-30 kg (control group, CG), n=7 in each group were included. After randomisation, the pigs were anaesthetised and intravenously poisoned with AT...
November 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29116077/convenient-iron-catalyzed-reductive-aminations-without-hydrogen-for-selective-synthesis-of-n-methylamines
#7
Kishore Natte, Helfried Neumann, Rajenahally V Jagadeesh, Matthias Beller
N-Methylated amines play an important role in regulating the biological and pharmaceutical properties of all kinds of life science molecules. In general, this class of compounds is synthesized via reductive amination reactions using high pressure of molecular hydrogen. Thus, on laboratory scale especially in drug discovery, activated (toxic) methyl compounds such as methyl iodide and dimethyl sulfate are still employed, which also generate significant amounts of waste. Therefore, the development of more convenient and operationally simple processes for the synthesis of advanced N-methylamines is highly desired...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29106712/investigation-of-ph-effect-on-cationic-solute-binding-to-keratin-and-partition-to-hair
#8
Lingyi Li, Senpei Yang, Tao Chen, Lujia Han, Guoping Lian
OBJECTIVE: In the process of hair treatment, various cationic actives contained in hair care products can be absorbed into hair fiber to modulate the physicochemical properties of hair such as color, strength, style and volume. There have been very limited studies on the binding and partition properties of hair care actives to hair. This study aimed to investigate the pH effects on cationic solute absorption into hair and binding to keratin. METHODS: The keratin binding and hair partition properties of three cationic solutes (theophylline, nortriptyline and amitriptyline) have been measured at different pH using fluorescence spectroscopy and equilibrium absorption experiment...
November 6, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29104684/effect-of-flunarizine-on-serum-glutamate-levels-and-its-correlation-with-headache-intensity-in-chronic-tension-type-headache-patients
#9
Khairul Putra Surbakti, Hasan Sjahrir, Rosita Juwita-Sembiring, Erna Mutiara
BACKGROUND: Some of the excitatory neurotransmitters including glutamate have been suggested to be involved in headache pathophysiology. To our knowledge, there is a lack of publication about flunarizine efficacy in chronic tension-type headache (CTTH) treatments and the roles of glutamate in CTTH pathophysiology. AIM: This study aimed to investigate the flunarizine effect on serum levels of glutamate and its correlation with headache intensity based on the Numeric Rating Scale for pain (NRS) scores in CTTH patients...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29099060/clinical-pharmacogenetics-of-cytochrome-p450-associated-drugs-in-children
#10
Ida Aka, Christiana J Bernal, Robert Carroll, Angela Maxwell-Horn, Kazeem A Oshikoya, Sara L Van Driest
Cytochrome P450 (CYP) enzymes are commonly involved in drug metabolism, and genetic variation in the genes encoding CYPs are associated with variable drug response. While genotype-guided therapy has been clinically implemented in adults, these associations are less well established for pediatric patients. In order to understand the frequency of pediatric exposures to drugs with known CYP interactions, we compiled all actionable drug-CYP interactions with a high level of evidence using Clinical Pharmacogenomic Implementation Consortium (CPIC) data and surveyed 10 years of electronic health records (EHR) data for the number of children exposed to CYP-associated drugs...
November 2, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29079070/pharmacologic-interventions-for-intractable-and-persistent-hiccups-a-systematic-review
#11
Nick B Polito, Shawn E Fellows
BACKGROUND: Chlorpromazine is the only drug approved by the US Food and Drug Administration for the treatment of hiccups; however, many other pharmacologic treatments have been proposed for intractable and persistent hiccups. Currently, there is little evidence to support the use of one agent over another. OBJECTIVE: This review aims to identify literature concerning the use of pharmacologic treatments for intractable and persistent hiccups with the goal of evaluating therapies in terms of their level of evidence, mechanism of action, efficacy, dosing, onset of action, and adverse effects...
October 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29069651/staphylococcus-aureus-%C3%AE-toxin-induces-inflammatory-cytokines-via-lysosomal-acid-sphingomyelinase-and-ceramides
#12
Jie Ma, Erich Gulbins, Michael J Edwards, Charles C Caldwell, Martin Fraunholz, Katrin Anne Becker
BACKGROUND/AIMS: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock syndrome. Toxins that are released from S. aureus mediate many of these effects. Here, we aimed to identify molecular mechanisms how α-toxin, a major S. aureus toxin, induces inflammation. METHODS: Macrophages were isolated from the bone marrow of wildtype and acid sphingomyelinase-deficient mice, stimulated with S...
October 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29068472/factors-affecting-the-dissipation-of-pharmaceuticals-in-freshwater-sediments
#13
Omar S A Al-Khazrajy, Ed Bergström, Alistair B A Boxall
Degradation is one of the key processes governing the impact of pharmaceuticals in the aquatic environment. Most studies on the degradation of pharmaceuticals have focused on soil and sludge with fewer exploring persistence in aquatic sediments. Here we investigate the dissipation of six pharmaceuticals from different therapeutic classes in a range of sediment types. Dissipation of each pharmaceutical was found to follow first-order exponential decay. Half-lives in the sediments ranged from 9.5 d (atenolol) to 78...
October 25, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29035882/regulation-of-arthritis-severity-by-the-acid-sphingomyelinase
#14
Nadine Beckmann, Katrin Anne Becker, Silke Walter, Jan U Becker, Melanie Kramer, Gabriele Hessler, Stefanie Weber, Joachim R Göthert, Klaus Fassbender, Erich Gulbins, Alexander Carpinteiro
BACKGROUND/AIMS: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. METHODS: We investigated arthritis severity by measuring joint swelling and pro-inflammatory cytokine production in a murine experimental model of inflammatory arthritis (antigen-induced arthritis). We analyzed acid sphingomyelinase knock-out mice and wild-type littermates, as well as mice treated with the pharmacological acid sphingomyelinase inhibitor amitriptyline...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29033248/use-of-oral-antidepressants-in-patients-with-chronic-pruritus-a-systematic-review
#15
Tessa A Kouwenhoven, Peter C M van de Kerkhof, Marijke Kamsteeg
BACKGROUND: Chronic pruritus is a common skin symptom with marked impact on quality of life. Adequate treatment can be challenging for clinicians, demanding the exploration of new treatment options such as oral antidepressants. OBJECTIVE: To evaluate the use of oral antidepressants in chronic pruritus by a systematic overview of the available relevant literature. METHODS: The PubMed, EMBASE, Cochrane, and Web of Science databases were searched...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29019272/amitriptyline-and-sexual-function-a-systematic-review-updated-for-sexual-health-practice
#16
Louis Wei-Hsi Chen, Melody Yun-Si Chen, Zhi-Ping Lian, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin, Yuan-Hsiang Chu, Kuo-Yen Chen
Amitriptyline is an old drug but is still prevalently used as the first-line treatment for a variety of common diseases. Surprisingly, knowledge of sexual risks with amitriptyline comes from only one clinical trial and several case reports from three decades ago. In the current study, a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) related to amitriptyline and sexual dysfunction (SD) was performed. The frequency, gender-difference, types, disease-specificity and time course of SD, and the relationship between SD and nonsexual adversity were studied...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29018010/unusual-complications-from-amitriptyline-intoxication
#17
Takeshi Nishimura, Hayato Maruguchi, Atsunori Nakao, Shinichi Nakayama
Althoughtricyclic antidepressants(TCAs) are frequently prescribed to patients with depression, these drugs can also be misused. A 21-year-old comatose patient was referred to our hospital presenting with ventricular tachycardia. Despite initial treatment including intravascular lipid emulsion, ventricular fibrillation occurred soon after arrival. Venoarterial extracorporeal membrane oxygenation and therapeutic hypothermia were administered. Refractory arrhythmia disappeared on the next day. A high concentration of amitriptyline was identified in his blood samples on arrival...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29016927/clinical-use-of-pregabalin-in-general-practice-in-catalonia-spain-a-population-based-cross-sectional-study
#18
Montserrat Viñas-Bastart, Míriam Oms-Arias, Àfrica Pedraza-Gutiérrez, Irene Lizano-Díez, Pilar Modamio, Eduardo L Mariño
Objective: The aim of this study was to determine the pattern of use of pregabalin and the appropriateness of treatment, so that interventions could be designed to improve various clinical approaches to the use of pregabalin to include unlicensed indications. Design: A descriptive, cross-sectional, multicenter study was performed between April 2014 and January 2015. Setting: Fifty-three primary health care centers covering 1,250,000 inhabitants...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29016824/nlrp3-inflammasome-contributes-to-lipopolysaccharide-induced-depressive-like-behaviors-via-indoleamine-2-3-dioxygenase-induction
#19
Seon-A Jeon, Eunju Lee, Inhwa Hwang, Boyoung Han, Sangjun Park, Seunghwan Son, Jungmin Yang, Sujeong Hong, Chul Hoon Kim, Junghyun Son, Je-Wook Yu
Background: Inflammation may play a significant role in the pathogenesis of depression, although the molecular target for the treatment of inflammation-mediated depressive symptoms remains to be elucidated. Recent studies have implicated the NLRP3 inflammasome in various psychiatric disorders, including depression. However, the underlying mechanism by which NLRP3 inflammasome activation mediates the progression of depressive-like behaviors remains poorly understood. Methods: We examined whether NLRP3 deficiency influenced depressive-like behaviors and cerebral inflammation following systemic administration of lipopolysaccharide in mice...
November 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28992598/global-transcriptomic-analysis-of-zebrafish-in-response-to-embryonic-exposure-to-three-antidepressants-amitriptyline-fluoxetine-and-mianserin
#20
Minghong Wu, Shuai Liu, Lei Hu, Haidong Qu, Chenyuan Pan, Penghui Lei, Yingjia Shen, Ming Yang
Antidepressants are among the most commonly detected pharmaceuticals in aqueous systems, and, as emerging organic pollutants, may exert negative effects on non-target aquatic organisms. Previously, it has been revealed that antidepressant exposure significantly inhibits the growth and development of fish during their early developmental stages. Thus, in the present study, we aimed to identify and compare the underlying mechanisms of action of different antidepressants at the transcriptional level using zebrafish (Danio rerio) embryos...
September 28, 2017: Aquatic Toxicology
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