Preeti Rana, Ramulu Parupalli, Abdul Akhir, Deepanshi Saxena, Rahul Maitra, Mohmmad Imran, Pradip Malik, Shaik Mahammad Ghouse, Swanand Vinayak Joshi, Danaboina Srikanth, Y V Madhavi, Arunava Dasgupta, Sidharth Chopra, Srinivas Nanduri
The emergence of antibiotic resistance to S. aureus and M. tuberculosis , particularly MRSA, VRSA, and drug-resistant tuberculosis, poses a serious threat to human health. Towards discovering new antibacterial agents, we designed and synthesized a series of new naphthalimide-thiourea derivatives and evaluated them against a panel of bacterial strains consisting of E. coli , S. aureus , K. pneumoniae , P. aeruginosa , A. baumannii and various mycobacterial pathogens. Compounds 4a, 4l, 4m, 4n, 4q, 9f, 9l, 13a, 13d, 13e, 17a, 17b, 17c, 17d, and 17e demonstrated potent antibacterial activity against S...
April 24, 2024: RSC medicinal chemistry