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A. Baumannii

Yu-Han Liu, Shu-Chen Kuo, Bing-Yu Yao, Zih-Syun Fang, Yi-Tzu Lee, Yuan-Chih Chang, Te-Li Chen, Che-Ming Jack Hu
Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingly prescribed to treat many drug-resistant, gram-negative bacteria. With the aim of improving the safety profile while preserving the antimicrobial activity of colistin, a nanoformulation is herein developed through coacervate complexation with polyanionic peptides. Upon controlled mixing of cationic colistin with polyglutamic acids, formation of liquid coacervates was demonstrated...
October 10, 2018: Acta Biomaterialia
François Perier, Severine Couffin, Mathieu Martin, Jean Bardon, Fabrice Cook, Roman Mounier
Acinetobacter baumannii meningitis and ventriculitis are difficult issues, due to the low diffusion of antibiotics in the cerebrospinal fluid (CSF) and bacterial multidrug resistance. The presence of an infected intraventricular hematoma, constituting an equivalent of undrained abscess, may promote biofilm formation and failure of medical treatment. In this case of ventriculostomy-related infection after ventricular hemorrhage, Acinetobacter baumannii was only sensitive to Colistin and Tigecycline. Despite a combination therapy involving intraventricular injections of Colistin, we observed a clinical and bacteriological failure...
October 9, 2018: World Neurosurgery
Binfei Li, Geqin Sun, Zhou Cheng, Chuangchuang Mei, Xiaozu Liao, Jianwei Li, Yong Yuan
OBJECTIVES: This study aims to analyze the nosocomial infection factors in post-cardiac surgery extracorporeal membrane oxygenation (ECMO) supportive treatment (pCS-ECMO). METHODS: The clinical data of the pCS-ECMO patients who obtained nosocomial infections (NI) were collected and analyzed retrospectively. Among the 74 pCS-ECMO patients, 30 occurred with NI, accounting for 40.5%; a total of 38 pathogens were isolated, including 22 strains of Gram-negative bacteria (57...
September 17, 2018: Heart Surgery Forum
Uthaibhorn Singkham-In, Tanittha Chatsuwan
PURPOSE: The emergence of carbapenem resistance in non-baumannii Acinetobacter has increased in clinical settings worldwide. We investigated the prevalence and mechanisms of carbapenem resistance in A. pittii and A. nosocomialis Thai isolates. METHODOLOGY: Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex isolates were identified by gyrB mulitplex PCR. Carbapenem susceptibilities were studied by the agar dilution method and carbapenemase genes were detected by multiplex PCR...
October 12, 2018: Journal of Medical Microbiology
Tze-Peng Lim, Reyna Wang, Gang Quan Poh, Tse-Hsien Koh, Thean-Yen Tan, Winnie Lee, Jocelyn Qi-Min Teo, Yiying Cai, Thuan-Tong Tan, Pui Lai Rachel Ee, Andrea L Kwa
Objectives: Treatment for nosocomial bloodstream infections (BSI) caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) is challenging. Rising antimicrobial resistance, especially in extended spectrum beta-lactamase production, inadvertently increases empiric carbapenem consumption. Three antipseudomonal carbapenems (imipenem, meropenem [MER], and doripenem [DOR]) are available commercially against MDR GNB in Singapore. The study aims to determine the most optimal empiric carbapenem dosing regimens (CDR) and evaluate their cost-effectiveness for GNB-BSI in the face of increasing MDR GNB...
2018: Infection and Drug Resistance
Yu-Chung Chuang, Aristine Cheng, Hsin-Yun Sun, Jann-Tay Wang, Yee-Chun Chen, Wang-Huei Sheng, Shan-Chwen Chang
OBJECTIVES: Acinetobacter baumannii (Ab) is an important cause of healthcare-associated infections. Multilocus sequence typing (MLST) provides a highly discriminative typing method. We aimed to determine the clinical impact of Ab sequence types (ST) in patients with bloodstream infection (BSI). METHODS: Patients with Ab-BSI were followed prospectively from 2009 through 2014. We randomly selected one-third of non-duplicate bacteremic isolates for MLST and correlated the Ab ST with the clinical course...
October 8, 2018: Journal of Infection
John M Farrow, Greg Wells, Everett C Pesci
For the opportunistic pathogen Acinetobacter baumannii, desiccation tolerance is thought to contribute significantly to the persistence of these bacteria in the healthcare environment. We investigated the ability of A. baumannii to survive rapid drying, and found that some strains exhibited a profoundly desiccation-resistant phenotype, characterized by the ability of a large proportion of cells to survive on a dry surface for an extended period of time. However, this phenotype was only displayed during the stationary phase of growth...
2018: PloS One
Raffaele Zarrilli, Maria Bagattini, Eliana Pia Esposito, Maria Triassi
PURPOSE OF REVIEW: MDR-Gram-negative bacteria are a great concern in the neonatal population, with a worldwide rise in the reported incidence and with very limited therapeutic options. Acinetobacter baumannii is responsible for many infections in neonates and outbreaks in neonatal intensive care unit (NICU); also, outbreaks caused by other Acinetobacter species have been reported. The aim of this review is to document the epidemiology of Acinetobacter spp. infections in neonates and risk factors for acquisition of Acinetobacter spp...
October 10, 2018: Current Infectious Disease Reports
Alessandra Oliva, Silvia Costantini, Massimiliano De Angelis, Stefania Garzoli, Mijat Božović, Maria Teresa Mascellino, Vincenzo Vullo, Rino Ragno
PURPOSE: Herein, an extended investigation of Tea tree oil (TTO) against a number of multi-drug resistant (MDR) microorganisms in liquid and vapor phases is reported. METHODS: The activity of TTO was tested against methicillin-sensitive Staphylococcus aureus (MSSA), Escherichia coli , and clinical strains of methicillin-resistant S. aureus (MRSA), extended-spectrum beta lactamases producer carbapenem-sensitive Klebsiella pneumoniae (ESBL-CS-Kp), carbapenem-resistant K...
October 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Min Kyung Kim, Nahee Kang, Su Jin Ko, Jonggwan Park, Eunji Park, Dong Won Shin, Seo Hyun Kim, Seung A Lee, Ji In Lee, Seung Hyun Lee, Eun Gi Ha, Seung Hun Jeon, Yoonkyung Park
Antimicrobial peptides (AMPs) are promising therapeutic agents for treating antibiotic-resistant bacterial infections. Previous studies showed that magainin 2 (isolated from African clawed fogs Xenopus laevis ) has antimicrobial activity against gram-positive and gram-negative bacteria. The present study was conducted to investigate the antibacterial activity of magainin 2 against Acinetobacter baumannii . Magainin 2 showed excellent antibacterial activity against A. baumannii strains and high stability at physiological salt concentrations...
October 5, 2018: International Journal of Molecular Sciences
Lillian J Juttukonda, Erin R Green, Zachery R Lonergan, Marie C Heffern, Christopher J Chang, Eric P Skaar
Acinetobacter baumannii is a Gram-negative opportunistic pathogen that causes diverse infections, including pneumonia, bacteremia, and wound infections. Due to multiple intrinsic and acquired antimicrobial-resistance mechanisms, A. baumannii isolates are commonly multi-drug resistant and infections are notoriously difficult to treat. The World Health Organization recently highlighted carbapenem-resistant A. baumannii as a 'critical priority' for the development of new antimicrobials because of the risk to human health posed by this organism...
October 8, 2018: Infection and Immunity
Kyle A Tipton, Chui-Yoke Chin, Marjan Farokhyfar, David S Weiss, Philip N Rather
Acinetobacter baumannii strain AB5075 forms two cell types distinguished by their opaque (VIR-O) or translucent (AV-T) colonies. VIR-O cells possess a thicker capsule and are more resistant to a variety of stressors. However, the direct role of capsule in these stressors was unknown. This study demonstrates that capsule is required for resistance to disinfectants, lysozyme and desiccation in Acinetobacter baumannii In addition, capsule is required for survival in a mouse lung model of infection.
October 8, 2018: Antimicrobial Agents and Chemotherapy
Haeun Lee, Woon Young Song, Minju Kim, Min Wook Lee, Soojeung Kim, Ye Song Park, Kyungwon Kwak, Man Hwan Oh, Hak Joong Kim
Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.
October 8, 2018: Organic Letters
Himen Salimizand, Abolfazl Raafati Zomorodi, Davood Mansury, Mostafa Khakshoor, Omid Azizi, Sepideh Khodaparast, Zohre Baseri, Pejman Karami, Sajjad Zamanlou, Hadi Farsiani, Yousef Amini, Bagher Moradi, Zahra Meshkat, Hana Salimizand, Hamid Sadeghian
PURPOSE: Acinetobacter baumannii-calcoaceticus complex (ABC) make a great burden on health-care systems due to hospital-acquired infections and antibacterial resistance. Aminoglycoside in combination with other antibacterials used as treatment options. However, ABC species overcome this class of antibacterials in different ways. This study provides a comprehensive report on the distribution of aminoglycoside modifying enzymes (AMEs) and 16S rRNA methylase in Acinetobacter baumannii and Acinetobacter nosocomialis isolated from various provinces in Iran...
October 4, 2018: Infection, Genetics and Evolution
Rima A Moghnieh, Zeina A Kanafani, Hussam Z Tabaja, Sima L Sharara, Lyn S Awad, Souha S Kanj
No uniformly organised collection of data regarding antimicrobial resistance has occurred in the countries of the Arab League. 19 countries of the Arab League have published data for antimicrobial susceptibility for the WHO priority organisms, and seven of 14 of these organisms are included in this Review (Escherichia coli, Klebsiella spp, Pseudomonas aeruginosa, Acinetobacter baumannii, Salmonella spp, Staphylococcus aureus, and Streptococcus pneumoniae). Although E coli and Klebsiella spp resistance to third-generation cephalosporins is common in all countries, with prevalence reaching more than 50% in Egypt and Syria, carbapenem resistance is emerging, albeit with a prevalence of less than 10%...
October 3, 2018: Lancet Infectious Diseases
Sónia G Pereira, Vanessa S Domingues, João Theriága, Maria de Jesus Chasqueira, Paulo Paixão
Introduction: Multiple-drug resistant bacteria are emerging exponentially in healthcare units, threatening public health and requiring novel therapeutic approaches. In 2017, World Health Organization published a list that frames antimicrobial resistant bacteria into priority levels for research of novel drugs to fight them. Methods & Materials: Antimicrobial resistant ESKAPE ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , Enterobacter sp...
2018: Open Microbiology Journal
Brettni Quinn, Nyah Rodman, Eugenio Jara, Jennifer S Fernandez, Jasmine Martinez, German M Traglia, Sabrina Montaña, Virginia Cantera, Kori Place, Robert A Bonomo, Andres Iriarte, María Soledad Ramírez
In the past few decades Acinetobacter baumannii has emerged as a notorious nosocomial pathogen because of its ability to acquire genetic material and persist in extreme environments. Recently, human serum albumin (HSA) was shown to significantly increase natural transformation frequency in A. baumannii. This observation led us to perform transcriptomic analysis of strain A118 under HSA induction to identify genes that are altered by HSA. Our results revealed the statistically significant differential expression of 296 protein-coding genes, including those associated with motility, biofilm formation, metabolism, efflux pumps, capsule synthesis, and transcriptional regulation...
October 3, 2018: Scientific Reports
Reza Akbari, Mojdeh Hakemi-Vala, Fatemeh Pashaie, Parvaneh Bevalian, Ali Hashemi, Kamran Pooshang Bagheri
BACKGROUND: Morbidity and mortality due to multidrug-resistant (MDR) bacteria are of great concern in burn patients. In this critical condition, synergism between antimicrobial peptides and conventional antibiotics would be a promising strategy. Accordingly, this study aimed to determine the therapeutic value of melittin as a natural peptide by examining its synergistic effect with conventional antibiotics against MDR isolates of Acinetobacter baumannii and Pseudomonas aeruginosa. MATERIALS AND METHODS: Fifteen clinical isolates for each kind of bacteria were collected from burn patients...
October 3, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Chin-Hao Yang, Yi-Cheng Chen, Shih-Yi Peng, Andy Po-Yi Tsai, Tony Jer-Fu Lee, Jui-Hung Yen, Je-Wen Liou
The increase in the prevalence of antibiotic-resistant bacteria has become a major public health concern. Antimicrobial peptides (AMPs) are emerging as promising candidates addressing this issue. In this study, we designed several AMPs by increasing α-helical contents and positive charges and optimizing hydrophobicity and amphipathicity in the Sushi 1 peptide from horseshoe crabs. A neural network-based bioinformatic prediction tool was used for the first stage evaluations of peptide properties. Among the peptides designed, Sushi-replacement peptide (SRP)-2, an arginine-rich and highly α-helical peptide, showed broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus and multidrug-resistant Acinetobacter baumannii; nevertheless, it showed little hemolytic and cytotoxic activity against mammalian cells...
October 2, 2018: Scientific Reports
Sanjeev Lalwani, Fahmi Hasan, Surbhi Khurana, Purva Mathur
To evaluate the potential risk factors which increase the incidence of post-trauma complications and mortality in pediatric population.A retrospective cohort study was conducted on patients below 18 years of age with a fatal outcome who were admitted to an Indian level-1 trauma center between January 2013 and December 2015. This cohort was analyzed to determine the demographics, injury mechanism, injury severity, microbiological profile, and cause of death.In total, 320 pediatric patients with a fatal outcome were studied which showed male preponderance (71...
September 2018: Medicine (Baltimore)
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