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A. Baumannii

Francisco Kennedy S F de Azevedo, Valéria Dutra, Luciano Nakazato, Camila Martines Mello, Marco Andrey Pepato, Alessandra Tammy Hayakawa Ito de Sousa, Doracilde Terume Takahara, Rosane Christine Hahn, Francisco José Dutra Souto
PURPOSE: Acinetobacter baumannii is a major cause of multidrug-resistant nosocomial infections. The characteristics of A. baumannii at two hospitals in a city in Central Brazil are described by analysing the phenotypes and molecular profiles of isolates recovered from 87 patients. METHODOLOGY: The isolates were identified and their antimicrobial susceptibility was evaluated using the the Bact/Alert 3D and Vitek2 methods. Patients' clinical data were obtained from medical files...
December 5, 2018: Journal of Medical Microbiology
Mustafa Sevindik
In the present study, antioxidant and antimicrobial potential of the Lentinus tigrinus (Bull.) Fr. mushroom was determined. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) of the mushroom were measured with Rel Assay kits. Antimicrobial activities were tested on 9 standard bacterial and fungal strains ( Staphylococcus aureus , Staphylococcus aureus MRSA, Enterococcus faecalis , Escherichia coli , Pseudomonas aeruginosa , Acinetobacter baumannii , Candida albicans , Candida krusei , and Candida glabrata ) with a modified agar dilution method...
2018: Advances in Pharmacological Sciences
Jasmine Moshiri, Darpan Kaur, Chido M Hambira, Jenna L Sandala, Jacob A Koopman, James R Fuchs, John S Gunn
Biofilm formation is a common strategy utilized by bacterial pathogens to establish persistence in a host niche. Salmonella enterica serovar Typhi, the etiological agent of Typhoid fever, relies on biofilm formation in the gallbladder to chronically colonize asymptomatic carriers, allowing for transmission to uninfected individuals. S. enterica serovar Typhimurium utilizes biofilms to achieve persistence in human and animal hosts, an issue of both clinical and agricultural importance. Here, we identify a compound that selectively inhibits biofilm formation in both S...
2018: Frontiers in Microbiology
Fahad S Aldoghaim, Gavin R Flematti, Katherine A Hammer
Essential oils from the Western Australian (WA) Eucalyptus mallee species Eucalyptus loxophleba , Eucalyptus polybractea , and Eucalyptus kochii subsp. plenissima and subsp. borealis were hydrodistilled from the leaves and then analysed by gas chromatography⁻mass spectrometry in addition to a commercial Eucalyptus globulus oil and 1,8-cineole. The main component of all oils was 1,8-cineole at 97.32% for E. kochii subsp. borealis , 96.55% for E. kochii subsp. plenissima , 82.95% for E. polybractea , 78.78% for E...
December 3, 2018: Microorganisms
Tzu Ping Ko, Chi Hung Huang, Shu Jung Lai, Yeh Chen
Undecaprenyl pyrophosphate (UPP) is an important carrier of the oligosaccharide component in peptidoglycan synthesis. Inhibition of UPP synthase (UPPS) may be an effective strategy in combating the pathogen Acinetobacter baumannii, which has evolved to be multidrug-resistant. Here, A. baumannii UPPS (AbUPPS) was cloned, expressed, purified and crystallized, and its structure was determined by X-ray diffraction. Each chain of the dimeric protein folds into a central β-sheet with several surrounding α-helices, including one at the C-terminus...
December 1, 2018: Acta Crystallographica. Section F, Structural Biology Communications
Heba Shehta Said, Abdalbagi Basheer Benmahmod, Ramadan Hassan Ibrahim
Acinetobacter baumannii is an opportunistic pathogen that has been held responsible for a lot of infections worldwide. Infections caused by this pathogen are difficult to control because of the widespread of antimicrobial resistance mechanisms. The aim of the present study is to assess the prevalence of extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases among isolates of A. baumannii collected from different clinical sources in Mansoura University Hospitals, Egypt. Antimicrobial susceptibility testing has demonstrated elevated resistance level to β-lactams, quinolones and aminoglycosides...
December 3, 2018: World Journal of Microbiology & Biotechnology
Simon Portsmouth, David van Veenhuyzen, Roger Echols, Mitsuaki Machida, Juan Camilo Arjona Ferreira, Mari Ariyasu, Peter Tenke, Tsutae Den Nagata
BACKGROUND: Carbapenem-resistant Gram-negative bacteria represent the highest priority for addressing global antibiotic resistance. Cefiderocol (S-649266), a new siderophore cephalosporin, has broad activity against Enterobacteriaceae and non-fermenting bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, including carbapenem-resistant strains. We assessed the efficacy and safety of cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections...
December 2018: Lancet Infectious Diseases
Min Hyung Kim, Seong Gyu Lee, Ki Sook Kim, Yoon Ji Heo, Ji Eun Oh, Su Jin Jeong
BACKGROUND: Environmental disinfection with continuously antimicrobial surfaces could offer superior control of surface bioburden. We sought to decide the efficacy of photocatalyst antimicrobial coating in reducing methicillin-resistant Staphylococcus aureus (MRSA) acquisition in high incidence setting. METHODS: We performed prospective cohort study involving patients hospitalized in medical intensive care unit. A titanium dioxide-based photocatalyst was coated on high touch surfaces and walls...
December 3, 2018: BMC Infectious Diseases
Yili Chen, Lu Ai, Penghao Guo, Han Huang, Zhongwen Wu, Xiaoling Liang, Kang Liao
BACKGROUND: Acinetobacter baumannii is a nosocomial pathogen which is reported as a major cause of morbidity and mortality in intensive care units (ICUs). However, there is a lack of analysis focused on multidrug-resistant Acinetobacter baumannii (MDRAB) infection among patients from pediatric intensive care unit (PICU) in China. The aim of this study was to investigate the molecular characterization of MDRAB isolated from PICU. METHODS: In this study, 86 isolates of MDRAB were collected from PICU patients, from the First Affiliated Hospital of Sun Yat-sen University...
December 4, 2018: BMC Infectious Diseases
Mathilde Lescat, Laurent Poirel, Aurélie Jayol, Patrice Nordmann
OBJECTIVES: Owing to the emergence of colistin resistance in nonfermenting Gram negative bacteria, reliable and rapid techniques for testing colistin susceptibility are needed. We evaluated the performances of the Rapid Polymyxin Acinetobacter and Pseudomonas tests using a collection of Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates. METHODS: Colistin susceptibility of A. baumannii and P. aeruginosa isolates (colistin susceptible and colistin resistant) was tested with the Rapid Polymyxin Acinetobacter and Pseudomonas tests and compared with the broth microdilution method...
December 1, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Andreas F Wendel, Monika Malecki, Robin Otchwemah, Carlos J Tellez-Castillo, Samir G Sakka, Frauke Mattner
Background: A. baumannii is a common nosocomial pathogen known for its high transmission potential. A high rate of carbapenem-susceptible Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB)-complex in clinical specimens led to the implementation of a pathogen-based surveillance on a 32-bed surgical intensive care unit (SICU) in a German tertiary care centre. Methods: Between April 2017 and March 2018, ACB-complex isolates with an epidemiological link to the SICU were further assessed...
2018: Antimicrobial Resistance and Infection Control
Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Mengyao Li, Heidi H Yu, Zhihui Zhou, Darren J Creek, Jing Zhang, Jian Li
Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii ; however, polymyxin resistance can emerge with monotherapy. Therefore, synergistic combination therapy is a crucial strategy to reduce polymyxin resistance. Methods: This study conducted untargeted metabolomics to investigate metabolic responses of a multidrug-resistant (MDR) A. baumannii clinical isolate, AB090342, to colistin and aztreonam alone, and their combination at 1, 4, and 24 h. Metabolomics data were analyzed using univariate and multivariate statistics; metabolites showing ≥ 2-fold changes were subjected to bioinformatics analysis...
2018: Frontiers in Microbiology
Ibrahim A Alotibi, Steve M Harakeh, Mohammed Al-Mamary, Abdalbasit A Mariod, Soad K Al-Jaouni, Saad Al-Masaud, Mona G Alharbi, Rashad R Al-Hindi
The objectives of this research were to identify certain chemical compounds that may be used as fingerprints of Saudi honey and to evaluate their antioxidant and antibacterial activities. Eleven Saudi 'monofloral' honey samples were analyzed and evaluated. Non-phenolic compounds, such as 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, methyl 3-hydroxyhexanaote and 5-hydroxymethyl-2-furancarboxaldehyde were present in different types of tested honey samples. Glyceraldehyde was only detected in five of the honey samples tested...
November 2018: Saudi Journal of Biological Sciences
Mona Shaaban, Abdelaziz Elgaml, El-Sayed E Habib
High incidence of antibiotic resistance among bacterial clinical isolates necessitates the discovery of new targets for inhibition of microbial pathogenicity without stimulation of microbial resistance. This could be achieved by targeting virulence determinants which cause host damage and disease. Many pathogenic bacteria elaborate signaling molecules for cellular communication. This signaling system is named quorum sensing system (QS), and it is contingent on the bacterial population density and mediated by signal molecules called pheromones or autoinducers (AIs)...
November 29, 2018: Microbial Pathogenesis
Thomas Vauchel, Romain Pirracchio, Maïté Chaussard, Matthieu Lafaurie, Martine Rouveau, Clotilde Rousseau, Mourad Benyamina, Sabri Soussi, François Dépret, Axelle Ferry, Haikel Oueslati, Marc Chaouat, Maurice Mimoun, Vincent Jarlier, Nabila Moreno, Alexandre Mebazaa, Matthieu Legrand
BACKGROUND: Multidrug-resistant (MDR) bacteria outbreaks represent a major threat in intensive care units. Patients may then be exposed to drug-related direct toxicity during such outbreaks. The objective of this study was to explore the impact of an outbreak of imipenem-resistant Acinetobacter baumannii (IR-AB) on renal outcomes. METHODS: We performed a before-and-after observational study in a French burn intensive care unit during an IR-AB outbreak: a 13-month period before (period A, October 2013-October 2014) and a 13-month period after outbreak control (period B, December 2014-December 2015)...
November 29, 2018: American Journal of Infection Control
Nidhi Bhardwaj, Surbhi Khurana, Minu Kumari, Rajesh Malhotra, Purva Mathur
INTRODUCTION: Antimicrobial resistance is an increasing problem worldwide especially among the surgical site infections (SSIs). SSI is becoming more serious due to hospital-acquired infections/nosocomial infections, which further leads to the overuse of broad-spectrum antibiotics. To investigate the antimicrobial resistance patterns among Gram-negative bacteria in SSI in in- and out-patients the present study was designed. METHODOLOGY: During the 4 years (January 2013-December 2016), the antimicrobial resistant pattern was studied in the admitted patients and in the patients who were followed up to the outpatients department (OPD) after discharge...
October 2018: Journal of Laboratory Physicians
Delia Muntean, Florin-George Horhat, Luminița Bădițoiu, Victor Dumitrașcu, Iulia-Cristina Bagiu, Delia-Ioana Horhat, Dan A Coșniță, Anca Krasta, Dorina Dugăeşescu, Monica Licker
Background and objective: Bacterial multidrug resistance is particularly common in Gram-negative bacilli (GNB), with important clinical consequences regarding their spread and treatment options. The aim of this study was to investigate the trend of multidrug-resistant GNB (MDR-GNB) in high-risk hospital departments, between 2000⁻2015, in intervals of five years, with the intention of improving antibiotic therapy policies and optimising preventive and control practices. Materials and methods: This is an observational, retrospective study performed in three departments of the most important tertiary healthcare unit in the southwestern part of Romania: the Intensive Care Unit (ICU), the General Surgery Department (GSD), and the Nutrition and Metabolic Diseases Department (NMDD)...
November 26, 2018: Medicina
Hayder Nsaif Jasim, Rand Riadh Hafidh, Ahmed Sahib Abdulamir
Objectives: Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii , a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and conflicts areas such as Iraq. Materials and Methods: Bacteriophages were isolated to highly resistant isolates of A. baumannii to form therapeutic phage cocktail, and to extract and evaluate native endolysin activity. Bacterial samples were collected in Al-Imamein Al-kadhimein Medical City Hospital...
November 2018: Iranian Journal of Basic Medical Sciences
Song Liu, Meng Wang, Liming Zheng, Wenxian Guan
BACKGROUND Antimicrobial resistance of nosocomial pathogens has become a worldwide problem that leads to major healthcare and economic burdens. Regional antimicrobial resistance profiles are needed to inform selection of proper antimicrobial agents. MATERIAL AND METHODS In collaboration with the Hospital Infection Control Office at our hospitals, we analyzed the constitution of nosocomial pathogens and the corresponding drug-resistance profiles. We paid particular attention to characteristics of pathogens that were derived from the bloodstream, and summarized the drug-resistance tendency of 2 specific bacteria within the most recent decade to reflect the development of resistance in regional China...
November 28, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
C Zhang, Y L Gong, X Q Luo, M X Liu, Y Z Peng
Objective: To analyze the distribution and drug resistance of pathogens from the wounds of thermal burn patients, so as to provide reliable basis for the rational use of antibiotics and the effective control over nosocomial infection. Methods: Wound samples of 1 310 thermal burn patients admitted into our burn wards from January 2012 to December 2017 were collected and retrospectively analyzed. API bacteria identification panels and automatical bacteria identification equipment were used to identify pathogens...
November 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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