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Barry E Gidal, Annie M Clark, Bob Anders, Frank Gilliam
OBJECTIVE: For extended-release drugs with multi-compartment kinetics, such as topiramate, effective half-life (t1/2eff ) may be a more clinically relevant parameter than elimination half-life (t1/2z ). Using topiramate as a real-life example, the objective was to compare these half-life values for immediate- and extended-release topiramate (TPM-IR and USL255, respectively) to understand how drug pharmacokinetics may impact drug dosing recommendations. METHODS: The t1/2z and t1/2eff for USL255 and TPM-IR were compared using data from a phase I study (N=36) of 200mg USL255 administered once daily (QD) or TPM-IR twice daily (BID); effect of sampling duration on t1/2z was investigated...
January 2017: Epilepsy Research
Bruce E Maryanoff
The role of phenotypic assessment in drug discovery is discussed, along with the discovery and development of TOPAMAX (topiramate), a billion-dollar molecule for the treatment of epilepsy and migraine.
July 14, 2016: ACS Medicinal Chemistry Letters
Diane S Aschenbrenner
No abstract text is available yet for this article.
July 2014: American Journal of Nursing
Vivek Ramakrishnan, Robert Dahlin, Omid Hariri, Syed A Quadri, Saman Farr, Dan Miulli, Javed Siddiqi
BACKGROUND: Seizures account for significant morbidity and mortality early in the course of traumatic brain injury (TBI). Although there is sufficient literature suggesting short-term benefits of antiepileptic drugs (AEDs) in post-TBI patients, there has been no study to suggest a time frame for continuing AEDs in patients who have undergone a decompressive craniectomy for more severe TBI. We examined trends in a level-II trauma center in southern California that may provide guidelines for AED treatment in craniectomy patients...
2015: Surgical Neurology International
S N Kozhechkin, Iu S Mednikova, L G Kolik
The effect of topiramate (topamax) on the electrical activity of frontal cortical neurons of neoencephalon was studied by microelectrode techniques in rats. Topiramate upon acute intraperitoneal administration and microionophoretic application dose-dependently reduced the frequency of spike activity within 17 - 30 min after injection at a dose of 40 and 80 mg/kg. At the same time, the agent did not change the membrane rest potential, and the magnitude and form of action potentials. Microionophoretically applied topiramate decreased the excitatory response to electroosmotically applied ethanol at "small doses" (ejected current < 50 nA) and enhanced the neuronal depression induced by ethanol at "large doses" (ejected current > 50 nA)...
2014: Eksperimental'naia i Klinicheskaia Farmakologiia
Heidi Collins Fantasia
Migraine headache is estimated to affect up to 28 percent of adolescents, most of whom are female. Chronic migraine in this population has been associated with reduced quality of life and academic disruption due to missed school days. Historically, migraine headache was treated episodically as it occurred. In March 2014 the U.S. Food and Drug Administration approved an existing medication, topiramate (Topamax®), for migraine prophylaxis in adolescents between the ages of 12 and 17. This is the first FDA approval of a drug for migraine prevention in this population...
October 2014: Nursing for Women's Health
(no author information available yet)
No abstract text is available yet for this article.
June 2014: Journal of Pain & Palliative Care Pharmacotherapy
V I Guzeva, V V Guzeva
Objective. To investigate the effect of modern antiepileptic drugs on the hormonal profile of girls with epilepsy. Materials and methods. Levels of thyroid-stimulating hormone (TSH), thyrogiobulin antibodies (a/b TG), triiodothyronine (T3), thyroxine (T4), parathyroid hormone (P) and cortisol (C) were determined in the blood of 50 girls with epilepsy, aged from 8 to 17 years. In 19 girls, repeated measures of TSH, a/b TG, T3, T4 and C were taken 2-12 months after the first study. Valproate, carbamazepine, and topamax were used for treatment...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
V Echeverry-Alzate, E Giné, K M Bühler, J Calleja-Conde, P Olmos, M A Gorriti, R Nadal, F Rodríguez de Fonseca, J A López-Moreno
BACKGROUND AND PURPOSE: Recent and ongoing clinical studies have indicated that topiramate (Topamax®) could be effective in treating ethanol or cocaine abuse. However, the effects of topiramate on the co-administration of ethanol and cocaine remain largely unknown. EXPERIMENTAL APPROACH: We studied the effects of topiramate, in Wistar rats, on operant ethanol self-administration with the co-administration of cocaine (i.p.). The psychomotor effects of topiramate were examined before ethanol self-administration and cocaine exposure...
June 2014: British Journal of Pharmacology
Herng-Sheng Lee, Shih-Yu Wang, Donald M Salter, Chih-Chien Wang, Shyi-Jou Chen, Hueng-Chuen Fan
BACKGROUND: This study investigated whether long-term treatment with antiepileptic drugs (AEDs) had negative effects on statural growth and serum calcium levels in children with epilepsy in Taiwan. METHODS: Children with epilepsy treated with one prescription of AEDs (monotherapy) for at least 1 year were selected. The AEDs included valproic acid (VPA; Deparkin) in 27 children (11 boys and 16 girls) aged 4-18 years, oxcarbazepine (Trileptal) in 30 children (15 boys and 15 girls) aged 5-18 years, topiramate (Topamax) in 19 children (10 boys and 9 girls) aged 6-18 years, and lamotrigine (Lamicta) in eight children (5 boys and 3 girls) aged 5-13 years...
2013: BMC Pediatrics
Niranjan N Singh, Pradeep Sahota
Sleep and headache have both generated curiosity within the human mind for centuries. The relationship between headache and sleep disorders is very complex. While Lieving in 1873 first observed that headaches were linked to sleep, Dexter and Weitzman in 1970 described the relationship between headache and sleep stages. Though our understanding of sleep and headache relationship has improved over the years with expanding knowledge in both fields and assessment tools such as polysomnography, it is still poorly understood...
December 2013: Current Treatment Options in Neurology
G Cosentino, P Paladino, S Maccora, S Indovino, B Fierro, F Brighina
AIM: Topiramate is a small molecule widely used for the treatment of epilepsy, migraine, bipolar disorders and alcoholism, and its availability as a generic formulation could significantly reduce the National Health Service expenditure. A generic formulation, available in Italy under the trademark Sincronil, recently showed superimposable blood levels, after oral administration to healthy volunteers, with the reference formulation. In the present study we report the results of an open label, parallel group, randomized, controlled study performed to evaluate the efficacy, tolerability and impact on disability of two different formulations of topiramate (Sincronil and Topamax) in patients with migraine without aura...
September 2013: Panminerva Medica
Marietta Charakida, Dimitris Tousoulis, Nicholas Finer
PURPOSE OF REVIEW: The incidence of obesity and its associated comorbidities have significantly increased over the years with adverse health and financial consequences for society. Lifestyle changes are essential for the prevention and treatment of obesity but their benefit appears limited as inadequate and nonsustained weight loss results have been reported. Pharmacotherapy is frequently advocated as part of a weight loss strategy. In this review, we will discuss the antiobesity drugs with Food and Drug Administration approval and their cardiovascular implications...
September 2013: Current Opinion in Cardiology
Iu V Solomatin, I S Vygovskaia
No abstract text is available yet for this article.
2013: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
William Gualtieri, Jan Janula
UNLABELLED: The purpose of this study is to present the first case of a pure 'topiramate maculopathy' without acute glaucoma and/or myopia, which form the classical syndrome. DESIGN: Interventional/observational case report. SETTING: Institutional University Teaching Hospital. PATIENT: A 22-year-old American female, after taking 100 mg of topiramate (Topamax®) a day for 6 days because of a migraine attack, complained of severe visual acuity deterioration of sudden onset in both eyes, regardless of distance (far or near), during the span of 1 day...
February 2013: International Ophthalmology
I G Rudakova
Topiramate (topamax) is an antiepileptic drug of the new generation that was first registered and introduced in clinical practice in 1995. Due to its effective clinical properties, the drug is used widely all over the world including Russia where it has been using since 1999. Topamax is a principally new antiepileptic drug (AED) with the unique mechanism of action, favorable pharmacokinetics, high efficacy and safety. During its existence, it is widely accepted as an AED of first choice for additional and initial treatment of many forms of epilepsy in children over 2 years old and adults including old patients of both sexes...
2012: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
(no author information available yet)
No abstract text is available yet for this article.
2011: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Jeannine M Conway, Angela K Birnbaum, Susan E Marino, James C Cloyd, Rory P Remmel
Topiramate (Topamax®) is an antiepileptic medication used as adjunctive and monotherapy in patients with epilepsy and for migraine prophylaxis. A GC-MS assay was developed that was capable of detecting topiramate plasma concentrations following a single rectal or oral dose administration. Topiramate plasma samples were prepared by solid-phase extraction and were quantified by GC-MS analysis. The topiramate standard curves were split from 0.1 to 4 µg/mL and from 4 to 40 µg/mL in order to give a more accurate determination of the topiramate concentration...
September 2012: Biomedical Chromatography: BMC
S N Sivkova, O A Milovanova, F M Zaĭkova
A clinical trial included 30 children, aged from 24 to 46 months, stratified into two groups on the basis of clinical-instrumental data: 22 (73%) patients with symptomatic focal epilepsy and 8 (27%) patients with cryptogenic (possibly symptomatic) focal epilepsy. Topamax (topiramate) was used as mono- (8 children) and combined (22 children) therapy. Mean treatment dose was 5,9 mg/kg per day. Efficacy of treatment was evaluated by the changes in frequency of seizures. After 6 months, the positive result (completed stopping of seizures or their reduction by 50% and more) was seen in 19 (63,75%) patients...
2011: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
M I Koreshkina
Forty-eight patients have been examined in the Centre of Headache Treatment. MRI of the brain revealed the changes in the white matter in 69% of patients, 39% had multiple foci (more than 3). The largest number of foci was seen in patients with frequent and chronic migraine without aura, but not in those with migraine with aura. The foci were located more often in frontal areas and less often in parietal and temporal areas. Twenty-three patients with frequent and chronic migraine received the preventive treatment with the anticonvulsant topiramate (topamax, capsules 25 and 50 mg)...
2011: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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