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Urinary biomarkers

Anne-Marie Saillenfait, Sophie Ndaw, Alain Robert, Jean-Philippe Sabaté
Organophosphate triesters (PEFRs) are used increasingly as flame retardants and plasticizers in a variety of applications, such as building materials, textiles, and electric and electronic equipment. They have been proposed as alternatives to brominated flame retardants. This updated review shows that biomonitoring has gained incrementally greater importance in evaluating human exposure to PEFRs, and it holds the advantage of taking into account the multiple potential sources and various intake pathways of PEFRs...
August 10, 2018: Archives of Toxicology
Vivienne X Guan, Yasmine C Probst, Elizabeth P Neale, Linda C Tapsell
This study compared self-reported sodium and potassium intakes with urinary biomarkers and identified predictive factors. Secondary analysis of the 3-month intensive phase of the HealthTrack study with control (C), interdisciplinary intervention (I), intervention plus 30 g walnuts/day (IW) arms (n = 149). Dietary data was derived from diet history (DH) interviews and biomarker measures from urine. Urine-derived sodium (all, p = 0.000) and potassium (C: p = 0.011; I: p = 0.000; IW: p = 0...
August 10, 2018: European Journal of Clinical Nutrition
Phil M Choi, Jake W O'Brien, Jiaying Li, Guangming Jiang, Kevin V Thomas, Jochen F Mueller
Systematic sampling and analysis of wastewater has become an important tool for monitoring consumption of drugs and other substances, and has been proposed as a method to evaluate aspects of population health using endogenous biomarkers. 1,4‑methylimidazoleacetic acid (MIAA) is an endogenous biomarker and metabolite of histamine turnover. Its urinary excretion is elevated in conditions such as mastocytosis, hay fever, hives, food allergies and anaphylaxis. The aim of this study was to develop and apply methods for MIAA in wastewater and compare its occurrence with antihistamine use in wastewater...
August 7, 2018: Environment International
Aydan Caglayan, Doruk Cevdi Katlan, Zafer Selcuk Tuncer, Kunter Yuce, Hasan Berkan Sayal, Belma Kocer-Gumusel
OBJECTIVES: Uterine myomas (UM) are responsible for significant morbidity and have adverse effects on quality of life in women. Reactive oxygen species (ROS) and antioxidant enzymes (AOE), as well as sex steroids play important roles in the reproductive physiology processes. Thus, we aimed to investigate the role of oxidant-antioxidant status in UM by measuring the AOE activities and lipid peroxidation (LPO) levels. This is the first study assessing these parameters together in UM based on also menopausal status and evaluating possible correlations between AOE activities, LPO markers, tumor biomarkers, female reproductive system hormone levels, comprehensively...
August 1, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Takeshi Osonoi, Maki Gouda, Mamiko Kubo, Kenji Arakawa, Toshio Hashimoto, Masanori Abe
BACKGROUND: Albuminuria characterizes the progression of kidney injury. The effect of canagliflozin on the excretion of microalbumin was assessed for investigating its renoprotective potential in Japanese patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: Twenty Japanese patients with T2DM and microalbuminuria were enrolled and administered with 100 mg of canagliflozin once a day for 12 weeks. These subjects were admitted to the clinic at the start and end of the treatment period for 24-h urine collection...
August 10, 2018: Diabetes Technology & Therapeutics
Sili Fan, Austin Yeon, Muhammad Shahid, Jennifer T Anger, Karyn S Eilber, Oliver Fiehn, Jayoung Kim
The biological basis for gender variability among disease states is not well established. There have been many prior efforts attempting to identify the unique urine metabolomic profiles associated with specific diseases. However, there has been little advancement in investigating the metabolomic differences associated with gender, which underlies the misconception that risk factors and treatment regimens should be the same for both male and female patients. This present study aimed to identify biologically-meaningful baseline sex-related differences using urine samples provided by healthy female and male participants...
August 8, 2018: Scientific Reports
Petra A Wark, Laura J Hardie, Gary S Frost, Nisreen A Alwan, Michelle Carter, Paul Elliott, Heather E Ford, Neil Hancock, Michelle A Morris, Umme Z Mulla, Essra A Noorwali, K Petropoulou, David Murphy, Gregory D M Potter, Elio Riboli, Darren C Greenwood, Janet E Cade
BACKGROUND: Online dietary assessment tools can reduce administrative costs and facilitate repeated dietary assessment during follow-up in large-scale studies. However, information on bias due to measurement error of such tools is limited. We developed an online 24-h recall (myfood24) and compared its performance with a traditional interviewer-administered multiple-pass 24-h recall, assessing both against biomarkers. METHODS: Metabolically stable adults were recruited and completed the new online dietary recall, an interviewer-based multiple pass recall and a suite of reference measures...
August 9, 2018: BMC Medicine
Christian Albert, Annemarie Albert, Rinaldo Bellomo, Siegfried Kropf, Prasad Devarajan, Sabine Westphal, Hassina Baraki, Ingo Kutschka, Christian Butter, Michael Haase, Anja Haase-Fielitz
AIM: To assess weather doctors' clinical risk-assessment for major adverse kidney events (MAKE) and acute kidney injury (AKI) after open-heart surgery would improve when being informed about neutrophil gelatinase-associated lipocalin (NGAL) test result at ICU admission. PATIENTS & METHODS: Clinical risk-assessment for MAKE and AKI were performed with and without providing NGAL test result and compared in an exploratory- and a validation-cohort using reclassification metrics, exemplary category-free net reclassification improvement (cfNRI)...
August 8, 2018: Biomarkers in Medicine
Jae-Woo Kwon, Hee-Won Park, Woo Jin Kim, Man-Goo Kim, Seung-Joon Lee
BACKGROUND: Exposure to low levels of volatile organic compounds (VOCs) in ordinary life is suspected to be related to oxidative stress and decreased lung function. This study evaluated whether exposure to ambient VOCs in indoor air affects airway inflammation. METHODS: Thirty-four subjects from the hospital that had moved to a new building were enrolled. Symptoms of sick building syndrome, pulmonary function tests, and fractional exhaled nitric oxide (FeNO) were evaluated, and random urine samples were collected 1 week before and after the move...
August 7, 2018: Environmental Health: a Global Access Science Source
Mariella Carrieri, Spatari Giovanna, Tranfo Giovanna, Sapienza Daniela, Luisa Scapellato Maria, Battista Bartolucci Giovanni, Manno Maurizio
The aim of the study was to investigate the effect of various factors that modulate the metabolism of benzene, including smoking habits, metabolic genotype of GST and co-exposure to toluene, on the levels of three biomarkers, i.e. urinary benzene (UB), S-phenylmercapturic acid (SPMA) and t,t-muconic acid (t,t-MA), in 146 refinery workers exposed to low levels of air benzene (AB) in the range <1.5-529.2 µg/m3 (mean value 32.6 µg/m3 ). The study confirmed the validity of SPMA as a good biomarker of benzene exposure even at low levels of exposure...
August 4, 2018: Toxicology Letters
Amit Tirosh, Naris Nilubol, Dhaval Patel, Electron Kebebew
OBJECTIVE: New clinical prognostic tools are needed to select the population of patients with neuroendocrine tumors (NETs) that have a high risk of disease progression and disease-specific mortality (DSM). Biochemical biomarker doubling time (DT) is used clinically for prognosis prediction in several solid malignancies. The aim of the current study was to determine whether 24-hour urinary 5-hydroxyindoleacetic acid (5-HIAA) level DT has any prognostic utility in patients with NETs. METHODS: Patients with NETs were enrolled in a prospective study with comprehensive biochemical analysis...
August 7, 2018: Endocrine Practice
Beloo Mirakhur, Marianne E Pavel, Rodney F Pommier, George A Fisher, Alexandria T Phan, Christine Massien, Nilani Liyanage, Susan Pitman Lowenthal, Aaron I Vinik
OBJECTIVE: Neuroendocrine tumors (NETs) are associated with elevated 5-hydroxyindoleacetic acid (5-HIAA) and chromogranin A (CgA) levels. This study aimed to analyze relationships between urinary 5-HIAA and plasma CgA levels and clinical outcomes. METHODS: Centrally assessed biomarker levels and correlations with progression-free survival (PFS) and carcinoid syndrome (CS) symptom control were evaluated in a pooled analysis of CLARINET (96-week randomized, double-blind, placebo-controlled) and ELECT (16-week randomized, double-blind, placebo-controlled, 32-week initial open-label and ≥ 2 year long term extension open label) studies of adults with NETs, with (ELECT) or without (CLARINET) CS at 97 institutions...
August 7, 2018: Endocrine Practice
Cristian C Constantinescu, Cedric Tresse, MingQiang Zheng, Alexandra Gouasmat, Vincent M Carroll, Laetitia Mistico, David Alagille, Christine M Sandiego, Caroline Papin, Kenneth Marek, John P Seibyl, Gilles D Tamagnan, Olivier Barret
PURPOSE: Synaptic vesicle protein 2A (SV2A) serves as a biomarker of synaptic density and positron emission tomography (PET) imaging of SV2A could provide a tool to assess progression of neurodegenerative diseases. Two tracers have primarily been reported and characterized in vivo: [11 C]UCB-J and [18 F]UCB-H. In early human studies, [11 C]UCB-J showed promising results, while its F-18-labeled analogue [18 F]UCB-H showed suboptimal specific signal in comparison to [11 C]UCB-J. Considering the limited use of [11 C]UCB-J to facilities with a cyclotron, having a F-18 variant would facilitate large, multicenter imaging trials...
August 6, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Congmin Liu, Jing Jin, Di Liang, Zhaoyu Gao, Yachen Zhang, Tiantian Guo, Yutong He
The present meta-analysis aimed to systematically evaluates the metastasis, clinical stage, and prognostic value regarding the expression levels of PVT1 in various cancers. Relevant literatures were searched in PubMed、Cochrane Library、Wed of science、Embase databases、Chinese National Knowledge Infrastructure and Wanfang from inception up to 22 August 2017. After data were extracted, a meta-analysis was performed using Review Manager 5.3 and Stata 12.0 software. The meta-analysis showed that high expression of PVT1 could predict more lymph node metastasis (LNM) (Odds ratio, OR = 2...
August 6, 2018: Pathology Oncology Research: POR
Felix S Seibert, Maximilian Sitz, Jürgen Passfall, Martin Haesner, Peter Laschinski, Martin Buhl, Frederic Bauer, Nina Babel, Nikolaos Pagonas, Timm H Westhoff
BACKGROUND/AIMS: Urinary biomarkers like neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) do not only allow an early diagnosis of acute kidney injury, but also provide prognostic information in this setting. The present prospective study investigates, whether the urinary biomarkers NGAL, KIM-1 and calprotectin have prognostic information in chronic kidney disease (CKD) as well. METHODS: Urinary calprotectin, NGAL and KIM-1 concentrations were assessed in a study population of 143 patients with stable CKD comprising diabetic and hypertensive nephropathy, glomerulonephritis/vasculitis, and autosomal dominant polycystic kidney disease...
August 3, 2018: Kidney & Blood Pressure Research
Linchen He, Xing Lucy Liu, Junfeng Jim Zhang
Oxidative stress is involved in the pathophysiology of many diseases and natural aging. Urinary 8‑hydroxy‑2'‑deoxyguanosine (8‑OHdG), a stable product of DNA oxidative damage, has been widely used as an oxidative stress biomarker. However, only reporting 8‑OHdG level, as commonly done previously, does not take into account of damaged DNA molecules that have not been repaired and excreted in urine. Melatonin is known to help with DNA repairs and hence can modify 8‑OHdG levels. 6‑sulfatoxymelatonin (aMT6s) is a major metabolite of melatonin excreted in urine...
July 29, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
R Beetz
Dilatations of the urinary tract are discovered in increasing numbers in intrauterine or postnatal sonographic screening examinations. Only few urinary tract anomalies (e. g. urethral valves) require immediate therapy; however, ureteropelvic stenosis and primary megaureter in particular require a prognostic classification between relevant obstructions needing correction and dilations which do not affect renal function. Ultrasound, diuresis scintigraphy and magnetic resonance imaging (MRI) remain the main pillars of advanced diagnostics despite an increasing number of biomarkers...
August 2018: Der Urologe. Ausg. A
Yan Huang, Gang Li, Kai Wang, Zhongyi Mu, Qingpeng Xie, Hongchen Qu, Hang Lv, Bin Hu
BACKGROUND Collagen type VI alpha 3 chain (COL6A3) has been proven to be a biomarker in the occurrence and development of bladder cancer, which is the most common malignant tumor in the urinary system. This study aimed to explore the effect and molecular mechanism of COL6A3 on EMT in vitro induced by TGF-β/Smad in bladder carcinoma. MATERIAL AND METHODS There were 42 patients included in the Kaplan-Meier survival analysis. A cell counting kit-8 (CCK-8) assay and an angiogenesis assay were used to measure cell proliferation and tube formation, respectively...
August 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Ali C Johnson, Richard A Zager
P21 is up-regulated in renal tubules in response to AKI and localizes in the nucleus where it induces cell cycle arrest (CCA). These events can mitigate early injury, but can also facilitate the onset of the cellular senescence/"aging" process. Hence, we asked: i) Can renal p21 up-regulation be gauged by plasma and/or urinary p21 assay? ii) Might p21 serve as an AKI / CCA biomarker? and iii) Does p21 accumulate during normal renal aging, and might plasma p21 reflect this process? Mice were subjected to either ischemia-reperfusion (I/R) or nephrotoxic (maleate) AKI...
August 1, 2018: American Journal of Physiology. Renal Physiology
Andrea Padoan, Daniela Basso, Carlo-Federico Zambon, Tommaso Prayer-Galetti, Giorgio Arrigoni, Dania Bozzato, Stefania Moz, Filiberto Zattoni, Rino Bellocco, Mario Plebani
Background: Lower urinary tract symptoms (LUTS) and prostate specific antigen-based parameters seem to have only a limited utility for the differential diagnosis of prostate cancer (PCa). MALDI-TOF/MS peptidomic profiling could be a useful diagnostic tool for biomarker discovery, although reproducibility issues have limited its applicability until now. The current study aimed to evaluate a new MALDI-TOF/MS candidate biomarker. Methods: Within- and between-subject variability of MALDI-TOF/MS-based peptidomic urine and serum analyses were evaluated in 20 and 15 healthy donors, respectively...
2018: Clinical Proteomics
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