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https://www.readbyqxmd.com/read/29244889/elderly-patients-with-ongoing-migraine-show-reduced-gray-matter-volume-in-second-somatosensory-cortex
#1
Sébastien Celle, Christelle Créac'h, Claire Boutet, Frédéric Roche, Florian Chouchou, Jean-Claude Barthélémy, Roland Peyron
AIMS: To identify structural changes in gray matter in suspected migraine generators (the hypothalamus and/or brainstem nuclei) and pain pathways and to evaluate whether structural changes in migraine are definitive or resolve with age. METHODS: Voxel-based morphometry (VBM) was used to assess differences in gray matter between 39 healthy controls (HC), 25 episodic migraine (EM) subjects, and 37 subjects with a history of migraine (HM). In addition, morphometric changes were specifically investigated in suspected migraine generators and/or pain pathways...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244264/personality-traits-and-anxiety-and-depressive-disorders-in-patients-with-medication-overuse-headache-versus-episodic-migraine
#2
Nima Mohseni, Mansooreh Togha, Seyed Masoud Arzaghi, Sepideh Nekooie, Mehrnaz Fallah Tafti, Farzad Fatehi
Objective: An episodic migraine (EM) may lead to medication-overuse headache (MOH), an abnormal behavioral pattern of noncompliance. Anxiety disorders, mood disorders, and disorders caused by psychoactive substances other than analgesics all have been reported with MOH at higher rates than with EM. The objective of this study was to evaluate the relationships between personality traits and anxiety and depressive disorders and headache type. Methods: In this cross-sectional study, 55 patients with EM and 50 patients with MOH were recruited from were recruited from 2 university hospital clinics in Tehran, Iran, from January 2013 to November 2015...
December 14, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29244233/inadequate-brain-glycogen-or-sleep-increases-spreading-depression-susceptibility
#3
Kivilcim Kilic, Hulya Karatas, Buket Donmez-Demir, Emine Eren-Kocak, Yasemin Gursoy-Ozdemir, Alp Can, Jean-Marie Petit, Pierre J Magistretti, Turgay Dalkara
OBJECTIVE: Glycogen in astrocyte endfeet contributes to maintenance of low extracellular glutamate and K+ concentrations around synapses. Sleep deprivation (SD), a common migraine trigger induces transcriptional changes in astrocytes reducing glycogen breakdown. We hypothesize that when glycogen utilization cannot match synaptic energy demand, extracellular K+ can rise to levels that activate neuronal pannexin-1 channels and downstream inflammatory pathway, which might be one of the mechanisms initiating migraine headaches...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29243813/antiepileptic-drug-monotherapy-for-epilepsy-a-network-meta-analysis-of-individual-participant-data
#4
REVIEW
Sarah J Nevitt, Maria Sudell, Jennifer Weston, Catrin Tudur Smith, Anthony G Marson
BACKGROUND: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29242523/migraine-cgrp-targeting-antibodies-reduce-migraine-frequency
#5
Heather Wood
No abstract text is available yet for this article.
December 15, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29241724/measures-of-ses-for-electronic-health-record-based-research
#6
Joan A Casey, Jonathan Pollak, M Maria Glymour, Elizabeth R Mayeda, Annemarie G Hirsch, Brian S Schwartz
INTRODUCTION: Although infrequently recorded in electronic health records (EHRs), measures of SES are essential to describe health inequalities and account for confounding in epidemiologic research. Medical Assistance (i.e., Medicaid) is often used as a surrogate for SES, but correspondence between conventional SES and Medical Assistance has been insufficiently studied. METHODS: Geisinger Clinic EHR data from 2001 to 2014 and a 2014 questionnaire were used to create six SES measures: EHR-derived Medical Assistance and proportion of time under observation on Medical Assistance; educational attainment, income, and marital status; and area-level poverty...
December 11, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29241470/-social-issues-in-the-doctor-s-clinic
#7
H Vos
Doctors are confronted with issues that arise in society. These social issues can affect patients' health. Solving these problems requires more than just prescribing a pill, as illustrated by the cases of three patients. The first patient is a 42-year-old male with cardiac symptoms, chronic lower back pain and an excessive use of tranquillizers. The welfare worker intervened and his demand for health care and use of tranquillizers diminished. The second patient is a 53-year-old female with symptoms of chronic back pain, migraine and depression...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29239213/features-of-aura-in-paediatric-migraine-diagnosed-using-the-ichd-3-beta-criteria
#8
Martina Balestri, Laura Papetti, Daniela Maiorani, Alessandro Capuano, Samuela Tarantino, Barbara Battan, Federico Vigevano, Massimiliano Valeriani
Background In children and adolescents, the prevalence rate of migraine with aura is 1.6%. Few studies concerning migraine with aura features in paediatric population have been reported. Aim The aim of our study was to investigate clinical features of aura in a retrospective cohort of children with migraine with aura. Furthermore, we studied whether the International Classification of Headache Disorder (ICHD) 3 beta version criteria could efficiently detect migraine with aura in a paediatric population. Results We included 164 patients who experienced aura associated with headache (mean age 9...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29239212/sarcoma-family-kinase-activity-is-required-for-cortical-spreading-depression
#9
Fan Bu, Yan Wang, Liwen Jiang, Dongqing Ma, John P Quinn, Minyan Wang
Objectives Sarcoma family kinase activity is associated with multiple diseases including ischemia and cancer; however, its role in the mechanism of migraine aura has been less well characterised. This study aims to investigate whether sarcoma family kinase is required for cortical spreading depression. Methods Cortical spreading depression was induced by topical application of K+ to the cerebral cortex and was monitored using electrophysiology in rats, and intrinsic optical signal in mouse brain slices. Drugs were perfused into the contralateral cerebral ventricle for pharmacological manipulations in rats...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29238692/migraine-related-vertigo
#10
Vithal D Udagatti, Rajendran Dinesh Kumar
Migraine related vertigo (MRV) is largely accepted in the vestibular community and probably represents the second most common cause of vertigo after benign positional vertigo by far exceeding Meniere's disease. The data on vestibular migraine management is still relatively poor, despite its enormous importance in daily practice. A 55-year old male presented with history of giddiness, imbalance, sweating and sensation of nausea with severe pulsating headache of one day duration. Ear, Nose and Throat examination was normal...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29237795/the-headache-of-terror-a-matched-cohort-study-of-adolescents-from-the-ut%C3%A3-ya-and-the-hunt-study
#11
Synne Øien Stensland, John-Anker Zwart, Tore Wentzel-Larsen, Grete Dyb
OBJECTIVE: To elaborate the risk of headache among adolescent survivors exposed to terror. METHODS: On July 22, 2011, a lone man opened gunfire, killing 69 people at a summer camp for adolescents on the Utøya islet in Norway. All 358 adolescent survivors 13 to 20 years of age were invited to participate in the Utøya interview study. Among the 213 (59%) respondents, half (49%) were male, the mean age was 17.7 years, and 13 (6%) were severely injured. For each survivor, 8 matched controls were drawn from the population-based Young-HUNT3 Study, conducted between 2006 and 2008, with a participation rate of 73%...
December 13, 2017: Neurology
https://www.readbyqxmd.com/read/29237386/the-combined-effects-of-%C3%AF-3-fatty-acids-and-nano-curcumin-supplementation-on-intercellular-adhesion-molecule-1-icam-1-gene-expression-and-serum-level-in-migraine-patients
#12
Neda Soveyd, Mina Abdolahi, Mahmoud Djalali, Mahsa Hatami, Abbas Tafakhori, Payam Sarraf, Niyaz Mohammadzadeh Honarvar
BACKGROUND: Migraine is an episodic headache that endothelial disorder and neuro inflammation basic. Intercellular Adhesion Molecule-1(ICAM-1) as an endothelial factor lead to adhesion of leukocytes to the walls of cerebral blood vessels which it's an important step in the inflammation process. Curcumin and omega-3 fatty acids by affecting on transcription factors can regulate the gene expression and serum level of ICAM-1.Thus we aimed to evaluate synergistic effects of ω-3 fatty acids and nano-curcumin on ICAM-1 gene expression and serum levels in migraine patients...
December 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29237284/pain-worsening-with-physical-activity-during-migraine-attacks-in-women-with-overweight-obesity-a-prospective-evaluation-of-frequency-consistency-and-correlates
#13
Samantha G Farris, J Graham Thomas, Ana M Abrantes, Richard B Lipton, Jelena Pavlovic, Todd A Smitherman, Megan B Irby, Donald B Penzien, Julie Roth, Kevin C O'Leary, Dale S Bond
Background Migraine is a neurological disease involving recurrent attacks of moderate-to-severe and disabling head pain. Worsening of pain with routine physical activity during attacks is a principal migraine symptom; however, the frequency, individual consistency, and correlates of this symptom are unknown. Given the potential of this symptom to undermine participation in daily physical activity, an effective migraine prevention strategy, further research is warranted. This study is the first to prospectively evaluate (a) frequency and individual consistency of physical activity-related pain worsening during migraine attacks, and (b) potential correlates, including other migraine symptoms, anthropometric characteristics, psychological symptoms, and daily physical activity...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29237283/ghrelin-attenuated-hyperalgesia-induced-by-chronic-nitroglycerin-cgrp-and-trpv1-as-targets-for-migraine-management
#14
Fereshteh Farajdokht, Gisou Mohaddes, Dariush Shanehbandi, Pouran Karimi, Shirin Babri
Background According to the neurovascular theory of migraine, activation of the trigeminovascular system contributes to the development of migraine. This study examined the effects of chronic intraperitoneal ghrelin (150 µg/kg) treatment on the development of chronic migraine induced by intermittent injection of nitroglycerin 10 mg/kg. Methods Baseline and post-drug (2 h following nitroglycerin injection) mechanical and thermal sensitivity were assessed by von Frey hair and tail immersion tests, respectively on days 1, 3, 5, 7, 9 and 11...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29237282/modulation-of-salience-network-intranetwork-resting-state-functional-connectivity-in-women-with-chronic-migraine
#15
X Michelle Androulakis, Chris Rorden, B Lee Peterlin, Kaitlin Krebs
Objective To investigate the intranetwork resting state fMRI connectivity within the Salience Network of chronic migraine with and without medication overuse headache. Methods We compared 351 pairs of intranetwork connectivity in chronic migraine (n = 13) and chronic migraine with medication overuse headache (n = 16) compared to matched controls, and between each chronic migraine subgroup. Results Compared to controls, 17 pairs of intranetwork connections in chronic migraine and 27 pairs in chronic migraine with medication overuse headache were decreased...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29236991/neurochemical-changes-in-the-medial-wall-of-the-brain-in-chronic-migraine
#16
David M Niddam, Kuan-Lin Lai, Shang-Yueh Tsai, Yi-Ru Lin, Wei-Ta Chen, Jong-Ling Fuh, Shuu-Jiun Wang
Migraine chronification is associated with a dysfunctional thalamocortical pathway. The present study addressed whether abnormal concentrations of neurochemicals exist in key brain regions of this pathway in chronic migraine. Magnetic resonance spectroscopic imaging of the bilateral medial walls of the brain was used to measure choline, creatine, glutamate and glutamine, myo-inositol, and N-acetyl-aspartate in chronic migraine patients and in matched groups of episodic migraine patients and healthy controls...
December 11, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29236896/sulcal-hyperintensity-mimicking-subarachnoid-hemorrhage-in-the-context-of-hemiplegic-migraine
#17
Elton Francisco Pavan Batista, Marcos Rosa, Marcelo Ramos Muniz
No abstract text is available yet for this article.
December 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29236660/migraine-headache-treated-with-famciclovir-and-celecoxib-a-case-report
#18
Bradford Lee Napier, Maki Morimoto, Erin Napier
INTRODUCTION: Herpes simplex virus (HSV) has been speculated to play a role in migraine headache pathophysiology. We present the first successful migraine headache treatment with therapy specifically targeting HSV infection. CASE PRESENTATION: A previously healthy 21-year-old white woman presented with a severe headache and was diagnosed with severe migraine headache disorder. She initially was treated with standard migraine headache medications without symptomatic improvement...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29235107/headache-characteristics-and-clinical-features-of-elderly-migraine-patients
#19
Pablo de Rijk, Noémie Resseguier, Anne Donnet
OBJECTIVE: To investigate the headache characteristics and clinical features of elderly migraine patients at a tertiary headache center. METHODS: We retrospectively reviewed 239 records of migraine patients, over the age of 64 at the first visit, who had migraine as defined by the International Classification of Headache Disorders 3rd edition (beta version) from 2006 to 2015 based on the Marseille registry at Timone Hospital. RESULTS: 13.8% (33/239) patients had migraine with aura only, 13...
December 13, 2017: Headache
https://www.readbyqxmd.com/read/29235068/migraine-treatment-current-acute-medications-and-their-potential-mechanisms-of-action
#20
REVIEW
Jonathan Jia Yuan Ong, Milena De Felice
Migraine is a common and disabling primary headache disorder with a significant socioeconomic burden. The management of migraine is multifaceted and is generally dichotomized into acute and preventive strategies, with several treatment modalities. The aims of acute pharmacological treatment are to rapidly restore function with minimal recurrence, with the avoidance of side effects. The choice of pharmacological treatment is individualized, and is based on the consideration of the characteristics of the migraine attack, the patient's concomitant medical problems, and treatment preferences...
December 12, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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