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Kadir Onk, Hulya Yalcintan, Mehmet Sari, Serpil Adiguzel Isik, Akin Yakan, Bulent Ekiz
Study was conducted to determine the effects of genotype and sex on the technological properties and fatty acid composition of duck meat. Native (n = 15) and Peking (n = 15) ducks were slaughtered at 10 wk old, and meat samples were taken from M. pectoralis major (breast) and M. peroneus longus (thigh). The pH24, drip loss, expressed juice, cooking loss, Warner-Bratzler shear force (WBSF), color variables, fatty acid composition, and sensory characteristics were examined. Ultimate pH of breast meat in Peking ducks (6...
August 11, 2018: Poultry Science
Yiyang Wang, Zihao Wang, Yuanyuan Shan
Ovomucin is known to be critical for keeping the high quality and freshness of thick albumen, but there is lack of understanding on the dynamics changes of this important protein during storage. This study aimed to investigate the relationship between ovomucin content and egg freshness during storage. Firstly, the viscoelasticity of albumen was shown to be much higher than that of ovomucin-depleted albumen from rheological analysis results, indicating that ovomucin is an important component in maintaining the natural viscoelasticity of albumen...
August 11, 2018: Poultry Science
Bing Li, Qian Wang, Jian-Zhong Guo, Wei-Wei Huan, Li Liu
The protonated amine modified hydrochar (PAMH) was synthesized by etherification, amination and protonated reaction with hydrochar, which was enriched with abundant protonated amine for methyl orange (MO) removal. PAMH was characterized by elemental analysis, scanning electron microscopy, nitrogen adsorption-desorption measurement, zeta potential and Fourier transform infrared. The sorption of MO from aqueous solution by PAMH was investigated by batch experiments. The results showed that sorption of MO was significantly influenced by the initial concentration of MO, temperature, contact time and ionic strength, while hardly affected by pH values ranging from 4 to 11...
August 7, 2018: Bioresource Technology
Zhenjie Sun, Liping Ouyang, Xiaohan Ma, Yuqin Qiao, Xuanyong Liu
Polyetheretherketone (PEEK) is ideal for dental and orthopedic applications because its mechanical properties are similar to cortical bones. However, its inherent inert ability hinders its clinical applications. In this work, bone morphogenetic protein-2 (BMP-2) was immobilized onto the sulfonated PEEK (SPEEK) using lyophilization technology. The surface morphologies of the samples were analyzed by field-emission scanning electron microscopy (FE-SEM), and the chemical compositions were analyzed by energy-dispersive X-ray spectrometry (EDS)...
August 8, 2018: Colloids and Surfaces. B, Biointerfaces
Yongbo Ding, Qinlu Lin, Jianquan Kan
Retrograded starch (RS III) decreased into nanoscale particles through high-speed shearing emulsification, and the unknown effects of shear speed and shear time on their particle size were explored in this study. The in vitro digestibility, structure properties, stability, and adsorption property of these nanoparticles were also determined. The prepared RS III nanoparticles showed notches and grooves on the surface, and measured an average size of approximately 300 nm with high luminosity. Resistant starch contents decreased, while in vitro digestibility results suggested that these nanoparticles still exhibited high resistance to digestion, indicating that RS III nanoparticles were suitable for colon-specific drug delivery as an encapsulating agent...
August 8, 2018: Colloids and Surfaces. B, Biointerfaces
Feng Qiu, Kyle W Becker, Frances C Knight, Jessalyn J Baljon, Sema Sevimli, Daniel Shae, Pavlo Gilchuk, Sebastian Joyce, John T Wilson
Cancer vaccines targeting patient-specific tumor neoantigens have recently emerged as a promising component of the rapidly expanding immunotherapeutic armamentarium. However, neoantigenic peptides typically elicit weak CD8+ T cell responses, and so there is a need for universally applicable vaccine delivery strategies to enhance the immunogenicity of these peptides. Ideally, such vaccines could also be rapidly fabricated using chemically synthesized peptide antigens customized to an individual patient. Here, we describe a strategy for simple and rapid packaging of peptide antigens into pH-responsive nanoparticles with endosomal escape activity...
July 30, 2018: Biomaterials
Philipe Costa, Marilia O Almeida, Marivane Lemos, Caroline Arruda, Rosana Casoti, Lincon Bordignon Somensi, Thaise Boeing, Marihá Mariott, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Bruna De Paoli Stein, Priscila de Souza, Ana Caroline Dos Santos, Jairo K Bastos, Luísa Mota da Silva, Sérgio Faloni de Andrade
ETHOPHARMACOLOGICAL RELEVANCE: The propolis is extensively used in folk medicine in natura or to prepare pharmaceutical formulations since ancient time to improve health or prevent diseases, among them gastrointestinal disorders. Aiming to contribute in the scientific validation about the popular use of Brazilian Green propolis (BGP) against gastritis and gastric ulcer, this work evaluated the antiulcer potential of isolated compounds from BGP, three prenylated p-coumaric acid derivatives and two flavonoids, respectively named: 3,5 diprenyl-4-hydroxycinnamic acid (artepillin C) (1), 3-prenyl-4-dihydroxycinnamoiloxy cinnamic acid (baccharin) (2), 3-prenyl-4-hydroxycinnamic acid (drupanin) (3), aromadendrin-4'-O-methyl-ether (4) and kaempferide (5)...
August 11, 2018: Journal of Ethnopharmacology
Hiraku Onishi, Osamu Sakata
Etilefrine hydrochloride (ET-HCl) is used in the treatment of hypotension. Dosage forms of orally administered tablets and parenteral injections are clinically available, but exhibit unfavorable characteristics, including cardiac toxicity, headaches, and damage at the injection site for the parenteral dosage form, and initially high plasma levels, fast elimination, and first-pass effects for its oral administration. Therefore, the buccal application of ET-HCl was herein investigated as an alternative to conventional administration routes...
August 11, 2018: International Journal of Pharmaceutics
Ren-Kuan Li, Zeng Chen, Xi-Juan Ying, Tzi Bun Ng, Xiu-Yun Ye
An agar-degrading bacterium, strain BN3, was isolated from a coastal soil sample collected in Taiwan Strait, China and identified to be a novel species of the genus Microbulbifer. The gene (N3-1) encoding for a novel β-agarase from the isolate was cloned and sequenced. It encoded a mature protein with 274 amino acids and a calculated molecular mass of 34.3 kDa. The deduced amino acid sequence manifested sequence similarity (61-84% identity) to characterized β-agarases in the glycoside hydrolase family 16...
August 11, 2018: International Journal of Biological Macromolecules
Svenja Dannewitz Prosseda, Xuefei Tian, Kazuya Kuramoto, Mario Boehm, Deepti Sudheendra, Kazuya Miyagawa, Fan Zhang, David Solow-Cordero, Joshua C Saldivar, Eric D Austin, James E Loyd, Lisa Wheeler, Adam Andruska, Michele Donato, Lingli Wang, Kay Huebner, Ross J Metzger, Purvesh Khatri, Edda Spiekerkoetter
RATIONALE: Pulmonary arterial hypertension (PAH) is characterized by progressive narrowing of pulmonary arteries resulting in right heart failure and death. Bone Morphogenetic Protein Receptor type-2 (BMPR2) mutations account for most familial PAH (FPAH) forms while reduced BMPR2 is present in many idiopathic PAH (IPAH) forms, suggesting dysfunctional BMPR2 signaling to be a key feature of PAH. Modulating BMPR2 signaling is therapeutically promising, yet how BMPR2 is downregulated in PAH is unclear...
August 14, 2018: American Journal of Respiratory and Critical Care Medicine
Mojgan Heshmat, Timofei Privalov
Knowing that the Papai's electron transfer (ET) and the Grimme's electric field (EF) models draw attention to somewhat different physical aspects, we are going to systematically (re-)examine interactions in the transition states (TSs) of the heterolytic H2-cleavage by the Frustrated Lewis Pairs (FLPs). Our main vehicle is the quantitative energy decomposition analysis (EDA) - a powerful method for elucidation of interactions - plus the analysis of molecular orbitals (MOs). Herein, the Lewis acid (LA) is B(C6F5)3 and the Lewis bases (LBs) are tBu3P, (o-C6H4Me)3P, 2,6-lutidine, 2,4,6-lutidine, MeN=C(Ph)Me imine, MeN(H)-C(H)PhMe amine, THF, 1,4-dioxane and acetone...
August 14, 2018: Journal of Physical Chemistry. A
Leman Akcan Yildiz, Ayse Gultekingil, Selman Kesici, Benan Bayrakci, Ozlem Teksam
OBJECTIVE: Carbon monoxide (CO) is a gas, which is produced by incomplete combustion of hydrocarbon-containing substances, and causes significant tissue and organ damage in the common event of CO poisoning. This study aims to evaluate the demographic, clinical, and laboratory characteristics of patients diagnosed with CO poisoning in the emergency department and to determine the factors associated with severe course in the acute phase of poisoning. METHODS: A total of 331 patients diagnosed with CO poisoning in Hacettepe University Children's Hospital, Pediatric Emergency Unit, between January 2004 and March 2014 were included in the study...
August 13, 2018: Pediatric Emergency Care
Raquel Marianna Lopes, Tais Scaramucci, Ana Cecilia Corrêa Aranha
PURPOSE: To evaluate the effect of desensitizing dentifrices on dentin wear and tubule occlusion using a three-phase, single blind, crossover in situ trial. METHODS: The dentifrices containing Arginine and calcium carbonate (1,450 ppmF) and Novamin, (~1,426 ppmF) were tested in two conditions: A: abrasion and B: erosion/abrasion. A dentifrice without desensitizing agents was used as control (1,450 ppmF). In each study phase, 10 volunteers used intra-oral appliances containing dentin specimens (pre-treated with EDTA, to simulate hypersensitive dentin), which were either submitted to erosion with a cola-like drink (pH 2...
August 2018: American Journal of Dentistry
Pedro Lavrador, Vítor M Gaspar, João F Mano
Naringin is a naturally occurring flavanone with recognized neuroprotective, cardioprotective, anti-inflammatory, and antiosteoporotic properties. Herein, the delivery of Naringin-loaded methoxy-poly(ethylene glycol)-maleimide-thiol-poly(l-lactide) (mPEGMSPLA) diblock polymeric micelles to human adipose-derived stem cells (hASCs) with the aim to augment its pro-osteogenic effect in these cells is reported for the first time. The synthesis of the diblock copolymer is performed via Michael-type addition reaction between hydrophilic methoxy-poly(ethylene glycol)-maleimide (mPEGMAL) and hydrophobic thiol-poly(l-lactide) (PLASH) and confirmed by 1 H NMR and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy...
August 14, 2018: Advanced Healthcare Materials
Laura M Barge, Frederick C Krause, John-Paul Jones, Keith Billings, Pablo Sobron
Gradients generated in hydrothermal systems provide a significant source of free energy for chemosynthetic life and may play a role in present-day habitability on ocean worlds. Electron/proton/ion gradients, particularly in the context of hydrothermal chimney structures, may also be relevant to the origins of life on Earth. Hydrothermal vents are similar in some ways to typical fuel cell devices: redox/pH gradients between seawater and hydrothermal fluid are analogous to the fuel cell oxidant and fuel reservoirs; the porous chimney wall is analogous to a separator or ion-exchange membrane and is also a conductive path for electrons; and the hydrothermal minerals are analogous to electrode catalysts...
August 14, 2018: Astrobiology
María Pérez-Iglesias, Pablo Espinet, Juan A Casares
The protonolysis of C-Au bonds in [AuRL] organometallic complexes has been studied by calorimetry for 12 R groups. The experimental data have been combined with density functional theory calculations to obtain bond dissociation energy (BDE) values. The C-Au BDE values show a good correlation with the corresponding isolobal C-H BDE values. The heat released in the protonolysis of [AuRL] has also been measured for R = Ph and L = P(OPh)3 , PPh3 , PMe3 , PCy3 , and IPr, and these values strongly depend on the trans influence of L because of the mutual destabilization of the L-Au and Au-C bonds...
August 14, 2018: Inorganic Chemistry
L A Prado, A Ferlay, P Nozière, P Schmidely
Dietary and ruminal factors modify the ruminal biohydrogenation (RBH) of polyunsaturated fatty acids (FA), with duodenal FA flows being quantitatively and qualitatively different from FA intake. Using a meta-analysis approach from a database on duodenal flows of FA in ruminants, this study aimed to determine predictive equations for duodenal and absorbed flows of saturated FA, C18:1, C18:2 and C18:3 isomers, odd- and branched-chain FA (OBCFA), C20:5n-3, C22:5n-3 and C22:6n-3 and to quantify the effects of dietary and digestive factors on those equations...
August 14, 2018: Animal: An International Journal of Animal Bioscience
Elham Keshmirizadeh, Hamid Modarress, Fatemeh Jahedi
The removal of Acid Blue62 (AB62) dye which is known as a pollutant agent and contains in wastewater of textile industry has been studied in this work by using five various cerium compounds as the oxidizing agents. The parameters involved in the oxidation reaction such as pH, initial dye concentration and the oxidizing agent dosage have been investigated using both batch and semi-batch reactors at ambient temperature. The results indicated that the rate of oxidation for various cerium reagents are in the following order CeF4 > (NH4 )2 Ce (NO3 )6 > Ce (SO4 )2 > CeCl3 > Ce (CH3 COO)3 where cerium fluoride (CeF4 ) had the highest removal yields, 99...
August 14, 2018: Environmental Technology
Sandra Babić, Dragana Mutavdžić Pavlović, Martina Biošić, Danijela Ašperger, Irena Škorić, Mislav Runje
Febantel is widely used anthelmintic drug active against a range of gastrointestinal parasites in animals. Despite the fact that it has been detected in the aquatic environment, there is no information on its environmental fate. Therefore, abiotic elimination processes of febantel in the aquatic environment have been studied. The results of direct and indirect photodegradation experiments showed that febantel was persistent against solar radiation. Kinetics of hydrolytic elimination was pH and temperature dependent with half-lives in the range from 210 min to 99 days...
August 13, 2018: Environmental Science and Pollution Research International
Aiping Zhang, Zhepei Gu, Weiming Chen, Qibin Li, Guobin Jiang
A microwave-Fenton technology was applied to dispose of the reverse-osmosis concentrated leachate. Influential factors on the treatment of concentrated leachate with the pure Fenton and microwave-Fenton method were investigated. For the conventional Fenton process, the removal efficiencies of chemical oxygen demand (CODCr ), UV254 , and the color number (CN) reached 84%, 87%, and 96%, respectively, with the biodegradability (BOD5 /CODCr ) increased from 0.13 to 0.51 at an initial pH of 5.0, Fe2+ of 0.04 mol/L, a n(H2 O2 )/n(Fe2+ ) ratio of 8 after a reaction time of 3 h...
August 13, 2018: Environmental Science and Pollution Research International
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