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SCC Head and Neck

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https://www.readbyqxmd.com/read/30108165/comprehensive-genomic-profiling-of-patient-matched-head-and-neck-cancer-cells-a-preclinical-pipeline-for-metastatic-and-recurrent-disease
#1
Lluís Nisa, David Barras, Michaela Medová, Daniel M Aebersold, Matúš Medo, Michaela Poliaková, Jonas Koch, Beat Bojaxhiu, Olgun Elicin, Matthias S Dettmer, Paolo Angelino, Roland Giger, Urs Borner, Marco D Caversaccio, Thomas E Carey, Liza Ho, Thomas A McKee, Mauro Delorenzi, Yitzhak Zimmer
Metastases and tumor recurrence have a major prognostic impact in head and neck squamous cell carcinoma (HNSCC); however, cellular models that comprehensively characterize metastatic and recurrent HNSCC are lacking. To this end, we obtained genomic, transcriptomic and copy-number profiles of the UM-SCC cell line panel, encompassing patient-matched metastatic and recurrent cells. UM-SCC cells recapitulate the most prevalent genomic alterations described in HNSCC, featuring common TP53, PI3K, NOTCH, and Hippo pathway mutations...
August 14, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/30103407/the-current-role-of-salvage-surgery-in-recurrent-head-and-neck-squamous-cell-carcinoma
#2
REVIEW
Marc Hamoir, Sandra Schmitz, Carlos Suarez, Primoz Strojan, Kate A Hutcheson, Juan P Rodrigo, William M Mendenhall, Ricard Simo, Nabil F Saba, Anil K D'Cruz, Missak Haigentz, Carol R Bradford, Eric M Genden, Alessandra Rinaldo, Alfio Ferlito
Chemoradiotherapy has emerged as a gold standard in advanced squamous cell carcinoma of the head and neck (SCCHN). Because 50% of advanced stage patients relapse after nonsurgical primary treatment, the role of salvage surgery (SS) is critical because surgery is generally regarded as the best treatment option in patients with recurrent resectable SCCHN. Surgeons are increasingly confronted with considering operation among patients with significant effects of failed non-surgical primary treatment. Wide local excision to achieve clear margins must be balanced with the morbidity of the procedure, the functional consequences of organ mutilation, and the likelihood of success...
August 10, 2018: Cancers
https://www.readbyqxmd.com/read/30101013/induction-chemotherapy-in-patients-with-resectable-laryngeal-cancer-a-meta-analysis
#3
Pei Gao, Liang Gong, Xuefeng Wang
Head and neck squamous cell carcinoma (SCC) ranks 6th among the most frequently diagnosed carcinomas globally. Laryngeal carcinoma is quite common, and 95% of the cases are SCCs. Since the introduction of larynx-preserving surgery, induction chemotherapy (IC) has played a substantial role. The aim of IC is to shrink or downstage primary laryngeal carcinomas, increasing the chances of complete surgical removal, particularly in cases with advanced but potentially resectable lesions. The aim of the present study was to investigate the value of IC in patients with resectable laryngeal cancer...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30092593/correlation-between-serum-squamous-cell-carcinoma-antigen-level-and-tumor-volume-in-head-and-neck-cancer
#4
Kitti Jantharapattana, Teerapol Kotamnivates, Siriporn Hirunpat, Roongrueng Jarumanokul
PURPOSE OF STUDY: An association of squamous cell carcinoma antigen (SCC-Ag) level with cancer prognosis has been reported in many studies. Our investigators conducted the first study determining a correlation between the SCC-Ag level and the tumor volume in head and neck cancer. PROCEDURES: The SCC-Ag level of patients were measured from the serum, whilst the tumor volume was calculated by the ellipsoid formula and verified by logistic software on radiology. The correlation between SCC-Ag level and tumor volume was analyzed...
August 9, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/30089396/third-generation-dual-energy-ct-with-80-150-sn-kv-for-head-and-neck-tumor-imaging
#5
Saravanabavaan Suntharalingam, Elena Stenzel, Axel Wetter, Nika Guberina, Lale Umutlu, Thomas Schlosser, Kai Nassenstein
Background Dual-energy CT (DECT) provides additional image datasets which enable improved tumor delineation or reduction of beam hardening artifacts in patients with head and neck squamous cell carcinoma (SCC). Purpose To assess radiation dose and image quality of third-generation DECT of the head and neck in comparison to single-energy CT (SECT). Material and Methods Thirty patients with SCC who underwent both SECT (reference tube voltage 120 kVp) and DECT (80/150 Sn kVp) of the head and neck region for staging were retrospectively selected...
August 8, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/30087832/biological-role-and-clinical-value-of-mir-99a-5p-in-head-and-neck-squamous-cell-carcinoma-hnscc-a-bioinformatics-based-study
#6
Yu-Ting Chen, Jian-Ni Yao, Yu-Tao Qin, Kai Hu, Fang Wu, Ye-Ying Fang
MicroRNAs (miRNAs) are confirmed to be tumor promoters or suppressors in multiple squamous cell carcinomas (SCCs). miR-99a-5p has been demonstrated to be downregulated in cancerous tissues, but its functional role in head and neck SCC (HNSCC) and its mechanism of action have not been fully elucidated. Here, we studied the expression of miR-99a-5p in HNSCC and performed a clinical value assessment and then extracted mature expression data from The Cancer Genome Atlas (TCGA) and microarrays from Gene Expression Omnibus (GEO)...
August 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/30078551/the-clinical-value-of-serum-squamous-cell-carcinoma-antigens-1-and-2-in-head-and-neck-squamous-cell-carcinoma
#7
Ryuji Yasumatsu, Takafumi Nakano, Kazuki Hashimoto, Ryunosuke Kogo, Takahiro Wakasaki, Takashi Nakagawa
OBJECTIVE: The usefulness of pretreatment measurement of SCC antigen in patients with head and neck SCC is still controversial. Our aim of this study was to evaluate the clinical usefulness of serum SCC antigen, SCCA1 and SCCA2 in the management of patients with head and neck SCC. METHODS: Serum samples for the analysis of SCCA1, SCCA2 and SCC antigen were taken from head and neck SCC patients before treatment. Serum SCC antigen was assayed with a solid phase immunoradiometric assay...
August 2, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/30077724/an-ex-vivo-human-tumour-assay-reveals-distinct-patterns-of-egfr-trafficking-in-squamous-cell-carcinoma-correlating-to-therapeutic-outcomes
#8
Shannon R Joseph, Daniel Gaffney, Rachael Barry, Lingbo Hu, Blerida Banushi, James W Wells, Duncan Lambie, Geoff Strutton, Sandro V Porceddu, Bryan Burmeister, Graham R Leggatt, Helmut Schaider, Riccardo Dolcetti, Ian H Frazer, Nicholas A Saunders, Matthew Foote, H Peter Soyer, Fiona Simpson
EGFR overexpression is associated with squamous cell carcinoma development. Altered endocytosis and polarization of receptor tyrosine kinases, including EGFR, affect migration and invasion in 3D culture. These studies have been completed via genetic sequencing, cell line or 3D in vitro and in vivo murine models. Here we describe an imaging method that allows ex-vivo examination of ligand-induced endocytosis of EGFR in non-dissociated human tumours. We analyzed sets of tumour samples from advanced cutaneous squamous cell carcinoma and Head and Neck squamous cell carcinoma, actinic keratosis, intra-epidermal carcinoma and cutaneous squamous cell carcinoma...
August 2, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30075156/reproducibility-of-pd-l1-immunohistochemistry-interpretation-across-various-types-of-genitourinary-and-head-neck-carcinomas-antibody-clones-and-tissue-types
#9
Chiyun Wang, Elan Hahn, Elzbieta Slodkowska, Antoine Eskander, Danny Enepekides, Kevin Higgins, Danny Vesprini, Stanley K Liu, Michelle R Downes, Bin Xu
Programmed death-ligand 1 (PD-L1) expression by tumor cells is a mechanism for downregulation of antitumor T cell responses and is a target for immunotherapy in various cancers. PD-L1 status as a predictor of treatment response has led to the development of multiple platforms with different reference cutoffs. We studied 128 cases of genitourinary and head/neck carcinomas, aiming to assess the frequency of PD-L1 positivity, interobserver reliability of PD-L1 interpretation and the concordance of PD-L1 scoring between small samples from tissue microarray (TMA) and whole sections (WS) using SP263 and SP142 clones...
July 31, 2018: Human Pathology
https://www.readbyqxmd.com/read/30071890/correction-to-hpv-dna-in-saliva-from-patients-with-scc-of-the-head-and-neck-is-specific-for-p16-positive-oropharyngeal-tumours
#10
Jason K Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakos, Martin Corsten, Stephanie Johnson-Obaseki
Following publication of the original article [1], the authors reported an error in one of the author names. In this Correction the incorrect and correct author names are listed.
August 2, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/30049189/molecular-grading-of-oral-squamous-cell-carcinomas-infected-with-ebv
#11
Theresia Indah Budhy
Background: Squamous Cell Carcinoma (SCC) is a type of cancer that is often found in oral cavity and areas of the head and neck. Viruses are major etiological factors through production of factors that can disturb proliferation and apoptosis regulators such as p53i, c-myc and bcl-2. This study aimed to determine the molecular grading of oral squamous cell carcinoma (OSCCs) infected with the Epstein-Barr Virus (EBV). Methods: Twenty-seven OSCC patients underwent biopsy to detect EBV infection through in situ hybridization for RNA EBV (EBER) and immunohistochemical analysis of latent membrane protein-1 (LMP-1) and EBV nuclear antigen-1 (EBNA-1)...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/30045608/subclinical-peripheral-neuropathy-in-patients-with-head-and-neck-cancer-a-quantitative-sensory-testing-qst-study
#12
Carlos J Roldan, Carrie Johnson, Sin-Ong Lee, Andrew Peng, Patrick M Dougherty, Billy Huh
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and chronic complication associated with cancer treatment. Prior investigations have demonstrated the presence of subclinical peripheral neuropathy in patients with colorectal cancer even before the patients had received chemotherapy. OBJECTIVE: To investigate subclinical peripheral neuropathy of the upper limbs in patients with squamous cell carcinoma (SCC) of the head and neck which developed before their exposure to neurotoxic anticancer agents...
July 2018: Pain Physician
https://www.readbyqxmd.com/read/30029671/functional-and-genomic-analyses-reveal-therapeutic-potential-of-targeting-%C3%AE-catenin-cbp-activity-in-head-and-neck-cancer
#13
Vinay K Kartha, Khalid A Alamoud, Khikmet Sadykov, Bach-Cuc Nguyen, Fabrice Laroche, Hui Feng, Jina Lee, Sara I Pai, Xaralabos Varelas, Ann Marie Egloff, Jennifer E Snyder-Cappione, Anna C Belkina, Manish V Bais, Stefano Monti, Maria A Kukuruzinska
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease. To date, few targeted therapies are available for HNSCC, and only a small fraction of patients have benefited from these treatments...
July 20, 2018: Genome Medicine
https://www.readbyqxmd.com/read/30027439/impact-of-anatomic-origin-of-primary-squamous-cell-carcinomas-of-the-nasal-cavity-and-ethmoidal-sinus-on-clinical-outcome
#14
Stefan Janik, Mariel Gramberger, Lorenz Kadletz, Johannes Pammer, Matthaeus Ch Grasl, Boban M Erovic
PURPOSE: Since squamous cell carcinomas (SCCs) of the nasoethmoidal complex are rare and aggressive malignancies, the purpose of this study was to evaluate whether anatomic subsites of SCCs of the nasal cavity and ethmoid sinuses affect clinical outcome. METHODS: We retrospectively analyzed data from 47 patients with primary SCCs of the nasal cavity and ethmoid sinuses who were treated at the Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, between 1993 and 2018...
July 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30014041/dual-blockade-of-pi3k-and-mek-in-combination-with-radiation-in-head-and-neck-cancer
#15
Kevin Blas, Thomas G Wilson, Nathan Tonlaar, Sandra Galoforo, Alaa Hana, Brian Marples, George D Wilson
Background and purpose: In this study we have combined fractionated radiation treatment (RT) with two molecular targeted agents active against key deregulated signaling pathways in head and neck cancer. Materials and methods: We used two molecularly characterized, low passage HNSCC cell lines of differing biological characteristics to study the effects of binimetinib and buparlisib in combination with radiation in vitro and in vivo . Results: Buparlisib was active against both cell lines in vitro whereas binimetinib was more toxic to UT-SCC-14...
June 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/30004064/metastatic-squamous-cell-carcinoma-in-autotransplanted-thyroid-a-diagnostic-dilemma
#16
Varuna Mallya, Shubhra Narayan, Shyama Jain
Metastasis to the thyroid is uncommon. Mostly, they are tumors that originate in the lung or head or neck. Metastases from breast or kidney carcinomas and metastatic melanoma have also been reported. Autotransplantation of benign thyroid tissue is a surgical procedure designed to achieve normal thyroid hormonal status following surgery. Metastasis into autotransplanted thyroid tissue has not been reported earlier. We report a case of squamous cell carcinoma (SCC) metastatic to autotrasplanted thyroid diagnosed on fine-needle aspiration...
July 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29983416/p38-mapk-pathway-and-its-interaction-with-trf2-in-cisplatin-induced-chemotherapeutic-response-in-head-and-neck-cancer
#17
Shomereeta Roy, Souvick Roy, Madhabananda Kar, Shweta Thakur, Yusuf Akhter, Amit Kumar, Francesco Delogu, Swatishree Padhi, Arka Saha, Birendranath Banerjee
TRF2 is a telomere binding protein, a component of the shelterin complex that plays a major role in maintaining the integrity of the genome. TRF2 is over-expressed in a number of human cancers including Head and Neck cancer and might play a key role in tumor initiation and development. p38 MAPK signaling pathway is strongly activated in response to various environmental and cellular stresses and thus overexpressed in most of the Head and Neck cancer cases. In this study, we investigated potential interactions of TRF2 with p38 in HNSCC cells and patient samples...
July 9, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29968910/c6-ceramide-motivates-the-anticancer-sensibility-induced-by-pkc412-in-preclinical-head-and-neck-squamous-cell-carcinoma-models
#18
Yanyan Zhu, Chaojie Wang, Yun Zhou, Ning Ma, Jianwei Zhou
The purpose of this study was to evaluate the anti-head and neck squamous cell carcinoma (anti-HNSCC) cell activity by C6 ceramide and multikinase inhibitor PKC412. Experiments were performed on HNSCC cell lines (SQ20B and SCC-9) and primary human oral carcinoma cells. Results showed that PKC412 inhibited HNSCC cell proliferation without provoking apoptosis activation. Cotreatment of C6 ceramide significantly augmented PKC412-induced lethality in HNSCC cells. PKC412 decreased Akt-mammalian target of rapamycin (mTOR) activation in HNSCC cells, facilitated with cotreatment of C6 ceramide...
July 3, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29963799/close-and-positive-margins-in-non-melanoma-skin-malignancies-of-the-head-and-neck-what-to-do-in-patients-over-75-years-of-age-a-preliminary-study
#19
Stefano Dallari, Giorgio Zaraca, Sara Giorgini, Marco Borgonzoni
BACKGROUND: The incidence of non-melanoma skin cancer (NMSC) of the head and neck is increasing among older adults where it is credited to have a poorer prognosis also because the radicality of the surgery is often missed for a too conservative approach. An assessment of the amount of tumor regrowth and its prognostic consequences, in patients with surgical margins close or involved and older than 75 years, seems thus worth to be pursued in order to provide the best therapeutic strategy...
June 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29954411/immunohistochemical-expression-of-epidermal-growth-factor-receptor-egfr-in-south-asian-head-and-neck-squamous-cell-carcinoma-association-with-various-risk-factors-and-clinico-pathologic-and-prognostic-parameters
#20
Atif Ali Hashmi, Zubaida Fida Hussain, Saher Aijaz, Muhammad Irfan, Erum Yousuf Khan, Samreen Naz, Naveen Faridi, Amir Khan, Muhammad Muzzammil Edhi
BACKGROUND: In this study, we intend to determine the immunohistochemical expression of EGFR in cases of head and neck squamous cell carcinoma and its association with prognostic clinico-pathologic features. METHODS: A total of 115 cases of head and neck squamous cell carcinoma treated at Liaquat National Hospital, Karachi, Pakistan, were included in the study. Clinico-pathologic features, risk factors, and recurrence status of cases were evaluated, and EGFR immunohistochemistry was performed...
June 28, 2018: World Journal of Surgical Oncology
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