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SCC Head and Neck

Nurhayat Ozkan Sevencan, Elcin Kal Cakmakliogullari, Aysegul Ertinmaz Ozkan, Burcak Kayhan
RATIONALE: Serratia marcescens (S. marcescens) is an opportunistic pathogen of the Enterobacteriaceae family. Although S. marcescens is known to cause sepsis, meningitis, endocarditis, urinary system and ocular infections, skin infections are sporadic. Squamous cell carcinoma (SCC) is the most aggressive skin cancer type that is often located in the head and neck region, and rarely in the scalp tissue. PATIENT CONCERNS: An 89-years-old male patient was diagnosed with SCC three years ago...
October 2018: Medicine (Baltimore)
V De Giorgi, L Salvati, A Barchielli, A Caldarella, A Gori, F Scarfì, I Savarese, N Pimpinelli, C Urso, D Massi
BACKGROUND: Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs) over the years. OBJECTIVE: The aim of our study was to evaluate incidence and survival of CACsand investigate their association with other skin neoplasms. METHODS: Population based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry (TCR) between 1985 and 2010. In order to determine if the occurence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, standardized incidence ratio (SIR) was calculated...
October 16, 2018: British Journal of Dermatology
Xavier León, Laura Pardo, Aina Sansa, Alejandro Fernández, Valle Camacho, Jacinto García, Montserrat López, Miquel Quer
BACKGROUND: The purpose of this study is to evaluate the prognostic significance of nodes with extracapsular spread (ECS) in patients treated with a planned neck dissection after chemoradiotherapy. METHODS: We carried out a retrospective study of 109 cN+ patients who achieved a complete response in the primary location after chemoradiotherapy and treated with a planned neck dissection. RESULTS: The 5-year disease-specific survival for patients without residual metastatic nodes in the neck dissection (pN0, n = 69) was 75...
October 11, 2018: Head & Neck
Abdulkader M Albasri, Walaa M Borhan
To determine the histopathological pattern of skin cancer in Madinah region of Kingdom of Saudi Arabia (KSA). Methods: This is a retrospective study including all cases with a histological diagnosis of skin cancer diagnosed at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia, between January 2006 and December 2017. Data included  age, gender, site and histology of the tumor were collected from histopathological reports and analyzed using Statistical Package for the Social Sciences  (SPSS) Version 21...
October 2018: Saudi Medical Journal
A Baus, D Culie, L T Duong, A Ben Lakhdar, J-B Schaaf, F Janot, F Kolb
Clear cell sarcomas (SCC), also called "soft-tissue melanoma", are rare and aggressive tumors that preferentially affect the lower limbs (tendons and fasciae) and which have also been described in head and neck localizations. Their clinical and immunohistochemical mimicry with melanoma makes it difficult to diagnose sarcomas. SCC treatment is mainly focused on large-scale resection surgery with adjuvant radiotherapy because of their low chemo-sensitivity and extreme lymphophilia. In case of head and neck localization, these treatments may lead to function and aesthetic sequelae thus requiring the use of modern techniques of reconstructive surgery...
September 24, 2018: Annales de Chirurgie Plastique et Esthétique
Nobuyuki Maruyama, Toshiyuki Nakasone, Osao Arakaki, Hirofumi Matsumoto, Tessho Maruyama, Akira Matayoshi, Takahiro Goto, Seiichi Saito, Naoki Yoshimi, Akira Arasaki, Kazuhide Nishihara
Second primary cancer (SPC) is an important prognostic factor for patients with head and neck cancer (HNC); therefore, the association between the prognosis and development of SPC has been well-reported. The use of 2-[18 F]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is valuable to examine cancer stage, evaluate treatment responses and investigate suspected relapses or metastases. In the present study, the case of a male patient who was diagnosed with three primary cancer types, including well to moderately differentiated squamous cell carcinoma (SCC) of the mandible, axillary cutaneous poorly differentiated SCC and prostate adenocarcinoma, was described...
October 2018: Oncology Letters
Matthew Fox, Marc Brown, Nicholas Golda, Dori Goldberg, Christopher Miller, Melissa Pugliano-Mauro, Chrysalyne Schmults, Thuzar Shin, Thomas Stasko, Yaohui G Xu, Kishwer Nehal
BACKGROUND: While progress has been made in defining the clinical and histopathologic features of high-risk cutaneous squamous cell carcinoma (HRcSCC), optimal staging guidelines remain elusive. OBJECTIVE: We seek to guide clinical practice regarding nodal staging options for patients with HRcSCC via review of evolving definitions of HRcSCC, nodal staging options and how nodal staging may impact treatment and affect outcomes. METHODS: Retrospective review of published peer-reviewed literature regarding risk stratification, nodal staging and treatment and outcomes for patients with HRcSCC via PubMed search...
September 15, 2018: Journal of the American Academy of Dermatology
Ming Guo, Abha Khanna, Jianping Wang, Michelle D Williams, Neda Kalhor, Yun Gong, Li Xu, Erich M Sturgis, Gregg Staerkel
CONTEXT: - Human papillomavirus (HPV) DNA in situ hybridization (ISH) assay and p16 immunohistochemistry (IHC) are used to determine high-risk HPV status in formalin-fixed, paraffin-embedded (FFPE) tissues in oropharyngeal squamous cell carcinoma (SCC). Although high sensitivity and specificity for HPV can be obtained by combined p16-IHC and HPV DNA-ISH, the occasional discrepancy between these assays has prompted evaluation of Cervista HPV assays in FFPE tissue from patients with oropharyngeal SCC...
September 17, 2018: Archives of Pathology & Laboratory Medicine
Mohammad-Hossein Taziki, Abdolreza Fazel, Fatemeh Salamat, Seyed-Mehdi Sedaghat, Mohammad Ashaari, Hossein Poustchi, Ramin Shakeri, Reza Hoseinpoor, Susan Hasanpour-Heidari, Gholamreza Roshandel
BACKGROUND: Golestan province, in Northern Iran, is a high-risk area for esophageal squamous cell carcinoma (SCC). SCC is also the most common histological type of cancers of the head and neck region including cancers of oral cavity, oropharynx, hypopharynx and larynx. We aimed to present the incidence rate of head and neck SCC (HNSCC) in Golestan province during 2004 and 2013. METHODS: Data on HNSCC were obtained from Golestan population-based cancer registry (GPCR)...
September 1, 2018: Archives of Iranian Medicine
Dong Jin Lee, Young-Gyu Eun, Young Soo Rho, Eui Hyun Kim, Sun Young Yim, Sang Hee Kang, Bo Hwa Sohn, Gee Hwan Kwon, Ju-Seog Lee
OBJECTIVES: Heterogeneity of head and neck squamous cell carcinomas (HNSCCs) results in unpredictable outcomes for patients with similar stages of cancer. Beyond the role of human papilloma virus (HPV), no validated molecular marker of HNSCCs has been established. Thus, clinically relevant molecular subtypes are needed to optimize HNSCC therapy. The purpose of this study was to identify subtypes of HNSCC that have distinct biological characteristics associated with clinical outcomes and to characterize genomic alterations that best reflect the biological and clinical characteristics of each subtype...
October 2018: Oral Oncology
A J Dalal, J Ingham, B Collard, G Merrick
We provide a non-melanoma skin cancer (NMSC) service for skin cancers of the head and neck in the south-west of England. We hypothesised that certain anatomical sites such as the nose and eyelid would have a higher incidence of close or involved margins than others, and that the choice of repair might influence the excised margins. We therefore retrospectively analysed the data of 500 consecutive NMSC that were operated on in the oral and maxillofacial surgery unit of Taunton and Somerset NHS Trust. The database reports were crosschecked against the Trust's own pathology reporting system to ensure that they were accurate...
September 12, 2018: British Journal of Oral & Maxillofacial Surgery
Abhinandan Bhattacharjee, Sarbani Giri, Mainak Roy, Adity Chakraborty
Context: Head neck cancer (HNCA) in North-East India accounts for 54.48% cancers at all sites, one of the highest in the country. Increased serum lactate dehydrogenase (LDH) activity is considered as a marker of cellular necrosis while serum alkaline phosphatase (ALP) is recognized as an important marker of induction of tumor cell differentiation. Considering the importance and need of biomarker in HNCA and there being no previous study on tumor markers from this highly prevalent region, we intended to examine the role of serum LDH and ALP in head and neck squamous cell carcinoma (HNSCC) and epithelial precursor lesions (EPLs) and also to find their correlation with the different histological grades of tumor...
July 2018: Journal of Cancer Research and Therapeutics
Ameya Asarkar, Paige Bundrick, Cherie-Ann O Nathan
No abstract text is available yet for this article.
September 8, 2018: Laryngoscope
Zachary James Drew
We present a case of a tongue squamous cell carcinoma (SCC) metastasizing to distal skeletal muscle detected on FDG PET/CT imaging. A 48-year-old man with locally recurrent tongue SCC underwent a restaging FDG PET/CT to investigate neck and unilateral leg pain. The PET scan showed large, intensely FDG-avid lesions in the right scalene and left hamstring muscles, which were biopsy proven as metastatic SCC. Skeletal muscle metastases from oropharyngeal SCCs are rare; however, PET/CT has allowed increased detection of atypical metastatic sites...
November 2018: Clinical Nuclear Medicine
Kalavani Peddapelli, Guttikonda Venkateswara Rao, Taneeru Sravya, Sravya Ravipati
Basaloid squamous cell carcinoma (BSCC) is a histologically distinct variant of SCC in the head-and-neck region it occurs most commonly in older men with a history of heavy smoking and alcohol abuse and usually presents as a high stage disease with widespread metastases and hence poor prognosis. BSCC is believed to arise from a totipotential primitive cell in the basal layer of the surface epithelium or from the salivary duct lining epithelium. BSCC is an uncommon tumor with a predilection for the upper aerodigestive tract, is a distinct variant of squamous carcinoma, due to its unique histological features and ominous clinical behavior...
May 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Shih-Hsien Yang, Tsai-Yu Lee, Chun An Ho, Chin-Yuh Yang, Wen-Yen Huang, Yu-Chun Lin, Shin Nieh, Yaoh-Shiang Lin, Su-Feng Chen, Fu-Huang Lin
Long-term nicotine-derived nitrosamine ketone (NNK) and arecoline exposure promotes carcinogenesis and head and neck squamous cell carcinoma (HNSCC) progression, although most associated data on the two were analyzed individually. The molecular mechanisms underlying tumor progression associated with the synergistic effects of NNK and arecoline remain unclear. We treated SCC-25 and FaDu cells with NNK and arecoline (separately or in combination) for 3 months. Comparative analysis was performed to investigate the mechanism underlying the acquisition of properties related to tumor promotion, including stemness, anti-apoptosis, and resistance to HNSCC therapeutics...
2018: PloS One
Kathryn P Scherpelz, Anthony C Wong, Mark W Lingen, Jerome B Taxy, Nicole A Cipriani
CONTEXT: Cervical lymph node metastasis in head and neck squamous cell carcinoma (HNSCC) is common. Preoperative chemoradiotherapy (preCRT) and postoperative chemoradiotherapy (postCRT) is frequently employed in such patients. OBJECTIVES: The prognostic value of viable SCC, treatment effect or no SCC in resected lymph nodes in patients who received or did not receive preCRT and postCRT was investigated. MATERIALS AND METHODS: Resected cervical lymph nodes from 146 patients with HNSCC were evaluated for viable SCC, treatment effect, or no SCC...
August 24, 2018: Histopathology
Stephanie Hehlgans, Patrick Booms, Ömer Güllülü, Robert Sader, Claus Rödel, Panagiotis Balermpas, Franz Rödel, Shahram Ghanaati
Vismodegib, an inhibitor of the Hedgehog signaling pathway, is an approved drug for monotherapy in locally advanced or metastatic basal cell carcinoma (BCC). Data on combined modality treatment by vismodegib and radiation therapy, however, are rare. In the present study, we examined the radiation sensitizing effects of vismodegib by analyzing viability, cell cycle distribution, cell death, DNA damage repair and clonogenic survival in three-dimensional cultures of a BCC and a head and neck squamous cell carcinoma (HNSCC) cell line...
August 23, 2018: International Journal of Molecular Sciences
Raymond J Cho, Ludmil B Alexandrov, Nicoline Y den Breems, Velina S Atanasova, Mehdi Farshchian, Elizabeth Purdom, Tran N Nguyen, Cristian Coarfa, Kimal Rajapakshe, Marco Prisco, Joya Sahu, Patrick Tassone, Evan J Greenawalt, Eric A Collisson, Wei Wu, Hui Yao, Xiaoping Su, Christina Guttmann-Gruber, Josefina Piñón Hofbauer, Raabia Hashmi, Ignacia Fuentes, Stephen C Benz, Justin Golovato, Erik A Ehli, Christel M Davis, Gareth E Davies, Kyle R Covington, Dedee F Murrell, Julio C Salas-Alanis, Francis Palisson, Anna L Bruckner, William Robinson, Cristina Has, Leena Bruckner-Tuderman, Matthias Titeux, Marcel F Jonkman, Elham Rashidghamat, Su M Lwin, Jemima E Mellerio, John A McGrath, Johann W Bauer, Alain Hovnanian, Kenneth Y Tsai, Andrew P South
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare inherited skin and mucous membrane fragility disorder complicated by early-onset, highly malignant cutaneous squamous cell carcinomas (SCCs). The molecular etiology of RDEB SCC, which arises at sites of sustained tissue damage, is unknown. We performed detailed molecular analysis using whole-exome, whole-genome, and RNA sequencing of 27 RDEB SCC tumors, including multiple tumors from the same patient and multiple regions from five individual tumors...
August 22, 2018: Science Translational Medicine
Chakra P Chaulagain, Kellie A Sprague, Monika Pilichowska, Janet Cowan, Andreas K Klein, Esha Kaul, Kenneth B Miller
The risk of late complications including secondary malignancies is increased in long-term survivors of allogeneic hematopoietic stem cell transplants (HSCT). There is limited literature on the biological behavior and clinical features of squamous cell carcinoma (SCC) of head and neck post-HSCT. We present the clinical and pathologic characteristics on six patients who were diagnosed with SCC while in remission following an allogeneic HSCT. Median follow-up was 8 years. Five patients (83%) developed SCC of tongue and one developed esophageal SCC...
August 20, 2018: Bone Marrow Transplantation
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