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SCC Head and Neck

Yuyang Li, Zhiming Xu, Jia Li, Shuofeng Ban, Congcong Duan, Weiwei Liu
Oral squamous cell carcinoma (OSCC) is one of the most common head and neck malignancies. Advanced stages of the disease are associated with poor survival, highlighting a need for new treatment modalities. We previously showed that the proinflammatory cytokine interleukin-18 (IL-18) has a tumor suppressive role in OSCC. Here, we investigated the effects of IL-18 on proliferation, migration, and invasion of OSCC cells ex vivo and in vitro , and in nude mouse xenografts. We report that expression of tankyrase 2 (TNKS2), β-catenin, and N-cadherin was higher in tumor cells than in normal mucosae, whereas the expression of IL-18 and E-cadherin was higher in normal than in tumor tissues...
December 2018: FEBS Open Bio
Douglas B Chepeha
BACKGROUND: Surgeons have developed various reconstructive techniques to minimize the rate of pharyngocutaneous fistula and optimize functional outcome after salvage laryngectomy or laryngopharyngectomy. METHODS: Multicenter retrospective review at 33 institutions of 486 patients with a history of squamous cell carcinoma (SCC) of the larynx or hypopharynx previously treated with primary chemoradiotherapy (CRT) who required salvage surgery. Outcomes evaluated were overall fistula rate, fistula requiring reoperation, and 12-month speech and swallowing function...
December 3, 2018: Head & Neck
M Nieberler, U Reuning, H Kessler, F Reichart, G Weirich, K-D Wolff
We assessed the use of peptides containing arginylglycylaspartic acid (RGD) that target integrin αvβ6 as a potential approach for a fluorescence-assisted intraoperative cytological assessment of bony resection margins (F-AICAB) in patients who had bone-infiltrating squamous cell carcinoma (SCC) of the head and neck. This was assessed to demarcate invasive carcinoma cells that stained for αvβ6. Specimens from bony resection margins (n=362) were defined as either malignant or benign according to the results of cytological and histological examinations...
November 27, 2018: British Journal of Oral & Maxillofacial Surgery
Yuxin Guo, Maria Cui-Ying Pang, Constance Ee-Hoon Teo, Jack Kian Chng
BACKGROUND: Surgical management of advanced head and neck tumours involving the carotid artery remains controversial with compromised survival outcomes and heightened risks of morbidity and mortality. CASE: We describe a case of a 74-year-old lady with previous T1N0M0 left tongue squamous cell carcinoma (SCC), who developed a left nodal recurrence encasing the left external carotid artery from the carotid bifurcation. She underwent an extended left radical neck dissection with carotid artery patch plasty and remains well to date, 10-months post-surgery...
November 27, 2018: Annals of Vascular Surgery
Sebastian Prochnow, W Wilczak, V Bosch, T S Clauditz, A Muenscher
OBJECTIVES: Nucleotide excision repair protein expression has been claimed to be responsible for platinum-based chemotherapy resistance. ERCC1, XPF and XPA, core proteins in DNA repair, were evaluated regarding their prognostic value in patients with head and neck squamous cell carcinoma by looking at overall survival and time to recurrence. MATERIALS AND METHODS: Tissue microarrays were constructed from 453 cases of HNSCC, including 222 oral (49%), 126 oropharyngeal (27...
November 29, 2018: Clinical Oral Investigations
Lisa M Rooper, Austin M McCuiston, William H Westra, Justin A Bishop
SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. However, SOX10 expression has not been extensively evaluated in other epithelial tumors that can mimic salivary origin. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows morphologic overlap with several salivary tumors, including adenoid cystic carcinoma, basal cell adenocarcinoma, and myoepithelial carcinoma...
November 29, 2018: Head and Neck Pathology
Melanie Boxberg, Peer-Hendrik Kuhn, Marianne Reiser, Anna Erb, Katja Steiger, Anja Pickhard, Ulrich Straßen, Isabelle Koob, Andreas Kolk, Arne Warth, Moritz Jesinghaus, Wilko Weichert
Squamous cell carcinoma (SCC) is the most common cancer of the head and neck region including-among others-laryngeal (LSCC) and hypopharyngeal (HSCC) subsites. LSCC/HSCC are heterogenous diseases with respect to patient outcome. Currently, tumor stage-based patient stratification is essential to predict prognosis and thus selection of the appropriate treatment modalities. In contrast, the prognostic impact of the current HSCC/LSCC grading system according to the WHO classification is limited. Recently, a novel grading system based on tumor budding activity (BA) and cell nest size (CNS) has been introduced for SCC in different anatomic regions of the upper aerodigestive tract...
November 20, 2018: American Journal of Surgical Pathology
William Fix, Jeremy R Etzkorn, Thuzar M Shin, Nicole Howe, Mehul Bhatt, Joseph F Sobanko, Christopher J Miller
BACKGROUND: Consensus guidelines recommend microscopic margin control based on high local recurrence risk features and tissue-rearranging reconstruction for keratinocyte carcinomas (KC) but not for cutaneous melanoma. OBJECTIVE: To compare high local recurrence risk features and frequency of tissue-rearranging reconstruction for head and neck KC versus melanoma. METHODS: Retrospective cohort study of KC versus melanoma treated at the Hospital of the University of Pennsylvania with Mohs micrographic surgery (MMS)...
November 17, 2018: Journal of the American Academy of Dermatology
Francesco Broccolo, Giulia Ciccarese, Agostino Rossi, Luca Anselmi, Francesco Drago, Antonio Toniolo
Background: Oral and oropharyngeal squamous cell carcinomas (OSCC and OPSCC) represent the majority of head and neck squamous cell carcinomas (HNSCC). Human papillomavirus (HPV) is an important etiologic factor together with Epstein-Barr virus (EBV). Little is known on the prevalence of major herpesviruses [EBV, cytomegalovirus (CMV) and HHV-6, - 7 and - 8] in HNSCCs. Methods: Fifty-one formalin-fixed paraffin-embedded (FFPE) tissue samples taken at surgery (40 oropharyngeal, 11 oral) were analyzed for 40 HPV genotypes (20 high-risk types), EBV, CMV, HHV-6, - 7 and - 8 by quantitative PCR...
2018: Infectious Agents and Cancer
D Pencharz, J Dunn, S Connor, A Siddiqui, N Sriskandan, S Thavaraj, J-P Jeannon, R Oakley, M Lei, T Guerrero-Urbano, G J Cook, T A Szyszko
AIM: To analyse the maximum standardised uptake value (SUVmax) ratio between tonsils in patients with and without tonsillar carcinoma to determine useful diagnostic thresholds. MATERIALS AND METHODS: Positron-emission tomography (PET)/computed tomography (CT) examinations of patients with suspected head and neck squamous cell carcinoma (SCC) and controls from April 2013 to September 2016 were reviewed retrospectively. Tonsillar SUVmax ratios (ipsilateral/contralateral for malignant tonsils, maximum/minimum for patients without [controls]) were calculated and used to construct a receiver operating characteristic (ROC) curve...
November 16, 2018: Clinical Radiology
William M Mendenhall, Roi Dagan, Curtis M Bryant, Rui P Fernandes
Treatment of head and neck cancer with curative intent consists of surgery and/or radiotherapy (RT) sometimes combined with adjuvant chemotherapy depending on the tumor site, extent, and histology. Herein, the authors review the role of RT in the management of head and neck mucosal squamous cell carcinoma (SCC). The authors focus on the outcomes of definitive RT and, depending on the primary site, postoperative RT. Unless otherwise specified, outcomes data cited are from the University of Florida.
February 2019: Oral and Maxillofacial Surgery Clinics of North America
M Lesnik, O De Crouy Chanel, M Lefèvre, S Samaha, S Périe, J Lacau St Guily, B Baujat
OBJECTIVES: Osteoradionecrosis (ORN) of the mandible is a common complication of head and neck radiotherapy and often requires surgical treatment. Squamous cell carcinoma (SCC) can be exceptionally discovered within zones of ORN on histological examination of the operative specimen. The authors discuss the management of these lesions based on a short patient series. MATERIALS AND METHODS: This single-centre retrospective study was based on patients managed between 2012 and 2014 for ORN with incidental discovery of microscopic SCC...
November 14, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
Paolo Bossi, Rosalba Miceli, Marco Benasso, Renzo Corvò, Andrea Bacigalupo, Giuseppe Sanguineti, Carlo Fallai, Marlo C Merlano, Gabriele Infante, Carla Dani, Valerio Di Giannantonio, Lisa Licitra
BACKGROUND: We evaluated the impact of center expertise, in terms of number of patients treated, on the overall survival (OS) and progression-free survival (PFS) of patients with head and neck squamous cell carcinoma (SCC). METHODS: We performed a pooled analysis including data from 6 randomized trials in head and neck SCC conducted in Italy. We evaluated the association between OS or PFS and the number of patients recruited by the center. RESULTS: The outcome of 903 patients who had received radiotherapy (RT) was analyzed (median follow-up 76 months)...
November 17, 2018: Head & Neck
Fei Liu, Shuai Yuan, Qigen Fang, Qiang Sun
The natural history of untreated head and neck squamous cell carcinoma (SCC) was not well defined. A total of 206 patients with untreated head and neck SCC were retrospectively enrolled. The 1-year survival rate for cancers arising in oral cavity, oropharynx, throat, and hypopharynx was 31%, 20%, 0%, and 3%, respectively, the difference was significant (p<0.001). 57.2% of the patients died within 12 months, median survival time was 11 months. The prognosis of untreated head and neck SCC patients is extremely unfavorable...
November 16, 2018: Clinical Otolaryngology
Kacper Guglas, Tomasz Kolenda, Anna Teresiak, Magda Kopczyńska, Izabela Łasińska, Jacek Mackiewicz, Andrzej Mackiewicz, Katarzyna Lamperska
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world. To improve the quality of diagnostics and patients' treatment, new and effective biomarkers are needed. Recent studies have shown that the expression level of different types of long non-coding RNAs (lncRNAs) is dysregulated in HNSCC and correlates with many biological processes. In this study, the response of lncRNAs in HNSCC cell lines after exposure to irradiation and cytotoxic drugs was examined...
November 14, 2018: Non-Coding RNA
Enyinnaya Ofo, Harry Spiers, Dae Kim, Umamaheswar Duvvuri
Carcinoma of unknown primary (CUP) comprises approximately 1%-5% of all head and neck malignancies. Primary site detection rates for metastatic cervical squamous cell carcinoma (SCC) remain variable, with current diagnostic imaging unable to identify all tumours. Prevailing evidence suggests that most head and neck CUP are located in the oropharynx. Diagnostic surgical efforts have been directed at sampling the entire oropharynx. Present techniques that make this possible include transoral robotic surgery (TORS)...
2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Weidong Shen, Naoko Sakamoto, Limin Yang
Purpose: Basaloid squamous cell carcinoma (BSCC) is a rare, high-grade variant of squamous cell carcinoma (SCC). Most published studies based on population-based datasets focus on prognostic differences between SCC and BSCC. Competing risk analyses for this disease have not been performed. We used Surveillance Epidemiology and End Results (SEER) data to calculate and model the cumulative incidence of death for patients with head and neck BSCC (HNBSCC) with competing risk approaches, and built a model to predict probability of cause-specific death for these patients...
2018: Journal of Cancer
Teruki Yanagi, Masashi Watanabe, Hiroo Hata, Shinya Kitamura, Keisuke Imafuku, Hiroko Yanagi, Akihiro Homma, Lei Wang, Hidehisa Takahashi, Hiroshi Shimizu, Shigetsugu Hatakeyama
TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. However, its role in stratified squamous epithelial cells and tumors has not been elucidated. Here we investigate the expression of TRIM29 in cutaneous head and neck squamous cell carcinomas (SCC) and its functions in the tumorigenesis of such cancers. TRIM29 expression was lower in malignant SCC lesions than in adjacent normal epithelial tissue or benign tumors. Lower expression of TRIM29 was associated with higher SCC invasiveness...
November 2, 2018: Cancer Research
Diva Shah, Digish Shah, Subhada Kanhere, Kintan Sanghavi, Kaustubh Patel
Metastasis to the thyroid gland is rare; furthermore, intrathyroid metastasis from head and neck squamous cell carcinoma (SCC) is very unusual, with only nine previously documented cases four from intrathyroid metastasis from nasopharyngeal carcinoma, two from oral cavity, one each from oropharynx, larynx, and parotid. The reported case series are unique in nature and illustrates the role of fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) and ultrasound-guided biopsy in diagnosing clinically occult isolated intrathyroidal metastasis, which helps in the best management for an isolated intrathyroid metastases...
October 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Yoon Ah Cho, Ji Myung Chung, Hyunmi Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
Purpose: The relationship between head and neck squamous cell carcinoma (HNSCC) and subtypes of tropomyosin-related kinase (Trk) has not been studied in-depth. In this study, we evaluated the expression patterns of TrkA, TrkB, and panTrk and their clinicopathological significance as well as association with p16 expression and human papilloma virus (HPV) status. Materials and Methods: Total of 396 radically resected oropharyngeal (n=121) and non-oropharyngeal (n=275) HNSCCs were included...
October 24, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
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