Mai Mochizuki, Rie Shibuya-Takahashi, Shin-Ichiro Kanno, Shungo Adachi, Haruna Fujimori, Akira Nakazato, Keitaro Fujii, Shinkichi Morita, Satoshi Saijoh, Tomoko Yamazaki, Takayuki Imai, Yukinori Asada, Kazunori Yamaguchi, Jun Yasuda, Norihisa Shindo, Kazuo Sugamura, Keiichi Tamai
RNAs, such as noncoding RNA, microRNA, and recently mRNA, have been recognized as signal transduction molecules. CD271, also known as nerve growth factor receptor, has a critical role in cancer, although the precise mechanism is still unclear. Here, we show that CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. We established CD271-/- cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines...
May 6, 2024: Cancer Science