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Hanna Grol-Prokopczyk
Objectives: This study identifies sociodemographic predictors of prescription opioid use among older adults (age 65+) during the peak decade of U.S. opioid prescription, and tests whether pain level and Medicaid coverage mediate the association between low wealth and opioid use. Predictors of prescription nonsteroidal anti-inflammatory drug (NSAID) use, and of opinions of both drug classes, are also examined. Method: Regressions of opioid and NSAID use on sociodemographic characteristics, pain level, and insurance type were conducted using Health and Retirement Study 2004 core and 2005 Prescription Drug Study data (n=3,721)...
August 13, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Chema Strik, Barend van den Beukel, Dagmar van Rijckevorsel, Martijn W J Stommel, Richard P G Ten Broek, Harry van Goor
The incidence of chronic postoperative abdominal pain (CPAP) after abdominal surgery is substantial and decreases overall quality of life. One in three patients report to have pain-related interference with mood, sleep and enjoyment of life and 12% visit the emergency department for pain related symptoms. Previous studies lack data on preoperative health and pain status, or are limited by small patient samples. The aim of this study is to assess risk factors for CPAP and gastrointestinal complaints six months after surgery...
August 11, 2018: Journal of Pain: Official Journal of the American Pain Society
Valery Isidorov, Łukasz Szoka, Jolanta Nazaruk
Birch buds (Gemmae Betulae) are widely used in Russian and Chinese traditional medicine mainly as a diuretic and diaphoretic agent but also as an antiseptic, anti-inflammatory and analgesic. Despite the long history of therapeutic use of birch buds in folk medicine, the existing information on their chemical composition and pharmacological effects is insufficient. This circumstance warrants further study of the chemistry and pharmacology of birch buds. The present study was designed to investigate (a) the chemical composition of buds from two species of white birch and (b) the in vitro cytotoxic effect of extracts from these sources on selected tumour cells...
2018: PloS One
Huai-Jin Li, Chun-Jing Li, Xiao-Na Wei, Jian Hu, Dong-Liang Mu, Dong-Xin Wang
BACKGROUND: Dexmedetomidine in combination with opioids has been used for postoperative analgesia. The purpose of this study was to investigate the impacts of dexmedetomidine supplemented intravenous analgesia on morphine consumption and subjective sleep quality in elderly patients after open abdominal surgery. METHODS: This was a pilot randomized controlled trial. 58 elderly patients (age ≥ 60 years) who underwent open abdominal surgery were randomized to receive either dexmedetomidine supplemented morphine analgesia (0...
2018: PloS One
Basilia Zingarelli, Craig M Coopersmith, Susanne Drechsler, Philip Efron, John C Marshall, Lyle Moldawer, W Joost Wiersinga, Xianzhong Xiao, Marcin F Osuchowski, Christoph Thiemermann
Pre-clinical animal studies are mandatory before new treatments can be tested in clinical trials. However, their use in developing new therapies for sepsis has been controversial because of limitations of the models and inconsistencies with the clinical conditions. In consideration of the revised definition for clinical sepsis and septic shock (Sepsis-3), a Wiggers-Bernard Conference was held in Vienna in May 2017 to propose standardized guidelines on pre-clinical sepsis modeling. The participants conducted a literature review of 260 most highly cited scientific articles on sepsis models published between 2003 and 2012...
August 14, 2018: Shock
Kaori Yoshida, Daisuke Nishizawa, Soichiro Ide, Tatsuya Ichinohe, Ken-Ichi Fukuda, Kazutaka Ikeda
INTRODUCTION: Opioid analgesics are widely used as effective analgesics for the treatment of moderate-to-severe pain. However, the analgesic efficacy of opioids is well known to vary widely among individuals, and effective pain treatment is hampered by vast individual differences. Although these differences in opioid requirements have been attributed to various factors, genetic factors are becoming increasingly relevant to the development of genome science. AIM: This review covers the association between opioid analgesic requirements and particularly gene polymorphisms...
March 2018: Neuropsychopharmacol Rep
Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kaori Takahashi, Kyoko Nakayama, Yuko Ebata, Ken-Ichi Fukuda, Kazutaka Ikeda
AIM: Interleukin-17A (IL-17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions. IL-17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of IL-17A to pain-related phenotypes in humans, we investigated the association between pain-related phenotypes and the rs2275913 single-nucleotide polymorphism (SNP) of the IL-17A gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers...
June 2018: Neuropsychopharmacol Rep
Yoshinori Aoki, Daisuke Nishizawa, Kaori Yoshida, Junko Hasegawa, Shinya Kasai, Kaori Takahashi, Yoshihiko Koukita, Tatsuya Ichinohe, Masakazu Hayashida, Ken-Ichi Fukuda, Kazutaka Ikeda
BACKGROUND: Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA binding proteins and is widely distributed in tissues. Several recent studies have demonstrated that this protein is involved in mechanisms that are related to pain and inflammation. However, unclear is whether polymorphisms of the ATF2 gene, which encodes the human ATF2 protein, influence pain or analgesic sensitivity. This study examined associations between the analgesic effect of fentanyl in the cold pressor-induced pain test and polymorphisms in the ATF2 gene in 355 Japanese subjects...
June 2018: Neuropsychopharmacol Rep
Shuang-Feng Li, Bi-Shan Ouyang, Xin Zhao, Ya-Ping Wang
Neuropathic pain often occurs during chemotherapy with oxaliplatin. AG490 has been shown to exert an antagonistic effect on inflammatory pain, but its effect on oxaliplatin-induced neuropathic pain remains poorly understood. This study sought to observe the analgesic effect of AG490 on acute neuropathic pain induced by a single oxaliplatin treatment and to address the possible mechanism. In this study, we established a model of oxaliplatin-induced acute neuropathic pain by intraperitoneal injection of 6 mg/kg oxaliplatin...
August 2018: Neural Regeneration Research
Chen-Hsun Ho, Chia-Chang Wu, Chao-Chuan Wu, Yao-Chou Tsai
Aims: We aimed to evaluate the safety and feasibility of laparoscopic total extraperitoneal (TEP) inguinal hernia repair in patients with the continuation of their antithrombotic agents. Settings and Design: This was prospective cohort study. Materials and Methods: A total of 115 patients who underwent TEP inguinal hernia repair between January 2015 and September 2016 were included in the analysis. Seventeen patients continued their antithrombotics (antithrombotic group); the other 98 had not been on antithrombotics (control group)...
August 7, 2018: Journal of Minimal Access Surgery
Shane R Hess, Laura A Lahaye, Andrew C Waligora, Adam P Sima, William A Jiranek, Gregory J Golladay
Intrathecal morphine (ITM) can be useful for postoperative analgesia following lower extremity joint arthroplasty, but concerns exist regarding potential dose-related side effects. In this study, we examined the safety and efficacy of ITM in patients undergoing lower extremity joint arthroplasty. We hypothesized that there would be (1) direct relationship between dosing and side effects, and (2) an inverse relationship between ITM dosing and 24-hour postoperative opioid requirement.
August 13, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
P K Musale, S Kothare
BACKGROUND: Deep carious lesions in immature permanent molars with pulp necrosis pose a serious challenge to contemporary paedodontic practice. A further complex clinical scenario is an immature permanent molar with varying root formation in both roots. This case report demonstrates the successful management of an immature permanent mandibular first molar. CASE REPORT: An 8-year-old boy was referred for endodontic management of 36 by a general practitioner. After clinical and radiographic evaluation, a diagnosis of recurrent chronic periapical abscess with abrupt root closure in the mesial root and cessation of root closure in the distal root was made...
August 13, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Magne A Flaten, Espen Bjørkedal, Peter S Lyby, Yngve Figenschau, Per M Aslaksen
Background: Associative learning has, in several studies, been modulated by the sex of the participant. Consistent with this, a recent review found that conditioned nocebo effects are stronger in females than in males. Purpose: It has been suggested that conditioned placebo responses are stronger in females, and this hypothesis was investigated in the present study. Cortisol and measures of negative emotions were taken to investigate if these processes could mediate any conditioned placebo effects. Methods: Cold pain was applied to the volar forearm...
2018: Frontiers in Psychology
Poonam S Ghodki, Priyanka S Shalu, Shalini P Sardesai
Background and Aims: Adductor canal block (ACB) is now an established component of multimodal analgesia for knee replacement surgery and is slowly replacing femoral nerve block (FNB). It is also gaining popularity for providing pain relief in knee arthroscopies including anterior cruciate ligament reconstruction surgery (ACLR). Data is lacking from the Indian subcontinent on comparing ACB to the traditional FNB for ACLR. Hence, we conducted the present study to compare ACB and FNB in ACLR under general anesthesia...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Navneh Samagh, Raghavendra K Pai, Thomas K Mathews, Kiran Jangra, Ravi G Varma
Background and Aims: Pre-emptive analgesia using caudal epidural technique is an underutilized technique in lumbosacral spine surgery patients. We intend to study if pre-emptive analgesia with a single caudal epidural injection of ropivacaine is an effective method of postoperative analgesia by assessing the quality and duration of pain relief and intraoperative opioid requirement. Material and Methods: Eighty patients undergoing lumbosacral spine surgeries by the posterior approach were randomized to ropivacaine (R) group ( n = 40) and saline (S) group ( n = 40)...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Sidharth S Routray, Nibedita Pani, Debasis Mishra, Sunita Nayak
Background and Aims: Analgesic effect of gabapentin and pregabalin is well-defined in the treatment of neuropathic pain. Postoperative pain after lumbar spine surgery limits the function of patients in the postoperative period, for which the search for ideal analgesic goes on. The aim of the present study was to compare pregabalin and gabapentin as a pre-emptive analgesic in elective lumbar spine surgeries. Material and Methods: In this randomized prospective study, 75 patients were allocated into three groups of 25 each...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Shaiqa Manzoor, Rajeev Taneja, Nishant Sood, Arun Puri, Geeta Kadayaprath
Background and Aims: Dexmedetomidine has been demonstrated to be safe and efficacious in prolonging the duration of peripheral nerve blocks. This study was designed to compare the duration, quality of postoperative analgesia, hemodynamic stability, and patient's satisfaction with addition of dexmedetomidine to bupivacaine versus plain bupivacaine in pectoral nerve block (Pecs) type I and II in breast surgeries. Material and Methods: This prospective randomized double-blind study was carried out in 60 American Society of Anesthesiologists grade I-III female patients, aged 18-70 years randomly allocated into two equal groups...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Muhammad Asghar Ali, Samina Ismail, Muhammad Sohaib, Asiyah Aman
Background and Aims: It is a common practice to add intrathecal lipophilic opioids to local anesthetics to improve the quality of subarachnoid block. This study was designed to find a dose of intrathecal fentanyl, which can improve the quality of surgical anesthesia with minimal side effects in parturients undergoing cesarean section under spinal anesthesia with intrathecal bupivacaine. Material and Methods: In a prospective randomized double-blind study, 243 parturients undergoing cesarean section under spinal anesthesia were randomly allocated to receive 10, 15, or 25 μg of intrathecal fentanyl with 10 mg of 0...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Vishwas Malik, Usha Kiran, Sandeep Chauhan, Neeti Makhija
Background and Aims: In patients undergoing open heart surgery, chest tubes are removed postoperatively when patients are well awake and stable. Pain during chest tube removal can be moderate to severe and can be the worst experience of hospitalization. Various modalities of pain relief during chest tube removal have been tried with variable results. We sought to examine the effect of transcutaneous electrical nerve stimulation (TENS) as an intervention for pain relief during chest tube removal after cardiac surgery...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Tomonori Furuya, Jitsu Kato, Yusuke Yamamoto, Noriya Hirose, Takahiro Suzuki
Background and Aims: Ultrasound (US)-guided transversus abdominis plane (TAP) block is used as a part of a multimodal analgesic regimen in the postoperative period. Lateral approach TAP block (LTAP) has been widely used for postoperative analgesia after lower abdominal surgeries. Posterior approach TAP block (PTAP), which is achieved by more posterior blockade of the anterior ramus of the spinal nerve, also provides profound postoperative analgesia after transverse lower abdominal incision...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
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