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Ambreen Askar Bangash, Zubair Durrani
OBJECTIVE: To reduce postoperative pain by using additional analgesic agent in between the usual parenteral analgesia that is used in the postoperative period in surgical patients. METHODS: The double-blind, randomised control intervention was conducted from June to November 2015 at Rehman Medical Institute, Peshawar, Pakistan, and comprised postoperative surgical patients of either gender aged 18 or more who had undergone uneventful elective surgery The subjects were divided into test and placebo groups...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Waqas Alam, Khan Muhammad Yaqub, Mobasher Ahmad Saeed
OBJECTIVE: To determine frequency of maternal hypotension during spinal anaesthesia for elective caesarean section by comparing fixed dose with height and weight-adjusted dose of hyperbaric 0.5% bupivacaine. METHODS: This randomised controlled trial was carried out at Pakistan Naval Ship Shifa Hospital, Karachi, and comprised patients with singleton pregnancy who were randomly divided into two groups. After preloading with 10ml/kg of Ringers lactate, Group A received fixed dose of 10mg of 0...
September 2018: JPMA. the Journal of the Pakistan Medical Association
Álvaro J Gutiérrez-Bautista, Juan Morgaz, María Del Mar Granados, Rafael J Gómez-Villamandos, Juan M Dominguez, José A Fernandez-Sarmiento, Daniel Aguilar-García, Rocío Navarrete-Calvo
OBJECTIVE: To evaluate and compare the analgesic efficacy and adverse effects of dexketoprofen and methadone using a noninferiority trial, during the first 24 postoperative hours in dogs undergoing orthopaedic surgery. STUDY DESIGN: Randomized, blinded clinical study. ANIMALS: A total of 38 healthy dogs undergoing orthopaedic surgery. METHODS: Dogs were premedicated with dexmedetomidine [1 μg kg-1 intravenously (IV)] followed by dexketoprofen (1 mg kg-1 IV; group DK) or methadone (0...
August 11, 2018: Veterinary Anaesthesia and Analgesia
Yaswanth Kuthati, Sheng-Hsiung Lin, Ing-Jung Chen, Chih-Shung Wong
Melatonin (N-acetyl-5-methoxytryptamine), secreted by the pineal gland is known to perform multiple functions including, antioxidant, anti-hypertensive, anti-cancerous, immunomodulatory, sedative and tranquilizing functions. Melatonin is also known to be involved in the regulation of body mass index, control the gastrointestinal system and play an important role in cardioprotection, thermoregulation, and reproduction. Recently, several studies have reported the efficacy of Melatonin in treating various pain syndromes...
October 10, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Angelo Sala, Ewgenij Proschak, Dieter Steinhilber, G Enrico Rovati
Chronic inflammation and pain is a major global health problem, and nonsteroidal anti-inflammatory drugs (NSAIDs) remain the most frequently prescribed drugs and common option for the treatment of inflammatory pain. However, they have the potential to cause serious complications, such as gastrointestinal (GI) lesions, bleeding and cardiovascular (CV) problems. NSAIDs exert their anti-inflammatory, analgesic and anti-pyretic actions by inhibiting the cyclooxygenases (COX)-1 and COX-2, key enzymes of the arachidonic acid (AA) cascade...
October 10, 2018: Biochemical Pharmacology
Sophie J Taylor, Michael Steer, Simon C Ashe, Penny J Furness, Sarah Haywood-Small, Kim Lawson
Background and aims Fibromyalgia is a complex condition characterised by widespread pain, sleep disturbance, fatigue and cognitive impairment, with a global mean prevalence estimated at 2.7%. There are inconsistencies in guidelines on the treatment of fibromyalgia leading to dissatisfaction from patients and healthcare professionals. This study investigated patient-reported outcomes of pharmacological and non-pharmacological treatment usage and effectiveness with an assessment of acceptability. Methods Nine hundred and forty-one participants completed a self-administered anonymous questionnaire giving quantitative data of demographics, treatment usage and treatment outcomes...
October 13, 2018: Scandinavian Journal of Pain
C J Mullington, D A Low, P H Strutton, S Malhotra
It is not clear how converting epidural analgesia for labour to epidural anaesthesia for emergency caesarean section affects either cutaneous vasomotor tone or mean body temperature. We hypothesised that topping up a labour epidural blocks active cutaneous vasodilation (cutaneous heat loss and skin blood flow decrease), and that as a result mean body temperature increases. Twenty women in established labour had body temperature, cutaneous heat loss and skin blood flow recorded before and after epidural top-up for emergency caesarean section...
October 13, 2018: Anaesthesia
Roxana Kargar, Vasilis Minas, Atefeh Gorgin Karaji, Khadijeh Shadjoo, Roya Padmehr, Arash Mohazzab, Anahita Enzevaei, Saghar Samimi Sadeh, Koorosh Kamali, Shaheen Khazali
OBJECTIVE: To compare the efficiency of laparoscopically-guided transversus abdominis plane block (LTAP) versus port-site local anaesthetic infiltration (LAI) in reducing postoperative pain following laparoscopic excision of endometriosis. DESIGN: A prospective, double-blind randomized controlled trial. SETTING: A tertiary referral centre for endometriosis and minimally invasive gynaecological surgery. POPULATION: Women undergoing laparoscopic excision of endometriosis from December 2015 through July 2016...
October 13, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Margaret Louise Phillips, Vijo Kuruvilla, Michael Bailey
BACKGROUND: Pain is a common stressor for ICU patients, necessitating routine assessment. For patients who are unable to communicate, self-report tools are unsuitable, and the use of an observational tool is required to assess pain appropriately. The Critical Care Pain Observation Tool (CPOT) is the most reliable tool currently available to assess pain in these patients. We investigated whether the implementation of the CPOT in one Australian ICU could increase frequency of appropriate pain assessments, and if this would affect the administration of analgesia and sedation...
October 9, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
Timothy H Mungroop, Bart F Geerts, Denise P Veelo, Timothy M Pawlik, Aurélie Bonnet, Mickaël Lesurtel, Koen M Reyntjens, Takehiro Noji, Chao Liu, Eduard Jonas, Christopher L Wu, Eduardo de Santibañes, Mohammed Abu Hilal, Markus W Hollmann, Marc G Besselink, Thomas M van Gulik
BACKGROUND: Fluid and pain management during liver surgery (eg, low central venous pressure) is a classic topic of controversy between anesthesiologists and surgeons. Little is known about practices worldwide. The aim of this study was to assess perioperative practices in liver surgery among and between surgeons and anesthesiologists worldwide that could guide the design of future international studies. METHODS: An online questionnaire was sent to 22 societies, including 4 international hepatopancreatobiliary societies, the American Society of Anesthesiologists, and 17 other (inter-)national societies...
October 9, 2018: Surgery
Mehnaz Ferdousi, David P Finn
Depending on its nature, duration, and intensity, stress can exert potent and bidirectional modulatory effects on pain, either reducing pain (stress-induced analgesia) or exacerbating it (stress-induced hyperalgesia). The descending pain pathway has been implicated in both stress-induced analgesia and stress-induced hyperalgesia. The endogenous opioid system is widely distributed throughout the descending pain pathway and regulates nociceptive signaling, emotionality, and the response to stress. Here we review the evidence for a key role of the endogenous opioid system in stress-induced modulation of pain in rodents and humans...
2018: Progress in Brain Research
Zhe-Hui Wang, Yuan-Tao Wang, Fei Cheng, Yu Hu
INTRODUCTION: This study aims to investigate the pathological features of a patient with paraganglioma in the lumbar spinal canal. CASE PRESENTATION: The patient was 36 years old male with electrical pain in the waist and buttock which occurred intermittently, and was not relieved under oral use of analgesics. Immunohistochemical staining was performed to diagnose the disease. The results revealed that the size of the tumor was 3.4 × 1.6 × 1.4 cm. The hematoxylin and eosin (H&E)-stained tumor cells mainly presented with an organ-like arrangement under low power microscope, showing prominent chrysanthemum-like, pseudo glandular or pseudo papillary arrangements...
October 2018: Medicine (Baltimore)
Wei Dai, Maocai Tang, Kaihua He
BACKGROUND: Dexmedetomidine has been used as an adjuvanty added to local anesthetics to prolong analgesia following peripheral nerve blockade. The aim of this meta-analysis was to investigate the effect and safety of dexmedetomidine added to ropivacaine in brachial plexus block (BPB). METHODS: A search strategy was created to identify eligible randomized clinical trial (RCT) in PubMed, Embase, and The Cochrane Library (updated May, 2018). The methodologic quality for each included study was evaluated using the Cochrane Tool for Risk of Bias by 2 independent researchers...
October 2018: Medicine (Baltimore)
B Chi, B Chau, E Yeo, P Ta
BACKGROUND: Treatment of spinal cord injury (SCI)-associated neuropathic pain is challenging, with limited efficacy and no definitive options, and SCI patients often show resistance to pharmacologic treatment. Virtual reality (VR) therapy is a non-invasive, non-pharmacologic alternative with minimal adverse effects. OBJECTIVE: To investigate the effect of VR therapy on SCI-associated neuropathic pain in a systematic review. METHODS: Articles needed to 1) be written in English; 2) include adult subjects, with at least half the study population with a SCI diagnosis; 3) involve any form of VR therapy; and 4) assess neuropathic pain by quantitative outcome measures...
October 9, 2018: Annals of Physical and Rehabilitation Medicine
Rahul Raghav, Raka Jain, Anju Dhawan, T S Roy, Punit Kumar
Nalbuphine is an agonist of κ-opioid receptors and a partial agonist of μ-opioid receptors, which can stimulate κ-receptors and antagonize the acute rewarding effects of morphine. It is widely used either as an analgesic or as an adjuvant with morphine. This present study aimed to compare the acute and chronic effects of nalbuphine on the naloxone-precipitated opiate-withdrawal in rats. Male adult Wistar albino rats (150-175 g, n = 160) were made physically dependent by administrating increasing dose of morphine (5-25 mg/kg; i...
October 9, 2018: Pharmacology, Biochemistry, and Behavior
Nicholas Atwal, Sherelle L Casey, Vanessa A Mitchell, Christopher W Vaughan
Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the profile of THC could be improved by co-administering it with the first-line neuropathic pain medication gabapentin. This was done using the chronic constriction injury (CCI) model of neuropathic pain in C57BL6 mice. At 8 days post-CCI nerve injury, acute systemic administration of gabapentin produced a dose-dependent decrease in CCI-induced mechanical and cold allodynia, and increased motor incoordination...
October 9, 2018: Neuropharmacology
Lisa Söderman, Måns Edlund, Lena Marions
INTRODUCTION: The objective of this study was to estimate the prevalence of dysmenorrhea among adolescents and its effect on daily life. MATERIAL AND METHODS: A web-based questionnaire, with questions regarding menstrual symptoms was distributed to all girls born year 2000 and residing in Stockholm City (n=3998). Questions regarding pain severity, other menstrual related symptoms, medical treatment, health care visits, social and academic absenteeism were included in the questionnaire...
October 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
Yoshihiro Uesawa, Naotaka Tsuji
Edible portions of bananas contain high levels of polyphenol oxidase, which catalyzes reactions in the melanin formation pathway. Tyrosine, a physiological substrate of polyphenol oxidase, has an analogous structure to acetaminophen. We investigated whether banana extract causes structural changes in acetaminophen and a decrease in its potency. Acetaminophen concentration in banana extract was measured under different conditions to characterize incompatibility. Reaction products in solution were identified using liquid chromatography/electrospray ionization/mass spectrometry (LC/ESI/MS)...
2018: PloS One
Nafisseh S Warner, Eleanor R Trousdale, Tim J Lamer
Celiac plexus neurolysis has been shown to be an effective analgesic option for patients with visceral pain related to intraabdominal malignancies. In the setting of significant tumor burden, the celiac plexus may be inaccessible, limiting the efficacy of the transcrural approach. This case report describes a novel single-needle approach to retrocrural celiac plexus blockade, allowing for rapid blockade with a needle trajectory contralateral to the aorta in a 73-year-old woman with altered anatomy secondary to advanced metastatic colorectal cancer...
October 11, 2018: A&A practice
Ilana Levy, Samuel Attias, Lior Cohen, Nadav Stoppelmann, Dan Steinberger, Ofra Grimberg, Eran Ben-Arye, Ibrahim Matter, Gideon Sroka, Mostafa Somri, Elad Schiff
Background Postoperative pain is common in patients hospitalized in surgical departments, yet it is currently not sufficiently controlled by analgesics. Acupuncture, a complementary medical practice, has been evaluated for its benefits in postoperative pain with heterogeneous results. We tested the feasibility of a controlled study comparing the postoperative analgesic effect of acupuncture together with standard-of-care to standard-of-care only. Methods In this pilot non-randomized controlled study conducted at a tertiary medical center in Israel, patients received either acupuncture with standard-of-care pain treatment (acupuncture group) or standard-of-care treatment only (control group) following surgery...
October 12, 2018: Journal of Complementary & Integrative Medicine
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