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Obliterative Bronchiolitis

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https://www.readbyqxmd.com/read/30472390/a-novel-myd88-inhibitor-attenuates-allograft-rejection-after-heterotopic-tracheal-transplantation-in-mice
#1
Min Yang, Gen Chen, Xue Zhang, Zuochuan Ding, Yan Miao, Yang Yang, Sheng Chang, Ping Zhou
BACKGROUND: After lung transplantation, the major complication limiting the long-term survival of allografts is obliterative bronchiolitis (OB), characterized by chronic rejection. Innate immune responses contribute to the development of OB. In this study, we used a murine heterotopic tracheal transplantation mouse model to examine the effects of a newtype of innate immune inhibitor, TJ-M2010-5. METHODS: Syngeneic tracheal grafts were transplanted heterotopically from C57BL/6 mice to C57BL/6 mice...
November 22, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/30211827/il-17a-is-critical-for-cd8-t-effector-response-in-airway-epithelial-injury-after-transplantation
#2
Ruochan Zhang, Huihui Fang, Rongjuan Chen, Jordi C Ochando, Yaozhong Ding, Jiangnan Xu
BACKGROUND: Airway epithelium is the primary target of trachea and lung transplant rejection, the degree of epithelial injury is closely correlated with obliterative bronchiolitis development. In this study, we investigated the cellular and molecular mechanisms of IL-17A-mediated airway epithelial injury after transplantation. METHODS: Murine orthotopic allogeneic trachea or lung transplants were implemented in wild type or RORγt mice. Recipients received anti-IL-17A or anti-IFNγ for cytokine neutralization, anti-CD8 for CD8 T cell depletion, or STAT3-inhibitor to suppress Th17/Tc17 development...
September 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29929518/obliterative-bronchiolitis-associated-with-rheumatoid-arthritis-analysis-of-a-single-center-case-series
#3
Erica Lin, Andrew H Limper, Teng Moua
BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune condition characterized by erosive inflammation of the joints. One rare pulmonary manifestation is obliterative bronchiolitis (OB), a small airways disease characterized by the destruction of bronchiolar epithelium and airflow obstruction. METHODS: We retrospectively reviewed the clinical data of patients with rheumatoid arthritis-associated obliterative bronchiolitis (RA-OB) from 01/01/2000 to 12/31/2015...
June 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29880387/azithromycin-fails-to-prevent-accelerated-airway-obliteration-in-t-bet-mouse-lung-allograft-recipients
#4
E A Lendermon, J M Dodd-O, T A Coon, X Wang, C R Ensor, N Cardenes, C L Koodray, H L Heusey, M F Bennewitz, P Sundd, G C Bullock, I Popescu, L Guo, C P O'Donnell, M Rojas, J F McDyer
BACKGROUND: Cellular and molecular mechanisms of acute and chronic lung allograft rejection have yet to be clearly defined, and obliterative bronchiolitis (OB) remains the primary limitation to survival in lung transplant recipients (LTRs). We have previously shown that T-bet-deficient recipients of full major histocompatibility complex (MHC)-mismatched, orthotopic left lung transplants develop accelerated obliterative airway disease (OAD) in the setting of acute cellular rejection characterized by robust alloimmune CD8+ interleukin (IL)-17 and interferon (IFN)-γ responses that are attenuated with neutralization of IL-17...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29697356/early-immune-response-to-acute-gastric-fluid-aspiration-in-a-rat-model-of-lung-transplantation
#5
Jui-Chih Chang, Sadé M Finn, Robert Patrick Davis, Nathan L Sanders, Zoie E Holzknecht, Mary Lou Everett, Andrew S Barbas, William Parker, Shu S Lin
OBJECTIVES: Chronic aspiration of gastric fluid contents can decrease long-term survival of pulmonary transplants due to development of obliterative bronchiolitis. However, little is known about the early immune response and the cascade of events involved in the development of obliterative bronchiolitis. MATERIALS AND METHODS: We utilized a rat orthotopic pulmonary transplant model and a single aspiration of either gastric fluid or normal saline to investigate the histologic, cellular, and cytokine changes associated with an acute gastric fluid aspiration event compared with normal saline at 2 and 10 days after aspiration...
April 26, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29394172/the-emerging-spectrum-of-exposure-related-bronchiolitis
#6
Silpa D Krefft, Carlyne D Cool, Cecile S Rose
PURPOSE OF REVIEW: Exposure-related bronchiolitis is increasingly recognized as an important but challenging clinical diagnosis. Acute and chronic inhalational exposures are associated with variable clinical presentations and a spectrum of histopathologic abnormalities affecting the small airways. This review provides an overview of the histologic patterns and occupational settings for exposure-related bronchiolitis, along with recent advances in disease diagnosis and management. RECENT FINDINGS: The entire histopathologic spectrum of bronchiolitis (constrictive, obliterative, proliferative, lymphocytic, respiratory) has been reported in exposure-related bronchiolitis...
April 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29327719/the-histomorphological-spectrum-of-restrictive-chronic-lung-allograft-dysfunction-and-implications-for-prognosis
#7
Jan H von der Thüsen, Elly Vandermeulen, Robin Vos, Birgit Weynand, Erik K Verbeken, Stijn E Verleden
Chronic lung allograft dysfunction continues to be the main contributor to poor long-term allograft survival after lung transplantation. The restrictive phenotype of chronic lung allograft dysfunction carries a particularly poor prognosis. Little is known about the pathogenetic mechanisms involved in restrictive chronic lung allograft dysfunction. In this study, we performed histomorphological and immunohistochemical analysis of restrictive chronic lung allograft dysfunction lungs. Explant lung tissue from 21 restrictive chronic lung allograft dysfunction patients was collected and histopathologic patterns of rejection, fibrosis and vascular changes were scored after routine histochemical stains and additional immunohistochemistry for endothelial markers and C4d...
May 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29236513/depletion-of-airway-submucosal-glands-and-tp63-krt5-basal-cells-in-obliterative-bronchiolitis
#8
Anthony M Swatek, Thomas J Lynch, Adrianne K Crooke, Preston J Anderson, Scott R Tyler, Leonard Brooks, Marina Ivanovic, Julia A Klesney-Tait, Michael Eberlein, Tahuanty Pena, David K Meyerholz, John F Engelhardt, Kalpaj R Parekh
RATIONALE: Obliterative bronchiolitis (OB) is a major cause of mortality after lung transplantation. Depletion of airway stem cells (SCs) may lead to fibrosis in OB. OBJECTIVES: Two major SC compartments in airways are submucosal glands (SMGs) and surface airway p63 (also known as TP63 [tumor protein 63])-positive/K5 (also known as KRT5 [keratin 5])-positive basal cells (BCs). We hypothesized that depletion of these SC compartments occurs in OB. METHODS: Ferret orthotopic left lung transplants were used as an experimental model of OB, and findings were corroborated in human lung allografts...
April 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28984536/airway-injury-in-an-in-vitro-human-epithelium-fibroblast-model-of-diacetyl-vapor-exposure-diacetyl-induced-basal-suprabasal-spongiosis
#9
William M Gwinn, Gordon P Flake, Ronald W Bousquet, Genie J Taylor, Daniel L Morgan
Inhalation exposure to diacetyl (DA) is associated with obliterative bronchiolitis (OB) in workers and induces OB-like fibrotic airway lesions in rats. The pathogenesis of OB is poorly understood in part due to complex interactions between airway epithelial, mesenchymal and blood-derived inflammatory cells. DA-induced airway toxicity in the absence of recruited-inflammatory/immune cells was characterized using an air-liquid interface (ALI) model consisting of human airway epithelium with (Epi/FT) and without (Epi) a mesenchymal component...
June 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28932572/chronic-lung-allograft-dysfunction-phenotypes-and-treatment
#10
REVIEW
Stijn E Verleden, Robin Vos, Bart M Vanaudenaerde, Geert M Verleden
Chronic lung allograft dysfunction (CLAD) remains a major hurdle limiting long-term survival post lung transplantation. Given the clinical heterogeneity of CLAD, recently two phenotypes of CLAD have been defined [bronchiolitis obliterans syndrome (BOS) vs. restrictive allograft syndrome (RAS) or restrictive CLAD (rCLAD)]. BOS is characterized by an obstructive pulmonary function, air trapping on CT and obliterative bronchiolitis (OB) on histopathology, while RAS/rCLAD patients show a restrictive pulmonary function, persistent pleuro-parenchymal infiltrates on CT and pleuroparenchymal fibro-elastosis on biopsies...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28863322/il-17-contributes-to-the-pathogenesis-of-obliterative-bronchiolitis-via-regulation-of-m1-macrophages-polarization-in-murine-heterotopic-trachea-transplantation-models
#11
Qingshu Meng, Jie Liu, Fang Lin, Luer Bao, Yuyu Jiang, Liang Zheng, Jinjun Tie, Lin Zhang, Xiaoting Liang, Lu Wei, Yuan Li, Huimin Fan, Xiaohui Zhou
Acute allograft rejection is a principal conundrum in lung obliterative bronchiolitis (OB). Monocytes/macrophages infiltration has been proved to be the main reason for acute rejection. IL-17 contributes to the recruitment and function of macrophages. However, the mechanism of IL-17 underlying OB progression remains elusive. In the present study, we showed that the deficiency of IL-17 attenuated the pathology of murine heterotopic trachea allografts. Compared to WT recipients, IL-17-/- mice displayed higher frequency of CD206+ cells and lower ratio of CD86+ cells among F4/80+ macrophages in allografts and spleens on day 7 post heterotopic trachea transplantation...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28638618/swyer-james-macleod-syndrome-a-rare-diagnosis-presented-through-two-adult-patients
#12
Sumit Mehra, Thilini Basnayake, Henrik Falhammar, Subash Heraganahally, Suryakant Tripathi
Swyer-James-MacLeod syndrome (SJMS) is a rare syndrome of acute obliterative bronchiolitis following an early childhood infective insult to the lungs. This causes arrest of alveolarization, affecting lung development with hypoplasia of the ipsilateral pulmonary artery and results in a characteristic radiological pattern, such as a unilateral hyperlucent lung with expiratory air-trapping and pruned-tree appearance on pulmonary angiogram. The clinical presentation is either recurrent chest infections, exertional dyspnoea or it may be an incidental finding...
September 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28619045/human-adipose-derived-mesenchymal-stem-cells-alleviate-obliterative-bronchiolitis-in-a-murine-model-via-ido
#13
Guoping Zheng, Guanguan Qiu, Menghua Ge, Jianping He, Lanfang Huang, Ping Chen, Wei Wang, Qi Xu, Yaoqin Hu, Qiang Shu, Jianguo Xu
BACKGROUND: Long-term survival of lung transplantation is hindered by the development of obliterative bronchiolitis (OB). Adipose-derived stem cells (ASCs) were documented to have more potent immunosuppressive ability than mesenchymal stem cells (MSCs) from bone marrow and placenta. The goal of our study is to evaluate the effect of repeated administration of ASCs on OB and the involvement of indoleamine 2,3-dioxygenase (IDO) mediating the protective effect of ASCs in a heterotopic tracheal transplantation (HTT) model...
June 15, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28345967/deaths-from-nonmalignant-respiratory-disease-in-styrene-exposed-workers-does-obliterative-bronchiolitis-contribute-to-mortality
#14
Randall J Nett, Nicole T Edwards, Avima M Ruder, Stephen J Bertke, Isna Keumala, Jean Cox-Ganser, Kristin J Cummings
No abstract text is available yet for this article.
May 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28215425/outcomes-of-lung-transplantation-for-infants-and-children-with-genetic-disorders-of-surfactant-metabolism
#15
COMPARATIVE STUDY
Whitney B Eldridge, Qunyuan Zhang, Albert Faro, Stuart C Sweet, Pirooz Eghtesady, Aaron Hamvas, F Sessions Cole, Jennifer A Wambach
OBJECTIVE: To compare outcomes of infants and children who underwent lung transplantation for genetic disorders of surfactant metabolism (SFTPB, SFTPC, ABCA3, and NKX2-1) over 2 epochs (1993-2003 and 2004-2015) at St Louis Children's Hospital. STUDY DESIGN: We retrospectively reviewed clinical characteristics, mortality, and short- and long-term morbidities of infants (transplanted at <1 year; n = 28) and children (transplanted >1 year; n = 16) and compared outcomes by age at transplantation (infants vs children) and by epoch of transplantation...
May 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28194087/occupational-bronchiolitis-induced-by-cotton-dust-exposure-in-a-nonsmoker
#16
Richa Mittal, Pawan Gupta, Sunil K Chhabra
The most well-known disease caused by cotton dust is byssinosis though it is also associated with chronic obstructive airways disease, and very rarely, interstitial lung disease. Obliterative bronchiolitis has never been reported in this setting. We report a 63-year-old, nonsmoker male, who presented with complaints of cough and exertional dyspnoea for 10 years. He had worked in textile industry for 35 years and symptoms had persisted even after quitting. Examination revealed prolonged expiration with expiratory wheeze, and pulmonary function tests revealed severe airflow limitation with air trapping and impaired diffusion capacity...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28186707/mesenchymal-stromal-cell-therapy-for-chronic-lung-allograft-dysfunction-results-of-a-first-in-man-study
#17
Daniel C Chambers, Debra Enever, Sharon Lawrence, Marian J Sturm, Richard Herrmann, Stephanie Yerkovich, Michael Musk, Peter M A Hopkins
Chronic lung transplant rejection (termed chronic lung allograft dysfunction [CLAD]) is the main impediment to long-term survival after lung transplantation. Bone marrow-derived mesenchymal stromal cells (MSCs) represent an attractive cell therapy in inflammatory diseases, including organ rejection, given their relative immune privilege and immunosuppressive and tolerogenic properties. Preclinical studies in models of obliterative bronchiolitis and human trials in graft versus host disease and renal transplantation suggest potential efficacy in CLAD...
April 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28138398/comparative-analysis-of-morphological-and-molecular-motifs-in-bronchiolitis-obliterans-and-alveolar-fibroelastosis-after-lung-and-stem-cell-transplantation
#18
Danny Jonigk, Berenice Rath, Paul Borchert, Peter Braubach, Lavinia Maegel, Nicole Izykowski, Gregor Warnecke, Wiebke Sommer, Hans Kreipe, Robert Blach, Adrian Anklamm, Axel Haverich, Matthias Eder, Michael Stadler, Tobias Welte, Jens Gottlieb, Mark Kuehnel, Florian Laenger
Chronic lung allograft dysfunction (CLAD) remains the major obstacle to long-term survival following lung transplantation (LuTx). Morphologically CLAD is defined by obliterative remodelling of the small airways (bronchiolitis obliterans, BO) as well as a more recently described collagenous obliteration of alveoli with elastosis summarised as alveolar fibroelastosis (AFE). Both patterns are not restricted to pulmonary allografts, but have also been reported following haematopoietic stem cell transplantation (HSCT) and radio chemotherapy (RC)...
January 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28120410/restrictive-allograft-syndrome-and-idiopathic-pleuroparenchymal-fibroelastosis-do-they-really-have-the-same-histology
#19
Maria A Montero, Tina Osadolor, Reena Khiroya, Maria Teresa Salcedo, Jan L Robertus, Alexandra Rice, Andrew G Nicholson, Antonio Roman, Victor Monforte
AIMS: Restrictive allograft syndrome (RAS) and idiopathic pleuroparenchymal fibroelastosis (IPPFE) are two different diseases reported to share the same histology. RAS relates to chronic allograft dysfunction in lung transplantation, with IPPFE being a rare condition in native lungs. Our aim is to compare their histologies alongside biopsies of usual interstitial pneumonia (UIP), to determine if there are differences that might help to elucidate the pathogenesis. METHODS AND RESULTS: We selected four postmortem allograft lungs from patients who developed a clear clinical RAS pattern, five biopsies diagnosed as IPPFE, five UIP biopsies and five sections of normal lung...
June 2017: Histopathology
https://www.readbyqxmd.com/read/28118023/il-17a-blockade-attenuates-obliterative-bronchiolitis-and-ifn-%C3%AE-cellular-immune-response-in-lung-allografts
#20
Pawan Kumar Gupta, Sarah R Wagner, Qiang Wu, Rebecca A Shilling
Obliterative bronchiolitis (OB), characterized by fibrous obliteration of the small airways, is a major impediment to long-term survival in lung allograft recipients. We found previously that IL-17A is produced primarily by CD4+ T cells and γδ T cells after lung transplant in a mouse model of orthotopic lung transplant. The absence of either subset of T cells was compensated for by expansion of the other subset, which suggested that systemic blockade of IL-17A was necessary. To determine the specific role of IL-17A in the development of OB, we treated lung allograft recipients with an IL-17A antagonistic antibody...
June 2017: American Journal of Respiratory Cell and Molecular Biology
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