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Dht causing alopecia

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https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#1
REVIEW
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2 ) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29087225/development-and-evaluation-of-finasteride-loaded-ethosomes-for-targeting-to-the-pilosebaceous-unit
#2
Vinny Wilson, Karthik Siram, Selvakumar Rajendran, Veintramuthu Sankar
Androgenetic alopecia, a major cause for baldness, is caused by the deposition of dihydrotestosterone (DHT) at the androgen receptors present in the pilosebaceous unit (PSU). Finasteride (FIN) is a potent 5α-reductase inhibitor capable of preventing the conversion of testosterone to DHT. But, its oral administration in males causes infertility. An attempt was made to prepare ethosomes of FIN with a size range 100-300 nm to enhance its delivery to the PSU. Finasteride loaded ethosomes (FES) were prepared using an ultra-probe sonicator and characterized for its size, morphology, surface charge and entrapment efficiency...
October 31, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28689207/design-of-finasteride-loaded-nanoparticles-for-potential-treatment-of-alopecia
#3
Luís V Roque, Inês S Dias, Nuno Cruz, Ana Rebelo, Amílcar Roberto, Patrícia Rijo, Catarina P Reis
BACKGROUND/AIMS: Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid compound with poor aqueous solubility, blocks the peripheral conversion of testosterone to dihydrotestosterone (DHT) in a significant reduction in DHT concentration, achieving satisfactory results in alopecia treatment. However, its oral intake generally causes severe side effects. Considering that there is currently no scientifically proven treatment, new drug delivery systems able to improve alopecia therapy are urgently required...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28296872/human-mesenchymal-stem-cell-derived-conditioned-media-for-hair-regeneration-applications
#4
REVIEW
Sushilkumar Ramdasi, Shashi Kant Tiwari
Hair loss can have major psychological impact on affected population belonging to varied ethnic background. Hair is a mini organ in itself and serves many distinguishing functions ranging from maintaining body temperature to promoting social interactions. Major cause of hair loss is androgenic alopecia. Hair follicles possess receptor for androgen. However, DHT (Dihydrotestosterone) in excess results into shrinkage of hair follicle affecting hair growth adversely. The present review is focused on etiology of hair loss, traditional treatment approach and their limitations with side effects with special emphasis on unique properties of stem cells, favourable growth factors secreted by stem cells and strategies to enhance favourable growth factor/cytokine production for hair loss therapeutics...
2016: Journal of Stem Cells
https://www.readbyqxmd.com/read/26923074/sulforaphane-promotes-murine-hair-growth-by-accelerating-the-degradation-of-dihydrotestosterone
#5
Mari Sasaki, Shohei Shinozaki, Kentaro Shimokado
Dihydrotestosterone (DHT) causes the regression of human hair follicles in the parietal scalp, leading to androgenic alopecia (AGA). Sulforaphane (SFN) increases the expression of DHT degrading enzymes, such as 3α-hydroxysteroid dehydrogenases (3α-HSDs), and, therefore, SFN treatment may improve AGA. To determine the effects of SFN on hair growth, we administered SFN (10 mg/kg BW, IP) or vehicle (DMSO) to ob/ob mice for six weeks and examined hair regeneration and the plasma levels of testosterone and DHT...
March 25, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26796631/identification-of-a-new-plant-extract-for-androgenic-alopecia-treatment-using-a-non-radioactive-human-hair-dermal-papilla-cell-based-assay
#6
Ruchy Jain, Orawan Monthakantirat, Parkpoom Tengamnuay, Wanchai De-Eknamkul
BACKGROUND: Androgenic alopecia (AGA) is a major type of human scalp hair loss, which is caused by two androgens: testosterone (T) and 5α-dihydrotestosterone (5α-DHT). Both androgens bind to the androgen receptor (AR) and induce androgen-sensitive genes within the human hair dermal papilla cells (HHDPCs), but 5α-DHT exhibits much higher binding affinity and potency than T does in inducing the involved androgen-sensitive genes. Changes in the induction of androgen-sensitive genes during AGA are caused by the over-production of 5α-DHT by the 5α-reductase (5α-R) enzyme; therefore, one possible method to treat AGA is to inhibit this enzymatic reaction...
January 21, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26175016/identification-of-5%C3%AE-reductase-isoenzymes-in-canine-skin
#7
Lucilene Bernardi de Souza, Manon Paradis, Gustavo Zamberlam, Marie-Odile Benoit-Biancamano, Christopher Price
BACKGROUND: Alopecia X in dogs is a noninflammatory alopecia that may be caused by a hormonal dysfunction. It may be similar to androgenic alopecia in men that is caused by the effect of dihydrotestosterone (DHT). The 5α-reductase isoenzymes, 5αR1 and 5αR2, and a recently described 5αR3, are responsible for the conversion of testosterone into DHT. However, which 5α-reductases are present in canine skin has not yet been described. OBJECTIVES: The main objective of this study was to determine the pattern of expression of 5α-reductase genes in canine skin...
October 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/24873677/potential-targets-in-the-discovery-of-new-hair-growth-promoters-for-androgenic-alopecia
#8
REVIEW
Ruchy Jain, Wanchai De-Eknamkul
INTRODUCTION: Androgenic alopecia (AGA) is the major type of scalp hair loss affecting 60 - 70% of the population worldwide. It is caused by two potent androgens, namely testosterone (T) and 5α-dihydrotestosterone (5α-DHT). Till date, only two FDA-approved synthetic drugs, minoxidil and finasteride, are used to cure AGA with only 35 and 48% success, respectively; therefore, a search for new drug based on the mechanism of androgens action is still needed. AREAS COVERED: Relevant literature was reviewed to identify current therapeutic targets and treatments for AGA...
July 2014: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/24858268/avicequinone-c-isolated-from-avicennia-marina-exhibits-5%C3%AE-reductase-type-1-inhibitory-activity-using-an-androgenic-alopecia-relevant-cell-based-assay-system
#9
Ruchy Jain, Orawan Monthakantirat, Parkpoom Tengamnuay, Wanchai De-Eknamkul
Avicennia marina (AM) exhibits various biological activities and has been traditionally used in Egypt to cure skin diseases. In this study, the methanolic heartwood extract of AM was evaluated for inhibitory activity against 5α-reductase (5α-R) [E.C.1.3.99.5], the enzyme responsible for the over-production of 5α-dihydrotestosterone (5α-DHT) causing androgenic alopecia (AGA). An AGA-relevant cell-based assay was developed using human hair dermal papilla cells (HHDPCs), the main regulator of hair growth and the only cells within the hair follicle that are the direct site of 5α-DHT action, combined with a non-radioactive thin layer chromatography (TLC) detection technique...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/24566563/androgenetic-alopecia
#10
REVIEW
B M Piraccini, A Alessandrini
Androgenetic alopecia (AGA) is the most common form of alopecia, affecting up to 80% of men and 50% of women in the course of their life. AGA is caused by a progressive reduction in the diameter, length and pigmentation of the hair. Hair thinning results from the effects of the testosterone metabolite dehydrotestosterone (DHT) on androgen-sensitive hair follicles. In women, AGA produces diffuse thinning of the crown region with maintenance of the frontal hairline (Ludwig pattern AGA). In premenopausal women, AGA can be a sign of hyperandrogenism, together with hirsutism and acnes...
February 2014: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/24116284/hair-loss-preventing-effect-of-grateloupia-elliptica
#11
Jung-Il Kang, Sang-Cheol Kim, Sang-Chul Han, Hye-Jin Hong, You-Jin Jeon, Bora Kim, Young-Sang Koh, Eun-Sook Yoo, Hee-Kyoung Kang
This study was conducted to evaluate the effect of Grateloupia elliptica, a seaweed native to Jeju Island, Korea, on the prevention of hair loss. When immortalized rat vibrissa dermal papilla cells were treated with extract of G. elliptica, the proliferation of dermal papilla cells significantly increased. In addition, the G. elliptica extract significantly inhibited the activity of 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), a main cause of androgenetic alopecia. On the other hand, the G...
January 2012: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/22223335/effects-of-hura-crepitans-and-its-active-ingredient-daphne-factor-f3-on-dihydrotestosterone-induced-neurotrophin-4-activation-and-hair-retardation
#12
Chiyoko Uchiyama, Kazuhiro Ishida, Takuya Tsutsui, Atsushi Naito, Kei Kurita, Hiroyuki Hanihara, Tetsushi Serizawa, Masami Fujiwara, Motoyasu Ohdera
Neurotrophin (NT)-4 is known to be an inducer of catagen in the hair cycle, but little is known of its role in the pathogenesis of androgenetic alopecia (AGA). We previously studied the gene expression of dermal papilla cells from AGA patients and controls and found that NT-4 was up-regulated in the AGA patients. In the present study, the etiological relationship between NT-4 and androgen, which is one of the causes of AGA, and the effect of an NT-4 inhibitor on hair growth were investigated. We established a NT-4 luciferase reporter assay system using a roughly 2-kb region upstream of the NT-4 transcriptional start site and investigated an accelerating effect of androgen on NT-4 transcription...
2012: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/21881585/dihydrotestosterone-inducible-il-6-inhibits-elongation-of-human-hair-shafts-by-suppressing-matrix-cell-proliferation-and-promotes-regression-of-hair-follicles-in-mice
#13
Mi Hee Kwack, Ji Sup Ahn, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
Autocrine and paracrine factors are produced by balding dermal papilla (DP) cells following dihydrotestosterone (DHT)-driven alterations and are believed to be key factors involved in male pattern baldness. Herein we report that the IL-6 is upregulated in balding DP cells compared with non-balding DP cells. IL-6 was upregulated 3  hours after 10-100  nM DHT treatment, and ELISA showed that IL-6 was secreted from balding DP cells in response to DHT. IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) were expressed in follicular keratinocytes, including matrix cells...
January 2012: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/21114370/the-role-of-non-aromatizable-testosterone-metabolite-in-metabolic-pathways
#14
REVIEW
M Dušková, H Pospíšilová
Dihydrotestosterone (DHT) originates via irreversible reduction of testosterone by catalytic activity of 5alpha-reductase enzyme and it is demonstratively the most effective androgen. Androgens influence adipose tissue in men either directly by stimulation of the androgen receptor or indirectly, after aromatization, by acting at the estrogen receptor. DHT as a non-aromatizable androgen could be responsible for a male type fat distribution. The theory of non-aromatizable androgens as a potential cause of a male type obesity development has been studied intensively...
2011: Physiological Research
https://www.readbyqxmd.com/read/20460827/saturable-binding-of-finasteride-to-steroid-5alpha-reductase-as-determinant-of-nonlinear-pharmacokinetics
#15
Rie Suzuki, Hiroki Satoh, Hisakazu Ohtani, Satoko Hori, Yasufumi Sawada
Finasteride, a steroid 5alpha-reductase (5alphaR) inhibitor, is used to treat benign prostatic hyperplasia and androgenetic alopecia. We aimed to develop a pharmacokinetic/pharmacodynamic model to explain its nonlinear pharmacokinetics and describe the serum concentration profile of dihydrotestosterone (DHT) after finasteride administration. We developed a pharmacokinetic model incorporating a compartment that represents the binding of finasteride to 5alphaR. We fitted this model to the time-concentration profiles of finasteride after repeated administration of finasteride 0...
2010: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/20300365/finasteride-its-impact-on-sexual-function-and-prostate-cancer
#16
B Anitha, Arun C Inamadar, S Ragunatha
Finasteride, a specific and competitive inhibitor of 5alpha-reductase enzyme Type 2, inhibits the conversion of testosterone to dihydrotestosterone (DHT). In adults, DHT acts as primary androgen in prostate and hair follicles. The only FDA-approved dermatological indication of finasteride is androgenetic alopecia. But, apprehension regarding sexual dysfunction associated with finasteride deters dermatologists from prescribing the drug and patients from taking the drug for androgenetic alopecia. Testosterone, through its humoral endocrine and local paracrine effects is relevant in central and peripheral modulation of sexual function than locally acting DHT...
January 2009: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/18789604/big-head-bald-head-skull-expansion-alternative-model-for-the-primary-mechanism-of-aga
#17
Paul J Taylor
Currently, the predominant hypothesis explains androgenetic alopecia (AGA) as a process reliant upon affected follicles being individually programmed to accumulate dihydrotestosterone (DHT), which then causes progressive follicular miniaturisation. The goal of this paper is to suggest that such miniaturisation may result from an exaggeration of the bone remodelling process causing a reduction in blood supply to the capillary network within the affected region. The bones of the human skull continue to grow during adulthood and observations made of those with AGA suggest that such growth may be responsible for the development of this condition...
January 2009: Medical Hypotheses
https://www.readbyqxmd.com/read/17657240/dihydrotestosterone-inducible-dickkopf-1-from-balding-dermal-papilla-cells-causes-apoptosis-in-follicular-keratinocytes
#18
COMPARATIVE STUDY
Mi Hee Kwack, Young Kwan Sung, Eun Jung Chung, Sang Uk Im, Ji Seop Ahn, Moon Kyu Kim, Jung Chul Kim
Recent studies suggest that androgen-driven alteration to the autocrine and paracrine factors produced by scalp dermal papilla (DP) cells may be a key to androgen-potentiated balding. Here, we screened dihydrotestosterone (DHT)-regulated genes in balding DP cells and found that dickkopf 1 (DKK-1) is one of the most upregulated genes. DKK-1 messenger RNA is upregulated in 3-6 hours after 50-100 nM DHT treatment and ELISA showed that DKK-1 is secreted from DP cells in response to DHT. A co-culture system using outer root sheath (ORS) keratinocytes and DP cells showed that DHT inhibits the growth of ORS cells, and neutralizing antibody against DKK-1 significantly reversed the growth inhibition of ORS cells...
February 2008: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/17646096/establishment-of-type-ii-5alpha-reductase-over-expressing-cell-line-as-an-inhibitor-screening-model
#19
Sunhyae Jang, Young Lee, Seong-Lok Hwang, Min-Ho Lee, Su Jin Park, In Ho Lee, Sangjin Kang, Seok-Seon Roh, Young-Joon Seo, Jang-Kyu Park, Jeung-Hoon Lee, Chang Deok Kim
Dihydrotestosterone (DHT) is the most potent male hormone that causes androgenetic alopecia. The type II 5alpha-reductase is an enzyme that catalyzes the conversion of testosterone (T) to DHT, therefore it can be expected that specific inhibitors for type II 5alpha-reductase may improve the pathophysiologic status of androgenetic alopecia. In this study, we attempted to establish the reliable and convenient screening model for type II 5alpha-reductase inhibitors. After transfection of human cDNA for type II 5alpha-reductase into HEK293 cells, the type II 5alpha-reductase over-expressing stable cells were selected by G418 treatment...
November 2007: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/17134421/the-natural-history-of-androgenetic-alopecia
#20
A Tosti, B M Piraccini, M Iorizzo, S Voudouris
Androgenetic alopecia (AGA) is the most common cause of hair loss, affecting up to 80% of men and 50% of women in their lifetime. Genetic predisposition to the disease is well known but the responsible genes have not been identified. Polymorphism in the androgen receptor gene has been recently detected in AGA.(1) Although the role of androgens, and particularly dihydrotestosterone (DHT), in causing the disease has been established for a long time, the natural history of AGA is still not completely understood...
January 2005: Journal of Cosmetic Dermatology
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