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Keywords Fluid Balance In Traumatic Bra...

Fluid Balance In Traumatic Brain Injury

https://read.qxmd.com/read/38265013/the-role-of-peritoneal-dialysis-in-the-treatment-of-acute-kidney-injury-in-neurocritical-patients-a-retrospective-brazilian-study
#1
JOURNAL ARTICLE
Daniela Ponce, Gonzalo Ramírez-Guerrero, André Luis Balbi
BACKGROUND: Acute kidney injury (AKI) occurs frequently in the neurocritical intensive care unit and is associated with greater morbidity and mortality. AKI and its treatment, including acute kidney replacement therapy, can expose patients to a secondary greater brain injury. This study aimed to explore the role of peritoneal dialysis (PD) in neurocritical AKI patients in relation to metabolic and fluid control, complications related to PD and outcome. METHODS: Neurocritical AKI patients were treated by PD (prescribed Kt/V = 0...
January 24, 2024: Peritoneal Dialysis International
https://read.qxmd.com/read/38118385/isotonic-balanced-fluid-versus-0-9-saline-in-patients-with-moderate-to-severe-traumatic-brain-injury-a-double-blinded-randomised-controlled-trial
#2
JOURNAL ARTICLE
Khadijah Poh, Aida Bustam, Mohd Shahnaz Hasan, Nor'azim Mohd Yunos, Chun Yoong Cham, Fang Jen Lim, Ahmad Zulkarnain Ahmad Zahedi, Aliyah Zambri, Muhaimin Noor Azhar
BACKGROUND AND IMPORTANCE: Traumatic brain injury (TBI) is a global health concern with significant economic impact. Optimal fluid therapy aims to restore intravascular volume, maintain cerebral perfusion pressure and blood flow, thus preventing secondary brain injury. While 0.9% saline (NS) is commonly used, concerns about acid-base and electrolyte imbalance and development of acute kidney injury (AKI) lead to consideration of balanced fluids as an alternative. OBJECTIVES: This study aimed to compare the outcomes of patients with moderate to severe TBI treated with Sterofundin (SF) versus NS...
December 10, 2023: American Journal of Emergency Medicine
https://read.qxmd.com/read/38043564/balanced-crystalloids-versus-saline-for-critically-ill-patients-best-living-a-systematic-review-and-individual-patient-data-meta-analysis
#3
JOURNAL ARTICLE
Fernando G Zampieri, Alexandre B Cavalcanti, Gian Luca Di Tanna, Lucas P Damiani, Naomi E Hammond, Flavia R Machado, Sharon Micallef, John Myburgh, Mahesh Ramanan, Balasubramanian Venkatesh, Todd W Rice, Matthew W Semler, Paul J Young, Simon Finfer
BACKGROUND: The effect of balanced crystalloids compared with that of saline in critically ill patients overall and in specific subgroups is unclear. We aimed to assess whether use of balanced solutions, compared with 0·9% sodium chloride (saline), decreased in-hospital mortality in adult patients in intensive care units (ICUs). METHODS: For this systematic review and individual patient data meta-analysis, we searched PubMed, Embase, and CENTRAL databases from inception until March 1, 2022 (updated Sept 1, 2023) for individually randomised and cluster-randomised trials comparing balanced solutions with saline for adult patients in the ICU...
March 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/37661277/acute-kidney-injury-in-neurocritical-care
#4
REVIEW
Faeq Husain-Syed, Tomonori Takeuchi, Javier A Neyra, Gonzalo Ramírez-Guerrero, Mitchell H Rosner, Claudio Ronco, Ashita J Tolwani
Approximately 20% of patients with acute brain injury (ABI) also experience acute kidney injury (AKI), which worsens their outcomes. The metabolic and inflammatory changes associated with AKI likely contribute to prolonged brain injury and edema. As a result, recognizing its presence is important for effectively managing ABI and its sequelae. This review discusses the occurrence and effects of AKI in critically ill adults with neurological conditions, outlines potential mechanisms connecting AKI and ABI progression, and highlights AKI management principles...
September 3, 2023: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/37593249/lung-injury-risk-in-traumatic-brain-injury-managed-with-optimal-cerebral-perfusion-pressure-guided-therapy
#5
JOURNAL ARTICLE
Celeste Dias, Alexandre de Castro, Rita Gaio, Ricardo Silva, Eduarda Pereira, Elisabete Monteiro
INTRODUCTION: Management of traumatic brain injury (TBI) has to counterbalance prevention of secondary brain injury without systemic complications, namely lung injury. The potential risk of developing acute respiratory distress syndrome (ARDS) leads to therapeutic decisions such as fluid balance restriction, high PEEP and other lung protective measures, that may conflict with neurologic outcome. In fact, low cerebral perfusion pressure (CPP) may induce secondary ischemic injury and mortality, but disproportionate high CPP may also increase morbidity and worse lung compliance and hypoxia with the risk of developing ARDS and fatal outcome...
April 2023: Journal of Critical Care Medicine
https://read.qxmd.com/read/37480461/neuroprotective-effects-of-nanowired-delivery-of-cerebrolysin-with-mesenchymal-stem-cells-and-monoclonal-antibodies-to-neuronal-nitric-oxide-synthase-in-brain-pathology-following-alzheimer-s-disease-exacerbated-by-concussive-head-injury
#6
JOURNAL ARTICLE
Hari Shanker Sharma, Dafin F Muresanu, Ala Nozari, José Vicente Lafuente, Anca D Buzoianu, Z Ryan Tian, Hongyun Huang, Lianyuan Feng, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Aruna Sharma
Concussive head injury (CHI) is one of the major risk factors in developing Alzheimer's disease (AD) in military personnel at later stages of life. Breakdown of the blood-brain barrier (BBB) in CHI leads to extravasation of plasma amyloid beta protein (ΑβP) into the brain fluid compartments precipitating AD brain pathology. Oxidative stress in CHI or AD is likely to enhance production of nitric oxide indicating a role of its synthesizing enzyme neuronal nitric oxide synthase (NOS) in brain pathology...
2023: Advances in Neurobiology
https://read.qxmd.com/read/37189468/review-on-the-role-of-salivary-biomarkers-in-the-diagnosis-of-mild-traumatic-brain-injury-and-post-concussion-syndrome
#7
REVIEW
Ioannis Mavroudis, Foivos Petridis, Ioana-Miruna Balmus, Alin Ciobica, Dragos Lucian Gorgan, Alina Costina Luca
(1) Background: While mild traumatic brain injuries (TBIs) are a major public health issue, post-concussion syndrome (PCS) remains a controversial entity. In both cases, the clinical diagnosis is mainly based on the symptoms and brain imaging evaluation. The current molecular biomarkers were described from blood and cerebrospinal fluid (CSF), yet both fluid collection methods are invasive. Saliva could be preferred in molecular diagnosis due to its non-invasive and non-expensive methods of acquisition, transport, and samples processing...
April 7, 2023: Diagnostics
https://read.qxmd.com/read/36128138/successful-conservative-management-of-a-large-acute-epidural-hematoma-in-a-patient-with-arrested-hydrocephalus-a-case-report
#8
Kevin Ivan Peñaverde Chan, Jose Francisco Abawag Aguilar, Kathleen Joy Ong Khu
BACKGROUND: Arrested hydrocephalus is a condition wherein congenital hydrocephalus spontaneously ceases to progress due to a balance between production and absorption of cerebrospinal fluid. These patients rarely present with pressure symptoms so conservative treatment may be instituted. There are, however, little data on the long-term outcomes of these patients and how they present in the presence of other intracranial pathologies as they transition into adulthood. We aim to add to the growing knowledge about the management of patients with arrested hydrocephalus who have sustained traumatic hematomas...
2022: Surgical Neurology International
https://read.qxmd.com/read/35965956/brain-lung-crosstalk-management-of-concomitant-severe-acute-brain-injury-and-acute-respiratory-distress-syndrome
#9
REVIEW
Nassim Matin, Kasra Sarhadi, C Patrick Crooks, Abhijit V Lele, Vasisht Srinivasan, Nicholas J Johnson, Chiara Robba, James A Town, Sarah Wahlster
PURPOSE OF REVIEW: To summarize pathophysiology, key conflicts, and therapeutic approaches in managing concomitant severe acute brain injury (SABI) and acute respiratory distress syndrome (ARDS). RECENT FINDINGS: ARDS is common in SABI and independently associated with worse outcomes in all SABI subtypes. Most landmark ARDS trials excluded patients with SABI, and evidence to guide decisions is limited in this population. Potential areas of conflict in the management of patients with both SABI and ARDS are (1) risk of intracranial pressure (ICP) elevation with high levels of positive end-expiratory pressure (PEEP), permissive hypercapnia due to lung protective ventilation (LPV), or prone ventilation; (2) balancing a conservative fluid management strategy with ensuring adequate cerebral perfusion, particularly in patients with symptomatic vasospasm or impaired cerebrovascular blood flow; and (3) uncertainty about the benefit and harm of corticosteroids in this population, with a mortality benefit in ARDS, increased mortality shown in TBI, and conflicting data in other SABI subtypes...
2022: Current Treatment Options in Neurology
https://read.qxmd.com/read/35902006/traumatic-brain-injury-alters-the-gut-derived-serotonergic-system-and-associated-peripheral-organs
#10
JOURNAL ARTICLE
Natosha M Mercado, Guanglin Zhang, Zhe Ying, Fernando Gómez-Pinilla
Most efforts to understand the pathology of traumatic brain injury (TBI) have been centered on the brain, ignoring the role played by systemic physiology. Gut-derived serotonin is emerging as a major regulator of systemic homeostasis involving various organs and tissues throughout the body. Here, we shed light on the roles occupied by gut-derived serotonin and its downstream metabolic targets in the systemic pathogenesis of TBI. Male C57BL/6J mice were subjected to a fluid percussion injury (FPI) and RT-qPCR was used to examine mRNA levels in intestine, liver, and adipose tissue...
July 25, 2022: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/35843046/hierarchical-endpoint-analysis-using-win-ratio-in-critical-care-an-exploration-using-the-balanced-solutions-in-intensive-care-study-basics
#11
JOURNAL ARTICLE
Fernando G Zampieri, Lucas P Damiani, Rodrigo S Biondi, Flávio G R Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Ary Serpa-Neto, Airton L O Manoel, Tamiris A Miranda, Thiago D Corrêa, Luciano C P Azevedo, Nilton B Silva, Flavia R Machado, Alexandre B Cavalcanti
PURPOSE: To reanalyze the results of the Balanced Solutions in Intensive Care Study (BaSICS) through hierarchical endpoint analysis with win ratio. METHODS: All patients with full data in BaSICS trial were elected for the analysis. BaSICS compared balanced solutions (Plasma Lye 148) versus 0.9% saline in critically ill patients requiring fluid challenge. The win ratio was defined as a hierarchical endpoint of 90-day mortality, recepit of kidney replacement therapy, hospital length-of-stay (LOS), and intensive care unit (ICU) LOS...
October 2022: Journal of Critical Care
https://read.qxmd.com/read/35713606/fracture-r-cnn-an-anchor-efficient-anti-interference-framework-for-skull-fracture-detection-in-ct-images
#12
JOURNAL ARTICLE
Xian Lin, Zengqiang Yan, Zhuo Kuang, Hang Zhang, Xianbo Deng, Li Yu
BACKGROUND: Skull fracture, as a common traumatic brain injury, can lead to multiple complications including bleeding, leaking of cerebrospinal fluid, infection and seizures. Automatic skull fracture detection (SFD) is of great importance, especially in emergency medicine. PURPOSE: Existing algorithms for SFD, developed based on hand-crafted features, suffer from low detection accuracy due to poor generalizability to unseen samples. Deploying deep detectors designed for natural images like Faster R-CNN for SFD can be helpful but are of high redundancy and with non-negligible false detections due to the cranial suture and skull base interference...
June 17, 2022: Medical Physics
https://read.qxmd.com/read/35451496/hippocampal-position-and-orientation-as-prognostic-biomarkers-for-posttraumatic-epileptogenesis-an-experimental-study-in-a-rat-lateral-fluid-percussion-model
#13
JOURNAL ARTICLE
Riccardo De Feo, Eppu Manninen, Karthik Chary, Elina Hämäläinen, Riikka Immonen, Pedro Andrade, Xavier Ekolle Ndode-Ekane, Olli Gröhn, Asla Pitkänen, Jussi Tohka
OBJECTIVE: This study was undertaken to identify prognostic biomarkers for posttraumatic epileptogenesis derived from parameters related to the hippocampal position and orientation. METHODS: Data were derived from two preclinical magnetic resonance imaging (MRI) follow-up studies: EPITARGET (156 rats) and Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx; University of Eastern Finland cohort, 43 rats). Epileptogenesis was induced with lateral fluid percussion-induced traumatic brain injury (TBI) in adult male Sprague Dawley rats...
July 2022: Epilepsia
https://read.qxmd.com/read/35436929/fluid-resuscitation-with-balanced-crystalloids-versus-normal-saline-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Wei-Hua Dong, Wen-Qing Yan, Xin Song, Wen-Qiang Zhou, Zhi Chen
BACKGROUND: Intravenous fluids are used commonly for almost all intensive care unit (ICU) patients, especially for patients in need of resuscitation. The selection and use of resuscitation fluids may affect the outcomes of patients; however, the optimal resuscitative fluid remains controversial. METHODS: We systematically searched PubMed, Embase, and CENTRAL. Studies comparing balanced crystalloids and normal saline in ICU patients were selected. We used the Cochrane Collaboration tool to assess the risk of bias in studies...
April 18, 2022: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/35307053/-international-clinical-research-of-critical-care-medicine-in-2021
#15
JOURNAL ARTICLE
Qingdong Li, Ziqi Rong, Pengyu Lu, Wei Huang
The progress of critical care medicine in 2021 is still encouraging. The new international guideline for management of sepsis and septic shock came out after 4 years. Besides, a couple of preferable clinical evidences were released including restrictive blood transfusion strategy for patients with acute myocardial infarction, prevention of peripheral venous catheter infection, heparin inhalation and driving pressure setting in patients with acute respiratory distress syndrome (ARDS), lower oxygenation target for acute hypoxemic respiratory failure, low level positive end-expiratory pressure in non-ARDS patients with respiratory failure, light sedation or non-sedation strategy, biological phenotypes, as well machine learning in sepsis and ARDS...
January 2022: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/34982298/the-potential-role-of-renin-angiotensin-system-in-mild-traumatic-brain-injury
#16
JOURNAL ARTICLE
João Luís Vieira Monteiro de Barros, Maíra Glória Cardoso, Caroline Amaral Machado, Érica Leandro Marciano Vieira, Rodrigo Moreira Faleiro, Vinícius Sousa Pietra Pedroso, Ana Cristina Simões E Silva, Leonardo Cruz de Souza, Antônio Lúcio Teixeira, Aline Silva de Miranda
Traumatic brain injury (TBI) is a serious public health problem, affecting 69 million people worldwide annually. Mild TBI (mTBI) comprises the majority of the cases and remains the most neglected TBI severity. Its intricate pathophysiology involves complex cellular and molecular processes that remain uncomprehended. Although the renin-angiotensin system (RAS) has its well-known roles in blood pressure regulation and fluid balance, accumulating evidence demonstrates its active expression and signaling in the central nervous system...
May 2022: Neurological Sciences
https://read.qxmd.com/read/34884185/a-multifunctional-low-volume-resuscitation-cocktail-improves-vital-organ-blood-flow-and-hemostasis-in-a-pig-model-of-polytrauma-with-traumatic-brain-injury
#17
JOURNAL ARTICLE
Alexander E St John, Xu Wang, Kristyn Ringgold, Esther B Lim, Diana Chien, Matthew L Statz, Susan A Stern, Nathan J White
The resuscitation of polytrauma with hemorrhagic shock and traumatic brain injury (TBI) is a balance between permissive hypotension and maintaining vital organ perfusion. There is no current optimal solution. This study tested whether a multifunctional resuscitation cocktail supporting hemostasis and perfusion could mitigate blood loss while improving vital organ blood flow during prolonged limited resuscitation. Anesthetized Yorkshire swine were subjected to fluid percussion TBI, femur fracture, catheter hemorrhage, and aortic tear...
November 23, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34883075/molecular-hydrogen-alleviates-lung-injury-after-traumatic-brain-injury-pyroptosis-and-apoptosis
#18
JOURNAL ARTICLE
Ting-Ting Li, Tian Sun, Yue-Zhen Wang, Qiang Wan, Wen-Zhi Li, Wan-Chao Yang
BACKGROUND: Traumatic brain injury (TBI)-induced acute lung injury (ALI) is a critical condition, and inflammation and apoptosis play essential roles. Molecular hydrogen (H2 ) exerts anti-inflammatory and anti-apoptotic effects. Our previous work has shown that 42% H2 can improve TBI. In the current study, we tested the hypothesis that inhalation of hydrogen (42% H2 , 21% O2 , balanced nitrogen) for 1 h per day can improve TBI-induced ALI. METHODS: Sprague-Dawley male rats were randomly divided into 3 groups...
January 5, 2022: European Journal of Pharmacology
https://read.qxmd.com/read/34560919/alzheimer-s-disease-neuropathology-is-exacerbated-following-traumatic-brain-injury-neuroprotection-by-co-administration-of-nanowired-mesenchymal-stem-cells-and-cerebrolysin-with-monoclonal-antibodies-to-amyloid-beta-peptide
#19
REVIEW
Hari Shanker Sharma, Dafin F Muresanu, Rudy J Castellani, Ala Nozari, José Vicente Lafuente, Anca D Buzoianu, Seaab Sahib, Z Ryan Tian, Igor Bryukhovetskiy, Igor Manzhulo, Preeti K Menon, Ranjana Patnaik, Lars Wiklund, Aruna Sharma
Military personnel are prone to traumatic brain injury (TBI) that is one of the risk factors in developing Alzheimer's disease (AD) at a later stage. TBI induces breakdown of the blood-brain barrier (BBB) to serum proteins into the brain and leads to extravasation of plasma amyloid beta peptide (ΑβP) into the brain fluid compartments causing AD brain pathology. Thus, there is a need to expand our knowledge on the role of TBI in AD. In addition, exploration of the novel roles of nanomedicine in AD and TBI for neuroprotection is the need of the hour...
2021: Progress in Brain Research
https://read.qxmd.com/read/34464684/morphine-attenuates-neuroinflammation-and-blood-brain-barrier-disruption-following-traumatic-brain-injury-through-the-opioidergic-system
#20
JOURNAL ARTICLE
Siavash Rahimi, Behzad Dadfar, Golvash Tavakolian, Arya Asadi Rad, Ali Rashid Shabkahi, Ali Siahposht-Khachaki
Endogenous opiates are suggested to have a role in the pathophysiology of traumatic brain injury (TBI). Furthermore, administration of opioidergic agents in TBI injured animals have been shown to affect the brain injury and provide neuroprotection post-TBI. This study aims to investigate the potential neuroprotective effects of morphine through inhibition of neuroinflammatory pathways in acute severe TBI. Male Wistar rats were divided into seven groups (24 rats per group): Sham, Vehicle (TBI + intraperitoneal (i...
November 2021: Brain Research Bulletin
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