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https://www.readbyqxmd.com/read/30043803/transient-and-flexible-polymer-memristors-utilizing-full-solution-processed-polymer-nanocomposites
#1
Zhe Zhou, Huiwu Mao, Xiangjing Wang, Tao Sun, Qing Chang, Yingying Chen, Fei Xiu, Zhengdong Liu, Juqing Liu, Wei Huang
Building transient and flexible memristors is a promising strategy for developing emerging memory technologies. Here, a transient and flexible memristor based on a polymer nanocomposite, with a configuration of silver nanowire (AgNW)/citric acid quantum dot (CA QD)-polyvinyl pyrrolidone (PVP)/AgNW, is fabricated using a full-solution process method. The obtained device exhibits reversible resistive switching behavior and a dynamic random access memory (DRAM) storage feature, with the significant merits of a high ON/OFF ratio, low switching voltage, excellent reproducibility and desirable high flexibility, indicating outstanding memory characteristics such as low misreading, low power operation and low cost potential...
August 9, 2018: Nanoscale
https://www.readbyqxmd.com/read/29846589/dynamics-of-drug-resistance-associated-mutations-in-hiv-1-dna-reverse-transcriptase-sequence-during-effective-art
#2
A Nouchi, T Nguyen, M A Valantin, A Simon, S Sayon, R Agher, V Calvez, C Katlama, A G Marcelin, C Soulie
Objectives: To investigate the dynamics of HIV-1 variants archived in cells harbouring drug resistance-associated mutations (DRAMs) to lamivudine/emtricitabine, etravirine and rilpivirine in patients under effective ART free from selective pressure on these DRAMs, in order to assess the possibility of recycling molecules with resistance history. Patients and methods: We studied 25 patients with at least one DRAM to lamivudine/emtricitabine, etravirine and/or rilpivirine identified on an RNA sequence in their history and with virological control for at least 5 years under a regimen excluding all drugs from the resistant class...
May 29, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29844830/dna-damage-regulated-autophagy-modulator-1-recovers-the-function-of-apoptosis-stimulating-of-p53-protein-2-on-inducing-apoptotic-cell-death-in-huh7-5-cells
#3
Dongjie Liu, Rui Li, Xianghua Guo, Lijun Pang, Yunjin Zang, Kai Liu, Dexi Chen
Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, but promoted autophagy development by inhibiting AKT/mTOR pathway. Inhibition of autophagy using 3-methyladenosine recovered the function of ASPP2 on inducing apoptotic cell death, indicating that ASPP2-induced autophagy has an anti-apoptotic role in Huh7...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29756454/short-communication-discordance-in-drug-resistance-mutations-between-blood-plasma-and-semen-or-rectal-secretions-among-newly-diagnosed-hiv-1-infected-thai-men-who-have-sex-with-men
#4
Akarin Hiransuthikul, Rapeeporn Wongkanya, Sunee Sirivichayakul, Deondara Trachunthong, Thanthip Sungsing, Tippawan Pankam, Praphan Phanuphak, Nittaya Phanuphak
Human immunodeficiency virus 1 (HIV-1) infection is most commonly transmitted by sexual contact across mucosal surfaces. Information on concordance in drug resistance profile between blood plasma and anogenital compartments in resource-limited settings is limited. We aimed to determine discordances in genotypic drug resistance-associated mutations (DRAMs) between blood plasma and semen or rectal secretions among newly diagnosed, antiretroviral therapy (ART)-naive, HIV-1-infected Thai men who have sex with men (MSM)...
July 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29717216/scandium-doping-brings-speed-improvement-in-sb-2-te-alloy-for-phase-change-random-access-memory-application
#5
Xin Chen, Yonghui Zheng, Min Zhu, Kun Ren, Yong Wang, Tao Li, Guangyu Liu, Tianqi Guo, Lei Wu, Xianqiang Liu, Yan Cheng, Zhitang Song
Phase change random access memory (PCRAM) has gained much attention as a candidate for nonvolatile memory application. To develop PCRAM materials with better properties, especially to draw closer to dynamic random access memory (DRAM), the key challenge is to research new high-speed phase change materials. Here, Scandium (Sc) has been found it is helpful to get high-speed and good stability after doping in Sb2 Te alloy. Sc0.1 Sb2 Te based PCRAM cell can achieve reversible switching by applying even 6 ns voltage pulse experimentally...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29677840/simulation-of-one-transistor-dynamic-random-access-memory-based-on-symmetric-double-gate-si-junctionless-transistor
#6
Bo Gyeong Kim, Jae Hwa Seo, Young Jun Yoon, Min Su Cho, Eunseon Yu, Jung-Hee Lee, Seongjae Cho, In Man Kang
In this study, one-transistor dynamic random-access memory (1T-DRAM) based on a symmetric double-gate Si junctionless transistor is proposed using technology computer-aided design simulation. The proposed device uses double gates that play different roles in realizing 1T-DRAM operation. Gate 1 is used as a switching node, and Gate 2 is used as a storage node. By controlling the different two gate workfunctions, a potential barrier is adjusted to store hole effectively. The operation characteristics were investigated regarding four different memory operation states to write "1", write "0", read, and hold...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677717/a-1t-dynamic-random-access-memory-cell-based-on-gated-thyristor-with-surrounding-gate-structure-for-high-scalability
#7
Hyungjin Kim, Sihyun Kim, Hyun-Min Kim, Kitae Lee, Sangwan Kim, Byung-Gook Pak
In this study, we investigate a one-transistor (1T) dynamic random access memory (DRAM) cell based on a gated-thyristor device utilizing voltage-driven bistability to enable high-speed operations. The structural feature of the surrounding gate using a sidewall provides high scalability with regard to constructing an array architecture of the proposed devices. In addition, the operation mechanism, I-V characteristics, DRAM operations, and bias dependence are analyzed using a commercial device simulator. Unlike conventional 1T DRAM cells utilizing the floating body effect, excess carriers which are required to be stored to make two different states are not generated but injected from the n+ cathode region, giving the device high-speed operation capabilities...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677710/volatile-and-nonvolatile-characteristics-of-asymmetric-dual-gate-thyristor-ram-with-vertical-structure
#8
Hyun-Min Kim, Dae Woong Kwon, Sihyun Kim, Kitae Lee, Junil Lee, Euyhwan Park, Ryoongbin Lee, Hyungjin Kim, Sangwan Kim, Byung-Gook Park
In this paper, the volatile and nonvolatile characteristics of asymmetric dual-gate thyristor random access memory (TRAM) are investigated using the technology of a computer-aided design (TCAD) simulation. Owing to the use of two independent gates having different gate dielectric layers, volatile and nonvolatile memory functions can be realized in a single device. The first gate with a silicon oxide layer controls the one-transistor dynamic random access memory (1T-DRAM) characteristics of the device. From the simulation results, a rapid write speed (<8 ns) and a large on-off current ratio (>107) can be achieved...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29540528/phospholipid-flippases-and-sfk1p-a-novel-regulator-of-phospholipid-asymmetry-contribute-to-low-permeability-of-the-plasma-membrane
#9
Tetsuo Mioka, Konomi Fujimura-Kamada, Nahiro Mizugaki, Takuma Kishimoto, Takamitsu Sano, Hitoshi Nunome, David E Williams, Raymond J Andersen, Kazuma Tanaka
Phospholipid flippase (type 4 P-type ATPase) plays a major role in the generation of phospholipid asymmetry in eukaryotic cell membranes. Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. We isolated Sfk1p, a conserved membrane protein in the TMEM150/FRAG1/DRAM family, as a multicopy suppressor of this sensitivity. Overexpression of SFK1 decreased PS/PE exposure in lem3Δ mutant cells...
May 15, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29508093/the-optimization-of-spacer-engineering-for-capacitor-less-dram-based-on-the-dual-gate-tunneling-transistor
#10
Wei Li, Hongxia Liu, Shulong Wang, Shupeng Chen, Qianqiong Wang
The DRAM based on the dual-gate tunneling FET (DGTFET) has the advantages of capacitor-less structure and high retention time. In this paper, the optimization of spacer engineering for DGTFET DRAM is systematically investigated by Silvaco-Atlas tool to further improve its performance, including the reduction of reading "0" current and extension of retention time. The simulation results show that spacers at the source and drain sides should apply the low-k and high-k dielectrics, respectively, which can enhance the reading "1" current and reduce reading "0" current...
March 5, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29501488/overexpression-of-apoptosis-inducing-factor-mitochondrion-associated-1-aifm1-induces-apoptosis-by-promoting-the-transcription-of-caspase3-and-dram-in-hepatoma-cells
#11
Dongjie Liu, Mingyang Liu, Wenjing Wang, Lijun Pang, Zhenchang Wang, Chunwang Yuan, Kai Liu
Full-length apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) (∼67 kDa) induces apoptosis in a caspase-independent manner when it is cleaved at its N-terminus to produce truncated AIFM1 (∼57 kDa). Here, we produced recombinant adenovirus AIFM1 (rAd-AIFM1) encoding full-length AIFM1 to detect whether full-length AIFM1 suppresses cell growth and induces apoptosis of hepatoma cell lines (HepG2 and Hep3B). Hepatocellular carcinoma (HCC) is one of the most difficult cancers to treat worldwide...
April 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29442188/damage-regulated-autophagy-modulator-1-in-oral-inflammation-and-infection
#12
Svenja Memmert, A V B Nogueira, A Damanaki, M Nokhbehsaim, S Eick, T Divnic-Resnik, A Spahr, B Rath-Deschner, A Till, W Götz, J A Cirelli, A Jäger, J Deschner
OBJECTIVES: Damage-regulated autophagy modulator (DRAM) 1 is a p53 target gene with possible involvement in oral inflammation and infection. This study sought to examine the presence and regulation of DRAM1 in periodontal diseases. MATERIAL AND METHODS: In vitro, human periodontal ligament fibroblasts were exposed to interleukin (IL)-1β and Fusobacterium nucleatum for up to 2 days. The DRAM1 synthesis and its regulation were analyzed by real-time PCR, immunocytochemistry, and ELISA...
February 13, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29417962/development-and-testing-of-a-novel-micro-raman-probe-and-application-of-calibration-method-for-the-quantitative-analysis-of-microfluidic-nitric-acid-streams
#13
Gilbert L Nelson, Amanda M Lines, Amanda J Casella, Job M Bello, Samuel A Bryan
To simplify and improve the safety of reprocessing used nuclear fuel, an initial assessment was made of Raman microscopy applied to microfluidic volumes with a view toward the on-line spectroscopic measurement of highly radioactive solutions. This study compares a microscopic Raman probe (excitation focal point diameter 70 μm) to a larger, well studied probe (excitation focal point diameter 125 μm) used in prior investigations. This was done by chemometrically modeling and predicting concentrations of HNO3 solutions (0 M to 8 M) as they flowed through microfluidic cells based upon spectra from each probe...
February 26, 2018: Analyst
https://www.readbyqxmd.com/read/29373753/dicer-partner-protein-tunes-the-length-of-mirnas-using-base-mismatch-in-the-pre-mirna-stem
#14
Li Zhu, Suresh K Kandasamy, Ryuya Fukunaga
Dicer partner proteins Drosophila Loquacious-PB (Loqs-PB) and human TRBP tune the length of miRNAs produced by Dicer from a subset of pre-miRNAs and thereby alter their target repertoire, by an unknown mechanism. Here, we developed a novel high-throughput method that we named Dram-seq (Dice randomized pre-miRNA pool and seq) to study length distributions of miRNAs produced from thousands of different pre-miRNA variants. Using Dram-seq, we found that a base-mismatch in the pre-miRNA stem can alter the length of miRNAs compared with a base-pair at the same position in both Drosophila and human, and is important for the miRNA length tuning by Loqs-PB...
April 20, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29372887/nram-a-disruptive-carbon-nanotube-resistance-change-memory
#15
D C Gilmer, T Rueckes, L Cleveland
Advanced memory technology based on carbon nanotubes (CNTs) (NRAM) possesses desired properties for implementation in a host of integrated systems due to demonstrated advantages of its operation including high speed (nanotubes can switch state in picoseconds), high endurance (over a trillion), and low power (with essential zero standby power). The applicable integrated systems for NRAM have markets that will see compound annual growth rates (CAGR) of over 62% between 2018 and 2023, with an embedded systems CAGR of 115% in 2018-2023 (http://bccresearch...
April 3, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29367738/differential-effects-of-reticulophagy-and-mitophagy-on-nonalcoholic-fatty-liver-disease
#16
Lijun Pang, Kai Liu, Daojie Liu, Fudong Lv, Yunjin Zang, Fang Xie, Jiming Yin, Ying Shi, Yanjun Wang, Dexi Chen
Autophagy affects the pathological progression of non-alcoholic fatty liver disease (NAFLD); however, the precise role of autophagy in NAFLD remains unclear. In this study, we want to identify the role of autophagy including reticulophagy and mitophagy in NAFLD pathogenesis. When HepG2 cells were treated with 400 μM oleic acid (OA), increased reticulophagy was induced 8 h after treatment, which correlated with an anti-apoptotic response as shown by the activation of the PI3K/AKT pathway, an increase in BCL-2 expression, and the downregulation of OA-induced lipotoxicity...
January 24, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29282893/autophagy-novel-applications-of-nonsteroidal-anti-inflammatory-drugs-for-primary-cancer
#17
REVIEW
Chen Yu, Wei-Bing Li, Jun-Bao Liu, Jian-Wei Lu, Ji-Feng Feng
In eukaryotic cells, autophagy is a process associated with programmed cell death. During this process, cytoplasmic proteins and organelles are engulfed by double-membrane autophagosomes, which then fuse with lysosomes to form autolysosomes. These autolysosomes then degrade their contents to recycle the cellular components. Autophagy has been implicated in a wide variety of physiological and pathological processes that are closely related to tumorigenesis. In recent years, an increasing number of studies have indicated that nonsteroidal anti-inflammatory drugs, such as celecoxib, meloxicam, sulindac, aspirin, sildenafil, rofecoxib, and sodium salicylate, have diverse effects in cancer that are mediated by the autophagy pathway...
February 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29161317/evaluating-architecture-impact-on-system-energy-efficiency
#18
Shijie Yu, Hailong Yang, Rui Wang, Zhongzhi Luan, Depei Qian
As the energy consumption has been surging in an unsustainable way, it is important to understand the impact of existing architecture designs from energy efficiency perspective, which is especially valuable for High Performance Computing (HPC) and datacenter environment hosting tens of thousands of servers. One obstacle hindering the advance of comprehensive evaluation on energy efficiency is the deficient power measuring approach. Most of the energy study relies on either external power meters or power models, both of these two methods contain intrinsic drawbacks in their practical adoption and measuring accuracy...
2017: PloS One
https://www.readbyqxmd.com/read/29125127/design-of-dynamic-genetic-memory
#19
Yu-Jia Hu, Chun-Liang Lin, Wei-Xian Li
In electronic systems, dynamic random access memory (DRAM) is one of the core modules in the modern silicon computer. As for a bio-computer, one would need a mechanism for storage of bio-information named 'data', which, in binary logic, has two levels, logical high and logical low, or in the normalised form, '1' and '0'. This study proposes a possible genetic DRAM based on the modified electronic configuration, which uses the biological reaction to fulfil an equivalent RC circuit constituting a memory cell...
December 2017: IET Systems Biology
https://www.readbyqxmd.com/read/29123192/targeted-mitochondrial-therapy-using-mitoq-shows-equivalent-renoprotection-to-angiotensin-converting-enzyme-inhibition-but-no-combined-synergy-in-diabetes
#20
Micheal S Ward, Nicole B Flemming, Linda A Gallo, Amelia K Fotheringham, Domenica A McCarthy, Aowen Zhuang, Peter H Tang, Danielle J Borg, Hannah Shaw, Benjamin Harvie, David R Briskey, Llion A Roberts, Manuel R Plan, Michael P Murphy, Mark P Hodson, Josephine M Forbes
Mitochondrial dysfunction is a pathological mediator of diabetic kidney disease (DKD). Our objective was to test the mitochondrially targeted agent, MitoQ, alone and in combination with first line therapy for DKD. Intervention therapies (i) vehicle (D); (ii) MitoQ (DMitoQ;0.6 mg/kg/day); (iii) Ramipril (DRam;3 mg/kg/day) or (iv) combination (DCoAd) were administered to male diabetic db/db mice for 12 weeks (n = 11-13/group). Non-diabetic (C) db/m mice were followed concurrently. No therapy altered glycaemic control or body weight...
November 9, 2017: Scientific Reports
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