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Ocular surface neoplasia

Steven S Bae, Clara C Chan
INTRODUCTION: To evaluate the indications and outcomes of manual blade superficial keratectomy STUDY DESIGN: Retrospective, nonrandomized, consecutive case series METHODS: Database search of patients from 2012-2017 who underwent superficial keratectomy was conducted at a tertiary care hospital cornea clinic. Charts of 121 patients (156 eyes) were reviewed who had at least 4 weeks of follow-up and both preoperative and postoperative measurements of best-corrected visual acuity or corneal cylinder...
December 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Nandini Venkateswaran, Carolina Mercado, Anat Galor, Carol L Karp
PURPOSE: To compare the efficacy of topical 5-fluorouracil 1% (5FU) and interferon alfa-2b 1 MIU/mL (IFN) eye drops as primary treatment modalities for ocular surface squamous neoplasia (OSSN). DESIGN: Retrospective, comparative, interventional case series. METHODS: Fifty-four patients who received 5FU and 48 patients who received IFN as primary therapy for OSSN were included. Primary outcome measures were the frequency of clinical resolution and time to OSSN recurrence by treatment modality...
November 21, 2018: American Journal of Ophthalmology
J M Pérez Dieste, M Castroviejo Bolíbar, M E Abad Collazo, C Sánchez Servate
No abstract text is available yet for this article.
November 16, 2018: Archivos de la Sociedad Española de Oftalmología
Purvasha Narang, Vikas Mittal, Vikas Menon, Anirban Bhaduri, Bhaskar Roy Chaudhuri, Santosh G Honavar
Purpose: To determine the role of primary limbal stem cell transplantation (LSCT) in managing extensive ocular surface squamous neoplasia (OSSN) with more than 3 quadrants of limbal involvement to prevent manifestations of limbal stem cell deficiency. Methods: A multi-center, comparative, and interventional clinical study of cases and historical controls was done. Patients with a limbal mass suggestive of OSSN involving more than 3 quadrants of limbus (> 9 clock hours) and no local, regional or systemic metastasis, who underwent primary surgical excision with or without adjuvant chemotherapy and had a minimum follow-up of 12 months were included in this study...
November 2018: Indian Journal of Ophthalmology
Hershel Patel, Lauren J Jeang, Ankit Shah, Edgar M Espana, Curtis E Margo
Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone. Cases: Two patients with 360 degrees of limbal involvement. Results: Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease...
September 2018: Ocular Oncology and Pathology
Alison D Early, Sarah Adelson, Craig J Miller, Thomas F Mauger
Objective: To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia. Materials and methods: This is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t -test...
2018: Clinical Ophthalmology
I-Hsin Ma, Fung-Rong Hu, I-Jong Wang, Wei-Li Chen, Ya-Jui Hsu, Hsiao-Sang Chu, Chang-Tsu Yuan, Yu-Chih Hou
BACKGROUND/PURPOSE: To describe the clinical and histologic characteristics of ocular surface squamous neoplasia (OSSN) and evaluate factors significant in recurrence at a university hospital in North Taiwan. METHODS: Patient charts, clinical features, and pathology records were retrospectively reviewed in patients with pathology-proved OSSN from January, 1994 to December, 2014. Clinicopathologic correlation was analyzed. RESULTS: Thirty-six patients were recruited...
September 25, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Q F Liang, J J Huang, K Cao, G Y Su, Z Q Wang, Y Zhang, B Li
Objective: To study the histopathology manifestation and imaging characteristics of in vivo confocal microscopy (IVCM) for diagnosis of ocular surface squamous neoplasia (OSSN) and analyze the reliability of IVCM in differential diagnosis from OSSN cases. Methods: A prospective study. Twenty-three patients (23 eyes) with OSSN were collected from September 2015 to November 2017 in Beijing Tongren Eye center. They were underwent the examinations sequentially as follows: visual examination; slit-lamp microscope examination and ocular surface photography; color fundus image; anterior segment optical coherence tomography examination; IVCM examination and histopathology examination after surgery...
September 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Carolina L Mercado, Cameron Pole, James Wong, Juan F Batlle, Fabiola Roque, Noah Shaikh, Juan C Murillo, Anat Galor, Carol L Karp
PURPOSE: To characterize vision-related and psychosocial quality of life (QoL) parameters in medically and surgically treated patients with OSSN. METHODS: Forty-one patients with OSSN treated with medical therapy consisting of interferon alpha 2b drops 1 MIU/ml (n = 22) or who underwent surgical excision (n = 19) were contacted. All subjects answered a quality of life assessment with an original questionnaire in which they were asked about a range of parameters...
September 11, 2018: Ocular Surface
Sonali V Kumar, D Joshi
No abstract text is available yet for this article.
July 2018: Medical Journal, Armed Forces India
Maria Vittoria Cicinelli, Alessandro Marchese, Francesco Bandello, Giulio Modorati
Ocular surface squamous neoplasia (OSSN) is the most common non-pigmented malignancy of the ocular surface and is represented in a wide range of histologic diagnoses, ranging from mild epithelial dysplasia to invasive squamous carcinoma. Although surgical excision is still the gold standard for OSSN treatment, interest in conservative medical approaches is steadily growing. We have reviewed all of the literature on OSSN published in English in the MEDLINE database up to May 2018, using the keywords "ocular surface squamous neoplasia," "squamous conjunctival carcinoma," and "conjunctival carcinoma in situ," with the aim to provide a comprehensive review of the most recent evidence on this distinct clinical entity...
July 20, 2018: Ophthalmology and Therapy
J Heichel, H-G Struck, A Glien
BACKGROUND: The cardinal symptom of lacrimal stenosis is epiphora and a subjective high level of discomfort due to continuous dacryorrhea. OBJECTIVE: The aim of the current paper is to present a structured review of common diagnostic and therapeutic strategies for lacrimal stenosis. MATERIALS AND METHODS: The most important diagnostic and therapeutic approaches are analysed using the existing literature and by reporting the authors' own experiences...
October 2018: HNO
Swati Singh, Ruchi Mittal, Arnav Ghosh, Devjyoti Tripathy, Suryasnata Rath
PURPOSE: To evaluate the imaging characteristics of intraepithelial and invasive ocular surface squamous neoplasia (OSSN) on high-resolution anterior segment optical coherence tomography (ASOCT). METHODS: In this prospective cross-sectional study, 17 consecutive patients (10 intraepithelial and 7 invasive) with histopathologically proven OSSN were included. All patients underwent slit-lamp imaging and time-domain ASOCT at premarked sites. Management included standard complete surgical excision with margin clearance and cryotherapy for all cases...
October 2018: Cornea
Mehenaz Hanbazazh, Kymberly A Gyure
CONTEXT: - Human papillomavirus (HPV) has a well-known role in the pathogenesis of squamous cell carcinoma and precursor lesions of the cervix, anogenital region, and head and neck, but its role in the development of squamous neoplasms of the eye, particularly the conjunctiva, remains unclear. OBJECTIVE: - To review recent evidence implicating HPV in the pathophysiology of ocular lesions. DATA SOURCES: - Published articles obtained from a PubMed search of the English literature were the primary sources for this review...
June 2018: Archives of Pathology & Laboratory Medicine
Justin Kuiper, Ankit Shah, Rebecca Kuennen, Lynn Schoenfield
Background/Aims: Atypical fibroxanthoma is an uncommon tumor that usually occurs in the skin of the head and neck of the elderly with significant sun exposure. We describe a unique case featuring a rare ocular surface conjunctival tumor (atypical fibroxanthoma) and provide insight on its characteristic clinical features, surgical management, and histology. Methods: A 71-year-old male fisherman with no pertinent ocular history presented to an academic center with a rapidly enlarging bulbar conjunctival mass in the right perilimbal region for the past several months...
April 2018: Ocular Oncology and Pathology
Swati Singh, Ashik Mohamed, Swathi Kaliki
PURPOSE: To evaluate outcomes of ocular surface squamous neoplasia (OSSN) based on American Joint Committee on Cancer (AJCC), 8th edition classification. METHODS: Retrospective, non-randomized interventional case series of 127 patients (136 eyes) with OSSN. RESULTS: On the basis of the AJCC (eighth edition), OSSN was classified as per T category as Tis (n = 14, 10%), T1 (n = 0), T2 (n = 4, 3%), T3 (n = 113, 83%), and T4 (n = 5, 4%)...
May 10, 2018: International Ophthalmology
Alba Maria M Shank, Leandro B C Teixeria, Richard R Dubielzig
Corneal vascular neoplasms (hemangioma and hemangiosarcoma) are rare in all species. Reported cases are single case reports in a single species. Archived cases of corneal hemangioma and hemangiosarcoma from dogs, cats, and horses were obtained from the Comparative Ocular Pathology Lab of Wisconsin (COPLOW, Madison, WI), tabulated, and examined. This retrospective study describes the breeds, ages, tumor types, and characteristics of vascular neoplasms that appeared to be primarily corneal in location, in feline, canine, and equine patients, with gross and histologic images...
April 24, 2018: Veterinary Ophthalmology
Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki
Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure...
2018: HIV/AIDS: Research and Palliative Care
Seda Ekizoglu, Turgut Ulutin, Jalal Guliyev, Nur Buyru
Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumor types, including neoplasia of the paranasal sinuses, oral cavity, trachea, pharynx and larynx. Laryngeal cancer is the most common type of HNSCC. The proline-rich 4 (PRR4) protein is synthesized in the acinar cells of human lacrimal glands. Previous studies have demonstrated that PRR4 may function as an antimicrobial protein protecting the ocular surface and the oral cavity. In order to determine differentially expressed genes (DEGs) in laryngeal tumors, a GeneFishing Assay was performed; 27 DEGs were identified...
April 2018: Oncology Letters
Lauren A Dalvin, Diva R Salomão, Sanjay V Patel
AIM: To determine population-based incidence of conjunctival tumours in Olmsted County, Minnesota. METHODS: The Rochester Epidemiology Project medical record linkage system was used to identify patients with conjunctival tumours in Olmsted County (1 January 1980 to 31 December 2015). Records were reviewed for demographics, types of tumours, histopathology, treatment and clinical course. Incidence rate of all tumours was calculated per 1 000 000 person-years. Poisson regression analysis was used to assess changes in incidence over time...
March 6, 2018: British Journal of Ophthalmology
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