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Lesa A Thompson, Yoshinori Ikenaka, Wageh S Darwish, Yared B Yohannes, Johan J van Vuren, Victor Wepener, Nico J Smit, Atnafu G Assefa, Ahmed Tharwat, Walaa Fathy Saad Eldin, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
The objective of this study was to identify potential mRNA expression changes in chicken livers associated with environmental exposure to dichloro-diphenyl-trichloroethane (DDT) and its metabolites (DDTs). In particular, we focused on genes relating to the immune system and metabolism. We analyzed liver samples from free-ranging chickens in KwaZulu-Natal, South Africa, for contamination by DDTs. This area predominantly uses DDT in its malaria control program, and homes are sprayed annually with the pesticide...
2018: PloS One
Amin Alousi, Tao Wang, Michael T Hemmer, Stephen R Spellman, Mukta Arora, Daniel R Couriel, Joseph Pidala, Paolo N Anderlini, Michael Boyiadzis, Christopher N Bredeson, Jean-Yves Cahn, Mitchell S Cairo, Shahinaz M Gadalla, Shahrukh K Hashmi, Robert Peter Gale, Junya Kanda, Rammurti T Kamble, Mohamed A Kharfan-Dabaja, Mark R Litzow, Olle Ringden, Ayman A Saad, Kirk R Schultz, Leo F Verdonck, Edmund K Waller, Jean A Yared, Shernan G Holtan, Daniel J Weisdorf
BACKGROUND: Peripheral Blood (PB) or Bone Marrow (BM) from unrelated donors can serve as a graft source for hematopoietic cell transplantation. Currently, PB is most commonly used in roughly 80% of adult recipients. Determining the long-term impact of graft source on outcomes would inform this decision. METHODS: Data collected by the Center for International Blood and Marrow Transplant Research (CIBMTR) from 5,200 adult recipients of a first transplant from a 8/8 or 7/8- human-leukocyte antigen matched unrelated donor for treatment of acute leukemia, chronic myeloid leukemia or myelodysplastic syndrome between the years of 2001-2011 were analyzed to determine the impact of graft source on Graft-versus-Host Disease (GVHD), Relapse-Free Survival (GRFS) defined as freedom from grade III/IV acute GVHD, chronic GVHD requiring immunosuppressive therapy, relapse, or death and overall survival...
October 3, 2018: Biology of Blood and Marrow Transplantation
Yared Debebe, Sharon R Hill, Habte Tekie, Rickard Ignell, Richard J Hopkins
BACKGROUND: Understanding the ecology of exophilic anophelines is a key step toward developing outdoor control strategies to complement existing indoor control tools against malaria vectors. This study was conducted to assess the movement pattern of exophilic Anopheles mosquitoes between blood meal sources and resting habitats, and the landscape factors dictating their resting habitat choice. RESULTS: Resting clay pots were placed at 5 m, 25 m, 50 m, 75 m and 100 m away from isolated focal houses, radiating from them in four directions...
October 5, 2018: Malaria Journal
Maxim Norkin, Bronwen E Shaw, Ruta Brazauskas, Heather R Tecca, Helen L Leather, Juan Gea-Banacloche, Rammurti Kamble, Zachariah DeFilipp, David A Jacobsohn, Olle Ringden, Yoshihiro Inamoto, Kimberly Kasow, David Buchbinder, Peter Shaw, Peiman Hematti, Raquel Schears, Sherif M Badawy, Hillard M Lazarus, Neel Bhatt, Biljana Horn, Saurabh Chhabra, Kristin Page, Betty Hamilton, Gerhard C Hildebrandt, Jean A Yared, Vaibhav Agrawal, Amer Beitinjaneh, Navneet Majhail, Tamila Kindwall-Keller, Richard F Olsson, Helene Schoemans, Robert Peter Gale, Siddhartha Ganguly, Ibrahim Ahmed, Harry C Schouten, Jane Liesveld, Nandita Khera, Amir Steinberg, Ami J Shah, Melhem Solh, David I Marks, Witold Rybka, Mahmoud Aljurf, Andrew C Dietz, Usama Gergis, Biju George, Sachiko Seo, Mary E D Flowers, Minoo Battiwalla, Bipin N Savani, Marcie L Riches, John R Wingard
BACKGROUND: We analyzed late fatal infections (LFI) in allogeneic stem cell transplant (HCT) recipients reported to the Center for International Blood and Marrow Transplant Research. METHODS: We analyzed the incidence, infection types and risk factors contributing to LFI in 10336 adult and 5088 pediatric subjects surviving ≥2 years after first HCT without relapse. RESULTS: Among 2245 adult and 377 pediatric subjects who died, infections were a primary or contributory cause of death in 687(31%) and 110(29%) subjects, respectively...
October 1, 2018: Biology of Blood and Marrow Transplantation
Gbolahan O Ogunbayo, Naoki Misumida, Karam Ayoub, Yared Hailemariam, Dustin Hillerson, Ayman Elbadawi, Ahmed Abdel-Latif, Susan Smyth, Khaled Ziada, Adrian W Messerli
BACKGROUND: Pharmacologic reperfusion therapy is a recommended and effective strategy in patients with ST-elevation myocardial infarction (STEMI) when percutaneous coronary intervention (PCI) is not available. This study investigates temporal trends and outcomes of fibrinolytic therapy (FT) in elderly patients with STEMI. METHODS: Using the Nationwide Inpatient Sample database, we extracted patients ≥80 years a primary diagnosis of STEMI admitted between 2010 and 2014...
September 30, 2018: Catheterization and Cardiovascular Interventions
Yared Gurmu, Jing Qian, Victor De Gruttola
Partnership duration data are commonly obtained through surveys that collect information on relationships that are ongoing during a fixed time window. This sampling mechanism leads to duration data that are left truncated and right censored; such data have been analysed using the standard truncation product limit estimator (TPLE). In this paper, we describe a common sampling scheme for collecting sexual partnership data, discuss a key assumption required for the TPLE to be unbiased, and provide the conditions under which the nonparametric maximum likelihood estimator of the relationship duration distribution is unique and consistent...
June 2018: Research & reviews. Journal of statistics and mathematical sciences
Nour Khalil, Aren Joe Bizdikian, Ziad Bakouny, Michel Salameh, Naji Bou Zeid, Fares Yared, Joeffroy Otayek, Khalil Kharrat, Gaby Kreichati, Ismat Ghanem, Renaud Lafage, Virginie Lafage, Ibrahim Obeid, Ayman Assi
PURPOSE: To investigate the different cervical strategies for maintaining horizontal gaze in asymptomatic subjects. METHODS: One hundred and forty-four asymptomatic adults filled the SF-36 quality of life questionnaire and underwent full-body biplanar radiographs. Chin brow vertical angle (CBVA) and postural and cervical parameters were measured. Subjects were grouped according to cervical spine curvature (C2-C7 angle): kyphotic (< - 5°), straight [- 5°, 5°], lordotic (> 5°)...
September 7, 2018: European Spine Journal
Tamar E Carter, Solomon Yared, Araya Gebresilassie, Victoria Bonnell, Lambodhar Damodaran, Karen Lopez, Mohammed Ibrahim, Seid Mohammed, Daniel Janies
Malaria is a major public health concern in Ethiopia. With the increase in malaria cases in the Somali Region of Ethiopia, understanding the distribution and identifying the species of malaria vectors is vital to public health. Here we report the first detection of Anopheles stephensi in Ethiopia, a malaria vector typically found in the Middle East, the Indian subcontinent, and China, but recently found in Djibouti. An entomological investigation was conducted during November to December 2016 in Kebri Dehar town of the Ethiopian Somali Regional State as ancillary work for Anopheles spp...
December 2018: Acta Tropica
Rawad A Yared, Hussein A Badran, Mohammed Hussein Kamareddine, Youssef Ghosn, Roula Bou Khalil, Khaled El Ajamy, Camil Chouairy, Said G Farhat
Malakoplakia is a rare chronic granulomatous disease that may affect many organs, including the lung, brain, adrenal glands, pancreas, bone, and the genitourinary tract. The gastrointestinal tract is the most common site of involvement outside of the urinary tract. Herein, we present a case of a 65-year-old male who presented with abdominal pain and unintentional weight loss. Physical examination findings were unremarkable, but colonoscopy revealed an isolated large, flat, soft, and pale lesion in the transverse colon...
May 2018: Case Reports in Gastroenterology
Nico J Wolmarans, Louis H Du Preez, Yared Beyene Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka, Nico J Smit, Victor Wepener
Organochlorine pesticides are highly persistent in aquatic ecosystems. Amphibians, specifically anurans, play an intricate part in the aquatic food web, and have very permeable skin which makes them prone to bioaccumulation of persistent pollutants. In this study the bioaccumulation of various legacy organochlorine pesticides (OCPs)-including dichlorodiphenyltrichloroethane (DDT), currently used for malaria vector control (MVC)-was assessed along with a set of biomarker responses in Müller's clawed frog Xenopus muelleri collected from the lower Phongolo River floodplain in South Africa...
September 1, 2018: Ecotoxicology
Yared Amare, Pauline Scheelbeek, Joanna Schellenberg, Della Berhanu, Zelee Hill
BACKGROUND: Timely interventions in the postnatal period are important for reducing newborn mortality, and early home visits to provide postnatal care are recommended. There has been limited success in achieving timely visits, and a better understanding of the realities of programmes is needed if improvements are to be made. METHODS: We explored barriers and facilitators to timely postnatal visits through 20 qualitative interviews and 16 focus group discussions with families and Health Extension Workers in four Ethiopian sites...
August 29, 2018: BMC Public Health
Saurabh Chhabra, Ying Liu, Michael T Hemmer, Luciano Costa, Joseph A Pidala, Daniel R Couriel, Amin M Alousi, Navneet S Majhail, Robert K Stuart, Dennis Kim, Olle Ringden, Alvaro Urbano-Ispizua, Ayman Saad, Bipin N Savani, Brenda Cooper, David I Marks, Gerard Socie, Harry C Schouten, Helene Schoemans, Hisham Abdel-Azim, Jean Yared, Jean-Yves Cahn, John Wagner, Joseph H Antin, Leo F Verdonck, Leslie Lehmann, Mahmoud D Aljurf, Margaret L MacMillan, Mark R Litzow, Melhem M Solh, Muna Qayed, Peiman Hematti, Rammurti T Kamble, Ravi Vij, Robert J Hayashi, Robert P Gale, Rodrigo Martino, Sachiko Seo, Shahrukh K Hashmi, Taiga Nishihori, Takanori Teshima, Usama Gergis, Yoshihiro Inamoto, Stephen R Spellman, Mukta Arora, Betty K Hamilton
The combination of a calcineurin inhibitor (CNI) such as tacrolimus (TAC) or cyclosporine (CYSP) with methotrexate (MTX) or with mycophenolate mofetil (MMF) has been commonly used for graft-versus-host disease (GVHD) prophylaxis after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (alloHCT), but there are limited data comparing efficacy of the 2 regimens. We evaluated 1564 adult patients who underwent RIC alloHCT for acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), and myelodysplastic syndrome (MDS) from 2000 to 2013 using HLA-identical sibling (matched related donor [MRD]) or unrelated donor (URD) peripheral blood graft and received CYSP or TAC with MTX or MMF for GVHD prophylaxis...
August 25, 2018: Biology of Blood and Marrow Transplantation
Awoke Kebede, Hadgu Gerensea, Freweyni Amare, Yared Tesfay, Girmay Teklay
OBJECTIVE: Anemia is a widespread health problem among pregnant women causing maternal/infant morbidity and mortality mainly in low-income countries. Understanding of the magnitude of anemia and related socio-demographic variables in a specific setting would help scale-up preventive and therapeutic measures in a locality. So that this study focuses on the magnitude of anemia and its associated factor among pregnant women attending antenatal care in public hospitals of shire town and using institution based cross-sectional study design on 480 randomly selected study subjects...
August 17, 2018: BMC Research Notes
Yeshambel Belyhun, Feleke Moges, Mengistu Endris, Banchamlak Asmare, Bemnet Amare, Damtew Bekele, Solomon Tesfaye, Martha Alemayehu, Fantahun Biadgelegne, Andargachew Mulu, Yared Assefa
OBJECTIVES: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. RESULTS: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections...
August 17, 2018: BMC Research Notes
Darryl L Hadsell, Louise A Hadsell, Monique Rijnkels, Yareli Carcamo-Bahena, Jerry Wei, Peter Williamson, Michael A Grusak
The breast-feeding neonate depends on mother's milk for both macronutrients and micronutrients including minerals. The goals of the present study were to document the effects of genetic background in mice on milk concentrations of select minerals and to use genome-wide association study (GWAS) to identify quantitative trait loci (QTL) regulating milk mineral concentrations. Milk samples from lactating mice in each of 31 different inbred strains of the mouse diversity panel (MDP) were analyzed by inductively coupled plasma-optical emission spectroscopy to determine the concentrations of calcium (Ca), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), sodium (Na), phosphorus (P), sulfur (S), and zinc (Zn)...
October 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
Ziad Bakouny, Ayman Assi, Fares Yared, Nour Khalil, Elie Mansour, Jean Jacques Yaacoub, Wafa Skalli, Ismat Ghanem
BACKGROUND: Hip instability is frequent in patients with Down syndrome. Recent studies have suggested that skeletal hip alterations are responsible for this instability; however, there are currently no studies simultaneously assessing femoral and acetabular anatomy in subjects with Down syndrome in the standing position. The aim was to analyze the three-dimensional anatomy of the Down syndrome hip in standing position. METHODS: Down syndrome subjects were age and sex-matched to asymptomatic controls...
October 2018: Clinical Biomechanics
Tomas Radivoyevitch, Robert M Dean, Bronwen E Shaw, Ruta Brazauskas, Heather R Tecca, Remco J Molenaar, Minoo Battiwalla, Bipin N Savani, Mary E D Flowers, Kenneth R Cooke, Betty K Hamilton, Matt Kalaycio, Jaroslaw P Maciejewski, Ibrahim Ahmed, Görgün Akpek, Ashish Bajel, David Buchbinder, Jean-Yves Cahn, Anita D'Souza, Andrew Daly, Zachariah DeFilipp, Siddhartha Ganguly, Mehdi Hamadani, Robert J Hayashi, Peiman Hematti, Yoshihiro Inamoto, Nandita Khera, Tamila Kindwall-Keller, Heather Landau, Hillard Lazarus, Navneet S Majhail, David I Marks, Richard F Olsson, Sachiko Seo, Amir Steinberg, Basem M William, Baldeep Wirk, Jean A Yared, Mahmoud Aljurf, Muneer H Abidi, Heather Allewelt, Amer Beitinjaneh, Rachel Cook, Robert F Cornell, Joseph W Fay, Gregory Hale, Jennifer Holter Chakrabarty, Sonata Jodele, Kimberly A Kasow, Anuj Mahindra, Adriana K Malone, Uday Popat, J Douglas Rizzo, Harry C Schouten, Anne B Warwick, William A Wood, Mikkael A Sekeres, Mark R Litzow, Robert P Gale, Shahrukh K Hashmi
BACKGROUND: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). METHODS: 9028 recipients of hematopoietic cell autotransplants (1995-2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS. RESULTS: 335 MDS/AML cases were diagnosed posttransplant (3...
July 19, 2018: Leukemia Research
Ziad Bakouny, Nour Khalil, Joeffroy Otayek, Aren Joe Bizdikian, Fares Yared, Michel Salameh, Naji Bou Zeid, Ismat Ghanem, Khalil Kharrat, Gaby Kreichati, Renaud Lafage, Virginie Lafage, Ayman Assi
OBJECTIVE The Ames-International Spine Study Group (ISSG) classification has recently been proposed as a tool for adult cervical deformity evaluation. This classification includes three radiographic cervical sagittal modifiers that have not been evaluated in asymptomatic adults. The aim of this study was to determine whether the sagittal radiographic modifiers described in the Ames-ISSG cervical classification are encountered in asymptomatic adults without alteration of health-related quality of life (HRQOL)...
July 27, 2018: Journal of Neurosurgery. Spine
G Mjaess, A Karam, C Labaki, J Otayek, F Yared, A J Bizdikian, Z Bakouny, W Skalli, I Ghanem, A Assi
No abstract text is available yet for this article.
September 2018: Gait & Posture
A Karam, C Labaki, G Mjaess, A J Bizdikian, F Yared, J Otayek, Z Bakouny, I Ghanem, W Skalli, A Assi
No abstract text is available yet for this article.
September 2018: Gait & Posture
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