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Awoke Kebede, Hadgu Gerensea, Freweyni Amare, Yared Tesfay, Girmay Teklay
OBJECTIVE: Anemia is a widespread health problem among pregnant women causing maternal/infant morbidity and mortality mainly in low-income countries. Understanding of the magnitude of anemia and related socio-demographic variables in a specific setting would help scale-up preventive and therapeutic measures in a locality. So that this study focuses on the magnitude of anemia and its associated factor among pregnant women attending antenatal care in public hospitals of shire town and using institution based cross-sectional study design on 480 randomly selected study subjects...
August 17, 2018: BMC Research Notes
Yeshambel Belyhun, Feleke Moges, Mengistu Endris, Banchamlak Asmare, Bemnet Amare, Damtew Bekele, Solomon Tesfaye, Martha Alemayehu, Fantahun Biadgelegne, Andargachew Mulu, Yared Assefa
OBJECTIVES: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. RESULTS: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections...
August 17, 2018: BMC Research Notes
Darryl L Hadsell, Louise A Hadsell, Monique Rijnkels, Yareli Carcamo-Bahena, Jerry Wei, Peter Williamson, Michael A Grusak
The breast-feeding neonate depends on mother's milk for both macronutrients and micronutrients including minerals. The goals of the present study were to document the effects of genetic background in mice on milk concentrations of select minerals and to use genome-wide association study (GWAS) to identify quantitative trait loci (QTL) regulating milk mineral concentrations. Milk samples from lactating mice in each of 31 different inbred strains of the mouse diversity panel (MDP) were analyzed by inductively coupled plasma-optical emission spectroscopy to determine the concentrations of calcium (Ca), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), sodium (Na), phosphorus (P), sulfur (S), and zinc (Zn)...
August 2, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
Ziad Bakouny, Ayman Assi, Fares Yared, Nour Khalil, Elie Mansour, Jean Jacques Yaacoub, Wafa Skalli, Ismat Ghanem
BACKGROUND: Hip instability is frequent in patients with Down syndrome. Recent studies have suggested that skeletal hip alterations are responsible for this instability; however, there are currently no studies simultaneously assessing femoral and acetabular anatomy in subjects with Down syndrome in the standing position. The aim was to analyze the three-dimensional anatomy of the Down syndrome hip in standing position. METHODS: Down syndrome subjects were age and sex-matched to asymptomatic controls...
October 2018: Clinical Biomechanics
Tomas Radivoyevitch, Robert M Dean, Bronwen E Shaw, Ruta Brazauskas, Heather R Tecca, Remco J Molenaar, Minoo Battiwalla, Bipin N Savani, Mary E D Flowers, Kenneth R Cooke, Betty K Hamilton, Matt Kalaycio, Jaroslaw P Maciejewski, Ibrahim Ahmed, Görgün Akpek, Ashish Bajel, David Buchbinder, Jean-Yves Cahn, Anita D'Souza, Andrew Daly, Zachariah DeFilipp, Siddhartha Ganguly, Mehdi Hamadani, Robert J Hayashi, Peiman Hematti, Yoshihiro Inamoto, Nandita Khera, Tamila Kindwall-Keller, Heather Landau, Hillard Lazarus, Navneet S Majhail, David I Marks, Richard F Olsson, Sachiko Seo, Amir Steinberg, Basem M William, Baldeep Wirk, Jean A Yared, Mahmoud Aljurf, Muneer H Abidi, Heather Allewelt, Amer Beitinjaneh, Rachel Cook, Robert F Cornell, Joseph W Fay, Gregory Hale, Jennifer Holter Chakrabarty, Sonata Jodele, Kimberly A Kasow, Anuj Mahindra, Adriana K Malone, Uday Popat, J Douglas Rizzo, Harry C Schouten, Anne B Warwick, William A Wood, Mikkael A Sekeres, Mark R Litzow, Robert P Gale, Shahrukh K Hashmi
BACKGROUND: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). METHODS: 9028 recipients of hematopoietic cell autotransplants (1995-2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS. RESULTS: 335 MDS/AML cases were diagnosed posttransplant (3...
July 19, 2018: Leukemia Research
Ziad Bakouny, Nour Khalil, Joeffroy Otayek, Aren Joe Bizdikian, Fares Yared, Michel Salameh, Naji Bou Zeid, Ismat Ghanem, Khalil Kharrat, Gaby Kreichati, Renaud Lafage, Virginie Lafage, Ayman Assi
OBJECTIVE The Ames-International Spine Study Group (ISSG) classification has recently been proposed as a tool for adult cervical deformity evaluation. This classification includes three radiographic cervical sagittal modifiers that have not been evaluated in asymptomatic adults. The aim of this study was to determine whether the sagittal radiographic modifiers described in the Ames-ISSG cervical classification are encountered in asymptomatic adults without alteration of health-related quality of life (HRQOL)...
July 27, 2018: Journal of Neurosurgery. Spine
G Mjaess, A Karam, C Labaki, J Otayek, F Yared, A J Bizdikian, Z Bakouny, W Skalli, I Ghanem, A Assi
No abstract text is available yet for this article.
July 19, 2018: Gait & Posture
A Karam, C Labaki, G Mjaess, A J Bizdikian, F Yared, J Otayek, Z Bakouny, I Ghanem, W Skalli, A Assi
No abstract text is available yet for this article.
July 2, 2018: Gait & Posture
A J Bizdikian, A Assi, Z Bakouny, F Yared, E Saghbini, G E Bakhos, S Esber, N Khalil, J Otayek, J Ghanimeh, C Sauret, W Skalli, I Ghanem
AIM: To determine a valid and reliable neck-shaft angle (NSA) measurement method while rotating the pelvises in increments of 5° in order to simulate patient malpositioning. MATERIALS AND METHODS: CT images of 17 patients were used to produce digitally reconstructed radiographs in frontal and lateral views and three-dimensional (3D)-reconstructions of the femurs, considered to be the reference standard. Malpositioning was simulated by axially rotating the frontal radiographs from 0° to 20°...
July 9, 2018: Clinical Radiology
A Massaad, A Assi, A J Bizdikian, F Yared, Z Bakouny, N Khalil, I Ghanem, H Pillet, X Bonnet, W Skalli
No abstract text is available yet for this article.
June 26, 2018: Gait & Posture
C Labaki, A Karam, G Mjaess, Z Bakouny, A J Bizdikian, F Yared, J Otayek, W Skalli, I Ghanem, A Assi
No abstract text is available yet for this article.
July 2, 2018: Gait & Posture
Henrique D Vasconcellos, Henrique T Moreira, Luisa Ciuffo, Chike C Nwabuo, Guilherme S Yared, Bharath Ambale-Venkatesh, Anderson C Armstrong, Satoru Kishi, Jared P Reis, Kiang Liu, Donald M Lloyd-Jones, Laura A Colangelo, Pamela J Schreiner, Stephen Sidney, Samuel S Gidding, Joao A C Lima
Aims: To evaluate the association of cumulative blood pressure (BP) from young adulthood to middle age with left atrial (LA) structure/function as assessed by three-dimensional echocardiography (3DE) in a large longitudinal bi-racial population study. Methods and results: We conducted a prospective post hoc analysis of individuals enrolled at the Coronary Artery Risk Development in Young Adults, which is a multi-centre bi-racial cohort with 30 years of follow-up...
June 29, 2018: European Heart Journal Cardiovascular Imaging
Yared Mekonnen, Daniel S Telake, Endeshaw Wolde
BACKGROUND: Ethiopia houses the second largest population of female adolescents in Africa. Adolescent childbearing can have detrimental effect to the health and wellbeing of women and their offspring. This study examined trends, sub-national variations and determinants of early childbearing (i.e. childbearing before age 20) in Ethiopia. METHODS: Data from the 2000-2011 Ethiopia Demographic and Health Surveys and from the 2014-2016 Performance Monitoring and Accountability surveys were pooled for this analysis...
July 3, 2018: BMC Pregnancy and Childbirth
Biniyam Alemayehu Ayele, Yared Mamushet Yifru
BACKGROUND: Migraine headache is a neurologic disorder which mainly affects younger and productive segment of population. Migraine not only causes pain; but also affects quality of life in terms of low productivity and economic loss. The main aim of this study was to examine migraine-related disability, co-morbid depression, and relationship between the two. METHODS: A cross-sectional study was conducted among migraineurs who visited two neurology referral clinics...
July 2, 2018: BMC Neurology
A Assi, Z Bakouny, F Yared, J Otayek, A J Bizdikian, I Ghanem, G Kreichati, H Pillet, X Bonnet, W Skalli
No abstract text is available yet for this article.
June 18, 2018: Gait & Posture
A Assi, Z Bakouny, A J Bizdikian, J Otayek, F Yared, V Lafage, N Khalil, A Massaad, I Ghanem, W Skalli
No abstract text is available yet for this article.
June 19, 2018: Gait & Posture
Yvonne J W Rozendaal, Yanan Wang, Yared Paalvast, Lauren L Tambyrajah, Zhuang Li, Ko Willems van Dijk, Patrick C N Rensen, Jan A Kuivenhoven, Albert K Groen, Peter A J Hilbers, Natal A W van Riel
The Metabolic Syndrome (MetS) is a complex, multifactorial disorder that develops slowly over time presenting itself with large differences among MetS patients. We applied a systems biology approach to describe and predict the onset and progressive development of MetS, in a study that combined in vivo and in silico models. A new data-driven, physiological model (MINGLeD: Model INtegrating Glucose and Lipid Dynamics) was developed, describing glucose, lipid and cholesterol metabolism. Since classic kinetic models cannot describe slowly progressing disorders, a simulation method (ADAPT) was used to describe longitudinal dynamics and to predict metabolic concentrations and fluxes...
June 2018: PLoS Computational Biology
Ayman Assi, Ziad Bakouny, Elie Mansour, Jean-Jacques Yaacoub, Fares Yared, Ismat Ghanem
STUDY DESIGN: This was a cross-sectional study. OBJECTIVE: The aim of this study was to describe the spinopelvic alignment of subjects with Down syndrome (DS). SUMMARY OF BACKGROUND DATA: Subjects with DS are known to suffer from a large prevalence of scoliosis. While scoliosis is known to significantly affect postural alignment, there are currently no studies on the spinopelvic alignment of subjects with DS. MATERIALS AND METHODS: In total, 41 subjects (28 female subjects and 13 male subjects) with DS, age and sex-matched to 41 asymptomatic subjects, underwent biplanar x-rays with 3-dimensional reconstructions of their spines and pelvises, followed by measurement of commonly used spinopelvic sagittal and coronal alignment parameters...
July 2018: Clinical Spine Surgery
Juan Carlos Sánchez-Salgado, Pablo Bilbao-Ramos, María Auxiliadora Dea-Ayuela, Francisco Hernández-Luis, Francisco Bolás-Fernández, José L Medina-Franco, Yareli Rojas-Aguirre
Leishmaniasis is a neglected tropical disease that currently affects 12 million people, and over 1 billion people are at risk of infection. Current chemotherapeutic approaches used to treat this disease are unsatisfactory, and the limitations of these drugs highlight the necessity to develop treatments with improved efficacy and safety. To inform the rational design and development of more efficient therapies, the present study reports a chemoinformatic approach using the ChEMBL database to retrieve benzimidazole as a target scaffold...
May 10, 2018: Molecular Diversity
Yared Hailemichael, Manisha Singh, Willem Overwijk
In a recent study, Kooreman and colleagues identify a set of genes expressed in both induced pluripotent stem cells (iPSCs) and cancer cells. Vaccination of mice with iPSCs induces prophylactic and therapeutic anticancer immunity to shared antigens, opening a possible avenue towards rapid generation of iPSC-based, personalized cancer vaccines.
June 2018: Trends in Molecular Medicine
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