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Yarely M Salinas-Vera, Laurence A Marchat, Dolores Gallardo-Rincón, Erika Ruiz-García, Horacio Astudillo-De La Vega, Raquel Echavarría-Zepeda, César López-Camarillo
Angiogenesis is an important hallmark of cancer serving a key role in tumor growth and metastasis. Therefore, tumor angiogenesis has become an attractive target for development of novel drug therapies. An increased amount of anti‑angiogenic compounds is currently in preclinical and clinical development for personalized therapies. However, resistance to current angiogenesis inhibitors is emerging, indicating that there is a need to identify novel anti‑angiogenic agents. In the last decade, the field of microRNA biology has exploded revealing unsuspected functions in tumor angiogenesis...
November 27, 2018: International Journal of Molecular Medicine
Yoshihiro Inamoto, Nuria Valdés-Sanz, Yoko Ogawa, Monica Alves, Luigi Berchicci, John Galvin, Hildegard Greinix, Gregory A Hale, Biljana Horn, Debra Kelly, Hien Liu, Scott Rowley, Helene Schoemans, Ami Shah, Maria Teresa Lupo Stanghellini, Vaibhav Agrawal, Ibrahim Ahmed, Asim Ali, Neel Bhatt, Michael Byrne, Saurabh Chhabra, Zack DeFilipp, Kristina Fahnehjelm, Nosha Farhadfar, Erich Horn, Catherine Lee, Sunita Nathan, Olaf Penack, Pinki Prasad, Seth Rotz, Alicia Rovó, Jean Yared, Steven Pavletic, Grzegorz W Basak, Minoo Battiwalla, Rafael Duarte, Bipin N Savani, Mary Ed Flowers, Bronwen E Shaw, Igor Petriček
Ocular graft-versus-host disease (GVHD) occurs in more than half of patients who develop chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged morbidity which affects activities of daily living and quality of life. Here we provide an expert review of ocular GVHD in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation...
November 24, 2018: Biology of Blood and Marrow Transplantation
Sisay Degno, Mueez Abrha, Yared Asmare, Abebe Muche
BACKGROUND: The foramen magnum (FM) is the largest opening and is outlet through which medulla oblongata and spinal cord along with meninges, vertebral arteries, anterior and posterior spinal arteries, tectorial membrane, alar ligaments, and spinal branch of the accessory nerve. Occipital condyle (OC) is an important part of craniovertebral or craniocervical junction located anterolaterally on either side of the FM. The objective of the study was to assess variations of FM and OC in Ethiopian dried adult skulls...
November 22, 2018: Journal of Craniofacial Surgery
Ziad Bakouny, Elie El Rassy, Fares Yared, Antoine Abi Lutfallah, Marwan Ghosn, Fadi Farhat, Joseph Kattan
Aim: The rationale for platelet-to-lymphocyte ratio (PLR) in chronic lymphocytic leukemia (CLL) is that both the platelet and lymphocyte counts are affected by the CLL pathogenesis and could influence treatment decision-making. Methods: Demographic and clinical data of CLL patients diagnosed at our institution between 1989 and 2013 were collected. Cox regression models were used to evaluate the role of PLR in the duration of watchful waiting, postdiagnosis survival and postchemotherapy survival...
December 2018: Future Science OA
Mariya Geube, Balaram Anandamurthy, Jean-Pierre Yared
Perioperative management of patients undergoing lung transplantation is one of the most complex in cardiothoracic surgery. Certain perioperative interventions, such as mechanical ventilation, fluid management and blood transfusions, use of extracorporeal mechanical support, and pain management, may have significant impact on the lung graft function and clinical outcome. This article provides a review of perioperative interventions that have been shown to impact the perioperative course after lung transplantation...
January 2019: Critical Care Clinics
Rodolfo Daniel Cervantes-Villagrana, Sendi Rafael Adame-García, Irving García-Jimenez, Víctor Manuel Color-Aparicio, Yarely Mabell Beltran-Navarro, Gabriele M König, Evi Kostenis, Guadalupe Reyes-Cruz, J Silvio Gutkind, José Vázquez-Prado
G protein-coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammalian cell migration. Rac and Rho GTPases exert opposing effects on cell morphology, and are stimulated downstream of Gβγ and Gα12/13 or Gαq , respectively. These Gα subunits might in turn favor Rho pathways by preventing Gβγ signaling to Rac. Here, we investigated whether Gβγ signaling to phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-REX1), a key Gβγ chemotactic effector, is directly controlled by Rho-activating Gα subunits...
November 16, 2018: Journal of Biological Chemistry
Claudio G Brunstein, Marcelo C Pasquini, Soyoung Kim, Mingwei Fei, Kehinde Adekola, Ibrahim Ahmed, Mahmoud Aljurf, Vaibhav Agrawal, Jeffrey J Auletta, Minoo Battiwalla, Nelli Bejanyan, Joseph Bubalo, Jan Cerny, Lynette Chee, Stefan O Ciurea, Cesar Freytes, Shahinaz M Gadalla, Robert Peter Gale, Siddhartha Ganguly, Shahrukh K Hashmi, Peiman Hematti, Gerhard Hildebrandt, Leona A Holmberg, Oscar B Lahoud, Heather Landau, Hillard M Lazarus, Marcos de Lima, Vikram Mathews, Richard Maziarz, Taiga Nishihori, Maxim Norkin, Richard Olsson, Ran Reshef, Seth Rotz, Bipin Savani, Harry C Schouten, Sachiko Seo, Baldeep M Wirk, Jean Yared, Shin Mineishi, John Rogosheske, Miguel-Angel Perales
There are limited data on whether to adjust high-dose chemotherapy prior to autologous hematopoietic cell transplant (autoHCT) in obese patients. This study explores the effects of dose adjustment on the outcomes of obese patients, defined as body mass index (BMI) ≥ 30 kg/m2 . Dose adjustment was defined as a reduction in standard dosing of ≥ 20%, based on ideal, reported dosing and actual weights. We included two groups of US patients who had received autoHCT between 2008 and 2014. Specifically, we included patients with multiple myeloma (MM, n=1696) treated with high-dose melphalan; and we included patients with Hodgkin or non-Hodgkin lymphomas (n=781) who received carmustine, etoposide, cytarabine, and melphalan (BEAM) conditioning...
November 10, 2018: Biology of Blood and Marrow Transplantation
Saurabh Chhabra, Kwang Woo Ahn, Zhen-Huan Hu, Sandeep Jain, Amer Assal, Jan Cerny, Edward A Copelan, Andrew Daly, Zachariah DeFilipp, Shahinaz M Gadalla, Robert Peter Gale, Siddhartha Ganguly, Betty K Hamilton, Gerhard Carl Hildebrandt, Jack W Hsu, Yoshihiro Inamoto, Abraham S Kanate, H Jean Khoury, Hillard M Lazarus, Mark R Litzow, Sunita Nathan, Richard F Olsson, Attaphol Pawarode, Olle Ringden, Jacob M Rowe, Ayman Saad, Bipin N Savani, Harry C Schouten, Sachiko Seo, Nirav N Shah, Melhem Solh, Robert K Stuart, Celalettin Ustun, Ann E Woolfrey, Jean A Yared, Edwin P Alyea, Matt E Kalaycio, Uday Popat, Ronald M Sobecks, Wael Saber
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment of chronic myeloid leukemia (CML). Optimal conditioning intensity for allo-HCT for CML in the era of tyrosine kinase inhibitors (TKIs) is unknown. Using the Center for International Blood and Marrow Transplant Research database, we sought to determine whether reduced-intensity/nonmyeloablative conditioning (RIC) allo-HCT and myeloablative conditioning (MAC) result in similar outcomes in CML patients. We evaluated 1395 CML allo-HCT recipients between the ages of 18 and 60 years...
November 13, 2018: Blood Advances
Jama Osman Hirsi, Yared Mamushet Yifru, Guta Zenebe Metaferia, James H Bower
INTRODUCTION: Pain is a common non-motor feature encountered by patients with Parkinson's disease. Recognition and accurate characterization of pain is crucial for the optimal treatment of Parkinson's disease patients. Pain has been associated with poverty and ethnicity. We determined the prevalence of pain in Parkinson's disease patients in Ethiopia. METHOD: We conducted a cross-sectional study for a six month period from April 01, 2017-September 30, 2017 with patients with Parkinson's disease who were attending two neurology referral clinics in Addis Ababa, Ethiopia to assess for the prevalence and the characterization of pain...
September 28, 2018: Parkinsonism & related Disorders
Alexandra Castillo-Ruiz, Morgan Mosley, Andrew J Jacobs, Yarely C Hoffiz, Nancy G Forger
Labor and a vaginal delivery trigger changes in peripheral organs that prepare the mammalian fetus to survive ex utero. Surprisingly little attention has been given to whether birth also influences the brain, and to how alterations in birth mode affect neonatal brain development. These are important questions, given the high rates of cesarean section (C-section) delivery worldwide, many of which are elective. We examined the effect of birth mode on neuronal cell death, a widespread developmental process that occurs primarily during the first postnatal week in mice...
November 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Tania Yareli Gutiérrez-López, Lennis Beatríz Orduña-Castillo, Magda Nohemí Hernández-Vásquez, José Vázquez-Prado, Guadalupe Reyes-Cruz
Calcium sensing receptor (CaSR) activates the NLRP3 inflammasome with consequences on homeostatic responses. However, little is known about how this process is orchestrated. Since proteolysis of critical regulators of NLRP3 inflammasome contribute to its activation, we aimed to understand how CaSR stimulates proteolytic pathways to activate the NLRP3 inflammasome. We found that proteasome and lysosome-dependent mechanisms are activated by CaSR to promote the degradation of important regulators of NLRP inflammasome...
November 10, 2018: Biochemical and Biophysical Research Communications
Lesa A Thompson, Yoshinori Ikenaka, Wageh S Darwish, Yared B Yohannes, Johan J van Vuren, Victor Wepener, Nico J Smit, Atnafu G Assefa, Ahmed Tharwat, Walaa Fathy Saad Eldin, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
The objective of this study was to identify potential mRNA expression changes in chicken livers associated with environmental exposure to dichloro-diphenyl-trichloroethane (DDT) and its metabolites (DDTs). In particular, we focused on genes relating to the immune system and metabolism. We analyzed liver samples from free-ranging chickens in KwaZulu-Natal, South Africa, for contamination by DDTs. This area predominantly uses DDT in its malaria control program, and homes are sprayed annually with the pesticide...
2018: PloS One
Amin Alousi, Tao Wang, Michael T Hemmer, Stephen R Spellman, Mukta Arora, Daniel R Couriel, Joseph Pidala, Paolo N Anderlini, Michael Boyiadzis, Christopher N Bredeson, Jean-Yves Cahn, Mitchell S Cairo, Shahinaz M Gadalla, Shahrukh K Hashmi, Robert Peter Gale, Junya Kanda, Rammurti T Kamble, Mohamed A Kharfan-Dabaja, Mark R Litzow, Olle Ringden, Ayman A Saad, Kirk R Schultz, Leo F Verdonck, Edmund K Waller, Jean A Yared, Shernan G Holtan, Daniel J Weisdorf
Peripheral blood (PB) and bone marrow (BM) from unrelated donors can serve as a graft source for hematopoietic cell transplantation (HCT). Currently, PB is most commonly used in roughly 80% of adult recipients. Determining the long-term impact of graft source on outcomes would inform this decision. Data collected by the Center for International Blood and Marrow Transplant Research from 5200 adult recipients of a first HCT from an 8/8 or 7/8 HLA antigen-matched unrelated donor for treatment of acute leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome between 2001 and 2011 were analyzed to determine the impact of graft source on graft-versus-host disease (GVHD) relapse-free survival (GRFS), defined as freedom from grade III/IV acute GVHD, chronic GVHD requiring immunosuppressive therapy, relapse, and death, and overall survival...
October 3, 2018: Biology of Blood and Marrow Transplantation
Yared Debebe, Sharon R Hill, Habte Tekie, Rickard Ignell, Richard J Hopkins
BACKGROUND: Understanding the ecology of exophilic anophelines is a key step toward developing outdoor control strategies to complement existing indoor control tools against malaria vectors. This study was conducted to assess the movement pattern of exophilic Anopheles mosquitoes between blood meal sources and resting habitats, and the landscape factors dictating their resting habitat choice. RESULTS: Resting clay pots were placed at 5 m, 25 m, 50 m, 75 m and 100 m away from isolated focal houses, radiating from them in four directions...
October 5, 2018: Malaria Journal
Maxim Norkin, Bronwen E Shaw, Ruta Brazauskas, Heather R Tecca, Helen L Leather, Juan Gea-Banacloche, Rammurti T Kamble, Zachariah DeFilipp, David A Jacobsohn, Olle Ringden, Yoshihiro Inamoto, Kimberly A Kasow, David Buchbinder, Peter Shaw, Peiman Hematti, Raquel Schears, Sherif M Badawy, Hillard M Lazarus, Neel Bhatt, Biljana Horn, Saurabh Chhabra, Kristin M Page, Betty Hamilton, Gerhard C Hildebrandt, Jean A Yared, Vaibhav Agrawal, Amer M Beitinjaneh, Navneet Majhail, Tamila Kindwall-Keller, Richard F Olsson, Helene Schoemans, Robert Peter Gale, Siddhartha Ganguly, Ibrahim A Ahmed, Harry C Schouten, Jane L Liesveld, Nandita Khera, Amir Steinberg, Ami J Shah, Melhem Solh, David I Marks, Witold Rybka, Mahmoud Aljurf, Andrew C Dietz, Usama Gergis, Biju George, Sachiko Seo, Mary E D Flowers, Minoo Battiwalla, Bipin N Savani, Marcie L Riches, John R Wingard
We analyzed late fatal infections (LFIs) in allogeneic stem cell transplantation (HCT) recipients reported to the Center for International Blood and Marrow Transplant Research. We analyzed the incidence, infection types, and risk factors contributing to LFI in 10,336 adult and 5088 pediatric subjects surviving for ≥2 years after first HCT without relapse. Among 2245 adult and 377 pediatric patients who died, infections were a primary or contributory cause of death in 687 (31%) and 110 (29%), respectively...
October 2, 2018: Biology of Blood and Marrow Transplantation
Gbolahan O Ogunbayo, Naoki Misumida, Karam Ayoub, Yared Hailemariam, Dustin Hillerson, Ayman Elbadawi, Ahmed Abdel-Latif, Susan Smyth, Khaled Ziada, Adrian W Messerli
BACKGROUND: Pharmacologic reperfusion therapy is a recommended and effective strategy in patients with ST-elevation myocardial infarction (STEMI) when percutaneous coronary intervention (PCI) is not available. This study investigates temporal trends and outcomes of fibrinolytic therapy (FT) in elderly patients with STEMI. METHODS: Using the Nationwide Inpatient Sample database, we extracted patients ≥80 years a primary diagnosis of STEMI admitted between 2010 and 2014...
September 30, 2018: Catheterization and Cardiovascular Interventions
Yared Gurmu, Jing Qian, Victor De Gruttola
Partnership duration data are commonly obtained through surveys that collect information on relationships that are ongoing during a fixed time window. This sampling mechanism leads to duration data that are left truncated and right censored; such data have been analysed using the standard truncation product limit estimator (TPLE). In this paper, we describe a common sampling scheme for collecting sexual partnership data, discuss a key assumption required for the TPLE to be unbiased, and provide the conditions under which the nonparametric maximum likelihood estimator of the relationship duration distribution is unique and consistent...
June 2018: Research & reviews. Journal of statistics and mathematical sciences
Nour Khalil, Aren Joe Bizdikian, Ziad Bakouny, Michel Salameh, Naji Bou Zeid, Fares Yared, Joeffroy Otayek, Khalil Kharrat, Gaby Kreichati, Ismat Ghanem, Renaud Lafage, Virginie Lafage, Ibrahim Obeid, Ayman Assi
PURPOSE: To investigate the different cervical strategies for maintaining horizontal gaze in asymptomatic subjects. METHODS: One hundred and forty-four asymptomatic adults filled the SF-36 quality of life questionnaire and underwent full-body biplanar radiographs. Chin brow vertical angle (CBVA) and postural and cervical parameters were measured. Subjects were grouped according to cervical spine curvature (C2-C7 angle): kyphotic (< - 5°), straight [- 5°, 5°], lordotic (> 5°)...
November 2018: European Spine Journal
Tamar E Carter, Solomon Yared, Araya Gebresilassie, Victoria Bonnell, Lambodhar Damodaran, Karen Lopez, Mohammed Ibrahim, Seid Mohammed, Daniel Janies
Malaria is a major public health concern in Ethiopia. With the increase in malaria cases in the Somali Region of Ethiopia, understanding the distribution and identifying the species of malaria vectors is vital to public health. Here we report the first detection of Anopheles stephensi in Ethiopia, a malaria vector typically found in the Middle East, the Indian subcontinent, and China, but recently found in Djibouti. An entomological investigation was conducted during November to December 2016 in Kebri Dehar town of the Ethiopian Somali Regional State as ancillary work for Anopheles spp...
December 2018: Acta Tropica
Rawad A Yared, Hussein A Badran, Mohammed Hussein Kamareddine, Youssef Ghosn, Roula Bou Khalil, Khaled El Ajamy, Camil Chouairy, Said G Farhat
Malakoplakia is a rare chronic granulomatous disease that may affect many organs, including the lung, brain, adrenal glands, pancreas, bone, and the genitourinary tract. The gastrointestinal tract is the most common site of involvement outside of the urinary tract. Herein, we present a case of a 65-year-old male who presented with abdominal pain and unintentional weight loss. Physical examination findings were unremarkable, but colonoscopy revealed an isolated large, flat, soft, and pale lesion in the transverse colon...
May 2018: Case Reports in Gastroenterology
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