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Jae Sun Uhm, Jaewon Oh, In Jeong Cho, Minsu Park, In Soo Kim, Moo Nyun Jin, Han Joon Bae, Hee Tae Yu, Tae Hoon Kim, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung, Seok Min Kang
PURPOSE: This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP). MATERIALS AND METHODS: We included 120 patients (age, 66.1±12.6 years; men, 54.2%) who underwent CRT implantation for heart failure (HF). Echocardiography was performed before and at 3, 6, and 12 months after CRT implantation. The 1-year HCCEP included all-cause mortality, hospitalization for HF, and New York Heart Association functional class for 12 months...
January 2019: Yonsei Medical Journal
Chan Bum Choi, Yong Beom Park, Sang Won Lee
Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of systemic necrotising vasculitides, which often involve small vessels, and which lead to few or no immune deposits in affected organs. According to clinical manifestations and pathological features, AAV is classified into three variants: microscopic polyangiitis, granulomatosis with polyangiitis (GPA), and eosinophilic GPA. The American College of Rheumatology 1990 criteria contributed to the classification of AAV, although currently the algorithm suggested by the European Medicines Agency in 2007 and the Chapel Hill Consensus Conference Nomenclature of Vasculitides proposed in 2012 have encouraged physicians to classify AAV patients properly...
January 2019: Yonsei Medical Journal
Shih-Yung Su, Wen-Chung Lee
BACKGROUND: Projections on liver diseases mortality can provide a basis for evaluating the World Health Organization's "25 by 25" goal and can help health care systems design appropriate control strategies. This study evaluated whether the 25 by 25 goal can be achieved in Taiwan and discussed possible future control strategies. METHODS: Age-period-cohort models are used to estimate the mortality trends of liver diseases from 1981 to 2016 and project these trends to 2035...
December 16, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Stefanie Parks, Matthew K Hoffman, Shivaprasad S Goudar, Archana Patel, Sarah Saleem, Sumera Aziz Ali, Robert L Goldenberg, Patricia L Hibberd, Janet Moore, Dennis Wallace, Elizabeth M McClure, Richard J Derman
OBJECTIVE: To describe the association of maternal anaemia with maternal, foetal and neonatal outcomes. DESIGN: Prospective cohort study. SETTING: Rural India and Pakistan. POPULATION: Pregnant women residing in the study catchment area. METHODS: We performed an analysis of a prospective pregnancy registry wherein haemoglobin is commonly obtained as well as maternal, foetal and neonatal outcomes through 42 days post-delivery...
December 16, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Joel Tehse, Changiz Taghibiglou
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and individuals under 45 year age. A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI. A better understanding of the pathophysiology behind TBI is essential for providing more effective treatment. Excitotoxicity as one of the secondary molecular events is a major contributing factor in apoptosis and neuronal death following the initial injury in TBI. Excitotoxicity is the rapid overload and influx of calcium into the cell cytoplasm, activating a series of deleterious signaling cascades causing the cell to undergo apoptosis...
December 16, 2018: European Journal of Neuroscience
Gaya Spolverato, Fabio Bagante, Diamantis Tsilimigras, Aslam Ejaz, Jordan Cloyd, Timothy M Pawlik
BACKGROUND: We sought to define the management of mixed hepatocellular carcinoma-intrahepatic cholangiocarcinoma (HCC-ICC) as well as characterize short- and long-term outcomes of patients with mixed HCC-ICC. METHODS: Patients diagnosed with HCC-ICC, HCC, or ICC between 2004 and 2015 were identified from the National Cancer Data Base using the International Classification of Diseases for Oncology codes. Short- and long-term outcomes were assessed using univariate and multivariate analyses...
December 16, 2018: Journal of Surgical Oncology
Nadezhda G Gumanova, Alexander D Deev, Alexander Y Kots, Svetlana A Shalnova
BACKGROUND: Nitric oxide (NO) is one of the key regulators of vascular function. Abnormal NO signaling is linked to various cardiovascular diseases. We studied associations between circulating levels of nitric oxide metabolites, nitrite and nitrate (NOx), and total and cardiovascular mortality in a prospective 8-year follow-up cohort study in 1869 patients aged over 55 years. MATERIALS AND METHODS: The Cox proportional hazard ratio (HR) regression models were adjusted for multiple risk-related variables...
December 16, 2018: European Journal of Clinical Investigation
Nayef A Alzahrani, Sarah J Valle, Oliver M Fisher, Paul H Sugarbaker, Yutaka Yonemura, Olivier Glehen, Dianne Goere, Charles Honore, Cecile Brigand, Ignace de Hingh, Vic J Verwaal, Marcello Deraco, Dario Baratti, Shigeki Kusamura, Mark Pocard, Pompiliu Piso, Loreen Maerz, Frederic Marchal, Brendan Moran, Edward A Levine, Frédéric Dumont, Denis Pezet, Karine Abboud, Mathew A Kozman, Winston Liauw, David L Morris
BACKGROUND AND OBJECTIVES: The aims of this multi-institutional study were to assess the feasibility of iterative cytoreductive surgery (iCRS)/hyperthermic intraperitoneal chemotherapy, iCRS in colorectal peritoneal carcinomatosis (CRPC), evaluate survival, recurrence, morbidity and mortality outcomes, and identify prognostic factors for overall survival. METHODS: Patients with CRPC that underwent an iCRS, with or without intraperitoneal chemotherapy, from June 1993 to July 2016 at 13 institutions were retrospectively analyzed from prospectively maintained databases...
December 16, 2018: Journal of Surgical Oncology
Eran Nizri, Marco Fiore, Chiara Colombo, Stefano Radaelli, Dario Callegaro, Roberta Sanfilippo, Claudia Sangalli, Paola Collini, Carlo Morosi, Silvia Stacchiotti, Paolo G Casali, Alessandro Gronchi
BACKGROUND: Patients with retroperitoneal sarcoma (RPSs) who undergo primary inadequate surgery before referral to specialized sarcoma centers may be considered for completion surgery (CS). We wanted to compare the outcome of these patients to those who underwent primary adequate surgery (PAS) at a single referral institution. METHODS: We identified 34 patients who were referred for CS after primary inadequate surgery. Using a propensity score based on validated RPS outcome risk factors, we managed to match 28 patients to patients with PAS...
December 16, 2018: Journal of Surgical Oncology
Sofie Bosch, Daniel J Berkhout, Ilhame Ben Larbi, Tim G de Meij, Nanne K de Boer
INTRODUCTION: The fecal volatolome, which is composed of fecal volatile organic compounds (VOCs), seems to hold potential as non-invasive biomarker for the detection of colorectal cancer (CRC) and its precursor lesions advanced adenomas (AA). The potential of the fecal volatolome has been subject of various studies using either chemical analytical or pattern-recognition techniques. The available literature on the potential of the fecal volatolome as CRC and AA biomarker was reviewed. METHODS: A systematic literature search was conducted in PubMed, Embase, the Cochrane Library, Google Scholar and ResearchGate using the following keywords: Colorectal Cancer, Advanced Adenoma, Volatile Organic Compound, Metabolome, Gas Chromatrography-Mass Spectrometry, Selected-Ion Flow-Tube Mass Spectrometry, eNose, and Fecal Biomarkers...
December 15, 2018: Journal of Cancer Research and Clinical Oncology
Nan Jiang, Huan Liu, Peng Wang, Jing Huang, Hui Han, Qinfu Wang
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant animal morbidity and mortality and economic losses worldwide. In this study, we analyzed the microbiota in bronchoalveolar lavage fluid (BAL), mucosa, and feces in cecum of the PRRSV-challenged pigs using the Illumina MiSeq sequencing platform, to investigate the role of microbiota in the pathogenesis and development of porcine reproductive and respiratory syndrome (PRRS). Quantitative insights into microbial ecology analyses indicated that the dominant bacterial groups in the lung from the PRRSV-challenged pigs were Haemophilus parasuis and Mycoplasma hyorhinis, with a relative abundance of 35-48% and 27-41%, respectively...
December 15, 2018: Current Microbiology
Patrick Kuhlman, Scott Isom, Timothy S Pardee, Cynthia Burns, Bernard Tawfik, Zanetta S Lamar, Bayard L Powell, Heidi D Klepin
PURPOSE: To investigate the impact of hyperglycemia and glycemic variability during intensive acute myeloid leukemia therapy (AML) on outcomes by age. METHODS: Retrospective study of 262 consecutive patients with newly diagnosed AML hospitalized for intensive induction. Hyperglycemia was assessed by mean blood glucose (BG) (mg/dL) during hospitalization and glycemic variability was determined by the standard deviation (SD) of mean BG. Outcomes were complete remission ± incomplete count recovery (CR + CRi), and overall survival (OS)...
December 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Yongqiang Huang, Haoyue Sheng, Junyu Zhang, Qi Liu, Dingwei Ye, Guohai Shi
BACKGROUND: We combined county-level socioeconomic status (SES), marital status and insurance status to introduce NBF-stage, which were further incorporated into the American Joint Committee on Cancer (AJCC) TNM staging system to generate an integrated staging system for better prognostication and decision-making for testicular cancer patients. METHODS: 15,324 eligible patients diagnosed with primary testicular cancer between January 1, 2007 and December 31, 2015 were strictly selected from the Surveillance, Epidemiology, and End Results (SEER) database...
December 15, 2018: World Journal of Urology
Xiaohong Wang, Na Shi, Huanling Shi, Hong Ye, Ning Li, Peng Sun, Dongfang Bai, Haipeng Yuan
BACKGROUND This study investigated the correlations between acute cerebral hemorrhage complicated with stress ulcer bleeding and corresponding indexes, including the Acute Physiology and Chronic Health Evaluation (APACHE) II score, vascular endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-α), and blood lipid factors. MATERIAL AND METHODS A total of 53 patients with acute cerebral hemorrhage complicated with stress ulcer bleeding were selected as the observation group and 50 patients with simple acute cerebral hemorrhage were selected as the control group...
December 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Shiyue Li, Guangfa Wang, Changhui Wang, Xinglin Gao, Faguang Jin, Huaping Yang, Baohui Han, Rui Zhou, Chengshui Chen, Liangan Chen, Chunxue Bai, Huahao Shen, Felix J F Herth, Nanshan Zhong
BACKGROUND: Chronic obstructive pulmonary disease (COPD) has become a leading cause of morbidity and mortality in China, with tobacco smoke, air pollution, and occupational biohazards being the major risk factors. OBJECTIVES: The REACH trial is a multicenter, prospective, randomized controlled trial undertaken in China to assess the safety and effectiveness of the Spiration® Valve System (SVS) compared to standard medical care in COPD patients with severe emphysema...
December 14, 2018: Respiration; International Review of Thoracic Diseases
Thomas Couri, Thomas G Cotter, Daniel Chen, Mary Hammes, Bharathi Reddy, Michelle Josephson, Heidi Yeh, Raymond T Chung, Sonali Paul
BACKGROUND: Hepatitis C virus (HCV)-infected organs are being transplanted in patients with and without HCV in the direct-acting antiviral era. Little is known about patient attitudes towards receiving an HCV-positive organ. OBJECTIVES: The aim of this study is to determine transplant candidates' attitudes towards receiving HCV-positive organs. METHODS: Adult solid organ transplant candidates were identified during a clinic visit or during outpatient hemodialysis from May to December 2017...
December 14, 2018: American Journal of Nephrology
Andrew C Nixon, Theodoros M Bampouras, Neil Pendleton, Sandip Mitra, Ajay P Dhaygude
BACKGROUND/AIMS: Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4-5 and those established on haemodialysis (G5D). METHODS: Ninety participants with CKD G4-5D were recruited from Nephrology Outpatient Clinics and 2 Haemodialysis Units between December 2016 and December 2017...
December 14, 2018: Nephron
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Jochen Börgermann, Heiner K Berthold, Stefan Pilz, Ioanna Gouni-Berthold, Jan F Gummert
BACKGROUND/AIMS: We aimed to investigate the effect of a moderately high vitamin D dose on lipid parameters and biochemical markers of vascular calcification (VC) in patients with established cardiovascular disease. METHODS: We included in this pre-specified secondary analysis of a randomized controlled trial 161 patients with advanced heart failure and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L (vitamin D group: n = 80; placebo group: n = 81), who received a daily vitamin D3 supplement of 4,000 IU for 3 years...
December 14, 2018: Annals of Nutrition & Metabolism
(no author information available yet)
OBJECTIVEPostoperative surgical site infections (SSIs) in neurosurgical patients carry a significant risk of increased morbidity and mortality. With SSIs accounting for approximately 20% of nosocomial infections and costing approximately $1.6 billion USD annually, there is a need for additional prophylaxis to improve current standards of care. Topical vancomycin is increasingly utilized in instrumented spinal and cardiothoracic procedures, where it has been shown to reduce the risk of SSIs. A randomized controlled trial assessing its efficacy in the general neurosurgical population is currently underway...
December 14, 2018: Journal of Neurosurgery
Gaurang P Nazar, Kiara C-M Chang, Swati Srivastava, Neil Pearce, Anup Karan, Christopher Millett
BACKGROUND: Despite the importance of decreasing tobacco use to achieve mortality reduction targets of the Sustainable Development Goals in low-income and middle-income countries (LMICs), evaluations of tobacco control programmes in these settings are scarce. We assessed the impacts of India's National Tobacco Control Programme (NTCP), as implemented in 42 districts during 2007-2009, on household-reported consumption of bidis and cigarettes. METHODS: Secondary analysis of cross-sectional data from nationally representative Household Consumer Expenditure Surveys (1999-2000; 2004-2005 and 2011-2012)...
December 15, 2018: Tobacco Control
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