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https://www.readbyqxmd.com/read/29325970/the-role-of-adjuvant-immunomodulatory-agents-for-treatment-of-severe-influenza
#1
REVIEW
David S Hui, Nelson Lee, Paul K Chan, John H Beigel
A severe inflammatory immune response with hypercytokinemia occurs in patients hospitalized with severe influenza, such as avian influenza A(H5N1), A(H7N9), and seasonal A(H1N1)pdm09 virus infections. The role of immunomodulatory therapy is unclear as there have been limited published data based on randomized controlled trials (RCTs). Passive immunotherapy such as convalescent plasma and hyperimmune globulin have some studies demonstrating benefit when administered as an adjunctive therapy for severe influenza...
January 8, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29310097/facile-hydrothermal-synthesis-of-branched-polyethylenimine-grafted-electrospun-polyacrylonitrile-fiber-membrane-as-a-highly-efficient-and-reusable-bilirubin-adsorbent-in-hemoperfusion
#2
Rui Zhao, Yumei Li, Xiang Li, Yanzi Li, Bolun Sun, Shen Chao, Ce Wang
Bilirubin is a pathogenic toxin in the blood of patients with liver failure, and bilirubin adsorbents have been applied to remove the extra bilirubin in hemoperfusion. However, the developing of high-performance adsorbents with satisfying removal ability, physical/chemical stability, biocompatibility and hemocompatibility still needs to be explored. In this study, branched polyethylenimine (bPEI) grafted electrospun polyacrylonitrile (PAN) fiber membrane (bPEIPANFM) was fabricated via a green hydrothermal process...
December 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29310045/densitometry-of-the-optically-magnified-dried-residues-representing-carbon-microparticles-as-a-simple-and-affordable-technique-for-determining-their-concentrations-in-aqueous-suspensions
#3
Bogdan I Gerashchenko, Oleksii S Sydorenko, Elisaveta A Snezhkova, Dmytro O Klymchuk, Vladimir G Nikolaev
In extracorporeal blood purification, such as hemoperfusion, activated carbon (activated charcoal) beads are commonly used as an adsorbent, but their judgment in terms of extent of microparticle release is of great importance since the microparticles may represent the risk of entering the bloodstream. To quantitatively assess the release of carbon microparticles (CMPs) in the samples of the aqueous perfusion medium, in which the beads have been perfused, the calibration procedure with different concentrations of CMPs is likely to be needed...
January 4, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29308749/-2017-clinical-breakthroughs-in-critical-care-medicine
#4
Wei Huang
New achievements in critical care medicine 2017 may include updating of "Surviving Sepsis Campaign" international guideline. Comparing evaluation of sequential (sepsis-related) organ failure assessment (SOFA) and quick sequential organ failure assessment (qSOFA), combination therapies with steroid, vitamin B1 and vitamin C in patients with sepsis, identification of endophenotype of sepsis, as well phenotype of acute respiratory distress syndrome (ARDS). However, it is also need to mention some of negative trials, such as levosimendan in patients undergoing cardiac surgery, low-dose immunoglobulin G and polymyxin B hemoperfusion for patient with septic shock, and enteral versus parenteral early nutrition in ventilated adults with shock...
January 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29245231/higher-efficacy-of-direct-hemoperfusion-using-coated-activated-charcoal-column-for-disopyramide-poisoning-a-case-report
#5
Shigekazu Iguchi, Naotaka Yamaguchi, Hiroki Takami, Takayuki Komatsu, Hirokazu Ookubo, Hajime Sekii, Kenji Inoue, Shinya Okazaki, Iwao Okai, Sonomi Maruyama, Tomohisa Nomura, Manabu Sugita
RATIONALE: Cases of severe disopyramide poisoning are rare and few have been reported. We report a case in which activated-charcoal column hemoperfusion was dramatically effective for life-threatening disopyramide poisoning. PATIENT CONCERNS: A teenage girl who had overdosed on disopyramide (total dose, 4950 mg) was brought to our hospital. She was resuscitated from short period cardiopulmonary arrest and subsequently showed severe cardiogenic shock and ventricular arrhythmia...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29221222/polymyxin-b-hemoperfusion-in-septic-shock-nothing-overmuch-meden-agan
#6
EDITORIAL
Stavroula Ilia, Panagiotis Briassoulis, George Briassoulis
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29204670/polymyxin-b-immobilized-hemoperfusion-and-mortality-in-critically-ill-adult-patients-with-sepsis-septic-shock-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#7
REVIEW
Tomoko Fujii, Riki Ganeko, Yuki Kataoka, Toshi A Furukawa, Robin Featherstone, Kent Doi, Jean-Louis Vincent, Daniela Pasero, René Robert, Claudio Ronco, Sean M Bagshaw
PURPOSE: Polymyxin B-immobilized hemoperfusion (PMX-HP) is an adjuvant therapy for sepsis or septic shock that clears circulating endotoxin. Prior trials have shown that PMX-HP improves surrogate endpoints. We aimed to conduct an evidence synthesis to evaluate the efficacy and safety of PMX-HP in critically ill adult patients with sepsis or septic shock. METHODS: We searched for randomized controlled trials (RCTs) in MEDLINE, EMBASE, the Cochrane Library, the Health Technology Assessment Database, CINAHL, "Igaku Chuo Zasshi", the National Institute of Health Clinical Trials Register, the World Health Organization International Clinical Trials Registry Platform, the University Hospital Medical Information Network Clinical Trials Registry, the reference lists of retrieved articles, and publications by manufacturers of PMX-HP...
December 4, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29156874/application-of-hemoperfusion-in-severe-acute-organophosphorus-pesticide-poisoning
#8
Zhenhe Li, Guixia Wang, Guodong Zhen, Yuliang Zhang, Jiaqiang Liu, Shanmei Liu
Background/aim: The aim of this research is to investigate the clinical efficacy of hemoperfusion in the treatment of severe acute organophosphorus pesticide poisoning (AOPP). Materials and methods: Patients meeting the inclusion criteria were divided into Groups 1 and 2 according to whether hemoperfusion was applied or not. Group 2 was observed as the control group. Conventional therapy for AOPP was given to Groups 1 and 2. Besides conventional treatment, patients in Group 1 were also treated with hemoperfusion therapy...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151409/-curative-effect-of-paraquat-detoxification-recipe-combined-with-continuous-hemoperfusion-in-the-treatment-of-patients-with-app-and-clinical-value-of-presepsin
#9
Weizhan Wang, Jing Li, Baoyue Zhu, Xun Gao, Qingmian Xiao, Hongna Qi, Yanqiao Ye, Yongjian Liu, Yongyan Han, Gongying Ma, Pu Wang
OBJECTIVE: To investigate the clinical effect of paraquat (PQ) detoxification recipe combined with continuous hemoperfusion (HP) in the treatment of patients with acute paraquat poisoning (APP) and clinical significance of soluble CD14 subtype (sCD14-st, Presepsin). METHODS: A prospective randomized controlled trial was conducted. 152 patients with moderate APP admitted to Department of Emergency Medicine of Harrison International Peace Hospital Affiliated to Hebei Medical University from July 2013 to June 2017 were enrolled, and they were randomly divided into three groups...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29128834/preparation-of-nano-caco3-polystyrene-nanocomposite-beads-for-efficient-bilirubin-removal
#10
Jian Chen, Guanghui Cheng, Yamin Chai, Wenyan Han, Wenhui Zong, Jie Chen, Chunran Li, Weichao Wang, Lailiang Ou, Yaoting Yu
A novel nano-CaCO3/polystyrene nanocomposite adsorbent (NPS-8) was synthesized for efficient bilirubin removal from human plasma. A comparison with the polystyrene adsorbent (PS-8), which was without the incorporation of nano-CaCO3, revealed that NPS-8 had superior bilirubin adsorption capacity and mechanical strength. The resulting nano-CaCO3 reinforced PS-8 (NPS-8) was tested by transmission electron microscopy (TEM), scanning electron microscopy (SEM), mechanical strength test, and bilirubin adsorption assays...
November 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29123880/efficacy-of-direct-hemoperfusion-with-a-polymyxin-b-immobilized-fiber-column-in-miliary-tuberculosis
#11
Yasumasa Kawano, Ryotaro Nagashima, Shinichi Morimoto, Yoshito Izutani, Reiko Yamasaki, Takeshi Nishida, Mitsutoshi Iwaasa, Hiroyasu Ishikura
Case: A 75-year-old woman presented with a 10-day history of intermittent fever, general fatigue, and progressive dyspnea. Although she had a low PaO2/FIO2 ratio, the cause of acute respiratory distress syndrome was not clear until day 9 in hospital. Outcome: We treated the patient with direct hemoperfusion with a polymyxin B-immobilized fiber column incidentally; the PaO2/FIO2 ratio improved following this therapy. Acid-fast bacilli, which were not seen in the sputum on admission, were detected in cultures from sputum, urine, bone marrow, liver biopsy, and blood samples, with a real-time polymerase chain reaction assay confirming tuberculosis...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29117643/advanced-electrocardiogram-ecg-analysis-in-the-amitriptyline-poisoned-pig-treated-with-activated-charcoal-hemoperfusion-cac-hp
#12
Tejs Jansen, Lotte C G Hoegberg, Thomas Eriksen, Christian Haarmark, Kim Dalhoff, Bo Belhage
Coated Activated Charcoal Hemoperfusion (CAC-HP) does not reduce the plasma concentration in amitriptyline (AT)-poisoned pigs. The aim of this non-blinded, randomised, controlled animal trial was to determine if CAC-HP reduces the pathological ECG changes caused by AT poisoning. Fourteen female Danish Land Race pigs (mean weight 27.7 kg, range 20-35 kg (CAC-HP) and 24.4 kg, range 18-30 kg (control group, CG), n=7 in each group were included. After randomisation, the pigs were anaesthetised and intravenously poisoned with AT...
November 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29116999/treatment-outcome-of-combined-continuous-venovenous-hemofiltration-and-hemoperfusion-in-acute-paraquat-poisoning-a-prospective-controlled-trial
#13
COMPARATIVE STUDY
Changbin Li, Dayong Hu, Wen Xue, Xinhua Li, Zhen Wang, Zisheng Ai, Yaxiang Song, Xinying Liu, Jiafeng Cheng, Shuling Fan, Limin Zhao, Liya Wang, Chandra Mohan, Ai Peng
OBJECTIVES: To investigate whether combined continuous venovenous hemofiltration and hemoperfusion among paraquat-poisoned patients would improve survival. DESIGN: Prospective, controlled interventional study over 4 years. SETTING: Single, tertiary, academic medical center. PATIENTS: We recruited patients admitted to Shanghai Tenth People's Hospital within 48 hours after paraquat ingestion. Exclusions were under 14 years old, ingestion of paraquat with other toxicants, pregnant, a history of chronic pulmonary disease, psychosis, hyperthyroidism, or diabetes with impaired liver or renal function...
January 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29093381/the-serum-ferritin-level-is-associated-with-the-treatment-responsivity-for-rapidly-progressive-interstitial-lung-disease-with-amyopathic-dermatomyositis-irrespective-of-the-anti-mda5-antibody-level-a-case-report
#14
Takeshi Osawa, Kozo Morimoto, Yuka Sasaki, Shuichi Matsuda, Kazunari Yamana, Ryozo Yano, Takashi Uchiyama, Hajime Goto
We herein report he case of a 61-year-old woman with rapidly progressive interstitial lung disease caused by clinically amyopathic dermatomyositis. Both the serum ferritin and anti-MDA5 antibody levels were elevated at the time of admission. Despite intensive treatment with corticosteroids, immunosuppressants, immunoglobulins and polymyxin B direct hemoperfusion, the patient died 75 days after symptom onset. Over the course of treatment, the anti-MDA5 antibody level continually decreased, while the serum ferritin level increased, suggesting that sequential measurements of the serum ferritin level might be useful for evaluating the treatment responsivity, irrespective of the anti-MDA5 antibody level...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29084247/the-effect-of-a-novel-extracorporeal-cytokine-hemoadsorption-device-on-il-6-elimination-in-septic-patients-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Dirk Schädler, Christine Pausch, Daniel Heise, Andreas Meier-Hellmann, Jörg Brederlau, Norbert Weiler, Gernot Marx, Christian Putensen, Claudia Spies, Achim Jörres, Michael Quintel, Christoph Engel, John A Kellum, Martin K Kuhlmann
OBJECTIVE: We report on the effect of hemoadsorption therapy to reduce cytokines in septic patients with respiratory failure. METHODS: This was a randomized, controlled, open-label, multicenter trial. Mechanically ventilated patients with severe sepsis or septic shock and acute lung injury or acute respiratory distress syndrome were eligible for study inclusion. Patients were randomly assigned to either therapy with CytoSorb hemoperfusion for 6 hours per day for up to 7 consecutive days (treatment), or no hemoperfusion (control)...
2017: PloS One
https://www.readbyqxmd.com/read/29082819/prognostic-comparison-of-goal-oriented-hemoperfusion-and-routine-hemoperfusion-combined-with-continuous-venovenous-hemofiltration-for-paraquat-poisoning
#16
Xuming Zhao, Yan Xiao, Jianliang Zhu, Zhiping Xu, Lijun Liu, Jinsong Zhang
Objective To investigate the impact of goal-oriented hemoperfusion (HP) with monitoring of the paraquat concentration on the prognosis of patients with acute paraquat poisoning. Methods This prospective observational study involved patients with acute paraquat poisoning admitted from March 2012 to September 2015. The patients received either goal-oriented or routine HP. All other treatments were the same between the two groups. The primary endpoint was 28-day mortality after poisoning. The secondary endpoints were the incidence of organ dysfunction within 7 days and 7-day mortality...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29081105/-experimental-study-scavenging-effect-of-paraquat-by-hemoperfusion
#17
Y H Pei, Y Z He, X G Zhang, B S Sun
Objective: To determine the scavenging effect and the change of metabolism of paraquat (PQ) using hemoperfusion (HP) once and twice within 12 hours after intoxication and explore the better scheme of HP. Methods: 18 beagles were randomly divided into 3 groups. Single HP group, Double HP group and Control group. Peripheral veins blood was collected at different times within 48 hours after exposure in each group. Toxin concentration was measured, analyzed and compared among 3 groups. Results: 6 hours after exposure, Single HP group and Double HP group has finished the first HP treatment, and the concentration of PQ was lower than that of the control group, the difference was statistically significant (P<0...
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29066188/early-hemoperfusion-for-emergency-treatment-of-carbamazepine-poisoning
#18
Xiangming Yang, Shiyu Xin, Yajie Zhang, Tiegang Li
OBJECTIVES: To investigate the clinical value of early hemoperfusion (HP) in emergency treatment of carbamazepine (CBZ) poisoning. METHODS: 104 patients with acute CBZ poisoning treated from August 2004 to October 2015 in the Emergency Department were reviewed. Patients were categorized into three groups: group A, who received HP treatment in the Emergency Department; group B, who received HP treatment in the blood purification room; and group C, who did not received HP treatment...
October 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29065861/clinical-effects-of-direct-hemoperfusion-using-a-polymyxin-b-immobilized-fiber-column-in-clinically-amyopathic-dermatomyositis-associated-rapidly-progressive-interstitial-pneumonias
#19
Hiroko Okabayashi, Hidenori Ichiyasu, Sayuri Hirooka, Kimitaka Akaike, Keisuke Kojima, Takayuki Jodai, Yasumiko Sakamoto, Hideharu Ideguchi, Shohei Hamada, Chieko Yoshida, Susumu Hirosako, Shinichiro Okamoto, Hirotsugu Kohrogi
BACKGROUND: Rapidly progressive interstitial pneumonias (RPIPs) associated with clinically amyopathic dermatomyositis (CADM) are highly resistant to therapy and have a poor prognosis. Multimodal therapies, including direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP), have a protective effect on RPIPs. We evaluated the effects of PMX-DHP on CADM-associated RPIPs. METHODS: We retrospectively enrolled 14 patients with CADM-associated RPIPs and acute respiratory failure treated with PMX-DHP, corticosteroids, and immunosuppressive agents...
October 24, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28991050/selective-lps-adsorption-using-polymyxin-b-immobilized-fiber-cartridges-in-sepsis-patients-following-cardiac-surgery
#20
Michael Yaroustovsky, Marina Abramyan, Ekaterina Komardina, Helen Nazarova, Dmitrii Popov, Marina Plyushch, Alina Soldatkina, Ekaterina Rogalskaya
Sepsis remains the leading cause of morbidity and mortality in intensive care units. The extracorporeal therapy in the complex treatment of sepsis seems to be the most promising direction.The aim of this study was to assess the safety and effectiveness of selective endotoxin adsorption on the basis of the analysis of our own experience with the intensive therapy for sepsis in adult cardiac surgical patients. MATERIALS AND METHODS: Our single-center study included 143 patients with sepsis...
October 4, 2017: Shock
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