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https://www.readbyqxmd.com/read/28704509/effects-of-hemoperfusion-and-continuous-renal-replacement-therapy-on-patient-survival-following-paraquat-poisoning
#1
Yadong Wang, Yao Chen, Lu Mao, Guangju Zhao, Guangliang Hong, Mengfang Li, Bin Wu, Xiaorong Chen, Meng Tan, Na Wang, Zhongqiu Lu
Mortality in patients with paraquat (PQ) poisoning is related to plasma PQ levels. Concentrations lower than 5,000 ng/mL are considered critical but curable. This study assessed the effects of hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the survival of PQ-poisoned patients with plasma PQ levels below 5,000ng/mL. We analyzed the records of 164 patients with PQ poisoning who were treated at the First Affiliated Hospital of Wenzhou Medical University in China between January 2011 and May 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28690852/is-polymyxin-b-immobilized-fiber-column-ineffective-for-septic-shock-a-discussion-on-the-press-release-for-euphrates-trial
#2
Toshiaki Iba, Lucy Fowler
The efficacy of polymyxin B-immobilized (PMX) fiber column on septic shock is still under debate. Recently, the result from "Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock (EUPHRATES)" trial has been announced as a press release. According to that report, less than a 5% mortality difference was recognized in the "per protocol population" (n = 244, 31.9 vs. 36.9%) and the decrease was not statistically significant. However, among the patients in refractory shock with a multiple organ dysfunction score of more than 9 and an EAA between 0...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28682903/acute-abrin-poisoning-treated-with-continuous-renal-replacement-therapy-and-hemoperfusion-successfully-a-case-report
#3
Jiliang Huang, Wenbin Zhang, Xin Li, Shufen Feng, Gang Ye, Hongcheng Wei, Xiaobing Gong
RATIONALE: Abrin is a highly toxic protein obtained from the seeds of Abrus precatorius, but poisoning due to ingestion of A precatorius is extremely rare in China. PATIENT CONCERNS: A 16-year-old girl, perfectly healthy before, was admitted to the department of gastroenterology owing to intentional ingestion of 10 crushed A precatorius seeds, with multiple episodes of somnolent and anxious mental status, vomiting, abdominal pain, diarrhea, hematochezia, and hematuria...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28640122/clinical-emergency-treatment-of-68-critical-patients-with-severe-organophosphorus-poisoning-and-prognosis-analysis-after-rescue
#4
Hui Dong, Yi-Bing Weng, Gen-Shen Zhen, Feng-Jie Li, Ai-Chun Jin, Jie Liu
This study reports the clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning, and analyzes the prognosis after rescue.The general data of 68 patients with severe organophosphorus poisoning treated in our hospital were retrospectively analyzed. These patients were divided into 2 groups: treatment group, and control group. Patients in the control group received routine emergency treatment, while patients in the treatment group additionally received hemoperfusion plus hemodialysis on the basis of routine emergency treatment...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28625246/-effects-of-high-flow-hemodialysis-on-the-biomarker-of-myocardium-injury-and-the-cardiac-function-related-records-in-uremia-patients
#5
Ling Tang, Xiaofeng Deng, Qing Dai, Hengfen Xiao, Yue Shu, Min Jiang, Ling Wei, Li Wang
OBJECTIVE: To investigate the effects of high flow hemodialysis (HFHD) on cardiac function in uremia patients. METHODS: A prospective randomized controlled study was conducted. Sixty patients who were diagnosed with uremia, taken maintenance hemodialysis (MHD) and 30 healthy controls admitted to the Second People's Hospital of Guiyang from December 2014 to June 2015 were enrolled. They were randomly divided into two groups: HFHD group (HFHD three times a week) and the routine hemodialysis group (HD group, HD three times a week), with 30 in each group...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28601867/novel-insights-into-the-direct-removal-of-endotoxin-by-polymyxin-b-hemoperfusion
#6
Alexander D Romaschin, Christina V Obiezu-Forster, Hisataka Shoji, David J Klein
AIM: To demonstrate the capacity of polymyxin B-direct hemoperfusion (PMX-DHP) column Toraymyxin® 20R (PMX-20R) in removing endotoxin (LPS) from perfused blood, serum and plasma. METHODS: Endotoxin-spiked bovine serum or plasma was perfused in PMX-20R as per the recommended performance testing protocol. Samples were taken at various time points to assess the amount of endotoxin removed during a 4-h session. In another set of experiments, FITC-labelled LPS (FITC-LPS) was spiked into a pool of human whole blood, followed by perfusion with the spiked blood for 2 h in order to allow FITC-LPS to bind PMX-20R...
June 10, 2017: Blood Purification
https://www.readbyqxmd.com/read/28600615/clinical-study-of-blood-purification-therapy-in-critical-care-in-japan-results-from-the-survey-research-of-the-japan-society-for-blood-purification-in-critical-care-in-2013
#7
Toshiaki Arimura, Masanori Abe, Hidetoshi Shiga, Hiroshi Katayama, Kazo Kaizu, Shigeto Oda
To clarify the clinical status of blood purification therapy (BPT) in critical care in Japan, we conducted a cohort study using data from a nationwide registry of the Japan Society for Blood Purification in Critical Care in 2013. We enrolled 2227 patients treated with BPT (female, 39.1%; mean age, 65.5 ± 12.1 years) in the intensive care units of 43 facilities. Patient characteristics, modes of BPT, and survival rate for each disease were investigated. In total, BPT was performed 3053 times. Continuous renal replacement therapy (CRRT) (57...
June 9, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28597511/successful-treatment-of-enterohemorrhagic-escherichia-coli-induced-acute-encephalopathy-and-hemolytic-uremic-syndrome-with-polymyxin-b-direct-hemoperfusion
#8
Hisashi Kaneda, Masaki Shimizu, Akihiro Yachie
No abstract text is available yet for this article.
June 8, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28592318/potential-survival-benefit-of-polymyxin-b-hemoperfusion-in-patients-with-septic-shock-a-propensity-matched-cohort-study
#9
Yoshihiko Nakamura, Taisuke Kitamura, Fumiaki Kiyomi, Mineji Hayakawa, Kota Hoshino, Yasumasa Kawano, Reiko Yamasaki, Takeshi Nishida, Mariko Mizunuma, Hiroyasu Ishikura
BACKGROUND: The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival of patients with septic shock. METHODS: This was a retrospective, multicenter study conducted on patients treated during a 3-year period. We performed propensity-score analyses of the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study database. The study included data on 1723 patients with septic shock aged 16 years or older...
June 7, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28589262/the-surgical-outcomes-of-lung-cancer-combined-with-interstitial-pneumonia-a-single-institution-report
#10
Daisuke Taniguchi, Naoya Yamasaki, Takuro Miyazaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Go Hatachi, Tomoyuki Kakugawa, Noriho Sakamoto, Hiroshi Mukae, Takeshi Nagayasu
PURPOSE: Several studies have reported that an acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection in patients with non-small cell lung cancer (NSCLC); however, the perioperative management strategy is controversial. METHODS: The data of lung cancer patients at Nagasaki University Hospital from June 1994 to October 2013 were retrospectively reviewed. RESULTS: Among all 1701 NSCLC patients who underwent lung resection, 59 (3...
June 6, 2017: Surgery Today
https://www.readbyqxmd.com/read/28554260/efficacy-of-direct-hemoperfusion-using-polymyxin-b-immobilized-fiber-column-pmx-dhp-in-rapidly-progressive-interstitial-pneumonias-results-of-a-historical-control-study-and-a-review-of-previous-studies
#11
Hidenori Ichiyasu, Yuko Horio, Aiko Masunaga, Yohei Migiyama, Yasumiko Sakamoto, Takayuki Jodai, Hideharu Ideguchi, Hiroko Okabayashi, Shohei Hamada, Chieko Yoshida, Susumu Hirosako, Shinichiro Okamoto, Hirotsugu Kohrogi
BACKGROUND: Direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) therapy has been approved for sepsis-associated acute respiratory distress syndrome, but its efficacy for other rapidly progressive interstitial pneumonias (RPIPs) is unclear. The purpose of this study was to examine the efficacy of PMX-DHP therapy for acute respiratory failure in patients with RPIPs, when compared with a historical control receiving conventional treatment without PMX-DHP. METHODS: This study comprised 77 patients with RPIPs in our institute between January 2002 and December 2015...
July 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28551515/hexanediamine-functionalized-poly-glycidyl-methacrylate-co-n-vinylpyrrolidone-particles-for-bilirubin-removal
#12
Xing Jiang, Dongxu Zhou, Xueliang Huang, Weifeng Zhao, Changsheng Zhao
In this study, we provided a facile method to prepare adsorbents with high content of amino groups for bilirubin removal. Poly (glycidyl methacrylate-co-N-vinylpyrrolidone) particle adsorbents were prepared through free radical solution copolymerization followed by a phase inversion technique. Amino groups were further introduced onto the particles by grafting 1,6-hexanediamine molecules. The porosity and specific surface area of the functional particles were 92.9% and 11.8m(2)/g, respectively. Flourier transform infrared spectroscopy and elemental analysis confirmed the successful functionalization of polymeric particles...
May 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28543432/clinically-amyopathic-dermatomyositis-with-rapidly-progressive-interstitial-pneumonia-the-relation-between-the-disease-activity-and-the-serum-interleukin-6-level
#13
Hazuki Yasuda, Takaharu Ikeda, Yasuhito Hamaguchi, Fukumi Furukawa
A 67-year-old woman exhibited chilblain-like erythema on the bilateral auricles, erythema with hyperkeratosis on the sides of fingers and the bilateral elbows, and erythema on the extensor/flexor sides of the finger joints and the iliac regions. Fine crackles were audible on the dorsal side of the bilateral lower lung regions. We diagnosed clinically amyopathic dermatomyositis accompanied by rapidly progressive interstitial pneumonia. While we initiated immunosuppressive therapy, the respiratory failure showed no responses...
May 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28535518/extracorporeal-sorbent-technologies-basic-concepts-and-clinical-application
#14
William R Clark, Fiorenza Ferrari, Gaetano La Manna, Claudio Ronco
Limitations imposed by the characteristics of some solutes and the structure of dialysis membranes have spurred new interest in the use of mechanisms beyond diffusion and convection for extracorporeal solute removal. Sorbents have been utilized for more than 50 years in extracorporeal blood treatments for specific purposes, and better understanding of their basic aspects may further expand the potential for their clinical application. In this chapter, the basic principles applying to sorbents are discussed, including composition and structure, along with the fundamental mechanisms of solute removal...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28525670/hemoadsorption-treatment-of-patients-with-acute-infective-endocarditis-during-surgery-with-cardiopulmonary-bypass-a-case-series
#15
Karl Träger, Christian Skrabal, Guenther Fischer, Thomas Datzmann, Janpeter Schroeder, Daniel Fritzler, Jan Hartmann, Andreas Liebold, Helmut Reinelt
INTRODUCTION: Infective endocarditis is a serious disease condition. Depending on the causative microorganism and clinical symptoms, cardiac surgery and valve replacement may be needed, posing additional risks to patients who may simultaneously suffer from septic shock. The combination of surgery bacterial spreadout and artificial cardiopulmonary bypass (CPB) surfaces results in a release of key inflammatory mediators leading to an overshooting systemic hyperinflammatory state frequently associated with compromised hemodynamic and organ function...
May 29, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28521219/antifouling-zwitterionic-hydrogel-coating-improves-hemocompatibility-of-activated-carbon-hemoadsorbent
#16
Nana Cai, Qingsi Li, Jiamin Zhang, Tong Xu, Weiqiang Zhao, Jing Yang, Lei Zhang
Activated carbon has been widely used in hemoperfusion treatments. However, its performance has been significantly compromised by their poor hemocompatibility. In this work, we developed a novel antifouling adsorbent based on zwitterionic poly-carboxybetaine (PCB) hydrogel and powdered activated carbon (PAC) to improve hemocompatibility. We found this new adsorbent (PCB-PAC) was highly stable with negligible leakage of activated carbon debris. It could efficiently resist protein adsorption and avoid any hemolysis effect...
October 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28501124/effects-of-endotoxin-absorber-hemoperfusion-on-microcirculation-in-septic-pigs
#17
Yu-Chang Yeh, Linda Chia-Hui Yu, Chun-Yu Wu, Ya-Jung Cheng, Chen-Tse Lee, Wei-Zen Sun, Jui-Chang Tsai, Tzu-Yu Lin
BACKGROUND: Endotoxins contribute to systemic inflammatory response and microcirculatory dysfunctions under conditions of sepsis. Polymyxin B hemoperfusion (PMX-HP) is used to remove circulating endotoxins and improve clinical outcomes. This study aims to investigate the effect of PMX-HP on microcirculation in septic pigs. MATERIALS AND METHODS: By using a septic pig model, we tested the hypothesis that PMX-HP can correct intestinal microcirculation, tissue oxygenation saturation, and histopathologic alterations...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28498064/polydopamine-polyethyleneimine-complex-adhered-to-micrometer-sized-magnetic-carbon-fibers-for-high-efficiency-hemoperfusion
#18
Rui-Lin Liu, Yan Wang, Xian-Li Ge, Pei Yu, Hui-Qin Liu, Ming-Chan Wang, Wen Lu, Qiang Fu
Carbon-based nanomaterials have recently attracted tremendous attention in adsorption, separation and biological fields. However, such modification is not always straightforward when the surface is not chemically reactive. Given this reason, most carbon materials modification processes employ reactive linkers or coupling agents, which are complicated and time-consuming. Herein, we report on a dopamine-polyethyleneimine (PEI) coating strategy to fabricate micrometer-sized magnetic carbon fiber (MSMCF)-based extracorporeal blood-cleansing sorbent for hemoperfusion...
May 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28455110/-combination-of-hemodialysis-and-hemofiltration-in-severe-caffeine-intoxication
#19
Eugénie Colin-Benoit, Raymond Friolet, Marco Rusca, Daniel Teta, Niels Gobin
A 21-year-old man ingested 75g of pure caffeine, in an attempt to commit suicide. This represents 7.5 times the minimal lethal dose. Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet. Mechanisms of action are dose-dependent. When caffeine overdosing occurs, neurologic, cardiovascular and renal systems are mainly affected...
May 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28445237/effects-of-polymyxin-b-hemoperfusion-on-mortality-in-patients-with-severe-sepsis-and-septic-shock-a-systemic-review-meta-analysis-update-and-disease-severity-subgroup-meta-analysis
#20
Tzu Chang, Yu-Kang Tu, Chen-Tse Lee, Anne Chao, Chi-Hsiang Huang, Ming-Jiuh Wang, Yu-Chang Yeh
OBJECTIVE: Several studies have reported a survival benefit for polymyxin B hemoperfusion treatment in patients with severe sepsis and septic shock. However, recently, a propensity-matched analysis and a randomized controlled trial reported no survival benefit for polymyxin B hemoperfusion treatment. We performed an up-to-date meta-analysis to determine the effect of polymyxin B hemoperfusion treatment on mortality in patients with severe sepsis and septic shock. DATA SOURCES: PubMed, Embase, and Cochrane Library were searched from inception to May 2016...
August 2017: Critical Care Medicine
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