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https://www.readbyqxmd.com/read/30510764/diffuse-pulmonary-lymphangiomatosis-treated-with-bevacizumab
#1
Ernest Onyeforo, Adrian Barnett, Debbie Zagami, David Deller, Iain Feather
Diffuse pulmonary lymphangiomatosis (DPL) is a rare disease caused by uncontrolled lymphatic vessel proliferation resulting in respiratory dysfunction. Lymphatic vessel growth is influenced by vascular endothelial growth factor (VEGF). It has been shown that bevacizumab, a monoclonal antibody to VEGF type A, may be helpful in treating diseases characterized by excessive vessel proliferation. We report the case of a 51-year-old man with DPL treated with 1 mg/kg bevacizumab every three weeks for 6 months. A significant improvement in lung infiltrates was seen on post-treatment computed tomography (CT) chest with a 17...
January 2019: Respirology Case Reports
https://www.readbyqxmd.com/read/30509655/computational-study-of-photo-thermal-ablation-of-large-blood-vessel-embedded-tumor-using-localized-injection-of-gold-nanoshells
#2
Abhijit Paul, Anup Paul
Attaining a precise necrosis of tumor sparing normal tissue during carcinomas thermo-therapy via nominally invasive scheme like irradiation of laser is a recent challenge. In this study, a combined diffusion and convective energy equations were solved using COMSOL Multiphysics to predict the tissue thermal profile during laser assisted thermo-therapy with different tissue vascular networks. A comparative analysis between intratumoral and intravenous loading scheme of silica-gold nanoshells (AuNs) was also performed...
December 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/30465068/population-and-culture-age-influence-the-microbiome-profiles-of-house-dust-mites
#3
Jan Hubert, Marta Nesvorna, Jan Kopecky, Tomas Erban, Pavel Klimov
Interactions with microorganisms might enable house dust mites (HDMs) to derive nutrients from difficult-to-digest structural proteins and to flourish in human houses. We tested this hypothesis by investigating the effects of changes in the mite culture growth and population of two HDM species on HDM microbiome composition and fitness. Growing cultures of laboratory and industrial allergen-producing populations of Dermatophagoides farinae (DFL and DFT, respectively) and Dermatophagoides pteronyssinus (DPL and DPT, respectively) were sampled at four time points...
November 21, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/30401642/denervated-mouse-dentate-granule-cells-adjust-their-excitatory-but-not-inhibitory-synapses-following-in-vitro-entorhinal-cortex-lesion
#4
Maximilian Lenz, Christos Galanis, Dimitrios Kleidonas, Meike Fellenz, Thomas Deller, Andreas Vlachos
Neurons adjust their synaptic strength in a homeostatic manner following changes in network activity and connectivity. While this form of plasticity has been studied in detail for excitatory synapses, homeostatic plasticity of inhibitory synapses remains not well-understood. In the present study, we employed entorhinal cortex lesion (ECL) of organotypic entorhino-hippocampal tissue cultures to test for homeostatic changes in GABAergic neurotransmission onto partially denervated dentate granule cells. Using single and paired whole-cell patch-clamp recordings, as well as immunostainings for synaptic markers, we find that excitatory synaptic strength is robustly increased 3 days post lesion (dpl), whereas GABAergic neurotransmission is not changed after denervation...
October 25, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/30305029/bio-efficacy-of-indigenous-biological-agents-and-selected-fungicides-against-branch-canker-disease-of-macrophoma-theicola-tea-under-field-level
#5
Mareeswaran Jeyaraman, Premkumar Samuel Asir Robert
BACKGROUND: Branch canker caused by Macrophoma theicola is a major stem disease of tea plants (Camellia spp.). In tea plantations, this disease causes crop loss and it is one of the major limiting factor for yield stagnation. In very few instances it causes considerable damage in new clearings (about 3 or 4 years old) and large number of bushes have been killed. As there is no control measures for branch canker disease in south Indian tea plantation, this field study was conducted in naturally infected pruned tea field at UPASI Tea Research Institute (Good Agricultural Practice), Valparai, Tamil Nadu, India...
October 10, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/30245060/global-collaboration-to-modernize-advanced-trauma-life-support-training
#6
Shalin G Gala, Marie L Crandall
BACKGROUND: Each year, thousands of surgeons and other trauma health care providers participate in the American College of Surgeon's Advanced Trauma Life Support (ATLS) program, which historically has allowed trainees to practice cricothyroidotomy, chest tube insertion, pericardiocentesis, venous cutdown, and diagnostic peritoneal lavage on live dogs, pigs, sheep, and goats. However, more than 99% of ATLS programs in the United States and Canada have now ended animal use, driven primarily by simulation technology advancements...
September 20, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/30189065/blunt-abdominal-trauma-splenectomy-and-post-splenectomy-vaccination
#7
Zsolt Stockinger, Daniel Grabo, Avi Benov, Homer Tien, Jason Seery, Ashley Humphries
Unlike penetrating abdominal injuries where the decision to operate is relatively straight forward, those combat casualties that sustain blunt abdominal trauma offer more of a diagnostic and clinical challenge. For unstable patients with a positive focused abdominal sonography in trauma or diagnostic peritoneal lavage, exploratory laparotomy should be undertaken immediately. All grade IV-V splenic injuries should undergo splenectomy, patients undergoing attempted splenic salvage should be monitored in the Role 3 facility and embolization of such splenic injuries may be considered if available...
September 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/30096934/epithelial-mesenchymal-transition-with-malignant-transformation-leading-multiple-metastasis-from-disseminated-peritoneal-leiomyomatosis
#8
Hsiao-Chen Chiu, Meng-Yu Wu, Chao-Hsu Li, Su-Cheng Huang, Giou-Teng Yiang, Hsuan-Shang Yen, Wei-Lin Liu, Chia-Jung Li, Woei-Yau Kao
Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausal women with a benign course, and it is often found incidentally during abdominal surgery. Malignant transformation is a rare clinical course of DPL. Only a few studies have focused on DPL transformation into a leiomyosarcoma...
August 9, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30088058/disseminated-peritoneal-leiomyomatosis-after-uterine-artery-embolization
#9
Kyle A Batton, Beau B Toskich, Jordan D LeGout, Candice W Bolan, Matthew T Grove, Jason T Lewis, J Mark McKinney, Tara J Brigham, Barbara L McComb
Disseminated peritoneal leiomyomatosis (DPL) is a rare variant of extrauterine leiomyomatosis with reported spontaneous and iatrogenic occurrences. It has been associated with hysterectomy and myomectomy. To our knowledge, reports have not yet substantiated occurrence following uterine artery embolization (UAE), which has become a routine minimally invasive alternative to surgery for the treatment of symptomatic leiomyomata. This report presents the case of a nulliparous premenopausal woman with no other contributory history who presented with DPL 3 years after UAE...
August 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29925816/a-new-method-of-high-precision-positioning-for-an-indoor-pseudolite-without-using-the-known-point-initialization
#10
Yinzhi Zhao, Peng Zhang, Jiming Guo, Xin Li, Jinling Wang, Fei Yang, Xinzhe Wang
Due to the great influence of multipath effect, noise, clock and error on pseudorange, the carrier phase double difference equation is widely used in high-precision indoor pseudolite positioning. The initial position is determined mostly by the known point initialization (KPI) method, and then the ambiguities can be fixed with the LAMBDA method. In this paper, a new method without using the KPI to achieve high-precision indoor pseudolite positioning is proposed. The initial coordinates can be quickly obtained to meet the accuracy requirement of the indoor LAMBDA method...
June 20, 2018: Sensors
https://www.readbyqxmd.com/read/29758641/evaluation-of-temperature-history-of-a-spherical-nanosystem-irradiated-with-various-short-pulse-laser-sources
#11
Arnab Lahiri, Pranab K Mondal
Spatiotemporal thermal response and characteristics of net entropy production rate of a gold nanosphere (radius: 50-200 nm), subjected to a short-pulse, femtosecond laser is reported. In order to correctly illustrate the temperature history of laser-metal interaction(s) at picoseconds transient with a comprehensive single temperature definition in macroscale and to further understand how the thermophysical response of the single-phase lag (SPL) and dual-phase lag (DPL) frameworks (with various lag-ratios') differs, governing energy equations derived from these benchmark non-Fourier frameworks are numerically solved and thermodynamic assessment under both the classical irreversible thermodynamics (CIT) as well as extended irreversible thermodynamics (EIT) frameworks is subsequently carried out...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29722034/surviving-in-the-urban-rural-interface-feeding-and-ranging-behavior-of-brown-howlers-alouatta-guariba-clamitans-in-an-urban-fragment-in-southern-brazil
#12
Fabiana M Corrêa, Óscar M Chaves, Rodrigo C Printes, Helena P Romanowski
Wild primates that live in urban areas face extreme threats that are less frequent in nonurban fragments, such as the presence of dangerous matrix elements (e.g., roads, power lines, buildings, and a high density of domestic dogs near food patches), that could influence their movements, feeding behavior, and survival. However, the scarcity of studies addressing this issue hinders our understanding of the behavioral adjustments that favor the survival of primates in urban areas. For 12 months, we studied a six-individual group of brown howlers (Alouatta guariba clamitans) in an urban fragment to determine (i) their diet richness and its relationships with food availability, (ii) their daily path length (DPL) and the matrix elements used during movement, and (iii) the main ecological drivers of the DPL...
June 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29695611/gsk-3-promotes-s-phase-entry-and-progression-in-c-elegans-germline-stem-cells-to-maintain-tissue-output
#13
Tokiko Furuta, Hyoe-Jin Joo, Kenneth A Trimmer, Shin-Yu Chen, Swathi Arur
Adult C. elegans germline stem cells (GSCs) and mouse embryonic stem cells (mESCs) exhibit a non-canonical cell cycle structure with an abbreviated G1 phase and phase-independent expression of Cdk2 and cyclin E. Mechanisms that promote the abbreviated cell cycle remain unknown, as do the consequences of not maintaining an abbreviated cell cycle in these tissues. In GSCs, we discovered that loss of gsk-3 results in reduced GSC proliferation without changes in differentiation or responsiveness to GLP-1/Notch signaling...
May 14, 2018: Development
https://www.readbyqxmd.com/read/29663136/memory-retrieval-induced-activation-of-adult-born-neurons-generated-in-response-to-damage-to-the-dentate-gyrus
#14
Andrea Aguilar-Arredondo, Angélica Zepeda
The dentate gyrus (DG) is a neurogenic structure that exhibits functional and structural reorganization after injury. Neurogenesis and functional recovery occur after brain damage, and the possible relation between both processes is a matter of study. We explored whether neurogenesis and the activation of new neurons correlated with DG recovery over time. We induced a DG lesion in young adult rats through the intrahippocampal injection of kainic acid and analyzed functional recovery and the activation of new neurons after animals performed a contextual fear memory task (CFM) or a control spatial exploratory task...
July 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29620425/disseminated-peritoneal-leiomyomatosis-dpl-a-case-report
#15
Alexander Gehring, Bernd Gerber, Claudia Tolla-Jensen, Reiko Wiessner
No abstract text is available yet for this article.
April 5, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29461130/treatment-of-facial-telangiectasia-with-narrow-band-intense-pulsed-light-in-chinese-patients
#16
Huihui Gan, Baishuang Yue, Yan Wang, Zhong Lu
OBJECTIVE: To evaluate the efficacy and safety of narrow-band intense pulsed light (DPL) in treating facial telangiectasia. METHOD: Thirty patients with facial telangiectasia underwent five sessions of treatment with DPL (500 nm~600 nm) at 4-week interval. The erythema index (EI), temperature, transepidermal water loss (TEWL), and lightness of the skin (L) were measured before each treatment session and at each follow-up. RESULT: Thirty cases completed treatment and follow-ups...
February 20, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29372723/dendritic-phospholipid-based-drug-delivery-systems
#17
Lei Jiang, Weizhi Chen, Sensen Zhou, Cheng Li, Xiaoke Zhang, Wei Wu, Xiqun Jiang
A class of new dendritic phospholipid compounds with different hydrophilic dendritic poly(l-lysine) peripheries from generations 1 (G1) to 3 (G3) (DPL-1 to DPL-3) were synthesised and nano-drug delivery systems based on these compounds were prepared (DPN-2 and DPN-3). DPL-1 couldn't self-assemble into nanocarriers. The size, TEM image, and the CD spectrum of DPN-2 and DPN-3 were experimentally examined. The effect of the peripheral structure of dendritic phospholipid-based nanocarriers on their biological performance and drug delivery efficiency was studied...
March 26, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29248554/induced-mutation-analysis-with-biochemical-and-molecular-characterization-of-high-yielding-lentil-mutant-lines
#18
Rafiul Amin Laskar, Amaj Ahmed Laskar, Aamir Raina, Samiullah Khan, Hina Younus
Induced mutagenesis generates macromolecular variations which ultimately alters the bio-physiological and morphological nature of the crop genotypes. In the present study, molecular characterization of six high yielding lentil mutant lines, developed from hydrazine hydrates (HZ) and gamma rays mutagenesis, was carried out with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and random amplified polymorphic DNA (RAPD) markers. Activity of nitrate reductase (NR) and content of chlorophyll and carotenoid were found to be significantly high in the mutant lines...
April 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29245295/lymphangiomatosis-involving-the-pulmonary-and-extrapulmonary-lymph-nodes-and-surrounding-soft-tissue-a-rare-case-report
#19
Xuhua Fang, Ziling Huang, Yu Zeng, Xuyou Zhu, Siqi Wang, Xiaoting Yu, Xian Li, Chunyan Wu, Xianghua Yi
BACKGROUND: Diffuse pulmonary lymphangiomatosis (DPL) mainly affects the lung and pleura. There are very few pathological reports of lung damage accompanied by diffuse involvement of the extrapulmonary lymph nodes and surrounding soft tissue. The clinicopathological significance of coexistence of pulmonary and extrapulmonary lesions is unknown. METHODS: Here, we report a 16-year-old male patient. The pathological specimens of the supraclavicular lymph node and soft tissue together with the lung biopsy were analyzed by pathological observation and immunohistochemical staining...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29175126/immunolocalization-of-connective-tissue-growth-factor-transforming-growth-factor-beta1-and-phosphorylated-smad2-3-during-the-postnatal-tooth-development-and-formation-of-junctional-epithelium
#20
Shubo Li, Yihuai Pan
Connective tissue growth factor (CTGF) is a downstream mediator of transforming growth factor-beta 1 (TGF-β1 ) and TGF-β1 -induced CTGF expression is regulated through SMAD pathway. However, there is no literature showing the expression of TGF-β1 -SMAD2/3-CTGF signaling pathway during postnatal tooth development and the formation of junctional epithelium (JE). Hence, we aimed to analyze the localization of TGF-β1 , CTGF and phosphorylated SMAD2/3 (p-SMAD2/3) in the developing postnatal rat molars. Wistar rats were killed at postnatal (PN) 0...
March 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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