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Aline Teixeira Mendes, Paula Barcellos da Silva, Bruna Barcelos Só, Lina Naomi Hashizume, Rodrigo Ricci Vivan, Ricardo Abreu da Rosa, Marco Antonio Húngaro Duarte, Marcus Vinícius Reis Só
This study aimed to evaluate the physicochemical properties of a calcium silicate-based sealer (Sealer Plus BC; MK Life, Porto Alegre, Brazil) compared with an epoxy-resin sealer (AH Plus; Dentsply DeTrey GmbH, Konstanz, Germany). Initial and final setting time was assessed based on ISO 6876:2012 and ASTM C266:03. Calcium ion release and pH were evaluated by filling polyethylene tubes with sealers and then immersing them in 10 mL of deionized water. Following experimental periods of 1, 24, 72 and 168 hours, the samples were measured regarding pH and calcium ion release with a pH meter and a colorimetric spectrophotometer, respectively...
November 2018: Brazilian Dental Journal
Camila Pauleski Zucuni, Luis Felipe Guilardi, Marilia Pivetta Rippe, Gabriel Kalil Rocha Pereira, Luiz Felipe Valandro
It evaluated the effect of aging by Low Temperature Degradation (LTD), executed after post- processing surface treatments (polishing, heat treatment and glazing), on the surface characteristics (micromorphology and roughness) and on the structural stability (phase transformation and mechanical behavior-flexural strength and structural reliability) of a ground yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) ceramic. Discs of Y-TZP (VITA In-Ceram YZ) were manufactured (ISO:6872-2015; 15 mm in diameter and 1...
September 2018: Brazilian Dental Journal
Chu-Jin Ruan, Xiao-Wei Zheng, Jian Wang, Lei Song, Ya-Xin Zhu, Wen-Bin Du, Zu-Jun Lu, Ying Huang, Li Huang, Xin Dai
A novel aerobic, Gram-stain-negative bacterium, designated strain 2ED5T , was isolated from a deep seawater sample in the north-west Indian Ocean. Cells of the strain were oval- to rod-shaped, and motile by a polar flagellum or sessile by a prostheca. The strain formed creamy white colonies on 2216E marine agar plates. It grew at 10-40 °C (optimum 28 °C) and pH 5.0-8.0 (optimum pH 6.0-7.0). The strain required 1-6 % (w/v) NaCl for growth and grew optimally in the presence of 2-3 % NaCl. Phylogenetic analysis based on the 16S rRNA gene sequence showed that strain 2ED5T was affiliated with the genus Hyphobacterium in the family Hyphomonadaceae of the class Alphaproteobacteria, sharing 95...
December 2018: International Journal of Systematic and Evolutionary Microbiology
Malgorzata Pawlaczyk-Luszczynska, Adam Dudarewicz, Małgorzata Zamojska-Daniszewska, Kamil Zaborowski, Paulina Rutkowska-Kaczmarek
Introduction: The overall objective of the study was to assess noise exposure and audiometric hearing threshold levels (HTLs) in call center operators. Materials and Methods: Standard pure-tone audiometry and extended high-frequency audiometry were performed in 78 participants, aged 19 to 44 years (mean ± standard deviation: 28.1 ± 6.3 years), employed up to 12 years (2.7 ± 2.9 years) at one call center. All participants were also inquired about their communication headset usage habits, hearing-related symptoms, and risk factors for noise-induced hearing loss (NIHL)...
September 2018: Noise & Health
Amy Inji Chang, Young Kon Kim, Ji Hye Min, Jisun Lee, Honsoul Kim, Soon Jin Lee
PURPOSE: To determine the differential features of inflammatory myofibroblastic tumor (IMT) and intrahepatic cholangiocarcinoma (ICC) manifesting as target appearance on gadoxetic acid-enhanced MRI. METHODS: Twenty-seven patients with 36 IMTs (1.2-6.0 cm) and 34 patients with 34 ICCs (1.5-6.0 cm) who underwent gadoxetic acid-enhanced MRI were enrolled in this study. Two reviewers evaluated morphology, signal intensity, and enhancement features of tumors on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and gadoxetic acid-enhanced imaging...
December 4, 2018: Abdominal Radiology
Gulsah Gundogdu, Yavuz Dodurga, Levent Elmas, Seymanur Yilmaz Tasci, Esen Sezen Karaoglan
Objective: Isoorientin (ISO) is a flavonoid compound extracted from plant species. The goal of this study was to determine the potential antiproliferative effects of ISO in HT-29 human colorectal adenocarcinoma cell line in vitro , specifically on cell viability, apoptosis, and cell cycle pathways. Materials and Methods: The cytotoxic effect of ISO isolated from E. spectabilis was measured using 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay in HT-29 cell lines...
October 2018: Eurasian Journal of Medicine
Joana Beigbeder, Lata Soccalingame, Didier Perrin, Jean-Charles Bénézet, Anne Bergeret
Biocomposites has gained increasing attention in recent years. The environmental impacts of end-of-life (EoL) treatments of those emerging materials should be evaluated before they are produced and installed commercially, to ensure a minimal impact of these products all along their life cycle. Life cycle assessment (LCA) was carried out to evaluate environmental impacts of the EoL treatments of wood flour (WF) reinforced polypropylene (PP/WF) and flax fibers reinforced polylactic acid (PLA/Fl). The aim was to evaluate which EoL was the most environmental friendly to manage those emerging wastes in France and to help stakeholders of the waste sectors in their decisions...
January 2019: Waste Management
Gokhan Zengin, Marcello Locatelli, Claudio Ferrante, Luigi Menghini, Giustino Orlando, Luigi Brunetti, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Lidia Leporini, Muhammad Zakariyyah Aumeeruddy, Mohamad Fawzi Mahomoodally
This study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2 O2 )-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-α and interleukin (IL)-6 gene expression in rat colon specimens...
December 5, 2018: International Journal of Environmental Health Research
Paola Simeone, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Maria Teresa Guagnano, Armando Tartaro, Riccardo C Bonadonna, Virginia Federico, Francesco Cipollone, Agostino Consoli, Francesca Santilli
Thromboxane (TX)-dependent platelet activation and lipid peroxidation, as reflected in vivo by the urinary excretion of 11-dehydro-TXB₂ and 8-iso-prostaglandin (PG)F2α , play a key role in atherothrombosis in obesity and type 2 diabetes mellitus (T2DM) since the earlier stages. Thirty-five metformin-treated obese subjects with prediabetes or newly-diagnosed T2DM were randomized to the glucagon-like peptide receptor agonist (GLP-RA) liraglutide (1.8 mg/day) or lifestyle counseling until achieving a comparable weight loss (-7% of initial body weight), to assess whether changes in subcutaneous (SAT) and visceral (VAT) adipose tissue distribution (MRI), insulin sensitivity (Matsuda Index) and beta-cell performance (multiple sampling OGTT beta-index), with either intervention, might affect TX-dependent platelet activation, lipid peroxidation and inflammation...
December 2, 2018: Nutrients
Tomislav Portada, Davor Margetić, Vjekoslav Štrukil
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates...
November 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xue Feng, David D Ackerly, Todd E Dawson, Stefano Manzoni, Blair McLaughlin, Robert P Skelton, Giulia Vico, Andrew P Weitz, Sally E Thompson
Despite the appeal of the iso/anisohydric framework for classifying plant drought responses, recent studies have shown that such classifications can be strongly affected by a plantꞋs environment. Here we present measured in-situ drought responses to demonstrate that apparent isohydricity can be conflated with environmental conditions that vary over space and time. In particular, we (1) use data from an oak species (Quercus douglasii) during the 2012 - 2015 extreme drought in California to demonstrate how temporal and spatial variability in the environment can influence plant water potential dynamics, masking the role of traits, (2) explain how these environmental variations might arise from climatic, topographic, and edaphic variability, (3) illustrate, through a "common garden" thought experiment, how existing trait-based or response-based isohydricity metrics can be confounded by these environmental variations, leading to Type-1 (false positive) and Type-2 (false negative) errors, and (4) advocate for the use of model-based approaches for formulating alternate classification schemes...
December 4, 2018: Plant, Cell & Environment
James Robertson, Catherine Yoshida, Simone Gurnik, Madison McGrogan, Kristin Davis, Gitanjali Arya, Stephanie A Murphy, Anil Nichani, John H E Nash
Previously we developed and tested the Salmonella GenoSerotyping Array (SGSA), which utilized oligonucleotide probes for O- and H- antigen biomarkers to perform accurate molecular serotyping of 57 Salmonella serotypes. Here we describe the development and validation of the ISO 17025 accredited second version of the SGSA (SGSA v. 2) with reliable and unambiguous molecular serotyping results for 112 serotypes of Salmonella which were verified both in silico and in vitro. Improvements included an expansion of the probe sets along with a new classifier tool for prediction of individual antigens and overall serotype from the array probe intensity results...
2018: PloS One
Claudia Ziegler Acemyan, Philip Kortum, Michael D Byrne, Dan S Wallach
BACKGROUND: From the project's inception, STAR-Vote was intended to be one of the first usable, end-to-end (e2e) voting systems with sophisticated security. To realize STAR-Vote, computer security experts, statistical auditors, human factors (HF)/human-computer interaction (HCI) researchers, and election officials collaborated throughout the project and relied upon a user-centered, iterative design and development process, which included human factors research and usability testing, to make certain the system would be both usable and secure...
December 4, 2018: Human Factors
Marc Thelen, Florent Vanstapel, Pika Meško Brguljan, Bernard Gouget, Guilaine Boursier, Edward Barrett, Christos Kroupis, Maria Lohmander, Luděk Šprongl, Tatjana Vodnik, Francisco Bernabeu-Andreu, Ines Vukasović, Çiğdem Sönmez, Solveig Linko, Duilio Brugnoni, Michel Vaubourdolle, Willem Huisman, Mauro Panteghini
ISO15189:2012 requires medical laboratories to document metrological traceability of their results. While the ISO17511:2003 standard on metrological traceability in laboratory medicine requires the use of the highest available level in the traceability chain, it recognizes that for many measurands there is no reference above the manufacturer's selected measurement procedure and the manufacturer's working calibrator. Some immunoassays, although they intend to measure the same quantity and may even refer to the same reference material, unfortunately produce different results because of differences in analytical selectivity as manufacturers select different epitopes and antibodies for the same analyte...
December 4, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Li Tuo, Xiao-Rui Yan, Fei-Na Li, Chao Yang, Ming-Biao An, Cheng-Hang Sun
A Gram-stain-positive, aerobic, short-rod-shaped, non-spore-forming actinobacterial strain, designated M8JJ-5T , was isolated from a surface-sterilized bark of Neriumindicum Mill. collected from Guizhou, China, and investigated by a polyphasic approach to determine its taxonomic position. Strain M8JJ-5T grew optimally without NaCl at 28 °C and at pH 7.0-8.0. Substrate mycelia and aerial mycelia were not formed, and no diffusible pigments were observed on the media tested. Phylogenetic analysis based on the 16S rRNA gene sequence showed that strain M8JJ-5T was most closely related to the type strains of genus Amnibacterium, and shared highest 16S rRNA gene sequence similarity of 97...
December 4, 2018: International Journal of Systematic and Evolutionary Microbiology
Eric Morignat, Emilie Gay, Jean-Luc Vinard, Carole Sala, Didier Calavas, Viviane Hénaux
Although heat and cold temperatures are known to have an impact on cattle mortality, no study has evidenced and quantified the influence of the prolonged exposure to extreme temperatures beyond the single effect of daily temperatures. We defined a heat (or cold) wave by a continuous variable indicating the number of successive days with temperatures above (or below) a given threshold. For heat wave, the threshold was set to the 95th or 99th percentile of the mean daily temperature distribution and for cold wave to the 1st or 5th percentile...
December 2018: Journal of Thermal Biology
Lina Abdouni, Ammar Olabi, Omar Obeid
Postprandial energy expenditure (PEE) is largely dependent on ATP production, which is may be affected by phosphorus (P) availability. Proteins are known to have high levels of P and induce high levels of PEE. This study aimed at assessing the effect of P in PEE of normal and high protein meals. A single-blind randomized crossover study was conducted with two groups of 12 healthy lean male subjects who received iso-caloric (554 Kcal) meals. Group1: normal protein (NPr) meal with or without P (500 mg) and group 2: high protein (HPr) meal with or without P (500 mg), on two visits separated by a minimum of 1-week washout period...
December 2018: Journal of Thermal Biology
Arun Kumaran Anguraj Vadivel, Kevin Krysiak, Gang Tian, Sangeeta Dhaubhadel
BACKGROUND: Soybean is a paleopolyploid that has undergone two whole genome duplication events. Gene duplication is a type of genomic change that can lead to novel functions of pre-existing genes. Chalcone synthase (CHS) is the plant-specific type III polyketide synthase that catalyzes the first committed step in (iso)flavonoid biosynthesis in plants. RESULTS: Here we performed a genome-wide search of CHS genes in soybean, and identified 21 GmCHS loci containing 14 unique GmCHS (GmCHS1-GmCHS14) that included 5 newly identified GmCHSs (GmCHS10-GmCHS14)...
December 4, 2018: BMC Plant Biology
Kazuomi Kario, Satoshi Hoshide, Kimiyo Saito, Keiko Sato, Haruna Hamasaki, Hiromi Suwa, Naoko Tomitani
OBJECTIVE: The aim of this study was to validate the TM-2441 ambulatory blood pressure monitoring (ABPM) device using the ISO 81060-2:2013 standard. PARTICIPANTS AND METHODS: Participants were healthy individuals aged more than 12 years who were recruited from among the outpatients and volunteers of Jichi Medical University (Tochigi, Japan). The same-arm sequence protocol (clinical validation) and the opposite-limb simultaneous method (ambulatory validation) from the ISO 81060-2:2013 standard were used...
November 29, 2018: Blood Pressure Monitoring
Kateryna Ohui, Eleonora Afanasenko, Felix Bacher, Rachel Lim Xue Ting, Ayesha Zafar, Nuria Blanco-Cabra, Eduard Torrents, Orsolya Domotor, Nora V May, Denisa Darvasiova, Eva A Enyedy, Ana D Popović-Bijelić, Johannes Reynisson, Peter Rapta, Maria Babak, Giorgia Pastorin, Vladimir B Arion
Six morpholine-(iso)thiosemicarbazone hybrids HL1‒HL6 and their copper(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized. Copper(II) complexes [Cu(L1‒6)Cl] (1‒6) formed weak dimeric associates in the solid state, which did not remain intact in solution as evidenced by ESI-MS. The lead proligands and copper(II) complexes displayed higher antiproliferative activity in cancer cells than Triapine. In addition, complexes 2‒5 were found to specifically inhibit the growth of Gram-positive bacteria S...
December 3, 2018: Journal of Medicinal Chemistry
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