Giulia Pericoli, Angela Galardi, Alessandro Paolini, Lucia Lisa Petrilli, Gerardo Pepe, Alessandro Palma, Marta Colletti, Roberta Ferretti, Ezio Giorda, Stefano Levi Mortera, Anna Burford, Andrea Carai, Angela Mastronuzzi, Alan Mackay, Lorenza Putignani, Chris Jones, Luisa Pascucci, Hector Peinado, Manuela Helmer-Citterich, Emmanuel de Billy, Andrea Masotti, Franco Locatelli, Angela Di Giannatale, Maria Vinci
BACKGROUND: Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-populations co-existing within the same tumour mass. We have previously shown that primary patient-derived and optical barcoded single-cell-derived clones function as interconnected networks. Here, we investigated the role of exosomes as a route for inter-clonal communication mediating PDHGG migration and invasion. RESULTS: A comprehensive characterisation of seven optical barcoded single-cell-derived clones obtained from two patient-derived cell lines was performed...
November 13, 2023: Cell & Bioscience