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(Neuropathic Pain)

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https://www.readbyqxmd.com/read/30334198/different-pain-states-of-trigeminal-neuralgia-make-significant-changes-in-the-plasma-proteome-and-some-biochemical-parameters-a-preliminary-cohort-study
#1
Asghar Farajzadeh, S Zahra Bathaie, Jalil Arabkheradmand, Seyed Mohammad Ghodsi, Soghrat Faghihzadeh
Trigeminal neuralgia (TN) with chronic and severe neuropathic pain leads to remarkable interference in daily living activities of patients. Unknown molecular mechanisms involved in TN pathophysiology are a challenge for complete treatment of the disease. The present study was conducted to investigate changes in the plasma proteome beside biochemical parameters, including calcitonin gene-related peptide (CGRP), nitric oxide (NO), amino acids, and vitamin D (Vit D) in different pain states in TN patients. Plasma samples were obtained from the control group (#13) and patients with purely paroxysmal type of classical TN (#13) before and after microvascular decompression (MVD)...
October 17, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/30333753/neurosteroids-in-pain-management-a-new-perspective-on-an-old-player
#2
REVIEW
Sonja L Joksimovic, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic
Since the discovery of the nervous system's ability to produce steroid hormones, numerous studies have demonstrated their importance in modulating neuronal excitability. These central effects are mostly mediated through different ligand-gated receptor systems such as GABAA and NMDA, as well as voltage-dependent Ca2+ or K+ channels. Because these targets are also implicated in transmission of sensory information, it is not surprising that numerous studies have shown the analgesic properties of neurosteroids in various pain models...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30328411/characterization-of-small-fiber-pathology-in-a-mouse-model-of-fabry-disease
#3
Lukas Hofmann, Dorothea Hose, Anne Grießhammer, Robert Blum, Frank Döring, Sulayman Dib-Hajj, Stephen Waxman, Claudia Sommer, Erhard Wischmeyer, Nurcan Üçeyler
Fabry disease (FD) is a life-threatening X-linked lysosomal storage disorder caused by α-galactosidase A (α-GAL) deficiency. Small fiber pathology and pain are major FD symptoms of unknown pathophysiology. α-GAL deficient mice (GLA KO) age-dependently accumulate globotriaosylceramide (Gb3) in dorsal root ganglion (DRG) neurons paralleled by endoplasmic stress and apoptosis as contributors to skin denervation. Old GLA KO mice show increased TRPV1 protein in DRG neurons and heat hypersensitivity upon i.pl...
October 17, 2018: ELife
https://www.readbyqxmd.com/read/30328377/beneficial-effects-of-electroacupuncture-on-neuropathic-pain-evoked-by-spinal-cord-injury-and-involvement-of-pi3k-mtor-mechanisms
#4
Yujie Wang, Yu Zhao, Xiaohui Ma, Jing Li, Junling Hou, Xiaohong Lv
The purpose of this study was to examine the beneficial effects of electroacupuncture (EA) on neuropathic pain evoked by spinal cord injury (SCI) and determine the underlying molecular mechanisms of these effects. SCI was induced in rats. Behavioral tests were performed to examine pain responses induced by mechanical and thermal stimulation. Western blot analysis was used to measure the protein expression of phosphorylated mammalian target of rapamycin (p-mTOR), mTOR-mediated phosphorylated ribosomal protein S6 kinase beta-1 (p-S6K1), and phosphorylated eukaryotic translation initiation factor 4E-binding protein 1 (p-4E-BP1) in the superficial dorsal horn of the spinal cord...
October 17, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/30327740/intraoperative-local-administration-of-platelet-rich-plasma-prp-during-neurolysis-surgery-for-the-treatment-of-digital-nerve-crush-injury
#5
Akira Ikumi, Yuki Hara, Eriko Okano, Sho Kohyama, Norihito Arai, Yu Taniguchi, Hisashi Sugaya, Tomokazu Yoshioka, Akihiro Kanamori, Masashi Yamazaki
The digital nerves are important for normal hand function. In addition to conventional therapies such as neurolysis, direct repair, and auto/allografts, new treatments administering growth factors and cells for promoting nerve regeneration exist. Platelet-rich plasma (PRP), an autologous product with proven therapeutic effects for musculoskeletal disorders, is a new treatment option for peripheral nerve injury. We hypothesized that PRP could stimulate healing of digital nerve injuries. In the current case report, intraoperative local administration of PRP was performed during neurolysis surgery for a healthy 28-year-old woman with digital nerve crush injury...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/30327606/preclinical-and-clinical-pharmacology-of-hydrocodone-for-chronic-pain-a-mini-review
#6
Luigi Cardia, Gioacchino Calapai, Domenico Quattrone, Cristina Mondello, Vincenzo Arcoraci, Fabrizio Calapai, Carmen Mannucci, Epifanio Mondello
Hydrocodone is one of the most prescribed oral analgesic drugs and it is one of the most abused drugs in general population. It is a mu-opioid agonist predominantly metabolized to the O-demethylated product hydromorphone and to the N-demethylated product norhydrocodone. The purpose of the study is to summarize the preclinical and clinical characteristics of hydrocodone. Pharmacokinetic aspect (terminal half-life, maximum serum concentration, and time to maximum serum concentration) of hydrocodone and the influence of metabolic genetic polymorphism in analgesic response to hydrocodone are also illustrated and commented...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30327427/re1-silencing-transcription-factor-controls-the-acute-to-chronic-neuropathic-pain-transition-and-chrm2-receptor-gene-expression-in-primary-sensory-neurons
#7
Jixiang Zhang, Shao-Rui Chen, Hong Chen, Hui-Lin Pan
Neuropathic pain is associated with persistent changes in gene expression in primary sensory neurons, but the underlying epigenetic mechanisms that cause these changes remain unclear. The muscarinic cholinergic receptors (mAChRs), particularly the M2 subtype (encoded by the cholinergic receptor muscarinic 2 [Chrm2] gene), are critically involved in the regulation of spinal nociceptive transmission. However, little is known about how Chrm2 expression is transcriptionally regulated. Here we show that nerve injury persistently increased the expression of RE1-silencing transcription factor (REST, also known as neuron-restrictive silencing factor [NRSF]), a gene-silencing transcription factor, in the dorsal root ganglion (DRG)...
October 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30326045/humanized-3f8-anti-gd2-monoclonal-antibody-dosing-with-granulocyte-macrophage-colony-stimulating-factor-in-patients-with-resistant-neuroblastoma-a-phase-1-clinical-trial
#8
Brian H Kushner, Irene Y Cheung, Shakeel Modak, Ellen M Basu, Stephen S Roberts, Nai-Kong Cheung
Importance: Chimeric and murine anti-GD2 antibodies are active against neuroblastoma, but the development of neutralizing antibodies can compromise efficacy. To decrease immunogenicity, hu3F8, a humanized anti-GD2 antibody, was constructed. Objective: To find the maximum-tolerated dose of hu3F8 with granulocyte-macrophage colony-stimulating factor. Design, Setting, and Participants: This phase 1 clinical trial used a 3 + 3 dose-escalation design in a single referral center (Memorial Sloan Kettering Cancer Center, New York, New York)...
September 20, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/30325872/dopamine-receptor-d2-but-not-d1-mediates-descending-dopaminergic-pathway-produced-analgesic-effect-in-a-trigeminal-neuropathic-pain-mouse-model
#9
Sufang Liu, Yuanyuan Tang, Hui Shu, Delton Tatum, Qian Bai, Joshua Crawford, Ying Xing, Mary Kay Lobo, Larry Bellinger, Phillip Kramer, Feng Tao
Neuropathic pain represents a challenge to clinicians, because it is resistant to commonly prescribed analgesics due to its largely unknown mechanisms. Here, we investigated a descending dopaminergic pathway-mediated modulation of trigeminal neuropathic pain. We performed chronic constriction injury of the infraorbital nerve from the maxillary branch of trigeminal nerve to induce trigeminal neuropathic pain in mice. Our retrograde tracing showed that the descending dopaminergic projection from hypothalamic A11 nucleus to spinal trigeminal nucleus caudalis is bilateral...
October 11, 2018: Pain
https://www.readbyqxmd.com/read/30325723/rapamycin-alleviates-proinflammatory-cytokines-and-nociceptive-behavior-induced-by-chemotherapeutic-paclitaxel
#10
Xiaoli Zhang, Nan Jiang, Jing Li, Dongyan Zhang, Xiaohong Lv
BACKGROUND/AIMS: Paclitaxel is largely used as a chemotherapeutic agent for the treatment of several types of cancers. However, one of the significant limiting complications of paclitaxel is painful peripheral neuropathy during its therapy. The purposes of this study were to examine (1) the effects of blocking mammalian target of rapamycin (mTOR) on mechanical and thermal hypersensitivity evoked by paclitaxel; and (2) the underlying mechanisms responsible for the role of mTOR in regulating paclitaxel-induced neuropathic pain...
October 16, 2018: Neurological Research
https://www.readbyqxmd.com/read/30324862/-express-cancer-pain-and-neuropathic-pain-are-associated-with-a%C3%AE-sensory-neuronal-plasticity-in-dorsal-root-ganglia-and-abnormal-sprouting-in-lumbar-spinal-cord
#11
Yong Fang Zhu, Jacek M Kwiecien, Wojciech Dabrowski, Robert Ungard, Kan Lun Zhu, Jan D Huizinga, James L Henry, Gurmit Singh
Evidence suggests that there are both nociceptive and neuropathic components of cancer-induced pain (CIP). We have observed that changes in intrinsic membrane properties and excitability of normally non-nociceptive Aβ sensory neurons are consistent in rat models of peripheral neuropathic pain (NEP) and CIP. This has prompted a comparative investigation of the intracellular electrophysiological characteristics of sensory neurons and of the ultrastructural morphology of the dorsal horn in rat models of NEP and CIP...
October 16, 2018: Molecular Pain
https://www.readbyqxmd.com/read/30324850/-express-pain-related-white-matter-tract-abnormalities-in-mtbi-patients-with-headache
#12
Albert Leung, Eric Yang, Michael Lim, Valerie Metzger-Smith, Rebecca Theilmann, David Song, Lisa Lin, Alice Tsai, Roland Lee
The occurrence of debilitating chronic persistent (24/7) headache after mild traumatic brain injury (MTBI) represents a central neuropathic pain state. Previous studies suggest that this chronic headache (HA) state can be attributed to altered supraspinal modulatory functional connectivity in both resting and evoked pain states. Abnormalities in the myelin sheaths along the supraspinal Superior Longitudinal Fasciculus (SLF) and Anterior Thalamic Radiation (ATR) are frequently associated with alteration in pain modulation related to functional connectivity deficit with the prefrontal cortex...
October 16, 2018: Molecular Pain
https://www.readbyqxmd.com/read/30324846/moving-toward-a-better-understanding-of-the-experience-and-measurement-of-breastfeeding-related-pain
#13
Kimberley T Jackson, Sheila O'Keefe-McCarthy, Tara Mantler
PURPOSE: Despite how commonly breastfeeding-related pain is experienced in the postpartum period, and its frequent implication in breastfeeding cessation, this unique type of pain is not well evaluated nor assessed. The purpose of this study was to gain a comprehensive description and understanding of breastfeeding-related pain among postpartum breastfeeding women. METHODS: This study employed a mixed methods approach using a descriptive-interpretive qualitative approach, in addition to administering the Short-Form McGill Pain Questionnaire, second version, to comprehensively gain both quantitative and qualitative descriptors of breastfeeding-related pain...
October 16, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/30324167/precipitating-events-in-child-and-adolescent-chronic-musculoskeletal-pain
#14
Andrew J Becker, Lauren C Heathcote, Inge Timmers, Laura E Simons
Introduction: The epidemiology of chronic pain in youth has been increasingly documented over the past decade. However, the precipitating events associated with the onset of pediatric chronic pain are not well studied. Objectives: Understanding the events that precede the onset of pain, and are reported by patients as germane to the early stages of their pain, may add one piece to the puzzle of the causal etiology of pediatric chronic pain disorders. Methods: We conducted a retrospective chart review of 320 young people attending a tertiary care chronic pain clinic with musculoskeletal chronic pain...
September 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/30324076/autologous-fat-transfer-as-a-treatment-for-peripheral-neuropathic-pain-without-apparent-cause
#15
Jip Beugels, Juliette E Hommes, Andrea J R Balthasar, René R W J van der Hulst, Andrzej A Piatkowski de Grzymala
Neuropathic pain has a far-reaching effect on the daily lives of patients. Recently, autologous fat transfer (AFT) has demonstrated promising results in patients with painful scars or after neuroma excision. However, there is a subgroup of patients who do not show any apparent cause for the pain. We hypothesized that in these patients, AFT alone in the area around the affected nerve might lead to beneficial results. Patients with clearly demarcated neuropathic pain and who had exhausted all other treatment options were referred by a pain specialist...
August 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/30322590/non-pharmacological-treatment-for-neuropathic-pain-invasive-and-non-invasive-cortical-stimulation
#16
REVIEW
X Moisset, J-P Lefaucheur
The use of medications in chronic neuropathic pain may be limited with regard to efficacy and tolerance. Therefore, non-pharmacological approaches, using electrical stimulation of the cortex has been proposed as an alternative. First, in the early nineties, surgically-implanted epidural motor cortex stimulation (EMCS) was proven to be effective to relieve refractory neuropathic pain. Later, non-invasive stimulation techniques were found to produce similar analgesic effects, at least by means of repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (M1)...
October 12, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/30322252/-post-decompressive-neuropathy-new-onset-post-laminectomy-lower-extremity-neuropathic-pain-different-from-the-preoperative-complaint
#17
Lorraine A T Boakye, Mitchell S Fourman, Nicholas T Spina, Dann Laudermilch, Joon Y Lee
Study Design: Level III retrospective cross-sectional study. Purpose: To define and characterize the presentation, symptom duration, and patient/surgical risk factors associated with 'postdecompressive neuropathy (PDN).' Overview of Literature: PDN is characterized by lower extremity radicular pain that is 'different' from pre-surgical radiculopathy or claudication pain. Although it is a common constellation of postoperative symptoms, PDN is incompletely characterized and poorly understood...
October 16, 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/30321532/lysophosphatidic-acid-and-its-receptor-lpa-1-mediate-carrageenan-induced-inflammatory-pain-in-mice
#18
Malavika Srikanth, Wee Siong Chew, Tatsuma Hind, Siew Mon Lim, Nicholas Wei Jie Hay, Jasmine Hui Min Lee, Rich Rivera, Jerold Chun, Wei-Yi Ong, Deron R Herr
Lysophosphatidic acid receptor 1 (LPA1 ) is one of six G protein-coupled receptors (GPCRs) activated by the bioactive lipid, lysophosphatidic acid (LPA). Previous studies have shown that LPA1 signaling plays a major role in the pathophysiology of neuropathic pain. It has also been shown that the inhibition of phospholipase A2 , an enzyme upstream of LPA synthesis, reduces mechanical allodynia in experimental inflammatory orofacial pain. This suggests that the LPA-LPA1 axis may mediate inflammatory pain in addition to its known role in neuropathic pain, but this activity has not been reported...
October 12, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30321415/chronic-neuropathic-pain-induces-dna-methylation-changes-in-the-dorsal-root-ganglion
#19
Kevin T Huang, David L Penn, John H Chi
No abstract text is available yet for this article.
November 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30320933/prevalence-and-cost-analysis-of-chronic-pain-after-hernia-repair-a-potential-alternative-approach-with-neurostimulation
#20
Aladine A Elsamadicy, Bilal Ashraf, Xinru Ren, Amanda R Sergesketter, Lefko Charalambous, Hanna Kemeny, Tiffany Ejikeme, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Theodore N Pappas, Shivanand P Lad
OBJECTIVES: Chronic pain (CP) affects a significant number of patients following hernia repair, ranging from 11 to 54% in the literature. The aim of this study was to assess the prevalence, overall costs, and health care utilization associated with CP after hernia repair. MATERIALS AND METHODS: A retrospective longitudinal study was performed using the Truven MarketScan® data base to identify patients who develop chronic neuropathic posthernia repair pain from 2001 to 2012...
October 15, 2018: Neuromodulation: Journal of the International Neuromodulation Society
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