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Hypoxic ischemic encephalopathy in newborn

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https://www.readbyqxmd.com/read/30506331/extracting-interesting-rules-from-gestation-course-data-for-early-diagnosis-of-neonatal-hypoxia
#1
Inna Skarga-Bandurova, Tetiana Biloborodova, Maksym Nesterov
The topic of neonatal hypoxia is of paramount importance to anyone who cares during pregnancy and childbirth. Modern medicine associates this pathology with severe problems in the prenatal period. Underlying diseases of the mother during pregnancy, her anamnesis of life are the leading causes of complications in the newborn. Nevertheless, patterns of fetal hypoxia and neonatal hypoxia, as well as mechanisms of hypoxic-ischemic encephalopathy in newborns, remains poorly known and require further research. This study is focused on finding risk factors related to the chronic fetal hypoxia and defining a group of signs for diagnosing neonatal hypoxia...
December 1, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/30473896/another-case-of-multilevel-cervical-disconnection-syndrome-presenting-as-neonatal-encephalopathy
#2
Kaylan M Brady, Jonathan A Blau, Spencer J Serras, Jeremy T Neuman, Richard Sidlow
Multilevel cervical disconnection syndrome (MCDS) is a rare malformation of the cervical spine previously documented in two toddlers. We present a case of a newborn first thought to have hypoxic-ischemic encephalopathy who was subsequently diagnosed with MCDS. The possibility of in utero presentation of the syndrome in this patient and the categorization of this syndrome in the spectrum of basilar skull/upper cervical malformation syndromes is discussed.
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/30468796/neuroprotection-by-cannabidiol-and-hypothermia-in-a-piglet-model-of-newborn-hypoxic-ischemic-brain-damage
#3
Lorena Barata, Luis Arruza, Maria-José Rodríguez, Esther Aleo, Eva Vierge, Enrique Criado, Elena Sobrino, Carlos Vargas, María Ceprián, Ana Gutiérrez-Rodríguez, William Hind, José Martínez-Orgado
OBJECTIVE: Hypothermia, the gold standard after a hypoxic-ischemic insult, is not beneficial in all treated newborns. Cannabidiol is neuroprotective in animal models of newborn hypoxic-ischemic encephalopathy. This study compared the relative efficacies of cannabidiol and hypothermia in newborn hypoxic-ischemic piglets and assessed whether addition of cannabidiol augments hypothermic neuroprotection. METHODS: One day-old HI (carotid clamp and FiO2 10% for 20 min) piglets were randomized to vehicle or cannabidiol 1 mg/kg i...
November 20, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/30449222/intrapartum-cardiotocography-with-and-without-computer-analysis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
Marta Campanile, Pietro D'Alessandro, Luigi Della Corte, Gabriele Saccone, Salvatore Tagliaferri, Bruno Arduino, Giuseppina Esposito, Francesca Giovanna Esposito, Antonio Raffone, Maria Gabriella Signorini, Giovanni Magenes, Mariarosaria Di Tommaso, Serena Xodo, Fulvio Zullo, Vincenzo Berghella
OBJECTIVE: To evaluate whether intrapartum cardiotocography with computer analysis decreases the incidence of newborn metabolic acidosis or obstetric intervention when compared with visual analysis through a systematic review with meta-analysis of randomized controlled trials. METHODS: The research was conducted using Medline, Embase, Web of Science, Scopus, ClinicalTrial.gov, Ovid and Cochrane Library as electronic databases from the inception of each database to May 2018...
November 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30447810/neonatal-encephalopathy-current-management-and-future-trends
#5
REVIEW
Elizabeth A Schump
It is well-documented in the literature that infants who suffer from hypoxic ischemic encephalopathy are at high risk for neurologic sequelae or even death. With the addition of therapeutic hypothermia into the treatment regimen for neonatal hypoxic ischemic encephalopathy, newborns afflicted with hypoxic ischemic encephalopathy were given the opportunity for a better outcome. Questions linger as to the most optimal treatment strategy of therapeutic hypothermia for these newborns. The goal of this article is to discuss current management strategies, as well as future trends, for infants with hypoxic ischemic encephalopathy...
December 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/30417430/major-concerns-about-late-hypothermia-study
#6
Lars Walløe, Nils Lid Hjort, Marianne Thoresen
No abstract text is available yet for this article.
November 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30382869/symptomatic-seizures-in-preterm-newborns-a-review-on-clinical-features-and-prognosis
#7
REVIEW
Carlotta Spagnoli, Raffaele Falsaperla, Michela Deolmi, Giovanni Corsello, Francesco Pisani
Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular haemorrhage, hypoxic-ischemic encephalopathy, central nervous system infections and transient metabolic derangements.Current definition of neonatal seizures requires detection of paroxysmal EEG-changes, and in preterm newborns the incidence of electrographic-only seizures seems to be particularly high, further stressing the crucial role of electroencephalogram monitoring in this population...
November 1, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/30373414/seizures-in-newborn-infants-without-hypoxic-ischemic-encephalopathy-antenatal-and-labor-related-risk-factors-a-case-control-study
#8
Olle Malmqvist, Andreas Ohlin, Johan Ågren, Maria Jonsson
OBJECTIVE: To identify antepartum and intrapartum risk factors for neonatal seizures in the absence of hypoxic ischemic encephalopathy (HIE). METHODS: Population-based case-control study. Of 98 484 births, 40 newborns at 34 gestational weeks or later had seizures within the first 7 days of life. Cases (n = 40) and controls (n = 160) were retrieved from the University hospitals of Örebro for 1994-2013 and Uppsala for 2003-2013. Demographics and characteristics of pregnancy, labor, delivery, and neonatal data were analyzed...
October 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30296665/a-comparison-of-levetiracetam-and-phenobarbital-for-the-treatment-of-neonatal-seizures-associated-with-hypoxic-ischemic-encephalopathy
#9
Lekha M Rao, Shaun A Hussain, Timothy Zaki, Alexander Cho, Teresa Chanlaw, Meena Garg, Raman Sankar
PURPOSE: Seizures are common in term infants with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia. Although phenobarbital (PHB) is generally considered first-line therapy, some centers have embraced third-generation antiepileptic drugs (AEDs) such as levetiracetam (LEV) given the impression of comparable efficacy and superior tolerability. We set out to compare the efficacy of PHB and LEV in a large single-center cohort. METHODS: We retrospectively identified consecutive newborns with HIE who were monitored with continuous video-electroencephalogram (VEEG) for the duration of therapeutic hypothermia...
November 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30282782/variation-in-use-by-nicu-types-in-the-united-states
#10
Erika M Edwards, Jeffrey D Horbar
: media-1vid110.1542/5828370139001PEDS-VA_2018-0457 Video Abstract BACKGROUND: Increased admissions of higher birth weight and less acutely ill infants to NICUs suggests that intensive care may be used inappropriately in these populations. We describe variation in use of NICU services by gestational age and NICU type. METHODS: Using the Vermont Oxford Network database of all NICU admissions, we assessed variation within predefined gestational age categories in the following proportions: admissions, initial NICU hospitalization days, high-acuity cases ≥34 weeks' gestation, and short-stay cases ≥34 weeks' gestation...
November 2018: Pediatrics
https://www.readbyqxmd.com/read/30280069/subcutaneous-fat-necrosis-and-hypercalcemia-after-therapeutic-hypothermia-in-patients-with-hypoxic-ischemic-encephalopathy-a-case-series
#11
Sourabh Verma, Sean M Bailey, Pradeep V Mally, Elena V Wachtel
Therapeutic hypothermia (TH) is provided to newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE) to improve survival and long-term neurodevelopmental outcomes. Although the benefits certainly outweigh the risks associated with therapeutic hypothermia, it is important to be mindful of potential rare side effects in the background of asphyxia-related injury to various body organs. One of those side effects includes subcutaneous fat necrosis (SCFN) that can occur in term newborns after perinatal hypoxia-ischemia or other stressing factors such as systemic hypothermia...
July 30, 2018: Curēus
https://www.readbyqxmd.com/read/30255158/oleoylethanolamide-and-palmitoylethanolamide-protect-cultured-cortical-neurons-against-hypoxia
#12
Manuel Portavella, Nieves Rodriguez-Espinosa, Pablo Galeano, Eduardo Blanco, Juan I Romero, Mariana I Holubiec, Fernando Rodriguez de Fonseca, Emilio Fernández-Espejo
Introduction: Perinatal hypoxic-ischemic (HI) encephalopathy is defined as a neurological syndrome where the newborn suffers from acute ischemia and hypoxia during the perinatal period. New therapies are needed. The acylethanolamides, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), possess neuroprotective properties, and they could be effective against perinatal HI. These lipid mediators act through peroxisome proliferator-activated receptors subtype α (PPARα), or transient receptor potential vanilloid (TRPV), such as TRPV subtype 1 and 4...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/30225791/evaluation-of-3k3a-activated-protein-c-to-treat-neonatal-hypoxic-ischemic-brain-injury-in-the-spiny-mouse
#13
Stacey J Ellery, Madeleine G Goss, Nadine Brew, Hayley Dickinson, Nadia Hale, Domenic A LaRosa, David W Walker, Flora Y Wong
Neonatal hypoxic ischemic encephalopathy (HIE) resulting from intrapartum asphyxia is a global problem that causes severe disabilities and up to 1 million deaths annually. A variant form of activated protein C, 3K3A-APC, has cytoprotective properties that attenuate brain injury in models of adult stroke. In this study, we compared the ability of 3K3A-APC and APC (wild-type (wt)) to attenuate neonatal brain injury, using the spiny mouse (Acomys cahirinus) model of intrapartum asphyxia. Pups were delivered at 38 days of gestation (term = 39 days), with an intrapartum hypoxic insult of 7...
September 17, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/30221657/huwe1-is-a-novel-mediator-of-protection-of-neural-progenitor-l2-3-cells-against-oxygen%C3%A2-glucose-deprivation-injury
#14
Xiaoqin Jiang, Jiyun Yang, Hedong Li, Yi Qu, Wenming Xu, Haiyan Yu, Yu Tong
Hypoxic‑ischemic encephalopathy is one of the most notable causes of brain injury in newborns. Cerebral ischemia and reperfusion lead to neuronal damage and neurological disability. In vitro and in vivo analyses have indicated that E3 ubiquitin protein ligase (Huwe1) is important for the process of neurogenesis during brain development; however, the exact biological function and the underlying mechanism of Huwe1 remain controversial. In the present study, neural progenitor cells, L2.3, of which we previously generated from rat E14...
September 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30199363/-neonatal-hypoxic-ischemic-encephalopathy
#15
Oscar Papazian
Hypoxic-ischemic encephalopathy is a clearly recognizable clinical syndrome of in term newborns due to fetal asphyxia at birth. The incidence is 1.5 (95% CI 1.3 to 1.7) but it ranges from 1-8 and 25 out of every 1000 born in developed and developing countries, respectively. The most frequent causes are detachment of the placenta, prolapse of the umbilical cord and uterine rupture. The diagnostic criteria include partial or total incapacity for the newborn to cry and breath at birth even when stimulated, requiring assisted ventilation in the delivery room, Apgar < 5 in 5 and 10 minutes, acidemia (pH ≤ 7 and / or bases deficit ≥ 12 mmol/l), alterations of the conscience and the reflexes of Moro, grasping and suction, muscular stretching and muscle tone...
2018: Medicina
https://www.readbyqxmd.com/read/30149778/perinatal-hypoxic-ischemic-brain-injury-in-large-animal-models-relevance-to-human-neonatal-encephalopathy
#16
Raymond C Koehler, Zeng-Jin Yang, Jennifer K Lee, Lee J Martin
Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our understanding of cellular mechanisms of neural injury in developing brain, but have limitations in simulating the range, accuracy, and physiology of clinical hypoxia-ischemia and the relevant systems neuropathology that contribute to the human brain injury pattern. Large animal models of perinatal hypoxia-ischemia, such as partial or complete asphyxia at the time of delivery of fetal monkeys, umbilical cord occlusion and cerebral hypoperfusion at different stages of gestation in fetal sheep, and severe hypoxia and hypoperfusion in newborn piglets, have largely overcome these limitations...
December 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/30149475/transplacental-lidocaine-intoxication
#17
V Demeulemeester, H V Hauthem, F Cools, J Lefevere
Neonatal seizures are frequent in neonatal intensive care and the most common cause is perinatal asphyxia. Among other causes, toxin exposure is rare.We present a boy with an uneventful vaginal birth, who presented one hour after birth with apnea, hypotonia, mydriasis, tongue fasciculation, and tonic seizures. There was no hypoxic ischemic encephalopathy and brain imaging was normal. Toxicology screening revealed a toxic concentration of lidocaine in his blood. The intoxication was transplacental, as a cord blood sample confirmed the toxic level...
August 21, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/30142532/identification-of-a-panel-of-cytokines-in-neonates-with-hypoxic-ischemic-encephalopathy-treated-with-hypothermia
#18
Serafina Perrone, Michael D Weiss, Fabrizio Proietti, Candace Rossignol, Sara Cornacchione, Francesco Bazzini, Marco Calderisi, Giuseppe Buonocore, Mariangela Longini
PURPOSE: Inflammation is a crucial but understudied mechanism of neuronal injury after hypoxia-ischemia. The aim was to identify a panel of cytokines involved in brain injury in neonates with hypoxic ischemic encephalopathy (HIE). METHODS: Ten newborns with HIE undergoing to therapeutic hypothermia (TH, HIE Group) and 8 healthy newborns (CTRL Group) were enrolled. For the HIE group, 5 samples were collected: between 0 and 6 h of life (time 1), 12 h (time 2), 24 h (time 3), 48 h (time 4) and 96 h of life (time 5)...
August 21, 2018: Cytokine
https://www.readbyqxmd.com/read/30130752/predictive-value-of-thompson-score-for-long-term-neurological-and-cognitive-outcome-in-term-newborns-with-perinatal-asphyxia-and-hypoxic-ischemic-encephalopathy-undergoing-controlled-hypothermia-treatment
#19
Marc R Mendler, Ines Mendler, Mohammad A Hassan, Benjamin Mayer, Harald Bode, Helmut D Hummler
BACKGROUND: The so-called Thompson-score (TS) for newborns with hypoxic-ischemic encephalopathy (HIE) was developed before the introduction of controlled hypothermia as clinical routine. Information on the predictive value of TS in newborns undergoing therapeutic hypothermia to estimate long-term outcome is limited. OBJECTIVES: To determine the predictive value of TS to estimate long-term cognitive and neurological outcome in newborns with perinatal asphyxia treated with controlled hypothermia...
2018: Neonatology
https://www.readbyqxmd.com/read/30097625/dose-dependent-reversal-of-kcc2-hypofunction-and-phenobarbital-resistant-neonatal-seizures-by-ana12
#20
B M Carter, B J Sullivan, J R Landers, S D Kadam
Neonatal seizures have an incidence of 3.5 per 1000 newborns; while hypoxic-ischemic encephalopathy (HIE) accounts for 50-60% of cases, half are resistant to 1st-line anti-seizure drugs such as phenobarbital (PB). Tyrosine receptor kinase B (TrkB) activation following ischemic injury is known to increase neuronal excitability by downregulation of K-Cl co-transporter 2 (KCC2); a neuronal chloride (Cl- ) co-transporter. In this study, three graded doses of ANA12, a small-molecule selective TrkB antagonist, were tested in CD1 mice at P7 and P10 following induction of neonatal ischemia by a unilateral carotid ligation...
August 10, 2018: Scientific Reports
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