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Daiane Anzilaggo, André O'Reilly Beringhs, Bianca Ramos Pezzini, Diva Sonaglio, Hellen Karine Stulzer
The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an important role in the dissolution and absorption phenomena. However, many factors can influence the performance and success of LS. Therefore this study aimed to evaluate through a factorial design, the factors such as drug state (solution or dispersion), nonvolatile solvent and coating material that influence the increase simvastatin (BSC II drug) apparent aqueous solubility and LS flow properties...
November 22, 2018: Colloids and Surfaces. B, Biointerfaces
Uwe Niedermayer, Thilo Egenolf, Oliver Boine-Frankenheim, Peter Hommelhoff
The concept of dielectric-laser acceleration provides the highest gradients among breakdown-limited (nonplasma) particle accelerators. However, stable beam transport and staging have not been shown experimentally yet. We present a scheme that confines the beam longitudinally and in one transverse direction. Confinement in the other direction is obtained by a single conventional quadrupole magnet. Within the small aperture of 420 nm we find the matched distributions, which allow an optimized injection into pure transport, bunching, and accelerating structures...
November 23, 2018: Physical Review Letters
Carolina Palomino-Camargo, Yuniesky González-Muñoz, Elevina Pérez-Sira, Victor Hugo Aguilar
This review assesses the Delphi methodology as an expert consulting technique in the area of Public Health, particularly with a focus on food safety management and prevention of foodborne diseases, providing researchers with methodological information for its use. The data was compiled during January-August 2017 in the databases of Scopus, Medline, and Scielo. It was evidenced that, with the technological advances, the method shows an upturn, obtaining results in less time and cost of process, and a greater reach to distant experts, diversifying its applicability in Food Safety and ATS prevention...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Camila Pauleski Zucuni, Luis Felipe Guilardi, Marilia Pivetta Rippe, Gabriel Kalil Rocha Pereira, Luiz Felipe Valandro
It evaluated the effect of aging by Low Temperature Degradation (LTD), executed after post- processing surface treatments (polishing, heat treatment and glazing), on the surface characteristics (micromorphology and roughness) and on the structural stability (phase transformation and mechanical behavior-flexural strength and structural reliability) of a ground yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) ceramic. Discs of Y-TZP (VITA In-Ceram YZ) were manufactured (ISO:6872-2015; 15 mm in diameter and 1...
September 2018: Brazilian Dental Journal
A Liebermann, J Detzer, B Stawarczyk
OBJECTIVES: The aim of this investigation was to test the tensile bond strength (TBS) between different computer-aided-design/manufacturing (CAD/CAM) ceramics after conditioning using different universal adhesive systems and resin composite cement. METHODS AND MATERIALS: Substrates of four CAD/CAM ceramics-1) VITABLOCS Mark II, 2) Initial LRF, 3) Celtra Duo, and 4) IPS e.max CAD (N=648, n=162)-were fabricated. VITABLOCS Mark II and Initial LRF were etched using 9% hydrofluoric acid for 60 seconds, Celtra Duo for 30 seconds, and IPS e...
December 5, 2018: Operative Dentistry
Xinan Zhang, Binghao Wang, Wei Huang, Gang Wang, Weigang Zhu, Zhi Wang, Weifeng Zhang, Antonio Facchetti, Tobin J Marks
Organic semiconductor-insulator blend films are widely explored for high-performance electronic devices enabled by unique phase separation and self-assembly phenomena at key device interfaces. Here we report the first demonstration of high-performance hybrid diodes based on p-n junctions formed by a p-type poly(3-hexylthiophene) (P3HT)-poly(methylmethacrylate) (PMMA) blend and n-type indium-gallium-zinc oxide (IGZO). The thin film morphology, microstructure, and vertical phase separation behavior of the P3HT films with varying contents of PMMA are systematically analyzed...
December 5, 2018: Nano Letters
Randall W Velliquette, Judith Aeschlimann, Julie Kirkegaard, Gayane Shakarian, Christine Lomas-Francis, Connie M Westhoff
BACKGROUND: Anti-CD47 (Hu5F9-G4) is a human monoclonal immunoglobulin G (IgG)4 antibody that is in clinical trials to treat hematologic or solid malignancies. CD47, a glycoprotein expressed on all cells, binds to signal-regulatory protein α on macrophages and regulates phagocytosis. Blocking CD47 is thought to enhance phagocytosis and promote antitumor responses. Here, we evaluate drug interference in pretransfusion testing, determine mitigation strategies, and compare interference with anti-CD38 (Daratumumab)...
December 5, 2018: Transfusion
D Delibashvili, Z Dumbadze, I Krynytska, M Marushchak, H Habor, L Holovatiuk
The use of food additives in food manufacturing has been a public health issue for many years. Currently, more than 3000 food additives have been approved and estimates has shown that each person may consume 3.6 to 4.5 kg of food additives per year on average. One of the most common food additives in Ukraine and in Europe is monosodium glutamate (MSG). This paper reports the effect of monosodium glutamate administration at "safe" (allowed) doses on the generation of reactive oxygen species and apoptosis in leukocyte blood suspension of rats...
October 2018: Georgian Medical News
C J Cooksey
Safranine was one of the earliest coal tar dyes following mauveine. By the end of the 19th century, many alkylated derivatives of safranine had been made. The history, identity, names, manufacture, analysis, toxicity, textile dyeing, and biological staining applications, plus some nonstaining uses of safranine, phenosafranine, methylene violet, amethyst violet, azocarmine, and Magdala red are described here.
December 5, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Rahul Rao, Cary L Pint, Ahmad E Islam, Robert S Weatherup, Stephan Hofmann, Eric R Meshot, Fanqi Wu, Chongwu Zhou, Nicholas Dee, Placidus B Amama, Jennifer Carpena-Nuñez, Wenbo Shi, Desiree L Plata, Evgeni S Penev, Boris I Yakobson, Perla B Balbuena, Christophe Bichara, Don N Futaba, Suguru Noda, Homin Shin, Keun Su Kim, Benoit Simard, Francesca Mirri, Matteo Pasquali, Francesco Fornasiero, Esko I Kauppinen, Michael Arnold, Baratunde A Cola, Pavel Nikolaev, Sivaram Arepalli, Hui-Ming Cheng, Dmitri N Zakharov, Eric A Stach, Jin Zhang, Fei Wei, Mauricio Terrones, David B Geohegan, Benji Maruyama, Shigeo Maruyama, Yan Li, W Wade Adams, A John Hart
Advances in the synthesis and scalable manufacturing of single-walled carbon nanotubes (SWCNTs) remain critical to realizing many important commercial applications. Here we review recent breakthroughs in the synthesis of SWCNTs and highlight key ongoing research areas and challenges. A few key applications that capitalize on the properties of SWCNTs are also reviewed with respect to the recent synthesis breakthroughs and ways in which synthesis science can enable advances in these applications. While the primary focus of this review is on the science framework of SWCNT growth, we draw connections to mechanisms underlying the synthesis of other 1D and 2D materials such as boron nitride nanotubes and graphene...
December 5, 2018: ACS Nano
Vladimir Elisashvili, Eva Kachlishvili, Michael L Chikindas
Spore-forming probiotic bacteria have received a wide and constantly increasing scientific and commercial interest. Among them, Bacillus species are the most studied and well-characterized Gram-positive bacteria. The use of bacilli as probiotic products is expanding especially rapidly due to their inherent ability to form endospores with unique survivability and tolerance to extreme environments and to produce a large number of valuable metabolites coupled with their bio-therapeutic potential demonstrating immune stimulation, antimicrobial activities and competitive exclusion...
December 5, 2018: Probiotics and Antimicrobial Proteins
Kyung-Bok Son
BACKGROUND: Regulatory approval and reimbursement decisions are necessary if new drugs are to become accessible in a timely manner. However, the process of regulatory approval and the establishment of reimbursement decisions varies across countries. This study aims to analyze the duration between regulatory approval and reimbursement decision for new drugs and to evaluate various factors affecting the timely availability of new medicines in the Korean market. The duration was subdivided into regulatory approval-reimbursement application and reimbursement application-reimbursement decision...
December 4, 2018: Health Economics Review
Eric Robinson, Dani Gaillard-Campbell, Thomas P Gross
Background: To date, there have been no published investigations on the cause of acetabular debonding, a rare failure phenomenon in metal-on-metal hip resurfacing where the acetabular porous coating delaminates from the implant while remaining well fixed to the pelvic bone. Purposes: This study aims to summarize the current understanding of acetabular debonding and to investigate the discrepancy in rate of debonding between two implant systems. Patients and Methods: To elucidate potential causes of debonding, we retrospectively analyzed a single-surgeon cohort of 839 hip resurfacing cases...
2018: Advances in Orthopedics
Marcos Renato de Assis, Valdair Pinto
Biological products or biopharmaceuticals are medicinal products derived from living systems and manufactured by modern biotechnological methods that differ widely from the traditional synthetic drugs. Monoclonal antibodies are the most rapidly growing type of biologic. They are much larger and more complex molecules with inherent diversity; therefore, different manufacturers cannot produce identical biological products, even with the same type of host expression system and equivalent technologies. Thus, legal follow-on biologics manufactured and marketed after patent expiration are usually referred to as biosimilars...
December 2018: Therapeutic Advances in Musculoskeletal Disease
Laura A Czerkies, Brian D Kineman, Sarah S Cohen, Heidi Reichert, Ryan S Carvalho
Background: For infants who are partially or exclusively fed infant formula, many options exist with compositional differences between formulas making choices difficult for caregivers and healthcare professionals. The protein in routine infant formulas differs by the source, fraction of cow's milk protein used, and degree of hydrolysis. All commercially available regulated infant formulas support growth and development, but different stool patterns have been observed based on formula composition...
2018: International Journal of Pediatrics
Martin Holtkamp
No abstract text is available yet for this article.
December 4, 2018: Nature Reviews. Neurology
Tianli Yang, Ren He, Guihua Nie, Wenlei Wang, Gui Zhang, Yunchu Hu, Lichao Wu
In this work, carbon quantum dots were first prepared through one-pot hydrothermal route of the propyl aldehyde and sodium hydroxide via an aldol condensation reaction, and a novel solid-phase extraction adsorbent of hollow calcite single crystals was prepared via the precipitation of metal nitrates by the CO2 diffusion method in the presence of CQDs and further applied for excessive Cd(II) ions removal from water. The spectra and morphologies of the etched calcite were investigated by X-ray diffraction, Fourier transform infrared spectrometry, Scanning electron microscope, and Transmission electron microscopy...
December 4, 2018: Scientific Reports
Ping Cao, Haihong Bai, Xinghe Wang, Jinjing Che
MIL77, which has a higher manufacturing capacity than ZMapp, comprises MIL77-1, MIL77-2, and MIL77-3. The mechanisms by which these antibodies inhibit glycoprotein are unclear. Infection by viruses with lipid-bilayer envelopes occurs via the fusion of the viral membrane with the membrane of the target cell. Therefore, the interaction between the antibodies and the EBOV membrane is crucial. We examined the interactions between MIL77 and the viral membrane using SPR. MIL77-1 selectively binds to viral membranes, while MIL77-2 and MIL77-3 do not...
December 4, 2018: Scientific Reports
Sarah E Jackson, Lion Shahab, Robert West, Jamie Brown
OBJECTIVES: Roll-your-own (RYO) cigarettes have become popular in the UK and reduce the cost of smoking, potentially mitigating the impact of tax increases on quitting. We examined whether RYO cigarette use was associated with reduced motivation to quit smoking, incidence of quit attempts and quit success. DESIGN: Cross-sectional survey. SETTING: England. PARTICIPANTS: 38 590 adults who reported currently smoking or having stopped within the past 12 months...
December 4, 2018: BMJ Open
He He, Christian John Reynolds, Zixiang Zhou, Yuan Wang, John Boland
Waste generation is linked to consumption both in households (Final demand) and in the supply chain. Gaining understanding into the driving forces that change of waste generation in the supply chain can contribute to solving issues of waste management. The environmentally-extend input-output model is an effective tool with which to investigate the relationship between economic activities and waste generation. In this paper structural decomposition analysis (SDA) is employed to analyse the determinants of changes of waste generation in Australian economy from 2007-2008 to 2013-2014...
January 2019: Waste Management
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