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Hailong Yin, Ming Xie, Lunyuan Zhang, Jingshui Huang, Zuxin Xu, Huaizheng Li, Renjing Jiang, Rongchang Wang, Xu Zeng
There has been increasing research focusing on the detection and occurrence of wastewater contamination in urban water systems. To find suitable markers to indicate industrial and domestic sewage flows inappropriately entering storm drains, this study investigated the occurrence and fate of 52 chemical markers through wastewater treatment facilities of manufacturers of agricultural and sideline products, beverage products, and pharmaceutical products, which are also consumed in our daily life. Of the 52 candidate markers, sodium, chloride, potassium, isomalto-oligosaccharide, acesulfame, theanine, glycerol, and clarithromycin were found to be conservative markers, with an average change in concentrations through the wastewater treatment processes of <30%...
August 1, 2018: Science of the Total Environment
Mahendra K Sreeramoju, George A Digenis
The purpose of this study was to investigate a potential nucleophilic addition mechanism in aqueous apomorphine formulation solutions in the presence of widely used anti-oxidants such as sodium metabisulfite (Na2 S2 O5 ). The findings of this investigation provide insights into how sodium metabisulfite influence the formation of particulate under the conditions leading to the auto-oxidation of apomorphine to apomorphine orthoquinone. The addition products resulting from the reaction of bisulfite nucleophile on apomorphine orthoquinone in a Michael addition fashion were identified and characterized using UV-visible spectroscopy and mass spectrometry...
August 13, 2018: Journal of Pharmaceutical Sciences
Shixiang Wang, Chifai Cheung, Mingjun Ren, Mingyu Liu
There are still significant challenges in the accurate positioning of optical freeform surfaces on the machine tool and the measurement instrument due to the high accuracy requirement and their complex shapes. This paper proposes a Fiducial-aided On-machine Positioning method (FAOPM) that combines on-machine measurement and off-machine measurement to precisely position optical freeform surfaces during the precision manufacturing cycle including rough machining, fine machining, measurement, and error compensation...
July 23, 2018: Optics Express
Chun-Ying Huang, Chun-Chieh Kang, Yu-Chi Ma, Yu-Cheng Chou, Jian-Huei Ye, Ru-Ting Huang, Chen-Zih Siao, Yu-Ching Lin, Yu-Hao Chang, Ji-Lin Shen, Tai-Yuan Lin
ZnO-based heterojunctions have found applications as self-powered ultraviolet photodetectors (PDs). However, high doping levels are not compatible with high mobility for metallic doped ZnO-based PDs so further development has been inhibited. This study demonstrates a method to increase the open-circuit voltage (Voc) that allows keeping a sufficiently high level of mobility of ZnO, using a ZnO nanorod/GaN heterojunction that incorporates graphene nanosheets as the active layer. These hybrid PDs have triple the value for Voc of PDs that have only pure ZnO and better exhibit photo-response characteristics...
August 16, 2018: Nanotechnology
Marta Ghirardello, Sara Mosca, Javier Marti-Rujas, Luca Nardo, Aviva Burnstock, Austin Nevin, Maria Bondani, Lucia Toniolo, Gianluca Valentini, Daniela Comelli
Recent studies have shown that modern pigments produced after the Second Industrial Revolution are complex systems characterized by a high level of heterogeneities. Therefore, it is fundamental to adopt a multi-analytical approach and highly-sensitive methods to characterize the impurities present within pigments. In this work we propose time-resolved and spectrally-resolved photoluminescence (PL) microscopy for the mapping of luminescent crystal defects and impurities in historical cadmium-based pigments. PL analysis is complemented by X-ray diffraction, X-ray fluorescence, Raman spectroscopies and Scanning Electron Microscopy to determine the chemical composition and crystal structure of samples...
August 16, 2018: Analytical Chemistry
Jaime-Jürgen Eulert-Grehn, Pia Lanmüller, Felix Schönrath, Natalia Solowjowa, Marcus Müller, Johanna Mulzer, Friedrich Kaufmann, Christoph Starck, Thomas Krabatsch, Volkmar Falk, Evgenij Potapov
OBJECTIVES: No continuous-flow right ventricular assist device for long-term support is available at the moment. Two continuous-flow ventricular assist devices used in a continuous-flow biventricular assist device configuration is an emerging option which has proven its feasibility but still is not approved for routine use. We present our technique and results of modifying the left ventricular assist device and making it suitable for right ventricular support. METHODS: Between September 2009 and October 2017, 39 patients received implantation of a continuous-flow ventricular assist device for right ventricular support in a continuous-flow biventricular assist device configuration...
August 2, 2018: Interactive Cardiovascular and Thoracic Surgery
Michael M Bornstein, Andy Wai Kan Yeung, Ray Tanaka, Thomas von Arx, Reinhilde Jacobs, Pek-Lan Khong
The aim of this study was to evaluate the health or pathology of bilateral maxillary sinuses using cone beam computed tomography (CBCT) with a low-dose protocol, and to analyze potential influencing factors. The study included only CBCT scans with complete visualization of bilateral maxillary sinuses. The scans were taken using a medium to large field of view and a low-dose protocol, as indicated by the manufacturer. CBCT images were analyzed with regard to the morphology of the sinus membrane and surrounding bone twice by one observer...
September 2018: International Journal of Periodontics & Restorative Dentistry
Thibaut Merlin, Simon Stute, Didier Benoit, Julien Bert, Thomas Carlier, Claude Comtat, Marina Filipovic, Frederic Lamare, Dimitris Visvikis
In tomographic medical imaging (PET, SPECT, CT), differences in data acquisition and organization are a major hurdle for the development of tomographic reconstruction software. The implementation of a given reconstruction algorithm is usually limited to a specific set of conditions, depending on the modality, the purpose of the study, the input data, or on the characteristics of the reconstruction algorithm itself. It causes restricted or limited use of algorithms, differences in implementation, code duplication, impractical code development, and difficulties for comparing different methods...
August 16, 2018: Physics in Medicine and Biology
Saba Farooqi, K Rajendran, Razia Khanam
Phthalates are used as plasticizers in a wide range of products and are known to affect the human health adversely. Hence the present study was carried out to identify and quantify the presence of 4 phthalates namely dimethyl phthalate (DMP), dibutyl phthalate (DBP), and diethyl phthalate (DEP), di (2-ethylhexyl) phthalate (DEHP) in the 2 baby products i.e baby oils and baby lotions. The daily exposure levels and hazard index of each phthalate was also calculated. It was an analytical study where 2 different brands of samples of baby oil and baby lotion each, from the date of manufacturing of 3, 10 and 20 months were collected...
August 16, 2018: Toxicology Mechanisms and Methods
Seyed Ali Johari, Kirsten Rasmussen, Mary Gulumian, Mahmoud Ghazi-Khansari, Norihisa Tetarazako, Shosaku Kashiwada, Saba Asghari, June Woo Park, Il Je Yu
This paper introduces a new standardized testing procedure for nanomaterial environmental toxicity (International Organization for Standardization/Technical Specification (ISO/TS) 20787): "aquatic toxicity assessment of manufactured nanomaterials in saltwater lakes using Artemia sp. nauplii" intended to generate more reliable and repeatable aquatic toxicity data testing manufactured nanomaterials, using Artemia sp., to evaluate their possible ecotoxicity in saltwater lake ecosystems. The principles behind testing with Artemia sp...
August 16, 2018: Toxicology Mechanisms and Methods
Bianca A M C Santos, Flavia Almada do Carmo, Walkiria Schlindwein, Gordon Muirhead, Carlos Rangel Rodrigues, Lucio M Cabral, Julian Westrup, Kendal Pitt
Screw feeder performance is a critical aspect in continuous manufacturing processes. Pharmaceutical excipients, such as mannitol, microcrystalline cellulose, lactose monohydrate and anhydrous dibasic calcium phosphate can present problems in ensuring a continuous stable feed rate due to their sub-optimal flow properties. In alignment with Quality by Design (QbD) goals, the aim of this work was to identify and explain critical sources of variability of some powder excipients delivery by screw feeding, in particular to continuous processing lines...
August 16, 2018: Drug Development and Industrial Pharmacy
Doaa Taha, Sebastian Spintzyk, Ahmed Sabet, Marwa Wahsh, Tarek Salah
OBJECTIVE: This in vitro study was conducted to assess the marginal adaptation and fracture resistance of computer aided design/computer aided manufacturer (CAD-CAM) fabricated endocrowns restoring endodontically treated molars using different machinable blocks with thermomechanical loading protocols. MATERIALS AND METHODS: Devitalized mandibular molars were prepared in a standardized way and divided into 4 groups (n = 10) to receive CAD/CAM fabricated endocrowns using four materials (Lithium disilicate ceramics, polymer infiltrated ceramics, zirconia-reinforced lithium silicate ceramics and resin nanoceramics...
August 16, 2018: Journal of Esthetic and Restorative Dentistry
Mangmang Zhang, Kun Zheng, Yunming Shen, Zhongkuan Lin, Zheming Li
With the continuous improvement and wide application of hospital information, more and more medical equipment is integrated into the hospital information systems, which brings new work contents and challenges for the traditional clinical engineers. This paper reviews and evaluates the current situation of networked medical equipment in the hospital. By applying the ISO 80001 and the MDS2 (Manufacturer Disclosore Statement for Medical Device Security), the paper puts forward the measures and suggestions for the security management of networked medical equipment...
July 30, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
Zhijin Fan, Neng Xie
This paper summarizes the current research status of 3D printed customized medical devices regulations in US and EU. Based on the discussion of 3D printed customized medical devices in the US and the European Union, some thoughts are put forward from design, manufacturing, testing and other aspects.
July 30, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
Lina Ma, Jigang Bai, Xuemin Liu, Yi Lyu, Xiaopeng Yan
Magnetic anchor technique can reduce the number of trocar in laparoscopic surgery. The laparoscopic magnetic anchor system consists of an external anchor magnet and the magnetic clutch system. Electromagnetic control laparoscopic surgery clutch system includes the internal grasper and the operating forceps. In this design, a permanent magnet is set at the tail of the internal grasper, and an electromagnetic device is installed at the head of the operating forceps. The magnetic field direction of the electromagnetic device can be changed by switching the positive pole and the negative pole of the electromagnetic device, so as to control the separation and combination of the operating forceps and the internal grasper...
July 30, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
Perceval Sondag, Lingmin Zeng, Binbing Yu, Réjane Rousseau, Bruno Boulanger, Harry Yang, Steven Novick
The USP<1032> guidelines recommend the screening of bioassay data for outliers prior to performing a relative potency (RP) analysis. The guidelines, however, do not offer advice on the size or type of outlier that should be removed prior to model fitting and calculation of RP. Computer simulation was used to investigate the consequences of ignoring the USP<1032> guidance to remove outliers. For biotherapeutics and vaccines, outliers in potency data may result in the false acceptance/rejection of a bad/good lot of drug product...
August 15, 2018: Pharmaceutical Statistics
K Ramesh Kumar, V Anbazhagan
Industrialization and extraction of natural resources have resulted in large-scale environmental contamination and pollution. We have collected the soil samples from five different industrial areas of Mettur (Chemplast Sanmar Limited, SIDCO-1, SIDCO-2, SIDCO-3, thermal power plant), Salem district, Tamil Nadu, India, and estimated the physical properties (pH, EC, and alkalinity), chemical properties (major and minor elements), and heavy metal analysis. Thermal power plant soil sample showed higher pH 5.01, EC 29...
August 15, 2018: Environmental Monitoring and Assessment
Mohaddeseh Ramezani, Seyed Masoud Hosseini, Seyed Abolhassan Shahzadeh Fazeli, Mohammad Ali Amozegar, Javad Fakhari
Background and Objectives: The microbial communities of traditional milk-based food are of great importance in its manufacturing process, especially when using raw milk with natural cultures. Liqvan (Lighvan or Levan) is a traditional Iranian buried cheese, which is made from raw ewe's milk without a starter addition. The aim of this study was to explore the fungal active population during this cheese manufacturing process by comparing DNA and RNA based culture independent method Denaturing Gradient Gel Electrophoresis (DGGE)...
June 2018: Iranian Journal of Microbiology
George Michelinakis, Manolis Pavlakis, Dimosthenis Igoumenakis
Rehabilitation of a partially dentate postmaxillectomy patient using a novel approach is presented in this report. The patient was referred to our practice by the oral and maxillofacial surgery department of the local general hospital for the evaluation and prosthetic treatment planning. He had undergone biopsy for a lesion located in the right quadrant of his maxilla and was scheduled for a hemimaxillectomy for removal of a squamous cell carcinoma. A surgical obturator was prepared for placement at the time of ablative surgery...
July 2018: Journal of Indian Prosthodontic Society
Shashikant P Patole, Muhamad F Arif, Rahmat A Susantyoko, Saif Almheiri, S Kumar
A combination of carbon nanotubes (CNT) and graphene in the form of macroscopic hybrid buckypaper (HBP), exhibits a unique set of properties that can be exploited for many emerging applications. Here, we present a simple, inexpensive and scalable approach for the synthesis of highly conductive auxetic graphene/CNT HBP via wet-filtration-zipping and demonstrate the electrical, electrochemical and mechanical performance (tensile, mode I and mode III fracture) of synthesized HBP. An overall increase in electrical conductivity of 247% is observed for HBP (50 wt...
August 15, 2018: Scientific Reports
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