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natural health products

Ioannis J Stavrou, Atalanti Christou, Constantina P Kapnissi-Christodoulou
Carob (Ceratonia Siliqua L., tree of the pea family Fabaceae) and its products have recently attracted great interest due to their polyphenolic composition. This review summarizes the polyphenolic compounds that are contained in different carob parts (leaves, pod, seeds, barks) and products (syrup, flour, fiber). It also states the main differences of polyphenolic composition due to environmental and natural reasons, such as region, variety, and gender, and due to the processes used for preparation, extraction and analysis...
December 15, 2018: Food Chemistry
Regine Eibl, Philipp Meier, Irène Stutz, David Schildberger, Tilo Hühn, Dieter Eibl
The production of drugs, cosmetics, and food which are derived from plant cell and tissue cultures has a long tradition. The emerging trend of manufacturing cosmetics and food products in a natural and sustainable manner has brought a new wave in plant cell culture technology over the past 10 years. More than 50 products based on extracts from plant cell cultures have made their way into the cosmetics industry during this time, whereby the majority is produced with plant cell suspension cultures. In addition, the first plant cell culture-based food supplement ingredients, such as Echigena Plus and Teoside 10, are now produced at production scale...
August 11, 2018: Applied Microbiology and Biotechnology
Nicholas Cummins, Alice Baird, Björn Schuller
Due to the complex and intricate nature associated with their production, the acoustic-prosodic properties of a speech signal are modulated with a range of health related effects. There is an active and growing area of machine learning research in this speech and health domain, focusing on developing paradigms to objectively extract and measure such effects. Concurrently, deep learning is transforming intelligent signal analysis, such that machines are now reaching near human capabilities in a range of recognition and analysis tasks...
August 9, 2018: Methods: a Companion to Methods in Enzymology
Beatriz Martínez, Pilar García, Ana Rodríguez
To move towards a safer and more sustainable food production chain, natural antimicrobials have been traditionally applied to enhance safety. This is well exemplified by the use of bacteriocins, antimicrobial peptides synthesized by bacteria, as food biopreservatives. However, as knowledge on bacteriocin biology develops, novel functions beyond food preservation emerge and a shift towards health applications is positioning bacteriocins as anti-infectives and modulators of gut microbiota. On the other hand, bacteriophages, viruses infecting bacteria, have been long regarded as a threat for dairy fermentations...
August 8, 2018: Current Opinion in Biotechnology
Ramzi A Mothana, Jamal M Khaled, Omar M Noman, Ashok Kumar, Mohamed F Alajmi, Adnan J Al-Rehaily, Mine Kurkcuoglu
BACKGROUND: Cancers and microbial infections are still a major health problem, therefore research on new anticancer and antimicrobial agents ought to be continued. Natural products including essential oils from medicinal plants continue to be an important resource to manage various diseases. Thus, the particular objectives of this study are to investigate the chemical composition, cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species namely P. cylindraceus Hocst...
August 10, 2018: BMC Complementary and Alternative Medicine
Kuan Z Huang, Yuefeng F Xie, Hao L Tang
Accidental spills and surface discharges of shale gas produced water could contaminate water resources and generate health concerns. The study explored the formation and speciation of disinfection by-products (DBPs) during chlorination of natural waters under the influence of shale gas produced water. Results showed the presence of produced water as low as 0.005% changed the DBP profile measurably. A shift to a more bromine substitution direction for the formation of trihalomethanes, dihaloacetic acids, trihaloacetic acids, and dihaloacetonitriles was illustrated by exploring the individual DBP species levels, bromine substitution factors, and DBP species fractions, and the effect was attributable to the introduction of bromide from produced water...
August 5, 2018: Science of the Total Environment
Rebecca Addo, Samuel Agyei Agyemang, Yesim Tozan, Justice Nonvignon
BACKGROUND: Over the past two decades, the focus of mental health care has shifted from institutionalisation to community-based programs and short hospital stays. This change means that there is an increased role for caregivers, mostly family members, in managing persons with mental illness. Although there is evidence to support the benefits of deinstitutionalisation of mental health care, there are also indications of substantial burden experienced by caregivers; the evidence of which is limited in sub-Saharan Africa...
2018: PloS One
Samer Hamidi, Khadeegha Alzouebi, Fevzi Akinci, Ferhat D Zengul
BACKGROUND: The purpose of this study is to investigate the association between educational attainment and life expectancy in 18 countries in MENA region. METHODS: We used World Bank database for a panel of 18 MENA countries during the years 1995 to 2009. We used Life Expectancy at Birth, as the key health care output measure. Additionally, we used six health care input independent variables. All variables were transformed into natural logarithms. We estimated the production function using Cobb-Douglas function...
August 9, 2018: International Journal of Health Planning and Management
Jae-Joon Lee, Hyun A Kim, Joomin Lee
BACKGROUND/OBJECTIVES: Obesity is a global health problem of significant importance which increases mortality. In place of anti-obesity drugs, natural products are being developed as alternative therapeutic materials. In this study, we investigated the effect of Brassica juncea L. leaf extract (BLE) on fat deposition and lipid profiles in high-fat, high-cholesterol diet (HFC)-induced obese rats. MATERIALS/METHODS: Male Sprague-Dawley rats were divided into four groups (n = 8 per group) according to diet: normal diet group (ND), high-fat/high-cholesterol diet group (HFC), HFC with 3% BLE diet group (HFC-A1), and HFC with 5% BLE diet group (HFC-A2)...
August 2018: Nutrition Research and Practice
Mengqi Wang, Hailiang Song, Xiaorui Zhu, Shiyu Xing, Meirong Zhang, Huimin Zhang, Xiaolong Wang, Zhangping Yang, Xiangdong Ding, Niel A Karrow, Sven König, Yongjiang Mao
The research reported in this Research Communication aimed to describe the influence of Toll-like receptor 4 gene polymorphisms on milk production traits in Chinese Holstein cows. Toll-like receptor 4 (TLR4) is an important member of the toll-like receptor gene family that is widely found in various organisms. Since TLR4 can identify molecular patterns from various pathogenic microorganisms and induce natural and acquired immunity, it plays an important role in disease resistance in dairy cows. Two single nucleotide polymorphisms (SNPs) of TLR4 (c...
August 8, 2018: Journal of Dairy Research
A S Cooke, K A Watt, E R Morgan, J A J Dungait
Antibodies at gastrointestinal mucosal membranes play a vital role in immunological protection against a range of pathogens, including helminths. Gastrointestinal health is central to efficient livestock production, and such infections cause significant losses. Fecal samples were taken from 114 cattle, across three beef farms, with matched blood samples taken from 22 of those animals. To achieve fecal antibody detection, a novel fecal supernatant was extracted. Fecal supernatant and serum samples were then analysed, using adapted enzyme-linked immunosorbent assay protocols, for levels of total immunoglobulin (Ig)A, IgG, IgM, and Teladorsagia circumcincta-specific IgA, IgG, IgM and IgE (in the absence of reagents for cattle-specific nematode species)...
August 8, 2018: Parasitology
Rong-Shing Chang, Chi-Shuo Chen, Ching-Lung Huang, Chiu-Ting Chang, Yujia Cui, Wei-Ju Chung, Wun-Yi Shu, Chi-Shiun Chiang, Chun-Yu Chuang, Ian C Hsu
Application of high-dosage UVB irradiation in phototherapeutic dermatological treatments present health concerns attributed to UV-exposure. In assessing UV-induced photobiological damage, we investigated dose-dependent effects of UVB irradiation on human keratinocyte cells (HaCaT). Our study implemented survival and apoptosis assays and revealed an unexpected dose response wherein higher UVB-dosage induced higher viability. Established inhibitors, such as AKT- (LY294002), PKC- (Gö6976, and Rottlerin), ERK- (PD98059), P38 MAPK- (SB203580), and JNK- (SP600125), were assessed to investigate UV-induced apoptotic pathways...
August 6, 2018: In Vitro Cellular & Developmental Biology. Animal
Sonja Marjanovic, Megan Sim, Talitha Dubow, Jennie Corbett, Emma Harte, Sarah Parks, Celine Miani, Joanna Chataway, Tom Ling
The demand for health services in England is both growing and changing in nature, yet resources are limited in their ability to respond to the scale and scope of need. As a result, the NHS is under increasing pressures to realise productivity gains, while continuing to deliver high quality care. RAND Europe and the University of Manchester have been commissioned to conduct a study to examine the potential of innovation to respond to the challenges the NHS faces, and to help deliver value for money, efficient and effective services...
March 2018: Rand Health Quarterly
Neil Garrett, Ana María González-Garzón, Lucy Foulkes, Liat Levita, Tali Sharot
Humans are better at integrating desirable information into their beliefs than undesirable. This asymmetry poses an evolutionary puzzle, as it can lead to an underestimation of risk and thus failure to take precautionary action. Here, we suggest a mechanism that can speak to this conundrum. In particular, we show that the bias vanishes in response to perceived threat in the environment. We report that an improvement in participants' tendency to incorporate bad news into their beliefs is associated with physiological arousal in response to threat indexed by galvanic skin response and self-reported anxiety...
August 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Grace E Cooper, Kristoffer Ostridge, Salim I Khakoo, Tom M A Wilkinson, Karl J Staples
Influenza A virus (IAV) is a major global public health burden due to its routine evasion of immunization strategies. Natural killer (NK) cells are innate cytotoxic cells with important antiviral activity in the human body, yet the function of these cells in the control of IAV infection is unclear. The aim of this study was to determine the role of lung NK cell cytotoxic responses to IAV. Human lung explants were infected ex vivo with IAV, and lung NK cell activation was analyzed by flow cytometry. Cytotoxic responses of NK cell subsets against IAV-infected macrophages were measured by flow cytometry and ELISA...
2018: Frontiers in Immunology
Kieran Jordan, Olivia McAuliffe
Listeria monocytogenes causes listeriosis, a rare foodborne disease with a mortality rate of 20%-30%. The elderly and immunocompromised are particularly susceptible to listeriosis. L. monocytogenes is ubiquitous in nature and can contaminate food-processing environments, posing a threat to the food chain. This is particularly important for ready-to-eat foods as there is no heat treatment or other antimicrobial step between production and consumption. Thus, occurrence and control of L. monocytogenes are important for industry and public health...
2018: Advances in Food and Nutrition Research
Linchen He, Xing Lucy Liu, Junfeng Jim Zhang
Oxidative stress is involved in the pathophysiology of many diseases and natural aging. Urinary 8‑hydroxy‑2'‑deoxyguanosine (8‑OHdG), a stable product of DNA oxidative damage, has been widely used as an oxidative stress biomarker. However, only reporting 8‑OHdG level, as commonly done previously, does not take into account of damaged DNA molecules that have not been repaired and excreted in urine. Melatonin is known to help with DNA repairs and hence can modify 8‑OHdG levels. 6‑sulfatoxymelatonin (aMT6s) is a major metabolite of melatonin excreted in urine...
July 29, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Jhones Luiz de Oliveira, Estefania Vangelie Ramos Campos, Leonardo F Fraceto
In recent years, the use of substances of natural origin, such as botanical pesticides, has emerged as a preferred alternative to the use of synthetic pesticides, the excessive use of which has raised a lot of concern over safety to human/animal health and the environment. Recent developments in nanotechnology have opened up a new avenue for the development of more efficient formulations that can overcome many of the obstacles generally faced in their use in the field, such as loss of activity because of degradation, instability, volatilization, etc...
August 3, 2018: Journal of Agricultural and Food Chemistry
Anderson C Camargo, Svetoslav D Todorov, N E Chihib, D Drider, Luís A Nero
Bacteriocins are antimicrobial peptides produced by bacteria Gram-negative and Gram-positive, including lactic acid bacteria (LAB), organisms that are traditionally used in food preservation practices. Bacteriocins have been shown to have an aptitude as biofilm controlling agents in Listeria monocytogenes biofilms, a major risk for consumers and the food industry. Biofilms protect pathogens from sanitization procedures, allowing them to survive and persist in processing facilities, resulting in the cross-contamination of the end products...
August 2, 2018: Molecular Biotechnology
Hasinika K A H Gamage, Sasha G Tetu, Raymond W W Chong, Daniel Bucio-Noble, Carly P Rosewarne, Liisa Kautto, Malcolm S Ball, Mark P Molloy, Nicolle H Packer, Ian T Paulsen
There is growing public interest in the use of fiber supplements as a way of increasing dietary fiber intake and potentially improving the gut microbiota composition and digestive health. However, currently there is limited research into the effects of commercially available fiber supplements on the gut microbiota. Here we used an in vitro human digestive and gut microbiota model system to investigate the effect of three commercial fiber products; NutriKane™, Benefiber® and Psyllium husk (Macro) on the adult gut microbiota...
2018: Frontiers in Microbiology
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