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integrative approach

Christiaan Hummel, Dimitris Poursanidis, Daniel Orenstein, Michael Elliott, Mihai Cristian Adamescu, Constantin Cazacu, Guy Ziv, Nektarios Chrysoulakis, Jaap van der Meer, Herman Hummel
For many years, Protected Areas (PA) have been an important tool for conserving nature. Recently, also societal aspects have been introduced into PA management via the introduction of the Ecosystem Services (ES) approach. This review discusses the historical background of PAs, PA management, and the ES approach. We then discuss the relevance and applicability of the ES approach for PA management, including the different definitions of ES, different classification methods, and the ways in which ES are measured...
October 6, 2018: Science of the Total Environment
Sudharani Nayak, Mrinal Kar Mohapatra, Bhuputra Panda
INTRODUCTION: Growing geriatric mental health needs of urban population in India pose several programmatic challenges. This study aimed to assess anxiety, depression and cognitive disorders among urban elderly, and explore availability of social support mechanisms and of a responsive health system to implement the national mental health programme. METHODS: 244 respondents were randomly selected from Berhampur city. We administered a semi-structured interview schedule to assess substance abuse, chronic morbidity, anxiety, depression and cognitive abilities...
October 3, 2018: Archives of Gerontology and Geriatrics
Rakesh K Pathak, Uttara Basu, Anis Ahmad, Shrita Sarkar, Anil Kumar, Bapurao Surnar, Saba Ansari, Katarzyna Wilczek, Michael E Ivan, Brian Marples, Nagesh Kolishetti, Shanta Dhar
Multimodal therapies are used to treat advanced cancers including castration-resistant prostate cancer to manage the biological characteristics of the tumors like inflammation, bone metastases, and participation of metabolically altered cancer stem cells (CSCs) that have integral roles in disease dissemination and progression. We developed a multifunctional polymer-based self-assembled technology to deliver a predefined stoichiometric combination of a chemotherapy and an anti-inflammatory agent in a stimuli responsive manner, to complement and improve the currently established treatment methods of prostate cancer...
September 5, 2018: Biomaterials
Silvia S Denham, Nicolás F Brignone, Leigh A Johnson, Raúl E Pozner
The Calyceraceae (47 spp.) is a small family of plants that is sister to the Asteraceae (∼ 25000 spp.), one of the largest families of angiosperms. Most members of Calyceraceae are endemic to the Andes and Patagonia, representing an excellent model within which to study diversification patterns in these regions. The single phylogenetic study of Calyceraceae conducted to date revealed that the boundaries of most genera and several species of this family require further analyses, especially the "Nastanthus-Gamocarpha" clade...
October 15, 2018: Molecular Phylogenetics and Evolution
Niko Prasetyo, Thomas S Hofer
The solvation of carbon dioxide in solution represents a key step for the capture and fixation CO2 in nature, which may be further influenced by the formation of (bi-)carbonate species and/or the formation of CO2 clusters in solution. The latter processes are strongly dependent on the exact environment of the liquid state (e.g. pH value, solvated ions, etc.) and may interfere with the experimental determination of structural, dynamical and thermodynamic properties. In this work a hybrid quantum mechanical/molecular mechanical (QM/MM) simula- tion approach at correlated ab initio level of theory (RI-MP2) has been applied in the framework of thermodynamic integration (TI) to study structure, dynamics and the hy- dration free energy of single carbon dioxide molecule in aqueous solution...
October 18, 2018: Journal of Chemical Theory and Computation
Stacey N Reinke, Beatriz Galindo-Prieto, Tomas Skotare, David Iain Broadhurst, Akul Singhania, Daniel Horowitz, Ratko Djukanovic, Timothy S C Hinks, Paul Geladi, Johan Trygg, Craig E Wheelock
Integration of multi-omics data remains a key challenge in fulfilling the potential of comprehensive systems biology. Multiple-block orthogonal projections to latent structures (OnPLS) is a projection method that simultaneously models multiple data matrices, reducing feature space without relying on a priori biological knowledge. In order to improve the interpretability of OnPLS models, the associated multi-block variable influence on orthogonal projections (MB-VIOP) method is used to identify variables with the highest contribution to the model...
October 18, 2018: Analytical Chemistry
Jiangfeng Gong, Jing-Chang Li, Jing Yang, Shulin Zhao, Ziyuan Yang, Kaixiao Zhang, Jianchun Bao, Huan Pang, Min Han
Orientation and hybridization of ultrathin two-dimensional (2D) nanostructures on interdigital electrodes is vital for developing high-performance flexible in-plane micro-supercapacitors (MSCs). Despite great progress has been achieved, integrating CuSe and Ni(OH)2 nanosheets to generate advanced nanohybrids with oriented arrangement of each component and formation of porous frameworks remains a challenge, and their application for in-plane MSCs has not been explored. Herein, the vertically-aligned CuSe@Ni(OH)2 hybrid nanosheet films with hierarchical open channels are skillfully deposited on Au interdigital electrodes/polyethylene terephthalate substrate via a template-free sequential electrodeposition approach, and directly employed to construct in-plane MSCs by choosing polyvinyl alcohol-LiCl gel as both the separator and solid electrolyte...
October 18, 2018: ACS Applied Materials & Interfaces
Carsten Sticht, Carolina De La Torre, Alisha Parveen, Norbert Gretz
miRWalk is an open-source platform providing an intuitive interface that generates predicted and validated miRNA-binding sites of known genes of human, mouse, rat, dog and cow. The core of miRWalk is the miRNA target site prediction with the random-forest-based approach software TarPmiR searching the complete transcript sequence including the 5'-UTR, CDS and 3'-UTR. Moreover, it integrates results other databases with predicted and validated miRNA-target interactions. The focus is set on a modular design and extensibility as well as a fast update cycle...
2018: PloS One
Christine Häger, Lydia M Keubler, Steven R Talbot, Svenja Biernot, Nora Weegh, Stephanie Buchheister, Manuela Buettner, Silke Glage, André Bleich
The fine-scale grading of the severity experienced by animals used in research constitutes a key element of the 3Rs (replace, reduce, and refine) principles and a legal requirement in the European Union Directive 2010/63/EU. Particularly, the exact assessment of all signs of pain, suffering, and distress experienced by laboratory animals represents a prerequisite to develop refinement strategies. However, minimal and noninvasive methods for an evidence-based severity assessment are scarce. Therefore, we investigated whether voluntary wheel running (VWR) provides an observer-independent behaviour-centred approach to grade severity experienced by C57BL/6J mice undergoing various treatments...
October 2018: PLoS Biology
M Oellerich, E Schütz, J Beck, P D Walson
Genomic analyses in oncologic care allow for the development of more precise clinical laboratory tests that will be critical for personalized pharmacotherapy. Traditional biopsy-based approaches are limited by the availability of sequential tissue specimens to detect resistance. Blood-based genomic profiling ("liquid biopsy") is useful for longitudinal monitoring of tumor genomes and can complement biopsies. Tumor-associated mutations can be identified in cell-free tumor DNA (ctDNA) from patient blood samples and used for monitoring disease activity...
October 16, 2018: Therapeutic Drug Monitoring
Neil Hanlon, Trish Reay, David Snadden, Martha MacLeod
This article critically exams efforts to achieve primary health care reform using a consultative and relationship-building approach. The study is set in a predominantly rural region of British Columbia, Canada, and concerns the efforts of a regional health authority to engage actively with community members to develop more integrated and patient-centered primary health care delivery. We examine points of tension between providers and administrators engaged in the reform process and show how these are often expressed discursively as a binary opposition involving central and local interests...
October 18, 2018: International Journal of Health Services: Planning, Administration, Evaluation
Helen Hickman, Chris Clarke, Emma Wolverson
Humour is a complex social and emotional experience which could constitute a positive resource for people endeavouring to live well with dementia. However, little is currently known about the shared use and value of humour in dyads where one person has dementia. The purpose of this study was therefore to explore how people with dementia and their care-partners experience, use and draw meaning from humour in relation to their shared experiences of dementia and their ongoing relationships. Ten participant dyads (the person with dementia and their spousal partner) took part in joint semi-structured interviews...
October 18, 2018: Dementia
Crystal R Smit, Rebecca N H de Leeuw, Kirsten E Bevelander, William J Burk, Laura Buijs, Thabo J van Woudenberg, Moniek Buijzen
OBJECTIVE: In this study, we tested an integrated model for why young adolescents consume fruit, vegetables, and water. The model was based on evidence from studies applying three dominant theoretical approaches, including planned behavior, social norms, and intrinsic motivation. METHOD: The integrated model was tested with structural equation modeling using four data-collection waves of the MyMovez Project (MyMovez, 2017) in which 953 young adolescents (53.9% girls; M age = 11...
October 18, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Tünde Csépány
The revolutionary progress of research in neuroimmu-nology has led to the introduction of disease modifying therapies in multiple sclerosis at the end of the last century. The International Panel on Diagnosis of Multiple Sclerosis originally proposed the 2001 McDonald criteria to facilitate the diagnosis of MS in patients with the first objective neurological symptom(s) suggesting demyelinating event, when magnetic resonance imaging is integrated with clinical and other paraclinical diagnostic methods. New terms have been introduced to substitute clinical information by MRI: dissemination in space - indicating a multifocal central demyelinating process and dissemination in time - indicating the development of new CNS lesions over time...
September 30, 2018: Ideggyógyászati Szemle
Yuan Chen, Rui Zhu, Fang Ma, Jialin Mao, Eugene C Chen, Edna Choo, Srikumar Sahasranaman, Lichuan Liu
GDC-0810 was under development as an oral anti-cancer drug for the treatment of estrogen receptor-positive breast cancer as a single agent or in combination. In vitro data indicated that GDC-0810 is a potent inhibitor of OATP1B1/1B3. To assess clinical risk, PBPK model was developed to predict the transporter drug-drug interaction (tDDI) between GDC-0810 and pravastatin in human. The PBPK model was constructed in Simcyp® by integrating in vitro and in vivo data for GDC-0810. The prediction of human pharmacokinetics (PK) was verified using GDC-0810 phase I clinical PK data...
October 18, 2018: Biopharmaceutics & Drug Disposition
A V Fedotova, O P Mironova
A nonspecific back pain is in the vast majority of all possible cases of dorsopathies. The sources of back pain may be myogenic dysfunction, intervertebral disc pathology or osteoarthritis of the archicular (facet) joints of the spine, including myofascial pain syndrome. A differentiated approach to the treatment of spondylarthrosis is still an unsolved problem. The article discusses important issues of integration of non-drug treatment methods and drug therapy of nonspecific back pain in patients with facet syndrome...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Esther Herrera-Luis, Natalia Hernandez-Pacheco, Susanne J Vijverberg, Carlos Flores, Maria Pino-Yanes
PURPOSE OF REVIEW: Asthma exacerbations have been suggested to result from complex interactions between genetic and nongenetic components. In this review, we provide an overview of the genetic association studies of asthma exacerbations, their main results and limitations, as well as future directions of this field. RECENT FINDINGS: Most studies on asthma exacerbations have been performed using a candidate-gene approach. Although few genome-wide association studies of asthma exacerbations have been conducted up to date, they have revealed promising associations but with small effect sizes...
October 16, 2018: Current Opinion in Pulmonary Medicine
Feng Wang, Ingo Wald, Qi Wu, Will Usher, Chris R Johnson
Adaptive mesh refinement (AMR) is a key technology for large-scale simulations that allows for adaptively changing the simulation mesh resolution, resulting in significant computational and storage savings. However, visualizing such AMR data poses a significant challenge due to the difficulties introduced by the hierarchical representation when reconstructing continuous field values. In this paper, we detail a comprehensive solution for interactive isosurface rendering of block-structured AMR data. We contribute a novel reconstruction strategy-the octant method-which is continuous, adaptive and simple to implement...
October 16, 2018: IEEE Transactions on Visualization and Computer Graphics
Mahardhika Pratama, Eric Dimla, Tegoeh Tjahjowidodo, Witold Pedrycz, Edwin Lughofer
Existing methodologies for tool condition monitoring (TCM) still rely on batch approaches which cannot cope with a fast sampling rate of a metal cutting process. Furthermore, they require a retraining process to be completed from scratch when dealing with a new set of machining parameters. This paper presents an online TCM approach based on Parsimonious Ensemble+ (pENsemble+). The unique feature of pENsemble+ lies in its highly flexible principle where both the ensemble structure and base-classifier structure can automatically grow and shrink on the fly based on the characteristics of data streams...
October 12, 2018: IEEE Transactions on Cybernetics
Stuart Golodetz, Tommaso Cavallari, Nicholas A Lord, Victor A Prisacariu, David W Murray, Philip H S Torr
Reconstructing dense, volumetric models of real-world 3D scenes is important for many tasks, but capturing large scenes can take significant time, and the risk of transient changes to the scene goes up as the capture time increases. These are good reasons to want instead to capture several smaller sub-scenes that can be joined to make the whole scene. Achieving this has traditionally been difficult: joining sub-scenes that may never have been viewed from the same angle requires a high-quality camera relocaliser that can cope with novel poses, and tracking drift in each sub-scene can prevent them from being joined to make a consistent overall scene...
October 15, 2018: IEEE Transactions on Visualization and Computer Graphics
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