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https://www.readbyqxmd.com/read/30545317/probiotics-streptococcus-salivarius-24smb-and-streptococcus-oralis-89a-interfere-with-biofilm-formation-of-pathogens-of-the-upper-respiratory-tract
#1
Alessandro Bidossi, Roberta De Grandi, Marco Toscano, Marta Bottagisio, Elena De Vecchi, Matteo Gelardi, Lorenzo Drago
BACKGROUND: Infections of the ears, paranasal sinuses, nose and throat are very common and represent a serious issue for the healthcare system. Bacterial biofilms have been linked to upper respiratory tract infections and antibiotic resistance, raising serious concerns regarding the therapeutic management of such infections. In this context, novel strategies able to fight biofilms may be therapeutically beneficial and offer a valid alternative to conventional antimicrobials. Biofilms consist of mixed microbial communities, which interact with other species in the surroundings and communicate through signaling molecules...
December 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30542067/microrna-amplification-and-detection-technologies-opportunities-and-challenges-for-point-of-care-diagnostics
#2
REVIEW
Vivek Priy Dave, Tien Anh Ngo, Anna-Karin Pernestig, Diana Tilevik, Krishna Kant, Trieu Nguyen, Anders Wolff, Dang Duong Bang
The volume of point of care (POC) testing continues to grow steadily due to the increased availability of easy-to-use devices, thus making it possible to deliver less costly care closer to the patient site in a shorter time relative to the central laboratory services. A novel class of molecules called microRNAs have recently gained attention in healthcare management for their potential as biomarkers for human diseases. The increasing interest of miRNAs in clinical practice has led to an unmet need for assays that can rapidly and accurately measure miRNAs at the POC...
December 12, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/30540715/intravenous-and-oral-tranexamic-acid-are-equivalent-at-reducing-blood-loss-in-thoracolumbar-spinal-fusion-a-prospective-randomized-trial
#3
Charles C Yu, Omar Kadri, Allen Kadado, Morenikeji Buraimoh, Jacob Pawloski, Stephen Bartol, Gregory Graziano
STUDY DESIGN: A prospective randomized trial of patients enrolled at a university affiliated tertiary medical center between February and December 2017. OBJECTIVE: To compare perioperative blood loss in patients undergoing elective posterior thoracolumbar fusion who were treated with IV versus PO TXA. SUMMARY OF BACKGROUND DATA: The use of antifibrinolytic agents such as tranexamic acid (TXA) to decrease operative blood loss and allogenic blood transfusions is well documented in the literature...
December 11, 2018: Spine
https://www.readbyqxmd.com/read/30539786/-the-m%C3%A3-nsteraner-memorandum-on-alternative-practitioners-analysis-and-evaluation-of-critical-commentaries
#4
Jan-Ole Reichardt, Daniel R Friedrich
With its "Münsteraner Memorandum on Alternative Practitioners" the author collective "Münsteraner Kreis" has recently criticized current German double standards for physicians versus alternative practitioners with regard to minimal competency and to quality assurance. The authors' main goal was to attract attention to the problem and to provide systematic arguments in favor of a healthcare system that is serving patients' needs more appropriately. Reactions to the Memorandum were numerous, divergent in their evaluations, often constructive, and frequently emotionally heated...
November 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/30537124/psychosocial-interventions-for-pain-management-in-older-adults-with-dementia-a-systematic-review-of-randomised-controlled-trials
#5
REVIEW
Lihui Pu, Wendy Moyle, Cindy Jones, Michael Todorovic
AIM: To assess the effectiveness of psychosocial interventions on pain in older adults living with dementia. DESIGN: A systematic review with meta-analysis of randomised controlled trials. DATA SOURCES: Scopus, ProQuest, EBSCO (CINAHL and MEDLINE), PubMed, OVID (PsycINFO), Web of Science and Cochrane Library were searched from their inception up to 2 May 2018. REVIEW METHODS: Risk of bias assessment and meta-analysis were conducted according to the Cochrane methods using RevMan 5...
December 10, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/30532793/the-impact-of-previous-pregnancy-loss-on-lactating-behaviors-and-use-of-herbal-medicines-during-breastfeeding-a-post-hoc-analysis-of-the-herbal-supplements-in-breastfeeding-investigation-habit
#6
Alessandra Bettiol, Niccolò Lombardi, Ettore Marconi, Giada Crescioli, Roberto Bonaiuti, Valentina Maggini, Eugenia Gallo, Alessandro Mugelli, Fabio Firenzuoli, Claudia Ravaldi, Alfredo Vannacci
Introduction: Complementary and alternative medicines (CAMs) are commonly used among lactating women, despite the poor knowledge of these products and of their safety. Perception of pregnancy- and breastfeeding-related difficulties and consequent use of CAMs may differ in bereaved women, by force of the distress related to previous loss, although no literature evidence is available. This Herbal supplements in Breastfeeding InvesTigation (HaBIT) post hoc analysis explored the impact of previous pregnancy loss on lactating behaviors and on use of CAMs during breastfeeding...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30528780/value-based-pricing-in-latin-america-how-far-away-are-we
#7
Aurelio Mejía, Ramiro Gilardino, Finn Børlum Kristensen, Louis P Garrison
In February and September of 2017, the International Society for Pharmacoeconomics and Outcomes Research Health Technology Assessment Council held roundtables focused on Latin America to discuss health technology assessment best practices, collaboration opportunities, and regional experiences regarding health policies to improve the affordability of and access to healthcare technologies. The access to high-cost technologies, increased social pressure to achieve universal coverage, population aging, and the limits of traditional mechanisms to control costs create political pressure to begin considering other pricing alternatives, including value-based pricing, in Latin America...
December 6, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/30528244/using-a-stated-preference-discrete-choice-experiment-to-assess-societal-value-from-the-perspective-of-decision-makers-in-europe-does-it-work-for-rare-diseases
#8
J López-Bastida, J M Ramos-Goñi, I Aranda-Reneo, M Trapero-Bertran, P Kanavos, B Rodriguez Martin
OBJECTIVES: To pilot the feasibility of using a discrete choice experiment (DCE) design to investigate individual preferences from the decision-maker perspective regarding the use of public funding for orphan drugs and generate prior information for future experimental designs. METHODS: A DCE was used on a convenience sample of participants from five European countries (England, France, Germany, Italy and Spain), exploring their preferences in distinct healthcare scenarios involving orphan drugs...
November 29, 2018: Health Policy
https://www.readbyqxmd.com/read/30513398/application-of-3d-printing-technology-and-quality-by-design-approach-for-development-of-age-appropriate-pediatric-formulation-of-baclofen
#9
Siddhant Palekar, Pavan Kumar Nukala, Saurabh M Mishra, Thomas Kipping, Ketan Patel
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult formulations, but medication errors can result in suboptimal efficacy and with significant safety concerns. The aim of proposed project was to explore a 3D printing technology for the development of customized minicaplets of baclofen for the pediatric population. Based on results of 3-point bend test, polyvinyl alcohol (PVA) with sorbitol (10% w/w) were selected for preparation of baclofen loaded filaments using hot melt extrusion (HME)...
December 1, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30510034/a-systematic-review-examining-the-impact-of-redirecting-low-acuity-patients-seeking-emergency-department-care-is-the-juice-worth-the-squeeze
#10
Scott William Kirkland, Amir Soleimani, Brian H Rowe, Amanda S Newton
OBJECTIVES: Diverting patients away from the emergency department (ED) has been proposed as a solution for mitigating overcrowding. This systematic review examined the impact of interventions designed to either bypass the ED or direct patients to other alternative care after ED presentation. METHODS: Seven electronic databases and the grey literature were searched. Eligible studies included randomised/controlled trials or cohort studies that assessed the effectiveness of pre-hospital or ED-based diversion interventions...
December 3, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/30509681/serious-adverse-events-attributed-to-remifentanil-patient-controlled-analgesia-during-labour-in-the-netherlands
#11
S L M Logtenberg, M L Vink, M B Godfried, I C M Beenakkers, F G Schellevis, B W Mol, C J Verhoeven
BACKGROUND: During labour, remifentanil patient-controlled analgesia is used as an alternative to neuraxial analgesia. Remifentanil is associated with hypoventilation and respiratory depression but the frequency of serious maternal and neonatal adverse events is unknown. The aim of this study was to estimate the number of serious adverse events attributed to the use of remifentanil patient-controlled analgesia during labour in The Netherlands and to investigate the circumstances (e.g...
November 2, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/30508488/the-economic-influence-of-breastfeeding-on-the-health-cost-of-newborns
#12
Esmeralda Santacruz-Salas, Isaac Aranda-Reneo, Álvaro Hidalgo-Vega, José M Blanco-Rodriguez, Antonio Segura-Fragoso
BACKGROUND: Breastfeeding provides health benefits for women and newborns. However, few studies have explored how these health benefits translate into economic savings. RESEARCH AIM: This study aimed to estimate the healthcare costs savings generated by exclusive breastfeeding for healthy newborns. METHODS: We designed a longitudinal two-group observational study that included healthy women and newborns ( N=236) in Toledo, Spain. Over the first 6-months of the infants' lives, we reviewed their clinical histories to determine their consumption of healthcare resources and the type of nutrition provided...
December 3, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/30506947/patient-and-carer-experience-of-blended-diet-via-gastrostomy-a-qualitative-study
#13
G Phillips
BACKGROUND: Home enteral feeding is becoming increasingly prevalent within the UK. The use of commercial prescription formula is considered best practice; however, increasingly, patients are choosing to use blended diet via gastrostomy. There is anecdotal evidence suggesting both physical and social benefits, although there are concerns regarding the safety and efficacy of this method of feeding. The present study explores the experiences of patients who are currently using or have used this method of feeding in the past...
December 2, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/30505843/telemedicine-and-prostate-cancer-survivorship-a-narrative-review
#14
REVIEW
Nnenaya Q Agochukwu, Ted A Skolarus, Daniela Wittmann
Prostate cancer survivors have unique needs that encompass diagnosis and treatment-related side effects. The provision of services for prostate cancer survivors is often limited by resources, time constraints in traditional clinic visits, payment, and patient and provider comfort with discussion of sensitive topics including sexual and urinary health, both of which are largely impacted by treatment. Telemedicine, the remote delivery of health care services using telephone, mobile, web, and video platforms, allows for potential cost savings, in addition to ease and comfort as patients can engage in telemedicine-based resources in the comfort of their homes...
2018: MHealth
https://www.readbyqxmd.com/read/30503596/repeat-pulmonary-valve-replacement-similar-intermediate-term-outcomes-with-surgical-and-transcatheter-procedures
#15
Hope Caughron, Dennis Kim, Norihiko Kamioka, Stamatios Lerakis, Altayyeb Yousef, Aneesha Maini, Shawn Reginauld, Anurag Sahu, Subhadra Shashidharan, Maan Jokhadar, Fred H Rodriguez, Wendy M Book, Michael McConnell, Peter C Block, Vasilis Babaliaros
OBJECTIVES: This study compares 30-day, 1-year, and 3-year echocardiographic findings and clinical outcomes of transcatheter pulmonary valve-in-valve replacement (TPVR) and repeat surgical pulmonary valve replacement (SPVR). BACKGROUND: In patients with adult congenital heart disease and previous pulmonary valve replacement (PVR) who require redo PVR, it is unclear whether TPVR or repeat SPVR is the preferred strategy. METHODS: We retrospectively identified 66 patients (TPVR, n = 36; SPVR, n = 30) with bioprosthetic pulmonary valves (PVs) who underwent either TPVR or repeat SPVR at Emory Healthcare from January 2007 to August 2017...
November 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30503373/an-update-on-recent-developments-in-the-prevention-and-treatment-of-staphylococcus-aureus-biofilms
#16
REVIEW
Maneesha K Suresh, Raja Biswas, Lalitha Biswas
Staphylococcus aureus (S. aureus) readily forms biofilms on prosthetic devices such as the pacemakers, heart valves, orthopaedic implants, and indwelling catheters. Its biofilms are recalcitrant to antibiotic therapy and pose a serious burden in the healthcare setting as they drastically increase the treatment cost and morbidity of the patient. Prevention and treatment of staphylococcal biofilms has therefore been an area of active research for the past two decades. While catheters coated with different antiseptics and antibiotics capable of preventing S...
November 27, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/30502779/cost-utility-analysis-of-apixaban-versus-warfarin-in-atrial-fibrillation-patients-with-chronic-kidney-disease
#17
Shoroq M Altawalbeh, Osama Y Alshogran, Kenneth J Smith
BACKGROUND: Warfarin use for stroke prevention in atrial fibrillation (AF) patients with chronic kidney disease is debated. Apixaban was shown to be safer than warfarin, with superior reduction in the risk of stroke, systemic embolism, mortality, and major bleeding irrespective of kidney function. OBJECTIVES: To evaluate the cost-utility of apixaban compared with warfarin in AF patients at different levels of kidney function. METHODS: A Markov model was used to estimate the cost effectiveness of apixaban compared with warfarin in AF patients at three levels of kidney function: estimated glomerular filtration rate (eGFR) of more than 80 ml/min, 50 to 80 ml/min, and 50 ml/min or less...
December 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/30501062/from-rapid-recommendation-to-online-preference-sensitive-decision-support-the-case-of-severe-aortic-stenosis
#18
Jack Dowie, Mette Kjer Kaltoft
The launch of 'Rapid Recommendations' by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) group, in collaboration with Making GRADE the Irresistible Choice (MAGIC) and the British Medical Journal (BMJ), is a very interesting recent development in e-healthcare. Designed to respond quickly to developments that have created new decision situations, their first project resulted from the arrival of minimally invasive Transcatheter Aortic Valve Implantation (TAVI) as an alternative to Surgical Aortic Valve Replacement (SAVR), for patients with symptomatic severe aortic stenosis...
November 29, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/30500557/a-pharmacoinformatic-approach-on-cannabinoid-receptor-2-cb2-and-different-small-molecules-homology-modelling-molecular-docking-md-simulations-drug-designing-and-adme-analysis
#19
S Vijayakumar, P Manogar, S Prabhu, M Pugazhenthi, P K Praseetha
CB2 receptor belongs to the family of G-protein coupled receptors (GPCRs), which extensively controls a range of pointer transduction. CB2 plays an essential role in the immune system. It also associates in the pathology of different ailment conditions. In this scenario, the synthetic drugs are inducing side effects to the human beings after the drug use. Therefore, this study is seeking novel alternate drug molecules with least side effects than conventional drugs. The alternative drug molecules were chosen from the natural sources...
November 22, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/30498156/books-get-well-soon-adventures-in-alternative-healthcare-chronic-fatigue-from-the-inside
#20
Dougal Jeffries
No abstract text is available yet for this article.
December 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
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