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https://www.readbyqxmd.com/read/30178515/a-randomized-clinical-trial-of-age-and-genotype-guided-tacrolimus-dosing-after-pediatric-solid-organ-transplantation
#1
Sandar Min, Tanya Papaz, Myriam Lafreniere-Roula, Nadya Nalli, Hartmut Grasemann, Steven M Schwartz, Binita M Kamath, Vicky Ng, Rulan S Parekh, Cedric Manlhiot, Seema Mital
BACKGROUND: Tacrolimus pharmacokinetics are influenced by age and CYP3A5 genotype with CYP3A5 expressors (CYP3A5*1/*1 or *1/*3) being fast metabolizers. However, the benefit of genotype-guided dosing in pediatric solid organ transplantation has been understudied. OBJECTIVE: To determine whether age and CYP3A5 genotype-guided starting dose of tacrolimus result in earlier attainment of therapeutic drug concentrations. SETTING: Single hospital-based transplant center...
September 3, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/30138813/nontargeted-metabolomics-approach-to-determine-metabolites-profile-and-antioxidant-study-of-tropical-almond-terminalia-catappa-l-fruit-peels-using-gc-qtof-ms-and-lc-qtof-ms
#2
Mital J Kaneria, K D Rakholiya, L R Marsonia, R A Dave, B A Golakiya
The objective of the present study was to identify the metabolome pattern and study the biological efficacy of Almond (Terminalia catappa L.) peels. In the present study, metabolite profiling was carried out using GC-QTOF-MS and LC-QTOF-MS techniques, from the potent extract showed highest antioxidant efficacy. Antioxidant efficacy of the various extracts derived by six different extraction methods was assessed by different assays viz. 2,2-diphenyl-1-picrylhydrazyl, superoxide, 2,2'-Azino-bis-(3-ethyl)benzothiazoline)-6-sulfonic acid diammonium salt radical cation inhibition assays and ferric reducing antioxidant power...
October 25, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30088266/fiberoptic-intubation-of-severely-obese-patients-through-supraglottic-airway-a-prospective-randomized-trial-of-the-ambu-%C3%A2-auragain%C3%A2-laryngeal-mask-vs-the-i-gel%C3%A2-airway
#3
Berthold Moser, Christian Keller, Laurent Audigé, Mital H Dave, Heinz R Bruppacher
INTRODUCTION: Airway management in severely obese patients remains a challenging issue for anaesthetists and may lead to life-threatening situations. Supraglottic airway devices, such as the i-gel™ or the AuraGain™, were developed, with the possibility to ventilate the patient or use them as a conduit for endotracheal intubation. METHODS: In our randomized prospective trial, we hypothesized a 10 seconds faster fiberoptic trans-device intubation time through the AuraGain™ laryngeal mask compared to the i-gel™ laryngeal mask in severely obese patients...
August 8, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/30057374/acquired-von-willebrand-syndrome-during-systemic-mastocytosis-an-analysis-of-21-cases
#4
Andrzej Mital, Witold Prejzner, Andrzej Hellmann
No abstract text is available yet for this article.
August 31, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29970754/poststreptococcal-glomerulonephritis-with-atypical-hemolytic-uremic-syndrome-an-unusual-presentation
#5
Mital Parekh, Abhijit Konnur, Sishir Gang
A 14-year-old female presented with oliguric dialysis requiring kidney injury due to acute poststreptococcal glomerulonephritis (PSGN) with hypertension strongly suggestive of atypical hemolytic uremic syndrome (aHUS) with microangiopathic hemolytic anemia and elevated factor H antibody levels. Renal biopsy revealed crescentic glomerulonephritis with typical subepithelial, intramembranous and mesangial electron-dense deposits (humps) on electron microscopy. She was treated with glucocorticoids following which she recovered, remained dialysis free and her Factor H antibody levels and depressed complement 3 levels normalized...
May 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29861570/autosomal-dominant-polycystic-kidney-disease-and-hypertension-masquerading-primary-aldosteronism
#6
P D Mital, K Abhijit, G Shishir
Hypertension is a frequent early manifestation of autosomal dominant polycystic kidney disease (ADPKD). Many mechanisms cause hypertension in ADPKD; however, primary aldosteronism (PA) as a possible manifestation of hypertension in ADPKD is extremely rare. The diagnosis of PA in ADPKD is extremely challenging because multiple renal cysts can mask the identification of adrenal adenomas, and ADPKD is associated with hypertension in majority of cases. Here, we report a unique case of a young lady with ADPKD with hypertension masquerading PA...
March 2018: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29806162/airway-dimensions-from-fetal-life-to-adolescence-a-literature-overview
#7
REVIEW
Mital H Dave, Kathrin Schmid, Markus Weiss
BACKGROUND: Data on airway dimensions in pediatric patients are important for proper selection of pediatric airway equipment such as endotracheal tubes, double-lumen tubes, bronchial blockers, or stents. The aim of the present work was to provide a synopsis of the available data on pediatric airway dimensions. METHODS: A systematic literature search was carried out in the PubMed database, Scopus, Embase, Web of Science, Prisma, and Google Scholar and secondarily completed by a reference search...
May 27, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29778489/trends-in-non-medical-prescription-opioids-and-heroin-co-use-among-adults-2003-2014
#8
Sasha Mital, Michael Windle, Hannah L F Cooper, Natalie D Crawford
BACKGROUND: Patterns in non-medical prescription opioid (NMPO) and heroin use have recently shifted, with evidence that NMPO-only users transition to NMPO and heroin co-use. Co-use is associated with increased risk of morbidity and overdose, highlighting the need for further investigation. This study aims to quantify, describe, and explore trends in co-use. METHODS: Using data from the 2003-2014 National Surveys on Drug Use and Health, we compared co-use to NMPO- and heroin-only use across demographic, substance use and mental health characteristics with chi-squared tests...
November 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29774745/interplay-between-copper-neprilysin-and-n-truncation-of-%C3%AE-amyloid
#9
Mariusz Mital, Wojciech Bal, Tomasz Frączyk, Simon C Drew
Sporadic Alzheimer's disease (AD) is associated with an inefficient clearance of the β-amyloid (Aβ) peptide from the central nervous system. The protein levels and activity of the Zn2+ -dependent endopeptidase neprilysin (NEP) inversely correlate with brain Aβ levels during aging and in AD. The present study considered the ability of Cu2+ ions to inhibit human recombinant NEP and the role for NEP in generating N-truncated Aβ fragments with high-affinity Cu2+ binding motifs that can prevent this inhibition...
June 4, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29714154/high-prevalence-of-abandoned-needlesticks-from-injecting-drug-users-in-milton-keynes-uk-analysing-access-to-needle-exchange-centres-and-drug-dependency-services
#10
Dushyant Mital, Steve Conway, Joanne Trueman
BACKGROUND: In 2015, Milton Keynes (MK) Council waste management team shows an increase in the numbers of abandoned used needles being found across MK. MK is an area of high Human Immunodeficiency Virus (HIV) prevalence and high Hepatitis C (HCV) in People Who Inject Drugs (PWID), the overriding concern was for the safety of the public. METHODS: Analysis of data collection to understand the scale and spread of the problem, preventing/ reducing the incidence of abandoned needles and looking at access to the designated Drug Dependency Unit (DDU) and the Blood Borne Virus (BBV) service...
2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/29442638/nickel-nanocatalyst-ex-solution-from-ceria-nickel-oxide-solid-solution-for-low-temperature-co-oxidation
#11
Amit Singhania, Shipra Mital Gupta
In this work, in situ growth of Ni nanocatalysts to attach onto the ceria (CeO2) surface through direct Ni ex-solution from the NiO-CeO2 solid solution in a reducing atmosphere at high temperatures with an aim to improve the catalytic activity, and stability for low temperature carbon monoxide (CO) oxidation reaction have been reported. The NiO-CeO2 solid solutions were prepared by solution combustion method, and the results of XRD and RAMAN showed that doping of Ni increases the oxygen vacancies due to charge compensation...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29437119/transplant-free-survival-and-interventions-at-6-years-in-the-svr-trial
#12
Jane W Newburger, Lynn A Sleeper, J William Gaynor, Danielle Hollenbeck-Pringle, Peter C Frommelt, Jennifer S Li, William T Mahle, Ismee A Williams, Andrew M Atz, Kristin M Burns, Shan Chen, James Cnota, Carolyn Dunbar-Masterson, Nancy S Ghanayem, Caren S Goldberg, Jeffrey P Jacobs, Alan B Lewis, Seema Mital, Christian Pizarro, Aaron Eckhauser, Paul Stark, Richard G Ohye
BACKGROUND: In the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for the Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared with a modified Blalock-Taussig shunt in patients with hypoplastic left heart and related syndromes. At 6 years, we compared transplant-free survival and other outcomes between the groups. METHODS: Medical history was collected annually using medical record review, telephone interviews, and the death index...
May 22, 2018: Circulation
https://www.readbyqxmd.com/read/29296639/novel-posterior-auricular-cutaneous-reaction-after-anti-tnf-%C3%AE-infusion-in-young-women-with-crohn-s-disease
#13
Lauren N Ko, Joanie Pinard, Joseph F Merola, Mital Patel
No abstract text is available yet for this article.
November 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/29284811/caregiver-burden-in-medical-versus-psychiatric-patients-a-cross-sectional-comparative-study
#14
Anu Kant Mital, Sayali Ganesh Sabnis, Vrushali Vishal Kulkarni
Background: An informal care-giver is generally an unpaid individual who looks after the personal and medical needs of the patient. India being a country of traditions and family values, this informal care-giver is usually a family member. These care-givers, being untrained in this job undergo tremendous stress. Available research studies the burden individually in the relatives of chronically medically ill patients and those of psychiatrically ill patients. Furthermore the previous research targets the burden in individual diseases...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29241793/hidradenitis-suppurativa-burden-of-disease-tool-pilot-testing-of-a-disease-specific-quality-of-life-questionnaire
#15
LETTER
Joanie Pinard, Ruth Ann Vleugels, Cara Joyce, Joseph F Merola, Mital Patel
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29238427/hiv-associated-nephropathy-in-africa-pathology-clinical-presentation-and-strategy-for-prevention
#16
REVIEW
Nazik Elmalaika Husain, Mohamed H Ahmed, Ahmed O Almobarak, Sufian K Noor, Wadie M Elmadhoun, Heitham Awadalla, Clare L Woodward, Dushyant Mital
The human immunodeficiency virus (HIV) infection can lead to progressive decline in renal function known as HIV-associated nephropathy (HIVAN). Importantly, individuals of African ancestry are more at risk of developing HIVAN than their European descent counterparts. An in-depth search on Google Scholar, Medline and PubMed was conducted using the terms "HIVAN" and "pathology and clinical presentation", in addition to "prevalence and risk factors for HIVAN", with special emphasis on African countries for any articles published between 1990 and 2017...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29209994/the-role-of-trypsin-chymotrypsin-in-tissue-repair
#17
REVIEW
Dilip Shah, Kushal Mital
Tissue damage of all types, such as surgical or accidental injuries, fractures, and burns, stimulates a well-orchestrated, physiological process of healing, which ultimately leads to structural and functional restoration of the damaged tissues. The tissue repair process can be broadly divided into four continuous and overlapping phases-hemostasis and coagulation, inflammation, proliferation, and remodeling. If the process is interrupted or halted during any stage, it leads to impaired healing and formation of a chronic wound...
January 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29184449/diabetes-metabolic-syndrome-and-dyslipidemia-in-people-living-with-hiv-in-africa-re-emerging-challenges-not-to-be-forgotten
#18
REVIEW
Nazik Elmalaika Husain, Sufian K Noor, Wadie M Elmadhoun, Ahmed O Almobarak, Heitham Awadalla, Clare L Woodward, Dushyant Mital, Mohamed H Ahmed
Background: The current challenge in managing people living with human immunodeficiency virus (PLWHIV) includes the identification and monitoring for comorbid health risks associated with HIV and its treatment and longer survival. Dyslipidemia, diabetes mellitus and metabolic syndrome are increasingly seen in PLWHIV. Objective: In this narrative review, we aimed to summarize the current knowledge about diabetes, dyslipidemia and metabolic syndrome in PLWHIV in Africa and also to discuss the challenges that patients as well as health authorities in Africa may face...
2017: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/29161781/in-silico-docking-studies-of-lupeol-with-mapk-pathway-proteins-raf-1-mek-erk
#19
Mital H Bhatt, Chirag K Prajapati, M N Reddy
Lupeol, A triterpenoid found in variety of plants is reported to have beneficial medicinal effects on several ailments. Lupeol is also found to show inhibitory effect on proliferation of breast cancer cells. Metastasis is considered to be a major cause for worldwide deaths related to cancer. Ras related MAPK Signaling Pathway is one of the crucial pathways leading to metastasis. Lupeols binding possibility with Ras is already reported. In present study, Interaction between with downstream proteins of Ras- MAPK pathway, Raf ,MEK ,ERK1/2 and their corresponding domains are studied using STRING Database and their structures are retrieved in PDB Format...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29159199/dna-mediated-gene-therapy-in-a-mouse-model-of-limb-girdle-muscular-dystrophy-2b
#20
Julia Ma, Christophe Pichavant, Haley du Bois, Mital Bhakta, Michele P Calos
Mutations in the gene for dysferlin cause a degenerative disorder of skeletal muscle known as limb girdle muscular dystrophy 2B. To achieve gene delivery of plasmids encoding dysferlin to hind limb muscles of dysferlin knockout mice, we used a vascular injection method that perfused naked plasmid DNA into all major muscle groups of the hind limb. We monitored delivery by luciferase live imaging and western blot, confirming strong dysferlin expression that persisted over the 3-month time course of the experiment...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
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