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https://www.readbyqxmd.com/read/28526919/antibodies-to-post-translationally-modified-insulin-as-a-novel-biomarker-for-prediction-of-type-1-diabetes-in-children
#1
Rocky Strollo, Chiara Vinci, Nicola Napoli, Paolo Pozzilli, Johnny Ludvigsson, Ahuva Nissim
AIMS/HYPOTHESIS: We have shown that autoimmunity to insulin in type 1 diabetes may result from neoepitopes induced by oxidative post-translational modifications (oxPTM). Antibodies specific to oxPTM-insulin (oxPTM-INS-Ab) are present in most newly diagnosed individuals with type 1 diabetes and are more common than autoantibodies to native insulin. In this study, we investigated whether oxPTM-INS-Ab are present before clinical onset of type 1 diabetes, and evaluated the ability of oxPTM-INS-Ab to identify children progressing to type 1 diabetes...
May 20, 2017: Diabetologia
https://www.readbyqxmd.com/read/28522458/a-key-role-for-apoplastic-h2o2-in-norway-spruce-phenolic-metabolism
#2
Teresa Laitinen, Kris Morreel, Nicolas Delhomme, Adrien Gauthier, Bastian Schiffthaler, Kaloian Nickolov, Günter Brader, Kean-Jin Lim, Teemu H Teeri, Nathaniel R Street, Wout A Boerjan, Anna Karkonen
Apoplastic events such as monolignol oxidation and lignin polymerization are difficult to study in intact trees. To investigate the role of apoplastic H2O2 in gymnosperm phenolic metabolism, an extracellular lignin-forming cell culture of Norway spruce (Picea abies) was used as a research model. Scavenging of apoplastic H2O2 by KI repressed lignin formation, in line with peroxidases activating monolignols for lignin polymerization. Time course analyses coupled to candidate substrate product pair network propagation revealed differential accumulation of low-molecular-weight phenolics, including (glycosylated) oligolignols, (glycosylated) flavonoids and proanthocyanidins, in lignin-forming and H2O2-scavenging cultures, and supported that monolignols are oxidatively coupled not only in the cell wall, but also in the cytoplasm where they are coupled to other monolignols and proanthocyanidins...
May 18, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28522299/most-advisable-strategy-in-search-of-asymptomatic-target-organ-damage-in-hypertensive-patients
#3
J Abellán-Huerta, L Prieto-Valiente, L Consuegra-Sánchez, S Montoro-García, A B Salguero-Merino, R Morales-López, J Abellán-Alemán, F Soria-Arcos
OBJECTIVE: To evaluate the diagnostic potential of seven examinations in order to define the most suitable strategy for target organ damage (TOD) search in hypertensive patients. METHODS: This is a descriptive, cross-sectional study. 153 consecutive treated and essential hypertensive patients were enrolled. Patients with established cardiovascular or chronic renal disease (stage ≥4) were excluded. TOD search was assessed by: glomerular filtration rate (GFR), albumin/creatinine ratio (ACR), electrocardiogram (ECG), echocardiogram (ECO), ankle-brachial index (ABI), pulse wave velocity (PWV), and carotid ultrasound (intima media thickness and presence of plaques)...
May 15, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28521554/social-factors-predictive-of-social-integration-for-adults-with-brain-injury
#4
Elisabeth Batchos, Amanda Easton, Christopher Haak, Nicole Ditchman
INTRODUCTION: Individuals with acquired brain injury (ABI) may not only struggle with physical and cognitive impairments, but may also face challenges reintegrating into the community socially. Research has demonstrated that following ABI, individuals' social networks tend to dwindle, support may decline, and isolation increases. This study examined factors impacting social integration in a community-based sample of 102 individuals with ABI. METHODS: Potential predictors included emotional support, instrumental support, problem solving confidence, and approach-avoidance style (AAS) of problem solving, while controlling for age, gender, education, and time since injury...
May 18, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28515094/inhibiting-the-osteocyte-specific-protein-sclerostin-increases-bone-mass-and-fracture-resistance-in-multiple-myeloma
#5
Michelle M McDonald, Michaela R Reagan, Scott E Youlten, Sindhu T Mohanty, Anja Seckinger, Rachael L Terry, Jessica A Pettitt, Marija K Simic, Tegan L Cheng, Alyson Morse, Lawrence M T Le, David Abi-Hanna, Ina Kramer, Carolyne Falank, Heather Fairfield, Irene M Ghobrial, Paul A Baldock, David G Little, Michaela Kneissel, Karin Vanderkerken, J H Duncan Bassett, Graham R Williams, Babatunde O Oyajobi, Dirk Hose, Tri G Phan, Peter I Croucher
Multiple myeloma is a plasma cell cancer that develops in the skeleton causing profound bone destruction and fractures. The bone disease is mediated by increased osteoclastic bone resorption and suppressed bone formation. Treatment with bisphosphonates, which inhibit bone resorption, prevents bone loss but fail to influence bone formation and do not replace lost bone, so patients continue to fracture. Stimulating bone formation to increase bone mass and fracture resistance is a priority; however, targeting tumor-derived modulators of bone formation has had limited success...
May 17, 2017: Blood
https://www.readbyqxmd.com/read/28513794/psychotropic-drug-use-among-older-adults-prevalence-and-associated-factors
#6
Mariza Miranda Abi-Ackel, Maria Fernanda Lima-Costa, Érico Castro-Costa, Antônio Ignácio de Loyola
Objective: Investigating the prevalence of psychotropic drug use among older adults and factors associated with it. Methods: This study was based on the Belo Horizonte Metropolitan Area Health Survey, conducted in 2003. It involved 1,635 elderly (60 years or older) citizens, who were residents of cities within the Belo Horizonte Metropolitan Area and were selected using complex randomize sampling. Logistic regression models were used to identify factors associated with psychotropic drug use, with a 5...
January 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28512556/pediatric-tuberculosis-in-northern-sardinia
#7
Maria Grazia Clemente, Elena Dore, Lidia Abis, Paola Molicotti, Stefania Zanetti, Paolina Olmeo, Roberto Antonucci
BACKGROUND AND OBJECTIVES: Migration flux is an increasing phenomenon in Italy, and it raises several public health issues and concerns in pediatric infectious diseases. This study investigated the clinical characteristics and outcomes of a pediatric population at high-risk for tuberculosis (TB) and the potential role of immigration as a risk factor. DESIGN: We performed an observational retrospective study of children referred to the only Pediatric Infectious Diseases Unit for Northern Sardinia over a 6-year-period (2009-2014)...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28512065/long-term-functional-and-psychosocial-outcomes-after-hypoxic-ischemic-brain-injury-a-case-controlled-comparison-to-traumatic-brain-injury
#8
Meredith Harbinson, Sareh Zarshenas, Nora Cullen
BACKGROUND: Despite the increasing rate of survival from Hypoxic-Ischemic Brain Injury (HIBI), there is a paucity of evidence on the long-term functional outcomes after inpatient rehabilitation among these non-traumatic patients compared to patients with Traumatic Brain injury (TBI). OBJECTIVES: To compare functional and psychosocial outcomes of patients with HIBI vs. case-matched patients with TBI 4 to11 years after brain insult. DESIGN: Retrospective, matched case-controlled study...
May 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28511704/the-use-of-kdna-minicircle-subclass-relative-abundance-to-differentiate-between-leishmania-l-infantum-and-leishmania-l-amazonensis
#9
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani
BACKGROUND: Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species. Many of these approaches use the kinetoplast DNA (kDNA) minicircles as the target sequence. These assays had potential cross-species amplification, due to sequence similarity between Leishmania species. Previous works demonstrated discrimination between L...
May 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28511149/analysis-of-extracellular-brain-chemistry-during-percutaneous-dilational-tracheostomy-a-retrospective-study-of-19-patients
#10
Jan Küchler, Jann Wojak, Abdulkareem Abusamha, Claudia Ditz, Volker Martin Tronnier, Jan Gliemroth
OBJECTIVE: The purpose of this study was to analyze changes in brain tissue chemistry around percutaneous dilational tracheostomy (PDT) in patients with acute brain injury (ABI) in a retrospective single-center analysis. PATIENTS AND METHODS: We included 19 patients who had continuous monitoring of brain tissue chemistry and intracranial pressure (ICP) during a 20h period before and after PDT. Different microdialysis parameters (lactate, pyruvate, lactate pyruvate ratio (LPR), glycerol and glutamate) and values of ICP, cerebral perfusion pressure (CPP) and brain tissue oxygenation (PBrO2) were recorded per hour...
May 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28510035/ketone-bodies-as-a-possible-adjuvant-to-ketogenic-diet-in-pdhc-deficiency-but-not-in-glut1-deficiency
#11
F Habarou, N Bahi-Buisson, E Lebigot, C Pontoizeau, M T Abi-Warde, A Brassier, K H Le Quan Sang, C Broissand, S Vuillaumier-Barrot, A Roubertie, A Boutron, C Ottolenghi, P de Lonlay
OBJECTIVE: Ketogenic diet is the first line therapy for neurological symptoms associated with pyruvate dehydrogenase deficiency (PDHD) and intractable seizures in a number of disorders, including GLUT1 deficiency syndrome (GLUT1-DS). Because high-fat diet raises serious compliance issues, we investigated if oral L,D-3-hydroxybutyrate administration could be as effective as ketogenic diet in PDHD and GLUT1-DS. METHODS: We designed a partial or total progressive substitution of KD with L,D-3-hydroxybutyrate in three GLUT1-DS and two PDHD patients...
May 17, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28507321/pet-imaging-of-dopamine-d2-receptor-internalization-in-schizophrenia
#12
J J Weinstein, E van de Giessen, R J Rosengard, X Xu, N Ojeil, G Brucato, R B Gil, L S Kegeles, M Laruelle, M Slifstein, A Abi-Dargham
Recent genetic, molecular and post-mortem studies suggest impaired dopamine (DA)-D2 receptor (D2R) trafficking in patients with schizophrenia (SZ). Imaging and preclinical studies have shown agonist-induced D2R internalization can be imaged with positron emission tomography (PET) using D2R radiotracers combined with psychostimulant challenge. This is feasible if radiotracer binding is measured when postchallenge DA levels have returned to baseline, following the initial competition phase between DA and radiotracer for binding to D2R...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28502918/ability-of-the-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-to-predict-the-3-month-outcome-in-patients-with-non-cardioembolic-stroke
#13
Hayato Matsushima, Naohisa Hosomi, Naoyuki Hara, Takeshi Yoshimoto, Shuichiro Neshige, Ryuhei Kono, Takahiro Himeno, Shinichi Takeshima, Kazuhiro Takamatsu, Yutaka Shimoe, Taisei Ota, Hirofumi Maruyama, Toshiho Ohtsuki, Masaru Kuriyama, Masayasu Matsumoto
AIM: Both the ankle brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are surrogates for atherosclerosis. In this study, we aimed to evaluate the ability of ABI and baPWV to predict stroke outcome in patients with first-ever non-cardioembolic stroke. METHODS: This study included consecutive patients with first-ever non-cardioembolic stroke admitted within 1 week after onset to Ota Memorial Hospital between January 2011 and December 2013. Baseline characteristics and National Institutes of Health stroke scale scores at admission were noted...
May 15, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28501323/reliable-and-practical-methods-for-cryopreservation-of-embryogenic-cultures-and-cold-storage-of-somatic-embryos-of-norway-spruce
#14
Saila Varis, Susanna Ahola, Laura Jaakola, Tuija Aronen
Somatic embryogenesis (SE) is considered as the most-effective method for vegetative propagation of Norway spruce (Picea abies L. Karst). For mass propagation, a cryopreservation method able to handle large numbers of embryogenic tissues (ETs) reliably and at low costs is needed. The aim of the present study was to compare pretreatments, cryoprotectants and slow-cooling devices for cryopreservation of Norway spruce ETs, with 12 variations of methods and a total of 136 spruce genotypes. Secondly, possible applications for cold storage of mature somatic embryos were studied with the aim of developing a flexible time window for embling production...
May 10, 2017: Cryobiology
https://www.readbyqxmd.com/read/28499862/successful-revascularization-of-aortic-arch-in-a-39-year-old-blunt-trauma-patient-with-acute-diffuse-axonal-injury-without-the-use-of-systemic-anticoagulation
#15
Andrew M Abi-Chaker, Keith M Jones, Priscilla Sanchez, Jordan Sasson, Xiaoyi Li, Jorge Rey
BACKGROUND: Blunt traumatic aortic injury is the second leading cause of death in trauma patients age 4 to 34. Of the patients that are able to receive treatment, mortality rates as high as 40% have been reported. Endovascular repair options have allowed for more expeditious repairs with reduced iatrogenic trauma; however, when the injury involves the ascending aorta or arch, current endografts lack fenestrations needed for cerebral blood flow. Traditionally, on pump cardiopulmonary bypass with systemic anticoagulation has been used to repair these injuries...
May 9, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28498053/autism-behavior-inventory-a-novel-tool-for-assessing-core-and-associated-symptoms-of-autism-spectrum-disorder
#16
Abi Bangerter, Seth Ness, Michael G Aman, Anna J Esbensen, Matthew S Goodwin, Geraldine Dawson, Robert Hendren, Bennett Leventhal, Anzalee Khan, Mark Opler, Adrianne Harris, Gahan Pandina
OBJECTIVE: Autism Behavior Inventory (ABI) is a new measure for assessing changes in core and associated symptoms of autism spectrum disorder (ASD) in participants (ages: 3 years-adulthood) diagnosed with ASD. It is a web-based tool with five domains (two ASD core domains: social communication, restrictive and repetitive behaviors; three associated domains: mental health, self-regulation, and challenging behavior). This study describes design, development, and initial psychometric properties of the ABI...
May 12, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28497223/successful-endovascular-treatment-of-popliteal-artery-entrapment-syndrome-a-case-report-with-3-years-follow-up
#17
Xiaodong Wang, Hongkun Zhang, Jin Yan, Ziying Lu
Popliteal artery entrapment syndrome (PAES) is a rare cause of lower extremity arterial ischemia, especially in elder patients. At present, the role of the endovascular technique for PAES is still mainly auxiliary, there is no successful case treated successfully by endovascular treatment without open surgery, and also the long-term follow-up after endovascular treatment are lacking. We successfully treated a 51-year-old man with pale, cold right foot by endovascular therapy only, including percutaneous transluminal angioplasty and catheter directed thrombolysis...
May 11, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28496174/npp-our-designs-for-the-future
#18
EDITORIAL
William A Carlezon, Anissa Abi-Dargham
No abstract text is available yet for this article.
June 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28494632/children-s-and-teachers-perspectives-on-adjustments-needed-in-school-settings-after-acquired-brain-injury
#19
Cornelia Kocher Stalder, Anders Kottorp, Maja Steinlin, Helena Hemmingsson
BACKGROUND: Children with acquired brain injury (ABI) often present with functional deficits that influence their societal participation and well-being. Successful reintegration into school calls for individual support to meet each child's adjustment needs. The adjustment needs of children with ABI in school settings have not previously been explored. AIM: The objectives of the present study were (a) to describe adjustment needs in school settings for children with ABI and (b) to explore differences and similarities between reports from the children and their teachers...
May 11, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28494288/growth-trends-of-beech-and-norway-spruce-in-switzerland-the-role-of-nitrogen-deposition-ozone-mineral-nutrition-and-climate
#20
Sabine Braun, Christian Schindler, Beat Rihm
Understanding the effects of nitrogen deposition, ozone and climate on tree growth is important for planning sustainable forest management also in the future. The complex interplay of all these factors cannot be covered by experiments. Here we use observational data of mature forests for studying associations of various biotic and abiotic factors with tree growth. A 30year time series on basal area increment of Fagus sylvatica L. and Picea abies Karst. in Switzerland was analyzed to evaluate the development in relation to a variety of predictors...
May 8, 2017: Science of the Total Environment
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