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CPR Performance

Chrispian W Theron, Michel Labuschagné, Jacobus Albertyn, Martha S Smit
Cytochrome P450 monooxygenases (P450) are enzymes with high potential as biocatalysts for industrial applications. Their large-scale applications are, however, limited by instability and requirement for coproteins and/or expensive cofactors. These problems are largely overcome when whole cells are used as biocatalysts. We previously screened various yeast species heterologously expressing self-sufficient P450s for their potential as whole-cell biocatalysts. Most P450s are, however, not self-sufficient and consist of two or three protein component systems...
October 19, 2018: Microbial Biotechnology
Teresa M MacDonald, Lisa Hui, Alice J Robinson, Kirsten M Dane, Anna L Middleton, Stephen Tong, Susan P Walker
OBJECTIVES: Fetal growth restriction (FGR) is a major risk factor for stillbirth and most commonly arises from uteroplacental insufficiency. Despite clinical examination and third trimester fetal biometry, cases of FGR often remain undetected antenatally. Placental insufficiency is known to be associated with altered blood flow resistance in maternal, placental, and fetal vessels. We evaluated the performance of individual, and combined Doppler blood flow resistance measurements for the prediction of term FGR...
October 18, 2018: Ultrasound in Obstetrics & Gynecology
Chunghee Joo, Joo-Won Min, Giyong Noh, Jaeho Seo
INTRODUCTION: Aortic dissection is a very rare but life-threatening condition associated with a high mortality. Unexpected sudden cardiac death due to aortic rupture following laparoscopic appendectomy is very rare and may be difficult to diagnose. However, early diagnosis of aortic dissection is essential for the timely treatment and outcome of aortic dissection. CASE PRESENTATION: A 50-year-old man underwent a laparoscopic appendectomy. Postoperatively, the patient complained of dyspnea and chest pain...
October 2018: Medicine (Baltimore)
Kate Hopper, Marlis L Rezende, Angela Borchers, Steven E Epstein
The efficacy of ventilation of dogs during cardiopulmonary resuscitation (CPR) with a tight fitting face mask or mouth-to-nose rescue breathing has not been evaluated. Twenty-four purpose bred research dogs: Dogs were randomized to be ventilated by cuffed orotracheal tube, tight fitting face mask, mouth-to-nose breathing or compressions only during CPR ( n = 6 in all groups). Orotracheal tube and face mask ventilation was performed on room air. Chest compressions were performed during the experimental procedure...
2018: Frontiers in Veterinary Science
N Patrick Mayr, Gunther Wiesner, Oliver Husser, Michael Joner, Jonathan Michel, Jürgen Knorr, Constanza Pellegrini, Sabine Bleiziffer, Heribert Schunkert, Rüdiger Lange, Peter Tassani-Prell
BACKGROUND: Transfemoral TAVR (tf-TAVR) under conscious sedation (CS) has become popular. The need of anesthesiologic support during tf-TAVR has been questioned. Critical events during the procedure might require immediate action. We analyzed the frequency of periprocedural critical adverse events (CAE) during tf-TAVR with CS in our institution. METHODS: Tf-TAVR has been performed at our institution since 2007. We excluded patients from the first four years to minimize the influence of any learning curve...
September 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Kazuhiko Omori, Kouhei Ishikawa, Hiroki Nagasawa, Ikuto Takeuchi, Kei Jitsuiki, Akihiko Kondo, Hiromichi Ohsaka, Youichi Yanagawa
OBJECTIVE: The aim of this study was to identify the prognostic factors of cardiopulmonary arrest (CPA) patients transported by a physician-staffed helicopter who received cardiopulmonary resuscitation (CPR) using AutoPulse (ZOLL Circulation, Sunnyvale, CA). METHODS: A total of 110 CPA patients who had CPR performed on them in the helicopter using AutoPulse were enrolled in this retrospective study. We used logistic regression analysis to examine the prognostic factors of CPA patients who were transported by a physician-staffed helicopter...
September 2018: Air Medical Journal
Roberto Roncon-Albuquerque, Sérgio Gaião, Paulo Figueiredo, Nuno Príncipe, Carla Basílio, Paulo Mergulhão, Sofia Silva, Teresa Honrado, Francisco Cruz, Manuel Pestana, Gerardo Oliveira, Luis Meira, Ana França, João Paulo Almeida-Sousa, Fernando Araújo, José-Artur Paiva
AIM: To assess the feasibility of an integrated program of extracorporeal cardiopulmonary resuscitation (ECPR) and uncontrolled donation after circulatory determination of death (uDCDD) in refractory cardiac arrest (rCA). METHODS: Single center, prospective, observational study of selected patients with in-hospital (IHCA) and out-of-hospital (OHCA) rCA occurring in an urban area of ~1.5 million inhabitants, between October-2016 and May-2018. 65 year old or younger patients without significant bleeding or comorbidities with witnessed nonasystolic cardiac arrests were triaged to ECPR if they had a reversible cause and high quality CPR lasting < 60 min...
October 12, 2018: Resuscitation
Zhenhua Li, Wei Yuan, Jie Li, Jiebin Li, Junyuan Wu, Yongzhen Zhao, Chunsheng Li
OBJECTIVE: This study aimed to identify whether esmolol attenuates cerebral cortex microcirculation blood flow due to epinephrine in prolonged ventricular fibrillation (VF) and cardiopulmonary resuscitation (CPR), and may improve neurological prognosis. METHODS: Male pigs were randomized into the esmolol+epinephrine group (group EE), the epinephrine group (group EP), and the normal saline group (group NS) (n = 8 each group). Untreated VF for 8 minutes was induced in pigs...
October 15, 2018: Journal of Cellular Biochemistry
Masood Ali Shaikh
Pakistan's population will cross the 200 million-mark in 2017. 'Couple Years of Protection' (CYP) is a proxy indicator for various contraceptive methods used. The Pakistan 'Contraceptive Performance Report 2015-2016' (CPR) in Pakistan, provides comparison with the previous year i.e. 2014-2015 in terms of CYP percent change at the district level in the country. In this study, CPR percent change data were mapped and cluster analysis was conducted, using GIS programmes to visualize spatial distribution in the country by district...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Marine Riou, Stephen Ball, Austin Whiteside, Janet Bray, Gavin D Perkins, Karen Smith, Kay L O'Halloran, Daniel M Fatovich, Madoka Inoue, Paul Bailey, Peter Cameron, Deon Brink, Judith Finn
BACKGROUND: In emergency ambulance calls for out-of-hospital cardiac arrest (OHCA), dispatcher-assisted cardiopulmonary resuscitation (CPR) plays a crucial role in patient survival. We examined whether the language used by dispatchers to initiate CPR had an impact on callers' agreement to perform CPR. METHODS: We analysed 424 emergency calls relating to cases of paramedic-confirmed OHCA where OHCA was recognised by the dispatcher, the caller was with the patient, and resuscitation was attempted by paramedics...
October 11, 2018: Resuscitation
Yangyang Zou, Limin Chen, Tianfeng Hua, Min Yang
OBJECTIVE: To investigate the protective function of endovascular cooling method on post-resuscitation syndrome (PRS) in porcine cardiac arrest (CA) model and its mechanism. METHODS: Ventricular fibrillation (VF) was electrically induced and untreated for 8 minutes in 15 healthy male porcines, cardiopulmonary resuscitation (CPR) was then initiated. All successful recovery animals were randomly divided into two groups by random number table. In normal temperature group, the core temperature was maintained at (38...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jianfeng Xu, Hao Pan, Xuemeng Xie, Jincheng Zhang, Yun Wang, Guangtian Yang
Brain damage is a leading cause of death in patients with cardiac arrest (CA). The accumulation of succinate during ischemia by succinate dehydrogenase (SDH) is an important mechanism of ischemia-reperfusion injury. It was unclear whether inhibiting the oxidation of accumulated succinate could also mitigate brain damage after CA. In this study, rats were subjected to a 6 min of CA, and cardiopulmonary resuscitation (CPR) was performed with administration of normal saline or dimethyl malonate (DMM, a competitive inhibitor of SDH)...
October 6, 2018: Neuroscience
Claire A Nordeen
Cardiopulmonary resuscitation (CPR) quality, including chest compression rate, depth, and fraction of hands-on time, is integral to cardiac arrest survival. Introducing mechanized devices to target these measures of quality in the challenging prehospital environment holds great promise. Comparing mechanical to manual CPR, animal models deliver favorable results on markers of perfusion and manikin studies demonstrate improved consistency of high-quality CPR performance with device use. Factoring in real-world application with prospective randomized human trials; however, repeatedly fails to show improvements in patient-centered outcomes and thus cannot be supported by current scientific evidence...
August 2018: Cardiology Clinics
Marc Schluep, Saskia Rijkenberg, Robert Jan Stolker, Sanne Hoeks, Henrik Endeman
PURPOSE: Little is known about long-term survival after In-Hospital Cardiac Arrest (IHCA). The purpose of this study is to report the one-year survival of patients after IHCA and to identify predicting factors. METHODS: Single-center retrospective study of all adult in-hospital CPR attempts conducted between 2003 and 2014 in a tertiary teaching hospital. Demographic and clinical variables of patients were obtained at 24 h pre-arrest, during CPR and post-CPR. All patients were tracked one year after discharge from hospital...
September 27, 2018: Journal of Critical Care
Hui Li, Xu Shen, Xia Xu, Yan Wang, Lihua Chu, Jialian Zhao, Ya Wang, Haihong Wang, Guohao Xie, Baoli Cheng, Hui Ye, Yaqi Sun, Xiangming Fang
BACKGROUND: The World Health Organization (WHO) has endorsed school bystander cardiopulmonary resuscitation (CPR) training programs. But related researches in China are limited. Therefore, we conducted this study to assess bystander CPR training in school children in China and the impact of neighborhood socio-economic status (SES) on. METHODS: A total of 1,093 students from seven schools in Zhejiang province participated in this study. Theoretical and practical bystander CPR training were conducted in instructor-led classes...
October 2018: Medicine (Baltimore)
Andrzej Bielski, Eva Rivas, Kurt Ruetzler, Jacek Smereka, Mateusz Puslecki, Marek Dabrowski, Jerzy R Ladny, Michael Frass, Oliver Robak, Togay Evrin, Lukasz Szarpak
BACKGROUND: Securing the airway and enabling adequate oxygenation and ventilation is essential during cardiopulmonary resuscitation (CPR). The aim of the study was to evaluate the success rate of blind intubation via the I-Gel and the Air-Q compared with direct laryngoscopy guided endotracheal intubation by inexperienced physician and to measure time to successful intubation. METHODS: The study was designed as a randomized, cross-over simulation study. A total of 134 physicians, from specialties other than Anesthesia or Emergency Medicine, who considered themselves skilled in endotracheal intubation but who have never used any kind of supraglottic airway device performed blind intubation via the I-Gel and Air-Q and direct laryngoscopy guided endotracheal intubation in 3 randomized scenarios: normal airway without chest compression during intubation attempt; normal airway with continuous chest compression during intubation attempt; difficult airway with continuous chest compression...
October 2018: Medicine (Baltimore)
Shavi Fernando, Euan Morrison Wallace, Beverley Vollenhoven, Nicholas Lolatgis, Nicole Hope, Melissa Wong, Mark Lawrence, Anthony Lawrence, Chris Russell, Kenneth Leong, Philip Thomas, Luk Rombauts
Purpose: To explore in a small pilot study whether oral melatonin, administered during ovarian stimulation increases clinical pregnancy rate (CPR) after IVF and what dose might be most effective. Methods: Pilot double-blind, dose-finding, placebo-controlled randomized clinical trial in private IVF clinics in Australia between September 2014 and September 2016. One hundred and sixty women having their first cycle of IVF or ICSI were randomized to receive placebo (n = 40), melatonin 2 mg (n = 41), melatonin 4 mg (n = 39), or melatonin 8 mg (n = 40) twice per day (BD) during ovarian stimulation...
2018: Frontiers in Endocrinology
Lindsey M Fejfar, Elizabeth A Rozanski, Megan K Mueller
OBJECTIVE To determine opinions of veterinary emergency health-care providers on the topic of owner-witnessed CPR in small animal emergency medicine and to identify reasons for opposition or support of owner-witnessed CPR. DESIGN Cross-sectional survey. SAMPLE 358 surveys completed by American College of Veterinary Emergency and Critical Care diplomates and residents as well as other emergency-care veterinarians and veterinary technicians between August 14, 2016, and September 14, 2016. PROCEDURES An internet-based survey was used to collect data on respondent demographics, CPR experience, and opinions about owner-witnessed CPR...
October 15, 2018: Journal of the American Veterinary Medical Association
F Fernández-Méndez, R Barcala-Furelos, M Otero-Agra, M Fernández-Méndez, M Santos-Folgar, A Rodríguez-Núñez
OBJECTIVE: To evaluate the quality of cardiopulmonary resuscitation (CPR) by lay people when guided by a mobile phone application with real-time feedback, with the comparison of three different mobile phone applications (APPs). DESIGN: A cross-sectional quasi-experimental study was carried out. PARTICIPANTS: A sample of 113 nursing students participated in the study. INTERVENTIONS: Three hands-only CPR tests with continuous compressions were performed: (i)without external help; (ii)with the mobile phone turned off; and (iii)guided by APP...
September 27, 2018: Medicina Intensiva
Jin Ho Beom, Min Joung Kim, Je Sung You, Hye Sun Lee, Ji Hoon Kim, Yoo Seok Park, Dong Min Shin, Hyun Soo Chung
OBJECTIVES: To analyse changes in the quality of cardiopulmonary resuscitation (CPR) according to driving patterns encountered during ambulance transport, using a virtual reality simulator. DESIGN: Prospective, cross-over, randomised study. SETTING: This study was conducted at the National Fire Service Academy, Cheonan-si, Korea. PARTICIPANTS: Emergency medical technicians (39 men and 9 women) attending the National Fire Service Academy for clinical training with ≥6 months field experience or having performed ≥10 CPR...
September 28, 2018: BMJ Open
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