Shan Yang, Zhekun Wang, Yunwei Hu, Kaile Zong, Xingjiang Zhang, Hui Ke, Pan Wang, Yuyo Go, Xi Hui Felicia Chan, Jianxin Wu, Qing Huang
Pearl powder is a famous traditional Chinese medicine that has a long history in treating palpitations, insomnia, convulsions, epilepsy, ulcers, and skin lightining. Recently, several studies have demonstrated the effects of pearl extracts on protection of ultraviolet A (UVA) induced irritation on human skin fibroblasts and inhibition of melanin genesis on B16F10 mouse melanoma cells. To further explore the effect we focused on the whitening efficacy of pearl hydrolyzed conchiolin protein (HCP) on human melanoma MNT-1 cells under the irritation of alpha-melanocyte-stimulating hormone ( α -MSH) or endothelin 1 (ET-1) to evaluate the intracellular tyrosinase and melanin contents, as well as the expression levels of tyrosinase ( TYR ), tyrosinase related protein 1 ( TRP-1 ), and dopachrome tautomerase ( DCT ) genes and related proteins...
April 18, 2023: International Journal of Molecular Sciences