keyword
MENU ▼
Read by QxMD icon Read
search

Hacat melanosome transfer

keyword
https://www.readbyqxmd.com/read/26581186/fk506-regulates-pigmentation-by-maturing-the-melanosome-and-facilitating-their-transfer-to-keratinocytes
#1
Hyejung Jung, Heesung Chung, Sung Eun Chang, Duk-Hee Kang, Eok-Soo Oh
Despite the clinical ability of topical tacrolimus (FK506) to effectively promote repigmentation in vitiligo, the underlying mechanism through which FK506 regulates melanogenesis was previously unclear. We found that FK506 treatment increased the melanin contents (especially that of eumelanin) in both melanocytes and melanoma cells. This treatment did not affect the transcription levels of tyrosinase, suggesting that FK506 increases melanin synthesis by regulating cellular levels of tyrosinase. Interestingly, FK506 promoted melanosome maturation by increasing melanosomal pH (a marker of melanosome maturation), thereby enhancing the stability of melanosome-localized tyrosinase...
March 2016: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/21532167/macelignan-inhibits-melanosome-transfer-mediated-by-protease-activated-receptor-2-in-keratinocytes
#2
Eun-Jung Choi, Young-Gyu Kang, Jaekyung Kim, Jae-Kwan Hwang
Skin pigmentation is the result of melanosome transfer from melanocytes to keratinocytes. Protease-activated receptor-2 (PAR-2) is a key mediator of melanosome transfer, which occurs as the melanocyte extends its dendrite toward surrounding keratinocytes that take up melanosomes by phagocytosis. We investigated the effects of macelignan isolated from Myristica fragrans HOUTT. (nutmeg) on melanosome transfer and the regulation of PAR-2 in human keratinocytes (HaCaT). HaCaT cells stimulated by the PAR-2-activating peptide Ser-Leu-Ile-Gly-Arg-Leu-NH₂ (SLIGRL) were treated with macelignan; PAR-2 expression was then determined by reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and immunocytochemistry...
2011: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/11924701/preliminary-approach-to-elucidate-the-role-of-pigment-as-a-binding-site-for-drugs-and-chemicals-in-anagen-hairs-pigments-as-carriers-for-3h-haloperidol-in-hacat-sk-mel-1-co-cultures
#3
L Pötsch, P Emmerich, G Skopp
In view of the melanin-binding characteristics of haloperidol and its differential uptake by pigment- and non-pigment-producing cells, a co-culture of HaCaT with Sk-Mel-1 cell lines was performed to investigate whether melanosomes act as carriers for drug molecules associated with the pigments. Initially, HaCaT and Sk-Mel-1 cells were separately cultivated in the presence of 3H-haloperidol (400 pmol/ml medium ) for 28 days followed by subsequent co-cultivation in the absence of 3H-haloperidol for 5 days. The transfer of pigments into the keratinocytes during co-culture was confirmed by transmission electron microscopy...
February 2002: International Journal of Legal Medicine
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"