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Chen Wang, Lukasz Kurgan
Drug-protein interactions (DPIs) underlie the desired therapeutic actions and the adverse side effects of a significant majority of drugs. Computational prediction of DPIs facilitates research in drug discovery, characterization and repurposing. Similarity-based methods that do not require knowledge of protein structures are particularly suitable for druggable genome-wide predictions of DPIs. We review 35 high-impact similarity-based predictors that were published in the past decade. We group them based on three types of similarities and their combinations that they use...
August 8, 2018: Briefings in Bioinformatics
Ryan R Guinness, Jonathan E Volk, Leo B Hurley, Tadd T Tobias, Julia L Marcus
We piloted a low-intensity outreach intervention to increase linkage to PrEP care among HIV-uninfected individuals with rectal sexually transmitted infections or syphilis. We sent a secure email message or letter with information about accessing PrEP. Of those sent an email, 12.4% were linked to PrEP care; linkage differed by race/ethnicity, ranging from 0% of Black individuals to 32% of Hispanic individuals (P = 0.019). No individuals sent letters were linked to PrEP care. A one-time secure email to high-risk patients is feasible to increase linkage to PrEP care...
August 12, 2018: AIDS and Behavior
Kassahun Ketema, Girmay Tsegay, Dereje Gedle, Gail Davey, Kebede Deribe
Background: Household food insecurity remained one of the most crucial challenges to economic development and has been aggravated by household health conditions. Nearly one billion people are undernourished of which 98% in developing countries like Ethiopia. Objective: To assess households' food insecurity among podoconiosis patients and non-podoconiosis in East and West Gojjam Zone, Ethiopia, 2016. Method: A community based comparative cross sectional study was conducted in East and West Gojjam, 2016...
July 2018: EC Nutr
Adele Krusche, Maret Dymond, Susannah E Murphy, Catherine Crane
OBJECTIVE: Prenatal depression, stress and anxiety are significant predictors of postnatal depression and also have a direct negative impact on the family. Helpful psychological interventions during pregnancy are scarce and expensive, and usually only available for a small percentage of those suffering or deemed to be at risk. The aim of this study was to evaluate the potential of an online mindfulness course for expectant mothers. DESIGN: A randomised study was conducted to explore differences between control and active participants allocated to take an online mindfulness course, offered free to research participants, or wait...
July 29, 2018: Midwifery
Di Yue, Xiaowei Wu, Haichen Song, Zhichun Zhou, Man Ye, Mengshan Zhu
OBJECTIVE: The acellular dermal matrix (ADM) used in correcting the tear trough deformity has been reported, but there were only a few cases. The long-term effectiveness of ADM was not clear. We aim to discuss the technique and the effect of using ADM to correct the tear trough deformity through more cases. METHODS: A retrospective study was conducted from January 2012 to January 2017. Twenty-six patients who showed obvious tear trough deformity with moderate or severe orbital fat bulging and excess of lower eyelid skin were treated with ADM to improve the appearance of the midface...
August 10, 2018: Aesthetic Plastic Surgery
Wendy Francesconi, Vincent Bax, Genowefa Blundo-Canto, Simon Willcock, Sandra Cuadros, Martha Vanegas, Marcela Quintero, Carlos A Torres-Vitolas
BACKGROUND: Wildlife has been traditionally used by forest communities as a source of protein, and the Peruvian Amazon is no exception. The articulation of colonist and indigenous communities to urban centers and markets results in changes in livelihood strategies and impacts on wildlife populations. To address the threat of overhunting and forest conversion, we provide a generalized characterization of colonist and indigenous communities and their hunting activities near Pucallpa, Ucayali, Peru...
August 10, 2018: Journal of Ethnobiology and Ethnomedicine
Marina Batalini de Macedo, César Ambrogi Ferreira do Lago, Eduardo Mario Mendiondo
Climate change scenarios tend to intensify extreme rainfall events and drought in Brazil threatening urban water security. Low Impact Development (LID) practices are decentralized alternatives for flood mitigation and prevention. Recently, their potential has increasingly been studied in terms of stormwater harvesting. However, there is still a lack of knowledge about their potentialities in subtropical climate regions. Therefore, this study evaluated the behavior of a bioretention cell in a Brazilian city, during the dry period, which is critical in terms of pollutant accumulation and water availability...
August 4, 2018: Science of the Total Environment
Deborah De Moortel, Nico Dragano, Christophe Vanroelen, Morten Wahrendorf
OBJECTIVES: Working more (overemployment) or less (underemployment) than preferred has been associated with poor mental health in cross-sectional studies, but longitudinal evidence is scarce. We investigate whether under- and overemployment is associated with 2-year changes of mental health and whether associations vary by job rewards (i.e. high earnings, job security, promotion prospects and occupational prestige). METHODS: We used two waves of the German Socio-Economic Panel (GSOEP), with information on mental health collected in 2006 and 2008...
August 9, 2018: International Archives of Occupational and Environmental Health
Adam B Cobb, Gail W T Wilson, Carla L Goad, Michael A Grusak
Alternative soil amendments (worm compost, pyrolyzed carbon [biochar]) and crop symbioses with arbuscular mycorrhizal (AM) fungi have the potential to reduce food production costs while promoting sustainable agriculture by improving soil quality and reducing commercial (N and P) fertilizer use. Our greenhouse studies investigated the influence of alternative soil amendments on AM fungi associated with cowpea ( Vigna unguiculata [L.] Walp.) and common bean ( Phaseolus vulgaris L.) by examining productivity and plant nutrition...
July 2018: Heliyon
Nasima Akhter, Naomi Saville, Bhim Shrestha, Dharma S Manandhar, David Osrin, Anthony Costello, Andrew Seal
Diet quality is an important determinant of nutrition and food security and access can be constrained by changes in food prices and affordability. Poverty, malnutrition, and food insecurity are high in Nepal and may have been aggravated by the 2008 food price crisis. To assess the potential impact of the food price crisis on the affordability of a nutritionally adequate diet in the rural plains of Nepal, data on consumption patterns and local food prices were used to construct typical food baskets, consumed by four different wealth groups in Dhanusha district in 2005 and 2008...
2018: Food Security
Tek B Sapkota, Jeetendra P Aryal, Arun Khatri-Chhetri, Paresh B Shirsath, Ponraj Arumugam, Clare M Stirling
Increasing agricultural production to meet the growing demand for food whilst reducing agricultural greenhouse gas (GHG) emissions is the major challenge under the changing climate. To develop long-term policies that address these challenges, strategies are needed to identify high-yield low-emission pathways for particular agricultural production systems. In this paper, we used bio-physical and socio-economic models to analyze the impact of different management practices on crop yield and emissions in two contrasting agricultural production systems of the Indo-Gangetic Plain (IGP) of India...
2018: Mitigation and adaptation strategies for global change
Mäkinen Hanna, Kaseva Janne, Virkajärvi Perttu, Kahiluoto Helena
The within-species diversity in response to weather and the gaps in the response diversity in the modern set of forage crop cultivars were determined using an approach that assessed the adaptive capacity under global climate change. The annual dry matter (DM) yields were recorded in multi-location MTT (Maa- ja elintarviketalouden tutkimuskeskus) Agrifood Research Official Variety Trials in Finland for modern forage crop cultivars from 2000 to 2012, as a response to agroclimatic variables critical to yield based on the year-round weather data...
2018: Mitigation and adaptation strategies for global change
Jenny Guido, Britany Telford, Luis E Llerena, Spiros Spiropoulos, Charlotte Huber, Andrew Cross, Michael Brannick
BACKGROUND: The Advanced Trauma Life Support® (ATLS® ) course provides a standard approach to trauma. Participants must pass the ATLS® post-test. We deployed the test online to allow ongoing psychometric item analysis and potential objective refinement. METHODS: A two-phase study was undertaken with the ACS COT permission. In the first phase, ATLS® post-test #2 was computerized and deployed using Qualtrics© . Data were collected from fourteen courses conducted between 2014 and 2015 (n = 306) at one ACS AEI site...
August 3, 2018: American Journal of Surgery
Adriana Guimarães Negromonte Bezerra, Vanessa Sá Leal, Pedro Israel Cabral de Lira, Juliana Souza Oliveira, Emilia Chagas Costa, Risia Cristina Egito de Menezes, Florisbela Arruda Câmara de Siqueira E Campos, Maria Izabel Siqueira de Andrade
OBJECTIVE: To identify the prevalence of iron-deficiency anemia and associated factors in women at reproductive age in the city of Vitoria de Santo Antão, Pernambuco. METHODS: Cross-sectional study with a representative sample of 322 women aged between 15 and 49 years. Anemia was diagnosed by measuring hemoglobin below 12 g/dL. The independent variables were: demographic and socioeconomic conditions (age, race/color, education, literacy, presence of children aged < 5 years in the household, regime of residence occupation, ownership of assets, and per capita income), housing conditions (number of people in the household, number of bedrooms, and basic sanitation), food and nutrition security and women's health conditions (menarche, number of pregnancies, history of miscarriages, body mass index, and ferritin)...
2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Filippo Cruciani, Roberto Perilli, Massimo Piccioni
In Italy, blindness and low vision are ruled by Law 138/2001: two categories of blindness (corresponding to the one in the current WHO classification), receiving economical remuneration, and three categories of low vision, not directly remunerated. The problem ensues that low vision patients, who better gain from rehabilitation, have no economical contribution to undergo such care pathways; moreover, in Italy the evaluation has not yet shifted from "visual function" to "functional vision", thus lacking a holistic evaluation of visual dysfunction impact on the patient's daily life skills...
July 2018: Recenti Progressi in Medicina
Anna García-Altés, Dolores Ruiz-Muñoz, Cristina Colls, Montse Mias, Nicolau Martín Bassols
BACKGROUND: The aim of this study is to analyse the health status, the use of public healthcare services and the consumption of prescription drugs in the population of Catalonia, taking into consideration the socioeconomic level of individuals and paying special attention to vulnerable groups. METHODS: Cross-sectional study of the entire population resident in Catalonia in 2015 (7.5 million people) using administrative records. Twenty indicators are analysed related to health, the use of healthcare services and consumption of prescription drugs...
August 6, 2018: Journal of Epidemiology and Community Health
Fiona Maccallum, Richard A Bryant
The death of a loved one has been associated with a wide range of mental health outcomes. Attachment theory is one of the primary paradigms for understanding bereavement outcome, yet there is comparatively little examination of the relationship between attachment style and bereavement responses. In this study we use Latent Class Analysis to identify subgroups of bereaved individuals based on patterns of prolonged grief (PG) and major depression symptom co-occurrence in 285 bereaved individuals. We then explored the relationship between these subgroups and attachment anxiety and avoidance...
July 27, 2018: Psychiatry Research
J A Safonova, E G Zotkin, G M Glazunova, E L Strukov
The purpose of the study was to analyze the frequency of detection of vitamin D deficiency in elderly people, identify clinically significant diseases, accompanied by a deficiency of vitamin 25(OH)D. A retrospective cohort study was conducted in 506 patients over 65 years of age (74,1±6,5 years). Patients were divided into three age groups: group A 65-74 years, group B 75-84 years, group C 85 years and older. The study of blood samples was carried out from September to May. The level of vitamin 25(OH)D was determined by the method of chemiluminescent immunoassay on the Abbott Architect 8000 analyzer (USA)...
2018: Advances in Gerontology, Uspekhi Gerontologii
Lucy J Allbaugh, Sallie A Mack, Hailey Drew Culmone, Ashley M Hosey, Sarah E Dunn, Nadine J Kaslow
Understanding the pathways leading to suicidal behavior is critical for the development and implementation of effective assessment efforts and suicide prevention programs in public health care systems. Childhood trauma, such as emotional abuse, is one robust risk factor, but only recently have efforts been made to determine mediators of the link between childhood emotional abuse and suicidal ideation. Given that adult survivors of childhood emotional abuse often have attachment difficulties and problems securing positive social support, these interpersonal factors may serve such a mediating role...
August 2018: Psychological Services
Craig D Newgard, Cynthia D Morris, Lindsey Smith, Jennifer N B Cook, Donald M Yealy, Sean Collins, James F Holmes, Nathan Kuppermann, Lynne D Richardson, Stephen Kimmel, Lance B Becker, Jane D Scott, Robert A Lowe, Clifton W Callaway, L Kris Gowen, Jill Baren, Alan B Storrow, Nicole Vasilevsky, Marijane White, Adrienne Zell
STUDY OBJECTIVE: We assess the productivity, outcomes, and experiences of participants in the National Institutes of Health/National Heart, Lung, and Blood Institute-funded K12 institutional research training programs in emergency care research. METHODS: We used a mixed-methods study design to evaluate the 6 K12 programs, including 2 surveys, participant interviews, scholar publications, grant submissions, and funded grants. The training program lasted from July 1, 2011, through June 30, 2017...
August 2, 2018: Annals of Emergency Medicine
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