Growh Hormone

OBJECTIVES: Since giant (≥40 mm) GH-secreting pituitary adenomas are rarely encountered, data on their characteristics and treatment outcomes are limited. We aimed to investigate the characteristics of giant GH-secreting pituitary adenomas and to compare their clinical, biochemical, imaging and histopathological features with non-giant macroadenomas. MATERIALS AND METHODS: We have evaluated 15 (six female/nine male) and 57 (29 female/28 male) patients with acromegaly in giant and <40 mm adenoma groups, respectively...

In 60 prepubertal children of both sexes, aged between 6.4 and 15.5 years, with normal or short stature and growing with heigh velocity standard aviation scores (SDS) between 2.69 and -5.75, we has performed 12h noctunral growh hormone (GH) profiles. We found a statistically significant relationship between growth velocity and growth hormone secreation in the group of 60 children with different degrees of GH deficiency, short normal children and children with normal stature. The relationship was expressed with a logarithmic type of curve...

It has been 70 years since the name inhibin was used to describe a gonadal factor that negatively regulated pituitary hormone secretion. The majority of this period was required to achieve purification and definitive characterization of inhibin, an event closely followed by identification and characterization of activin and follistatin (FS). In contrast, the last 15-20 years saw a virtual explosion of information regarding the biochemistry, physiology, and biosynthesis of these proteins, as well as identification of activin receptors, and a unique mechanism for FS action-the nearly irreversible binding and neutralization of activin...