Quinn Lee, Wan Ching Chan, Xinyan Qu, Ying Sun, Hazem Abdelkarim, Jonathan Le, Uzma Saqib, Mitchell Y Sun, Kevin Kruse, Avik Banerjee, Ben Hitchinson, Melissa Geyer, Fei Huang, Victor Guaiquil, Amelia A Mutso, Martin Sanders, Mark I Rosenblatt, Mark Maienschein-Cline, Matthew S Lawrence, Vadim Gaponenko, Asrar B Malik, Yulia A Komarova
Wet age-related macular degeneration (AMD), characterized by leaky neovessels emanating from the choroid, is a main cause of blindness. As current treatments for wet AMD require regular intravitreal injections of anti-vascular endothelial growth factor (VEGF) biologics, there is a need for the development of less invasive treatments. Here, we designed an allosteric inhibitor of end binding-3 (EB3) protein, termed EBIN, which reduces the effects of environmental stresses on endothelial cells by limiting pathological calcium signaling...
September 26, 2023: Cell reports medicine