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Carol A Mancuso, Roland Duculan, Frank P Cammisa, Andrew A Sama, Alexander P Hughes, Darren R Lebl, Federico P Girardi
STUDY DESIGN: Cross-sectional mixed methods analysis of sources of expectations of lumbar surgery. OBJECTIVE: To ascertain sources of expectations and compare them to clinical characteristics. SUMMARY OF BACKGROUND DATA: Understanding where patients obtain expectations of lumbar surgery is necessary in order to develop interventions to foster appropriate expectations. METHODS: This was a qualitative-quantitative study of 428 patients interviewed preoperatively with a 20-item validated survey which asks patients how much improvement they expect per item...
August 6, 2018: Spine
Joshua Schroeder, Joseph Weinstein, Stephan Nikolaus Salzmann, Janina Kueper, Jennifer Shue, Andrew Anthony Sama, Federico Pablo Girardi
STUDY DESIGN: Retrospective radiological review and analysis of 79 patients who underwent primary anterior cervical discectomy and fusion (ACDF) of 2 or 3 levels between 2011 and 2013. PURPOSE: This study aimed to determine the effect of the local placement of a steroid-soaked gelatin sponge after ACDF on prevertebral soft tissue swelling. OVERVIEW OF LITERATURE: Although ACDF has become a popular choice for cervical fusion, the surgical involvement of the delicate anatomy of the neck frequently results in tissue irritation and edema...
August 2018: Asian Spine Journal
Seyed Amir Malekpour, Parsa Pakzad, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Ruzbeh Tusserkani, Bahram Goliaei, Mehdi Sadeghi
Based on previous studies, empirical distribution of the bacterial burst size varies even in a population of isogenic bacteria. Since bacteriophage progenies increase linearly with time, it is the lysis time variation that results in the bacterial burst size variations. Here, the burst size variation is computationally modeled by considering the lysis time decisions as a game. Each player in the game is a bacteriophage that has initially infected and lysed its host bacterium. Also, the payoff of each burst size strategy is the average number of bacteria that are solely infected by the bacteriophage progenies after lysis...
May 3, 2018: Journal of Bioinformatics and Computational Biology
Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L Stapleton, David Zagzag, Luis Chiriboga, Sharon L Gardner, Jeffrey H Wisoff, John G Golfinos, David Capper, Volker Hovestadt, Marc K Rosenblum, Dimitris G Placantonakis, Sarah E LeBoeuf, Thales Y Papagiannakopoulos, Lukas Chavez, Sama Ahsan, Charles G Eberhart, Stefan M Pfister, David T W Jones, Matthias A Karajannis
Pineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk of pineoblastoma, but genetic drivers of sporadic pineoblastoma remain unknown. Here, we analyzed pediatric and adult pineoblastoma samples (n = 23) using a combination of genome-wide DNA methylation profiling and whole-exome sequencing or whole-genome sequencing...
July 20, 2018: Nature Communications
Michael E Steinhaus, Stephan N Salzmann, Francis Lovecchio, Grant D Shifflett, Jingyan Yang, Janina Kueper, Andrew A Sama, Federico P Girardi, Frank P Cammisa, Alexander P Hughes
STUDY DESIGN: Retrospective case-control study. OBJECTIVE: To report culturing patterns and results in the setting of presumed aseptic revision spinal surgery. SUMMARY OF BACKGROUND DATA: The indications for obtaining cultures in revision spinal surgery remain unclear in the absence of a definitive diagnosis of infection. Culture results and risk factors for having positive cultures in this setting have not been previously studied. METHODS: We retrospectively reviewed 595 consecutive revision spine surgeries performed by four senior spine surgeons between 2008 and 2013...
July 13, 2018: Spine
Bandar N Aljafen, Saud M Alfayez, Mohammed H Alanazy, Naael Alazwary, Sama M Alohali, Taim Muayqil
OBJECTIVE: To descriptively assess Epilepsy Monitoring Units (EMUs) and the provided services in Saudi Arabia and compare them based on the geographic region. METHODS: In this cross-sectional study, an electronic questionnaire was emailed to all directors of EMUs in Saudi Arabia from July 2013 to January 2016, with constant updates being made by all respondents throughout the period of data collection. RESULTS: All EMU directors participated...
July 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Yoel Rojas, Catherine Sinnott, Cesar Colasante, John Samas, Richard Reish
BACKGROUND: Polyethylene (Medpor) and Silicone are two of the most popular materials used today for facial skeleton implantation. Previous studies have identified common complications with the use of these implants, but patient follow up has been short. This review of literature examines complications and patient follow up in cases using Medpor and Silicone implants for reconstructive and aesthetic surgeries of the mid and lower face over the last 20 years. METHOD: A literature search was conducted through the PUBMED database...
July 3, 2018: Plastic and Reconstructive Surgery
Sama Al-Junaid, Priti Acharya
Root resorption is a common but undesirable side-effect of orthodontic treatment. It is a well-recognised phenomenon largely associated with impacted or unerupted teeth and in most cases, is mild and does not affect longevity of the affected teeth. This case report of a medically fit and healthy Caucasian boy who was undergoing orthodontic treatment at the Eastman Dental Hospital, UCLH (EDH) for management of his severe hypodontia, presents an unusual incident of bilateral resorption of his maxillary first permanent molars by the unerupted second molars...
July 5, 2018: Journal of Orthodontics
Mara Lombardi, Alfredo Rossi, Maria C Fortuna, Valentina Garelli, Elisa Sama, Daniela Senis, Claudia Costa
BACKGROUND: Actinic keratosis (AKs) are premalignant skin lesions characterized by high rate of transformation in squamous cell carcinoma if not treated. Pre-clinical published data on parrodiene-derivative 2,4,6-octatrienoic acid, encourages us to study andto evaluate the effect of a topical product containing it in patients affected by mild to moderate actinic keratosis. METHODS: 70 subjects with at least 1-3 clinically diagnosed actinic keratosis lesions, nonhyperkeratotic, non-hypertrophic, localized on the face (I-II degree actinic keratosis) were enrolled in the study...
June 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Sama I Sayin, Theresa Baumeister, Timothy C Wang, Michael Quante
The incidence of esophageal adenocarcinoma (EAC) and its precursor lesion Barrett's esophagus (BE) has been increasing steadily in the western world in recent decades. Understanding the cellular origins of BE and the conditions responsible for their malignant transformation would greatly facilitate risk assessment and identification of patients at risk of progression, but this topic remains a source of debate. Here, we review recent findings that have provided support for the gastroesophageal junction (GEJ) as the main source of stem cells that give rise to BE and EAC...
August 2018: Digestive Diseases and Sciences
Soheila Molaei, Sama Babaei, Mostafa Salehi, Mahdi Jalili
Diffusion of information in complex networks largely depends on the network structure. Recent studies have mainly addressed information diffusion in homogeneous networks where there is only a single type of nodes and edges. However, some real-world networks consist of heterogeneous types of nodes and edges. In this manuscript, we model information diffusion in heterogeneous information networks, and use interactions of different meta-paths to predict the diffusion process. A meta-path is a path between nodes across different layers of a heterogeneous network...
June 22, 2018: Scientific Reports
Sama Kalyana Chakravarthy, Rajagopalaboopathi Jayasudha, Konduri Ranjith, Anirban Dutta, Nishal Kumar Pinna, Sharmila S Mande, Savitri Sharma, Prashant Garg, Somasheila I Murthy, Sisinthy Shivaji
Dysbiosis in the gut microbiome has been implicated in several diseases including auto-immune diseases, inflammatory diseases, cancers and mental disorders. Keratitis is an inflammatory disease of the eye significantly contributing to corneal blindness in the developing world. It would be worthwhile to investigate the possibility of dysbiosis in the gut microbiome being associated with Keratitis. Here, we have analyzed fungal and bacterial populations in stool samples through high-throughput sequencing of the ITS2 region for fungi and V3-V4 region of 16S rRNA gene for bacteria in healthy controls (HC, n = 31) and patients with fungal keratitis (FK, n = 32)...
2018: PloS One
Diana M Sama, Shaun W Carlson, Binoy Joseph, Stefanie Saenger, Friedrich Metzger, Kathryn E Saatman
BACKGROUND: Traumatic brain injury can result in lasting cognitive dysfunction due to degeneration of mature hippocampal neurons as well as the loss of immature neurons within the dentate gyrus. While endogenous neurogenesis affords a partial recovery of the immature neuron population, hippocampal neurogenesis may be enhanced through therapeutic intervention. Insulin-like growth factor-1 (IGF-1) has the potential to improve cognitive function and promote neurogenesis after TBI, but its short half-life in the systemic circulation makes it difficult to maintain a therapeutic concentration...
2018: Restorative Neurology and Neuroscience
Majid Zarrin, Sama Faramarzi
AIM: The main goal of the present study was to find azole-resistant and molecular analysis of cyp51A gene in Aspergillus fumigatus . MATERIALS AND METHODS: Fifty-eight A. fumigatus strains including environmental, clinical and reference isolates were assessed in this investigation. Azole susceptibility testing for itraconazole and voriconazole was carried out for A. fumigatus isolates. PCR was performed based on cyp51A gene sequence for all isolates. RESULTS: Susceptibility testing verified the minimum inhibitory concentrations (MICs) for itraconazole (0...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
Alfréd Trnka, Peter Samaš, Tomáš Grim
Animals often show correlated suites of consistent behavioural traits, i.e., personality or behavioural syndromes. Does this conflict with potential phenotypic plasticity which should be adaptive for animals facing various contexts and situations? This fundamental question has been tested predominantly in studies which were done in non-breeding contexts and under laboratory conditions. Therefore, in the present study we examined the temporal stability of behavioural correlations in a breeding context and under natural conditions...
August 2018: Behavioural Processes
Silvia Vezzani, Elisa Giannetta, Barbara Altieri, Arcangelo Barbonetti, Giuseppe Bellastella, Rosaria Certo, Angelo Cignarelli, Francesca Cinti, Settimio D'Andrea, Giulia Di Dalmazi, Stefano Frara, Silvia Garelli, Giuseppe Giuffrida, Maria Ida Maiorino, Chiara Mele, Teresa Mezza, Maria Grazia Pani, Maria Teresa Samà, Chiara Satta, Daniele Santi
OBJECTIVE: The adherence by endocrinologists to guideline regarding levothyroxine (LT4) therapy and the compliance of patients may impact the management of hypothyroidism. The aim of this study was to compare the adherence of Italian endocrinologists to the ATA/AACE and ETA guidelines on the management of newly diagnosed primary hypothyroidism and to validate the Italian version of the Morisky-Green Medical Adherence Scale-8 (MMAS-8) questionnaire as applied to the evaluation of the adherence of patients with hypothyroidism to LT4 treatment...
May 2018: Endocrine Practice
Roger Luckmann, Mary E Costanza, Mary Jo White, Christine F Frisard, Milagros Rosal, Susan Sama, Michelle R Landry, Robert Yood
As population health has become a focus of health care payers and providers, interest has grown in mail, phone, and other forms of outreach for improving population rates of cancer screening. Translational research is needed to compare the effectiveness and cost of low- and high-intensity behavioral outreach interventions for promoting cancer screening. The purpose of the article is to compare the effectiveness in promoting biannual mammograms of three interventions delivered over 4 years to a primary care population with a high baseline mammography adherence of 83...
May 23, 2018: Translational Behavioral Medicine
Stephan N Salzmann, Courtney Ortiz Miller, John A Carrino, Jingyan Yang, Jennifer Shue, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
BACKGROUND CONTEXT: Sacral fractures are a rare but potentially devastating complication. Long-fusion constructs, including the sacrum, that do not extend to the pelvis may result in sacral fractures. Besides established risk factors including gender, age, and number of levels fused, body mass index (BMI), pelvic parameters, and bone mineral density (BMD) have also been proposed as potential risk factors for postoperative sacral fractures. The literature supporting this, however, is limited...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
Alejandro Casas, Maria Montes de Oca, Ana Mb Menezes, Fernando C Wehrmeister, Maria Victorina Lopez Varela, Laura Mendoza, Larissa Ramírez, Marc Miravitlles
Background: Limited information is available regarding medication use in COPD patients from Latin America. This study evaluated the type of medication used and the adherence to different inhaled treatments in stable COPD patients from the Latin American region. Methods: This was an observational, cross-sectional, multinational, and multicenter study in COPD patients attended by specialist doctors from seven Latin American countries. Adherence to inhaled therapy was assessed using the Test of Adherence to Inhalers (TAI) questionnaire...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Veronica Lanza Cariccio, Annalisa Samà, Placido Bramanti, Emanuela Mazzon
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis are characterized by a chronic and selective process of neuronal cell death. Although the causes of neurodegenerative diseases remain still unknown, it is now a well-established idea that more factors, such as genetic, endogenous, and environmental, are involved. Among environmental causes, the accumulation of mercury, a heavy metal considered a toxic agent, was largely studied as a probable factor involved in neurodegenerative disease course...
May 18, 2018: Biological Trace Element Research
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