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https://www.readbyqxmd.com/read/30343044/regional-bone-mineral-density-differences-measured-by-qct-does-the-standard-clinically-used-l1-l2-average-correlate-with-the-entire-lumbosacral-spine
#1
Stephan N Salzmann, Toshiyuki Shirahata, Jingyan Yang, Courtney Ortiz Miller, Brandon B Carlson, Colleen Rentenberger, John A Carrino, Jennifer Shue, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
BACKGROUND CONTEXT: Quantitative computed tomography (QCT) of the lumbar spine is used as an alternative to dual-energy X-ray absorptiometry in assessing bone mineral density (BMD). The average BMD of L1-L2 is the standard reportable metric used for diagnostic purposes according to current recommendations. The density of L1 and L2 has also been proposed as a reference value for the remaining lumbosacral vertebrae and is commonly used as a surrogate marker for overall bone health. Since regional BMD differences within the spine have been proposed, it is unclear if the L1-L2 average correlates with the remainder of the lumbosacral spine...
October 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/30335543/c-type-natriuretic-peptide-dampens-fibroblast-growth-factor-23-expression-through-mapk-signaling-pathway-in-human-mesangial-cells
#2
Yang Fang Wu, Dong Dong Zhang, Si Yan Liu, Huang Huang Luo, Guang Mei Jiang, Yao Xu, Yue Wu, Jing Jing Wang, Fei Fei Liu, Sama Samadli, Wei Wei, Bo Hu, Peng Hu
C-type natriuretic peptide (CNP) is believed to be produced locally in the kidneys and possess several renoprotective properties. In contrast, fibroblast growth factor (FGF) -23 elevates in the early stage of chronic kidney disease and predicts its outcomes. Currently, several studies have demonstrated that CNP and FGF-23 act through a close pathway, and moreover, FGF-23/mitogen-activated protein kinase (MAPK) can be obviously suppressed by CNP. In the present study, human mesangial cells (MCs) were incubated in serum-containing medium in the absence or presence of CNP (0, 10 and 100 pM) for 24, 48 and 72 h, respectively...
October 18, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/30306837/influence-of-mesophilic-and-thermophilic-conditions-on-the-anaerobic-digestion-of-food-waste-focus-on-the-microbial-activity-and-removal-of-long-chain-fatty-acids
#3
Xiaohui Guo, Kang Kang, Gaoyuan Shang, Xiunan Yu, Ling Qiu, Guotao Sun
The mesophilic reactor (MR) exhibited advantages in biogas production and performance stability over thermophilic reactor (TR) during the long-term anaerobic digestion (AD) of food waste (FW) with stepwise organic loading rate elevating. It was interesting to explore the mechanism causing the divergences in performances between these two reactors. The microbial activity was compared on day 110 when TR began to deteriorate. The results show that MR had significantly higher specific acetoclastic methanogenic activities (SAMA) and specific propionate and butyrate oxidative activities (SPOA and SBOA) than TR...
October 11, 2018: Waste Management & Research
https://www.readbyqxmd.com/read/30270842/emergency-admissions-in-sub-saharan-africa-example-of-the-surgical-emergency-admissions-unit-at-the-sylvanus-olympio-teaching-hospital-of-lom%C3%A3-togo
#4
S Adam, D H Sama, T Mouzou, A Akakpovi, K Tomta, M Bellier
The management of patients in emergency departments is an important indicator of the quality of a healthcare system. In sub-Saharan Africa, emergency care is characterized by human and material difficulties. The purpose of this work was to assess the difficulties in managing emergencies at the surgical emergency admissions unit of Sylvanus Olympio teaching hospital of Lomé. This descriptive prospective study took place during the last 6 months of 2013. Epidemiological, clinical, and therapeutic data were collected...
August 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/30270831/causes-of-deaths-in-the-intensives-care-unit-of-sylvanus-olympio-teaching-hospital-lom%C3%A3-togo
#5
P Egbohou, H D Sama, T Mouzou, S Assenouwe, G Akala-Yoba, F Tchetike, K Tomta
To analyze the causes of deaths in the intensive care unit (ICU) at the CHU Sylvanus Olympio (CHU SO) teaching hospital of Lomé. This retrospective study examined the files of patients who died in the ICU of CHU SO, during the 12-month period from November 2012 to October 2013. Of 732 patients admitted to the ICU, 237 died, for a mortality rate of 32.38%. Men accounted for 163 (68.8%) of the deaths, and women 74 (31.2%), for a M/F ratio of 2.2. The average age of patients who died was 41.7 years; the age group 21-30 years comprised 16% of the deaths, that 31-40 years 19...
August 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/30262956/dysbiosis-in-the-gut-bacterial-microbiome-of-patients-with-uveitis-an-inflammatory-disease-of-the-eye
#6
Sama Kalyana Chakravarthy, Rajagopalaboopathi Jayasudha, Gumpili Sai Prashanthi, Mohammed Hasnat Ali, Savitri Sharma, Mudit Tyagi, Sisinthy Shivaji
Uveitis (UVT), an inflammatory disease of the eye significantly contributes to vision impairment and blindness. Uveitis is associated with systemic infectious and autoimmune diseases, but in most cases, the aetiology remains unidentified. Dysbiosis in the gut microbiome has been implicated in autoimmune diseases, inflammatory diseases, cancers and mental disorders. In a mice model of autoimmune UVT, it was observed that manipulating the gut microbiome reduces the inflammation and disease severity. Further, alterations in the bacterial gut microbiome and their metabolites were reported in UVT patients from a Chinese cohort...
December 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/30258752/does-the-addition-of-either-a-lateral-or-posterior-interbody-device-to-posterior-instrumented-lumbar-fusion-decrease-cost-over-a-6-year-period
#7
Paul Schadler, Peter Derman, Lily Lee, Huong Do, Federico P Girardi, Frank P Cammisa, Andrew A Sama, Jennifer Shue, Stelios Koutsoumbelis, Alexander P Hughes
Study Design: Retrospective case-control study. Objectives: Few studies have compared the costs of single-level (1) posterior instrumented fusion alone (PSF), (2) posterior interbody fusion with PSF (PLIF), and (3) lateral interbody fusion with PSF (circumferential LLIF). The purpose of this study was to compare costs associated with these procedures. Methods: Charts were reviewed and patients followed-up with a telephone questionnaire. Medicare reimbursement data was used for cost estimation from the payer's perspective...
August 2018: Global Spine Journal
https://www.readbyqxmd.com/read/30258603/-salmonella-spp-and-campylobacter-spp-in-poultry-feces-and-carcasses-in-ouagadougou-burkina-faso
#8
Assèta Kagambèga, Alexandre Thibodeau, Valentina Trinetta, Daniel K Soro, Florent N Sama, Évariste Bako, Caroline S Bouda, Aïssata Wereme N'Diaye, Philippe Fravalo, Nicolas Barro
The importance of Salmonella  and  Campylobacter as foodborne pathogens is well recognized worldwide. Poultry and poultry products are commonly considered as the major vehicles of Salmonella and Campylobacter infection in humans. The aim of this study was to investigate the hygienic status of poultry facilities and determine the prevalence of Salmonella and Campylobacter in slaughtered poultry feces and carcasses in four different markets in Ouagadougou, capital city of Burkina Faso. A total of 103 poultry feces and 20 carcasses were analyzed using microbiological standard methods...
September 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/30221862/-endometrial-pattern-in-early-pregnancy-and-correlation-with-ectopic-pregnancy
#9
Sama Yasin, Yael Sciaky-Tamir, Emad Mostafa, Iris Ohel-Shani, Etty Daniel-Spiegel
INTRODUCTION: Ectopic-pregnancy is a leading cause of pregnancy-related maternal death in the first trimester. Early sonographic diagnostic ability of ectopic-pregnancy is limited. There is an increasing need to identify sonographic markers that can assist with the diagnosis. OBJECTIVES: To characterize the endometrial-pattern by transvaginal-ultrasound as an early marker for ectopic-pregnancy, before demonstration of tubal mass. METHODS: A multicenter prospective study that included 52 women with a positive HCG test, referred to the ultrasound-unit with a diagnosis of pregnancy of unknown location...
September 2018: Harefuah
https://www.readbyqxmd.com/read/30199015/probing-the-limits-of-egg-recognition-using-egg-rejection-experiments-along-phenotypic-gradients
#10
Lindsay Canniff, Miri Dainson, Analía V López, Mark E Hauber, Tomáš Grim, Peter Samaš, Daniel Hanley
Brood parasites lay their eggs in other females' nests, leaving the host parents to hatch and rear their young. Studying how brood parasites manipulate hosts into raising their young and how hosts detect parasitism provide important insights in the field of coevolutionary biology. Brood parasites, such as cuckoos and cowbirds, gain an evolutionary advantage because they do not have to pay the costs of rearing their own young. However, these costs select for host defenses against all developmental stages of parasites, including eggs, their young, and adults...
August 22, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30188953/chronic-obstructive-pulmonary-disease-with-short-acting-inhaled-pharmacotherapy-increases-the-risk-of-prostate-cancer-a-two-stage-database-approach
#11
Hui-Wen Lin, Li-Fong Lin, Hung-Chou Chen, Tsan-Hon Liou, Shih-Wei Huang
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at a higher risk of many types of cancer. However, specific investigation of the risk of prostate cancer and the influence of COPD pharmacotherapy in patients with COPD is lacking. This study investigated the risk and influence of COPD pharmacotherapy on risk of prostate cancer in patients with COPD. METHODS: This retrospective cohort study used data from Taiwan's Longitudinal Health Insurance Database 2005 (LHID2005)...
2018: PloS One
https://www.readbyqxmd.com/read/30169729/malignant-peripheral-nerve-sheath-tumors-show-decreased-global-dna-methylation
#12
J Stephen Nix, Michael C Haffner, Sama Ahsan, Jessica Hicks, Angelo M De Marzo, Jaishri Blakeley, Eric H Raabe, Fausto J Rodriguez
Malignant peripheral nerve sheath tumors (MPNST) are aggressive spindle cell neoplasms that may occur sporadically, often in association with radiation exposure, or in the clinical context of Neurofibromatosis type 1. MPNST are known to harbor genetic alterations affecting the function of polycomb repressive complex 2 (PRC2), resulting in profound changes to global H3K27me3 levels. Recent evidence suggests a link between the polycomb complex and DNA methylation. Given the established epigenetic alterations found in MPNST, we aimed to further explore global methylation changes including 5-methylcystosine (5mC), 5-hydroxymethylcytosine (5hmC), and H3K27me3 levels using previously validated immunolabeling protocols in a representative cohort of 28 peripheral nerve sheath tumors (MPNST [n = 8], localized cutaneous neurofibroma [n = 10], and plexiform neurofibroma [n = 10])...
October 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/30147308/burden-of-disease-associated-with-a-copd-eosinophilic-phenotype
#13
Hector Ortega, Jean-Pierre Llanos, Marie-Hélène Lafeuille, Guillaume Germain, Mei Sheng Duh, Christopher F Bell, Susan R Sama, Beth Hahn
Purpose: Based on blood and sputum samples, up to 40% of patients with COPD have eosinophilic inflammation; however, there is little epidemiology data characterizing the health care burden within this sub-population. Given that COPD-attributable medical costs in the USA are predicted to approach $50 billion by 2020, we analyzed the effect of blood eosinophil counts and exacerbations on health care resource utilization and costs. Patients and methods: This cross-sectional study used electronic medical records and insurance claims data from the Reliant Medical Group (January 2011-December 2015)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30142468/the-association-between-fecal-microbiota-and-different-types-of-colorectal-polyp-as-precursors-of-colorectal-cancer
#14
Sama Rezasoltani, Hamid Asadzadeh Aghdaei, Hossein Dabiri, Abbas Akhavan Sepahi, Mohammad Hossein Modarressi, Ehsan Nazemalhosseini Mojarad
BACKGROUND: Colon cancer (CRC) is a heterogeneous disorder, arising from precursors-adenoma and serrated polyp. Previous studies have demonstrated the relationship between the human gut microbiota and CRC; however, its correlation to the different early precursors of CRC is not properly understood. Here, we studied the relationship between targeted gut bacteria and different colorectal polyp types, location, size and grade of dysplasia. MATERIAL AND METHODS: In the present case-control descriptive study, selected fecal bacteria were assessed in 118 patients, referred for standard screening colonoscopy, including 31 normal controls, 21 hyperplastic polyp (HP), 16 sessile serrated polyp (SSA), 29 tubular adenoma (TA) and 21 villous/tubuvillous polyp (VP/TVP) cases, between 2015 and 2017, by absolute quantitative real time PCR technique (q PCR) in different ethnicity of Iranian population...
August 22, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30138790/enhanced-cellular-response-elicited-by-addition-of-amniotic-fluid-to-alginate-hydrogel-electrospun-silk-fibroin-fibers-for-potential-wound-dressing-application
#15
Sama Ghalei, Jhamak Nourmohammadi, Atefeh Solouk, Hamid Mirzadeh
This study aimed to evaluate a novel bioactive wound dressing from alginate hydrogel-electrospun silk fibroin (SF) fibers with the ability to deliver amniotic fluid (AF) to the wound site. AF is highly enriched with multiple therapeutic agents that can promote cellular response and wound healing. In this study, electrospun SF fibers were first fabricated by electrospinning method and then combined with the alginate hydrogel (ALG) containing AF. Different dressings were made by changing the alginate to AF ratio...
August 16, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30130418/effects-of-systemic-corticosteroids-on-blood-eosinophil-counts-in-asthma-real-world-data
#16
Hector Ortega, Jean-Pierre Llanos, Marie-Helene Lafeuille, Mei Sheng Duh, Guillaume Germain, Dominique Lejeune, Susan Sama, Chris Bell, Beth Hahn
INTRODUCTION: Systemic corticosteroids (SCS) are effective anti-inflammatory therapies for patients with severe or persistent asthma. Use of SCS reduces blood eosinophil counts; the magnitude and duration of reduction in real-world settings needs further investigation. OBJECTIVE: To examine the SCS effect on blood eosinophil counts over time among patients with asthma in a real-world setting. METHODS: This retrospective study used Reliant Medical Group (Worcester, MA) electronic medical records between January 2011 and December 2015...
October 16, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/30114454/how-to-navigate-dermatology-care-for-the-uninsured
#17
EDITORIAL
Samantha Shwe, Sama Kassira, Dong Joo Kim, Ashley Elsensohn, Patrick Lee
No abstract text is available yet for this article.
August 13, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/30086082/sources-of-patients-expectations-of-lumbar-surgery
#18
Carol A Mancuso, Roland Duculan, Frank P Cammisa, Andrew A Sama, Alexander P Hughes, Darren R Lebl, Federico P Girardi
STUDY DESIGN: Cross-sectional mixed methods analysis of sources of expectations of lumbar surgery. OBJECTIVE: To ascertain sources of expectations and compare them to clinical characteristics. SUMMARY OF BACKGROUND DATA: Understanding where patients obtain expectations of lumbar surgery is necessary in order to develop interventions to foster appropriate expectations. METHODS: This was a qualitative-quantitative study of 428 patients interviewed preoperatively with a 20-item validated survey which asks patients how much improvement they expect per item...
August 6, 2018: Spine
https://www.readbyqxmd.com/read/30060373/effect-of-steroid-soaked-gelatin-sponge-on-soft-tissue-swelling-following-anterior-cervical-discectomy-and-fusion-a-radiographic-analysis
#19
Joshua Schroeder, Joseph Weinstein, Stephan Nikolaus Salzmann, Janina Kueper, Jennifer Shue, Andrew Anthony Sama, Federico Pablo Girardi
STUDY DESIGN: Retrospective radiological review and analysis of 79 patients who underwent primary anterior cervical discectomy and fusion (ACDF) of 2 or 3 levels between 2011 and 2013. PURPOSE: This study aimed to determine the effect of the local placement of a steroid-soaked gelatin sponge after ACDF on prevertebral soft tissue swelling. OVERVIEW OF LITERATURE: Although ACDF has become a popular choice for cervical fusion, the surgical involvement of the delicate anatomy of the neck frequently results in tissue irritation and edema...
August 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/30051743/modeling-the-probability-distribution-of-the-bacterial-burst-size-via-a-game-theoretic-approach
#20
Seyed Amir Malekpour, Parsa Pakzad, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Ruzbeh Tusserkani, Bahram Goliaei, Mehdi Sadeghi
Based on previous studies, empirical distribution of the bacterial burst size varies even in a population of isogenic bacteria. Since bacteriophage progenies increase linearly with time, it is the lysis time variation that results in the bacterial burst size variations. Here, the burst size variation is computationally modeled by considering the lysis time decisions as a game. Each player in the game is a bacteriophage that has initially infected and lysed its host bacterium. Also, the payoff of each burst size strategy is the average number of bacteria that are solely infected by the bacteriophage progenies after lysis...
May 3, 2018: Journal of Bioinformatics and Computational Biology
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