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Mohammad Hossein Harirchian, Zinat Mohammadpour, Farzad Fatehi, Negar Firoozeh, Sama Bitarafan
BACKGROUND & AIMS: Vitamin A is considered as a supplement that effect on autoimmune diseases. We aimed to systematically review the effect of vitamin A on cytokines in patients with autoimmune disease. METHODS: Two researchers searched Scopus and PubMed until May 2018. Researchers extracted data from 6 eligible published papers. Extracted data included the gene expression of the inflammatory and anti-inflammatory cytokines. RESULTS: Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-γ and T-bet) and anti-inflammatory (TGF-β and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases...
November 14, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Parastoo Shabani, Sama Izadpanah, Ali Aghebati-Maleki, Elham Baghbani, Amir Baghbanzadeh, Ali Fotouhi, Babak Bakhshinejad, Leili Aghebati-Maleki, Behzad Baradaran
Osteosarcoma (OS) is the most common primary malignant tumor of the bone with a strong tendency to early metastasis, and occurs in growing bones more commonly in children and adolescents. Considering the limited therapeutic methods and lack of 100% success of these methods, developing innovative therapies with high efficacy and lower side effects is needed. Meanwhile, miRNAs and the studies indicating the involvement of miRNAs in OS development have attracted attentions as a result of the frequent abnormalities in expression of miRNAs in cancer...
November 18, 2018: Journal of Cellular Biochemistry
Sama Rezasoltani, Maryam Sharafkhah, Hamid Asadzadeh Aghdaei, Ehsan Nazemalhosseini Mojarad, Hossein Dabiri, Abbas Akhavan Sepahi, Mohammad Hossein Modarressi, Mohammad Mehdi Feizabadi, Mohammad Reza Zali
BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer, and presents a considerable disease burden, worldwide. Recently, the gut microbiota has been proposed as a potential risk factor for CRC, and even adenomatous polyps (AP). Here, the aim of this study was to investigate the role of selected gut bacteria as fecal bacterial biomarkers, in early detection of CRC and AP. MATERIAL AND METHODS: Fecal samples (n = 93) were collected from Taleghani Hospital, Tehran, Iran, between 2015 and 2017, from normal controls (NC), AP cases and CRC stage I patients, who were undergoing screening for colonoscopy...
November 12, 2018: Journal of Microbiological Methods
Jennifer E Davoren, Deane M Nason, Jotham Coe, Keith Dlugolenski, Christopher J Helal, Anthony R Harris, Erik LaChapelle, Sidney Liang, Yue Liu, Rebecca E O'Connor, Christine C Orozco, Brajesh Kumar Rai, Michelle Salafia, Brian M Samas, Wenjian Xu, Rouba Kozak, David Gray
The discovery of D1 subtype-selective agonists with drug-like properties has been an enduring challenge for the greater part of 40 years. All known D1-selective agonists are catecholamines which bring about receptor desensitization and undergo rapid metabolism thus limiting their utility as a therapeutic for chronic illness such as Schizophrenia and Parkinson's disease. Our high-throughput screening efforts on D1 yielded a single non-catecholamine hit, PF-4211 (6) that was developed into a series of potent D1 receptor agonist leads with high oral bioavailability and CNS penetration...
November 15, 2018: Journal of Medicinal Chemistry
Ferdinando Carlo Maria Cananzi, Eleonora Maddalena Minerva, Laura Samà, Laura Ruspi, Federico Sicoli, Lorenzo Conti, Uberto Fumagalli Romario, Vittorio Lorenzo Quagliuolo
BACKGROUND AND OBJECTIVES: Several inflammation markers were found to have a prognostic value in cancer. We investigated the significance of preoperative white cell ratios in determining gastrointestinal stromal tumors (GISTs) outcome. METHODS: Clinicopathological features of patients who underwent surgery for GIST were reviewed. The following peripheral blood inflammation markers were calculated: neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), neutrophil-white blood cell ratio (NWR), lymphocyte-white cell ratio (LWR), monocyte-white cell ratio (MWR), and platelet-white cell ratio (PWR)...
November 13, 2018: Journal of Surgical Oncology
Arsenij Kokorin, Christoph Weise, Simko Sama, Alexander Weng
Ribosome-inactivating proteins (RIPs) are enzymes with N-glycosylase activity that remove adenine bases from the ribosomal RNA. In theory, one single RIP molecule internalized into a cell is sufficient to induce cell death. For this reason, RIPs are of high potential as toxic payload for anti-tumor therapy. A considerable number of RIPs are synthesized by plants that belong to the carnation family (Caryophyllaceae). Prominent examples are the RIPs saporin from Saponaria officinalis L. or dianthin from Dianthus caryophyllus L...
November 3, 2018: Phytochemistry
Pradnya Velankar, Kongkiat Chaikriangkrai, Ninad Dewal, Sayf Khaleel Bala, Belqis Elferjani, Sama Alchalabi, Su Min Chang
Coronary computed tomographic angiography (CCTA) with prospective electrocardiographic gating reduces radiation exposure, but its prognostic power for predicting cardiovascular risk in patients with suspected CAD has not been fully validated. To determine whether prospective gating performs as well as retrospective gating in this population, we compared these scan modes in patients undergoing 64-slice CCTA. From January 2009 through September 2011, 1,407 patients underwent CCTA; of these, 915 (mean age, 57...
August 2018: Texas Heart Institute Journal
Dianna L Ng, Edda Vuhahula, Li Zhang, Emily G Waterhouse, Kristie L White, Beatrice Paul Mushi, Msiba Selekwa Nyeriga, Godfrey Sama Philipo, Elia J Mmbaga, Sujay Sheth, Katherine Van Loon, Amie Y Lee, Ronald Balassanian
BACKGROUND: Fine-needle aspiration biopsy (FNAB) is a minimally invasive, cost-effective diagnostic tool that can be used in low-resource settings. However, adequacy and accuracy of FNAB is highly dependent on the skills of the operator and requires specialized training. Poor technique can preclude definitive diagnoses because of insufficient quality or quantity of FNAB samples. We evaluated the efficacy of an intensive training experience in Tanzania on improving ultrasound-guided FNAB techniques...
October 2018: Journal of Global Oncology
Ascensius Achuo Mforteh, Collince Tchakounte, Carlson-Babila Sama, Stephane Eteme-Messi, Willy Djiognouo, Sama Dohbit, Pascal Foumane
Background: There are increasing reports of term live abdominal pregnancies even though the diagnosis of abdominal pregnancy is made preoperatively only in 45% of cases which partly explains the high maternal and perinatal morbidity and mortality associated with abdominal pregnancy. Case Report: We report a rare case of misdiagnosed term abdominal pregnancy complicated by fetal demise due to cord round neck in a 29-year-old G3P2002 at 39-week and 1-day gestation...
2018: Case Reports in Obstetrics and Gynecology
Peter Samaš, Jarkko Rutila, Marcel Honza, Michal Kysučan, Tomáš Grim
Virulent brood parasites refrain from arduous parental care, often kill host progeny and inflict rearing costs upon their hosts. Quantifying the magnitude of such costs across the whole period of care (from incubation through to parasite fledgling independence) is essential for understanding the selection pressures on hosts to evolve antiparasitic defences. Despite the central importance of such costs for our understanding of coevolutionary dynamics, they have not yet been comprehensively quantified in any host of any avian brood parasite...
October 24, 2018: Proceedings. Biological Sciences
E Danielle Sims, Sama Anvari, Yung Lee, Zainab Samaan, Laura Banfield, Lehana Thabane, M Constantine Samaan
Purpose: Several countries are legalizing the use of medicinal cannabis and easing restrictions on its recreational use. While adults have been the primary target of these initiatives, expanding access to cannabis will likely lead to increased use by children. While the effects of cannabis on pediatric neuropsychological and mental health outcomes have been broadly studied, there are limited data on the physical health effects of cannabis, including endocrine health. Animal studies have shown that chronic cannabis use leads to delayed sexual maturation; however, its effects on pubertal outcomes in children are not well studied...
2018: Adolescent Health, Medicine and Therapeutics
Mohamed Ismail Abdul Aziz, Ling Eng Tan, David Bin-Chia Wu, Fiona Pearce, Gerald Seng Wee Chua, Liang Lin, Ping-Tee Tan, Kwong Ng
Purpose: To assess the comparative efficacy of short-acting muscarinic antagonists (SAMAs), long-acting muscarinic antagonists (LAMAs), LAMA in combination with long-acting beta-agonists (LABAs; LAMA/LABAs) and inhaled corticosteroids (ICS) in combination with LABA (ICS/LABAs) for the maintenance treatment of COPD. Materials and methods: We systematically reviewed 74 randomized controlled trials (74,832 participants) published up to 15 November 2017, which compared any of the interventions (SAMA [ipratropium], LAMA [aclidinium, glycopyrronium, tiotropium, umeclidinium], LAMA/LABA [aclidinium/formoterol, indacaterol/glycopyrronium, tiotropium/olodaterol, umeclidinium/vilanterol] and ICS/LABA [fluticasone/vilanterol, budesonide/formoterol, salmeterol/fluticasone]) with each other or with placebo...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Stephan N Salzmann, Toshiyuki Shirahata, Jingyan Yang, Courtney Ortiz Miller, Brandon B Carlson, Colleen Rentenberger, John A Carrino, Jennifer Shue, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
BACKGROUND CONTEXT: Quantitative computed tomography (QCT) of the lumbar spine is used as an alternative to dual-energy X-ray absorptiometry in assessing bone mineral density (BMD). The average BMD of L1-L2 is the standard reportable metric used for diagnostic purposes according to current recommendations. The density of L1 and L2 has also been proposed as a reference value for the remaining lumbosacral vertebrae and is commonly used as a surrogate marker for overall bone health. Since regional BMD differences within the spine have been proposed, it is unclear if the L1-L2 average correlates with the remainder of the lumbosacral spine...
October 18, 2018: Spine Journal: Official Journal of the North American Spine Society
Yang Fang Wu, Dong Dong Zhang, Si Yan Liu, Huang Huang Luo, Guang Mei Jiang, Yao Xu, Yue Wu, Jing Jing Wang, Fei Fei Liu, Sama Samadli, Wei Wei, Bo Hu, Peng Hu
C-type natriuretic peptide (CNP) is believed to be produced locally in the kidneys and possess several renoprotective properties. In contrast, fibroblast growth factor (FGF) -23 elevates in the early stage of chronic kidney disease and predicts its outcomes. Currently, several studies have demonstrated that CNP and FGF-23 act through a close pathway, and moreover, FGF-23/mitogen-activated protein kinase (MAPK) can be obviously suppressed by CNP. In the present study, human mesangial cells (MCs) were incubated in serum-containing medium in the absence or presence of CNP (0, 10 and 100 pM) for 24, 48 and 72 h, respectively...
November 2018: Journal of Interferon & Cytokine Research
Xiaohui Guo, Kang Kang, Gaoyuan Shang, Xiunan Yu, Ling Qiu, Guotao Sun
The mesophilic reactor (MR) exhibited advantages in biogas production and performance stability over thermophilic reactor (TR) during the long-term anaerobic digestion (AD) of food waste (FW) with stepwise organic loading rate elevating. It was interesting to explore the mechanism causing the divergences in performances between these two reactors. The microbial activity was compared on day 110 when TR began to deteriorate. The results show that MR had significantly higher specific acetoclastic methanogenic activities (SAMA) and specific propionate and butyrate oxidative activities (SPOA and SBOA) than TR...
November 2018: Waste Management & Research
S Adam, D H Sama, T Mouzou, A Akakpovi, K Tomta, M Bellier
The management of patients in emergency departments is an important indicator of the quality of a healthcare system. In sub-Saharan Africa, emergency care is characterized by human and material difficulties. The purpose of this work was to assess the difficulties in managing emergencies at the surgical emergency admissions unit of Sylvanus Olympio teaching hospital of Lomé. This descriptive prospective study took place during the last 6 months of 2013. Epidemiological, clinical, and therapeutic data were collected...
August 1, 2018: Médecine et Santé Tropicales
P Egbohou, H D Sama, T Mouzou, S Assenouwe, G Akala-Yoba, F Tchetike, K Tomta
To analyze the causes of deaths in the intensive care unit (ICU) at the CHU Sylvanus Olympio (CHU SO) teaching hospital of Lomé. This retrospective study examined the files of patients who died in the ICU of CHU SO, during the 12-month period from November 2012 to October 2013. Of 732 patients admitted to the ICU, 237 died, for a mortality rate of 32.38%. Men accounted for 163 (68.8%) of the deaths, and women 74 (31.2%), for a M/F ratio of 2.2. The average age of patients who died was 41.7 years; the age group 21-30 years comprised 16% of the deaths, that 31-40 years 19...
August 1, 2018: Médecine et Santé Tropicales
Sama Kalyana Chakravarthy, Rajagopalaboopathi Jayasudha, Gumpili Sai Prashanthi, Mohammed Hasnat Ali, Savitri Sharma, Mudit Tyagi, Sisinthy Shivaji
Uveitis (UVT), an inflammatory disease of the eye significantly contributes to vision impairment and blindness. Uveitis is associated with systemic infectious and autoimmune diseases, but in most cases, the aetiology remains unidentified. Dysbiosis in the gut microbiome has been implicated in autoimmune diseases, inflammatory diseases, cancers and mental disorders. In a mice model of autoimmune UVT, it was observed that manipulating the gut microbiome reduces the inflammation and disease severity. Further, alterations in the bacterial gut microbiome and their metabolites were reported in UVT patients from a Chinese cohort...
December 2018: Indian Journal of Microbiology
Paul Schadler, Peter Derman, Lily Lee, Huong Do, Federico P Girardi, Frank P Cammisa, Andrew A Sama, Jennifer Shue, Stelios Koutsoumbelis, Alexander P Hughes
Study Design: Retrospective case-control study. Objectives: Few studies have compared the costs of single-level (1) posterior instrumented fusion alone (PSF), (2) posterior interbody fusion with PSF (PLIF), and (3) lateral interbody fusion with PSF (circumferential LLIF). The purpose of this study was to compare costs associated with these procedures. Methods: Charts were reviewed and patients followed-up with a telephone questionnaire. Medicare reimbursement data was used for cost estimation from the payer's perspective...
August 2018: Global Spine Journal
Assèta Kagambèga, Alexandre Thibodeau, Valentina Trinetta, Daniel K Soro, Florent N Sama, Évariste Bako, Caroline S Bouda, Aïssata Wereme N'Diaye, Philippe Fravalo, Nicolas Barro
The importance of Salmonella  and  Campylobacter as foodborne pathogens is well recognized worldwide. Poultry and poultry products are commonly considered as the major vehicles of Salmonella and Campylobacter infection in humans. The aim of this study was to investigate the hygienic status of poultry facilities and determine the prevalence of Salmonella and Campylobacter in slaughtered poultry feces and carcasses in four different markets in Ouagadougou, capital city of Burkina Faso. A total of 103 poultry feces and 20 carcasses were analyzed using microbiological standard methods...
September 2018: Food Science & Nutrition
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