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https://www.readbyqxmd.com/read/29967673/normal-electrical-activity-of-the-brain-in-obsessive-compulsive-patients-after-anodal-stimulation-of-the-left-dorsolateral-prefrontal-cortex
#1
Hamidreza Ghaffari, Ali Yoonessi, Mohammad Javad Darvishi, Akbar Ahmadi
Introduction: Transcranial Direct Current Stimulation (tDCS) has been used as a non-invasive method to increase the plasticity of brain. Growing evidence has shown several brain disorders such as depression, anxiety disorders, and chronic pain syndrome are improved following tDCS. In patients with Obsessive-Compulsive Disorder (OCD), increased brain rhythm activity particularly in the frontal lobe has been reported in several studies using Eectroencephalogram (EEG). To our knowledge, no research has been done on the effects of electrical stimulation on brain signals of patients with OCD...
March 2018: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29913818/multivariate-pattern-analysis-of-evoked-brain-potentials-by-temporal-matching-pursuit-and-support-vector-machine
#2
Carina Graversen, Christina Brock, Jens Brøndum Frøkjær, Georg Dimcevski, Dario Farina, Asbjørn Mohr Drewes
Background/aims Electroencephalography (EEG) recorded as evoked brain potentials (EPs) reflects the cortical processing to an external event. This approach is often used to study the altered response to acute pain in chronic pain patients compared to healthy volunteers. However, discrimination of the responses from the study populations is a non-trivial task, which calls for improved objective methods. Methods To develop and validate a new methodology, we analyzed data from 16 type-1 diabetes mellitus patients and 15 age and gender matched volunteers, by means of brain activity recorded from 62 EEG channels...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913746/neuroimaging-of-the-human-visceral-pain-system-a-methodological-review
#3
Jens Brøndum Frøkjær, Søren Schou Olesen, Carina Graversen, Trine Andresen, Dina Lelic, Asbjørn Mohr Drewes
During the last decades there has been a tremendous development of non-invasive methods for assessment of brain activity following visceral pain. Improved methods for neurophysiological and brain imaging techniques have vastly increased our understanding of the central processing of gastrointestinal sensation and pain in both healthy volunteers as well as in patients suffering from gastrointestinal disorders. The techniques used are functional magnetic resonance imaging (fMRI), positron emission tomography (PET), electroencephalography (EEG)/evoked brain potentials (EPs), magnetoencephalography (MEG), single photon emission computed tomography (SPECT), and the multimodal combinations of these techniques...
July 1, 2018: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29876262/-motoring-in-idle-the-default-mode-and-somatomotor-networks-are-overactive-in-children-and-adolescents-with-functional-neurological-symptoms
#4
Kasia Kozlowska, Chris J Spooner, Donna M Palmer, Anthony Harris, Mayuresh S Korgaonkar, Stephen Scher, Leanne M Williams
Objective: Children and adolescents with functional neurological symptom disorder (FND) present with diverse neurological symptoms not explained by a disease process. Functional neurological symptoms have been conceptualized as somatoform dissociation, a disruption of the brain's intrinsic organization and reversion to a more primitive level of function. We used EEG to investigate neural function and functional brain organization in children/adolescents with FND. Method: EEG was recorded in the resting eyes-open condition in 57 patients (aged 8...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29865015/several-days-of-muscle-hyperalgesia-facilitates-cortical-somatosensory-excitability
#5
E De Martino, L Petrini, S Schabrun, T Graven-Nielsen
Background and aims Maladaptive plasticity in neural circuits has been proposed in chronic musculoskeletal pain and has been discussed as a key component of the transition from acute to chronic pain. The induction of delayed onset muscle soreness (DOMS) in healthy individuals is one method that can be used to investigate the adaptations of neural circuits in response to several days of muscle hyperalgesia. The aim of this study was to determine the adaptations of the sensory cortex in response to muscle hyperalgesia induced by eccentric exercise of the wrist extensor muscles...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29763673/the-distribution-of-pain-activity-across-the-human-neonatal-brain-is-sex-dependent
#6
Madeleine Verriotis, Laura Jones, Kimberley Whitehead, Maria Laudiano-Dray, Ismini Panayotidis, Hemani Patel, Judith Meek, Lorenzo Fabrizi, Maria Fitzgerald
In adults, there are differences between male and female structural and functional brain connectivity, specifically for those regions involved in pain processing. This may partly explain the observed sex differences in pain sensitivity, tolerance, and inhibitory control, and in the development of chronic pain. However, it is not known if these differences exist from birth. Cortical activity in response to a painful stimulus can be observed in the human neonatal brain, but this nociceptive activity continues to develop in the postnatal period and is qualitatively different from that of adults, partly due to the considerable cortical maturation during this time...
September 2018: NeuroImage
https://www.readbyqxmd.com/read/29421164/the-long-term-impact-of-neurofeedback-on-symptom-burden-and-interference-in-patients-with-chronic-chemotherapy-induced-neuropathy-analysis-of-a-randomized-controlled-trial
#7
Sarah Prinsloo, Diane Novy, Larry Driver, Randall Lyle, Lois Ramondetta, Cathy Eng, Gabriel Lopez, Yisheng Li, Lorenzo Cohen
CONTEXT: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment and may adversely affect quality of life (QOL) for years. OBJECTIVES: We explored the long-term effects of electroencephalographic neurofeedback (NFB) as a treatment for CIPN and other aspects of QOL. METHODS: Seventy-one cancer survivors (mean age 62.5; 87% females) with CIPN were randomized to NFB or to a waitlist control (WLC) group. The NFB group underwent 20 sessions of NFB where rewards were given for voluntary changes in electroencephalography...
May 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29343982/increased-theta-band-eeg-power-in-sickle-cell-disease-patients
#8
Michelle Case, Sina Shirinpour, Huishi Zhang, Yvonne H Datta, Stephen C Nelson, Karim T Sadak, Kalpna Gupta, Bin He
Objective: Pain is a major issue in the care of patients with sickle cell disease (SCD). The mechanisms behind pain and the best way to treat it are not well understood. We studied how electroencephalography (EEG) is altered in SCD patients. Methods: We recruited 20 SCD patients and compared their resting state EEG to that of 14 healthy controls. EEG power was found across frequency bands using Welch's method. Electrophysiological source imaging was assessed for each frequency band using the eLORETA algorithm...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29321621/functional-brain-network-mechanism-of-hypersensitivity-in-chronic-pain
#9
UnCheol Lee, Minkyung Kim, KyoungEun Lee, Chelsea M Kaplan, Daniel J Clauw, Seunghwan Kim, George A Mashour, Richard E Harris
Fibromyalgia (FM) is a chronic widespread pain condition characterized by augmented multi-modal sensory sensitivity. Although the mechanisms underlying this sensitivity are thought to involve an imbalance in excitatory and inhibitory activity throughout the brain, the underlying neural network properties associated with hypersensitivity to pain stimuli are largely unknown. In network science, explosive synchronization (ES) was introduced as a mechanism of hypersensitivity in diverse biological and physical systems that display explosive and global propagations with small perturbations...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29175204/cerebral-peak-alpha-frequency-predicts-individual-differences-in-pain-sensitivity
#10
Andrew J Furman, Timothy J Meeker, Jeremy C Rietschel, Sooyoung Yoo, Janusiya Muthulingam, Mariya Prokhorenko, Michael L Keaser, Ronald N Goodman, Ali Mazaheri, David A Seminowicz
The identification of neurobiological markers that predict individual predisposition to pain are not only important for development of effective pain treatments, but would also yield a more complete understanding of how pain is implemented in the brain. In the current study using electroencephalography (EEG), we investigated the relationship between the peak frequency of alpha activity over sensorimotor cortex and pain intensity during capsaicin-heat pain (C-HP), a prolonged pain model known to induce spinal central sensitization in primates...
February 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29163341/effects-of-transcranial-direct-current-stimulation-transcranial-pulsed-current-stimulation-and-their-combination-on-brain-oscillations-in-patients-with-chronic-visceral-pain-a-pilot-crossover-randomized-controlled-study
#11
Aurore Thibaut, Cristina Russo, Aura Maria Hurtado-Puerto, Jorge Leon Morales-Quezada, Alícia Deitos, John Christopher Petrozza, Steven Freedman, Felipe Fregni
Objective: Chronic visceral pain (CVP) syndromes are persistently painful disorders with a remarkable lack of effective treatment options. This study aimed at evaluating the effects of different neuromodulation techniques in patients with CVP on cortical activity, through electreocephalography (EEG) and on pain perception, through clinical tests. Design: A pilot crossover randomized controlled study. Settings: Out-patient. Subjects: Adults with CVP (>3 months)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29132064/patients-and-caregivers-contributions-for-differentiating-epileptic-from-psychogenic-nonepileptic-seizures-value-and-limitations-of-self-reporting-questionnaires-a-pilot-study
#12
Giuseppe Erba, Elisa Bianchi, Giorgia Giussani, John Langfitt, Adam Juersivich, Ettore Beghi
PURPOSE: Questionnaires investigating semiology and comorbidities of psychogenic non-epileptic seizures (PNES) have been used mainly to help physicians expedite referrals to epilepsy centres for confirmation of diagnosis rather than as alternative diagnostic tool when video-EEG monitoring (VEM), the current gold standard, is not available or is inconclusive. METHODS: We developed one structured questionnaire for patients, exploring subjective experiences and vulnerabilities and one for eyewitnesses, focused on features observable during typical events to study prospectively 50 consecutive adult patients with PNES or epileptic seizures (ES) admitted for VEM...
December 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29108430/exploration-of-the-pathophysiology-of-chronic-pain-using-quantitative-eeg-source-localization
#13
Leslie S Prichep, Jaini Shah, Henry Merkin, Emile M Hiesiger
Chronic pain affects more than 35% of the US adult population representing a major public health imperative. Currently, there are no objective means for identifying the presence of pain, nor for quantifying pain severity. Through a better understanding of the pathophysiology of pain, objective indicators of pain might be forthcoming. Brain mechanisms mediating the painful state were imaged in this study, using source localization of the EEG. In a population of 77 chronic pain patients, significant overactivation of the "Pain Matrix" or pain network, was found in brain regions including, the anterior cingulate, anterior and posterior insula, parietal lobule, thalamus, S1, and dorsolateral prefrontal cortex (DLPFC), consistent with those reported with conventional functional imaging, and extended to include the mid and posterior cingulate, suggesting that the increased temporal resolution of electrophysiological measures may allow a more precise identification of the pain network...
March 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29084278/the-cortical-responses-to-evoked-clinical-pain-in-patients-with-hip-osteoarthritis
#14
Mikkel Gram, Joachim Erlenwein, Frank Petzke, Deborah Falla, Michael Przemeck, Miriam I Emons, Michael Reuster, Søren S Olesen, Asbjørn M Drewes
BACKGROUND: Experimental models have been used extensively to evaluate pain using e.g., visual analogue scales or electroencephalography (EEG). Stimulation using tonic pain has been shown to better mimic the unpleasantness of chronic pain, but has mainly been evoked by non-clinical stimuli. This study aims to, evaluate the EEG during clinical pain in patients scheduled for total hip replacement with control and resting conditions. METHODS: The hip scheduled for replacement was moved by the examiner to evoke pain for 30 seconds while recording EEG...
2017: PloS One
https://www.readbyqxmd.com/read/28884750/brain-imaging-tests-for-chronic-pain-medical-legal-and-ethical-issues-and-recommendations
#15
REVIEW
Karen D Davis, Herta Flor, Henry T Greely, Gian Domenico Iannetti, Sean Mackey, Markus Ploner, Amanda Pustilnik, Irene Tracey, Rolf-Detlef Treede, Tor D Wager
Chronic pain is the greatest source of disability globally and claims related to chronic pain feature in many insurance and medico-legal cases. Brain imaging (for example, functional MRI, PET, EEG and magnetoencephalography) is widely considered to have potential for diagnosis, prognostication, and prediction of treatment outcome in patients with chronic pain. In this Consensus Statement, a presidential task force of the International Association for the Study of Pain examines the capabilities of brain imaging in the diagnosis of chronic pain, and the ethical and legal implications of its use in this way...
October 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28758313/altered-theta-oscillations-in-resting-eeg-of-fibromyalgia-syndrome-patients
#16
N Fallon, Y Chiu, T Nurmikko, A Stancak
BACKGROUND: Fibromyalgia syndrome (FM) is a chronic pain disorder characterized by widespread pain, sleep disturbance, fatigue and cognitive/affective symptoms. Functional imaging studies have revealed that FM and other chronic pain syndromes can affect resting brain activity. This study utilized electroencephalographic (EEG) recordings to investigate the relative power of ongoing oscillatory activity in the resting brain. METHODS: A 64-channel EEG was recorded at rest in 19 female FM patients and 18 healthy, age-matched, control subjects...
January 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28724985/increased-neural-noise-and-impaired-brain-synchronization-in-fibromyalgia-patients-during-cognitive-interference
#17
A J González-Villar, N Samartin-Veiga, M Arias, M T Carrillo-de-la-Peña
Fibromyalgia (FM) and other chronic pain syndromes are associated with cognitive dysfunction and attentional deficits, but the neural basis of such alterations is poorly understood. Dyscognition may be related to high levels of neural noise, understood as increased random electrical fluctuations that impair neural communication; however, this hypothesis has not yet been tested in any chronic pain condition. Here we compared electroencephalographic activity (EEG) in 18 FM patients -with high self-reported levels of cognitive dysfunction- and 22 controls during a cognitive control task...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28390217/painful-engrams-oscillatory-correlates-of-working-memory-for-phasic-nociceptive-laser-stimuli
#18
Elia Valentini, Valentina Nicolardi, Salvatore Maria Aglioti
Research suggests that working memory (WM) is impaired in chronic pain. Yet, information on how potentially noxious stimuli are maintained in memory is limited in patients as well as in healthy people. We recorded electroencephalography (EEG) in healthy volunteers during a modified delayed match-to-sample task where maintenance in memory of relevant attributes of nociceptive laser stimuli was essential for subsequent cued-discrimination. Participants performed in high and low load conditions (i.e. three vs...
July 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28158269/predictors-of-opioid-efficacy-in-patients-with-chronic-pain-a-prospective-multicenter-observational-cohort-study
#19
Kasper Grosen, Anne E Olesen, Mikkel Gram, Torsten Jonsson, Michael Kamp-Jensen, Trine Andresen, Christian Nielsen, Gorazd Pozlep, Mogens Pfeiffer-Jensen, Bart Morlion, Asbjørn M Drewes
Opioids are increasingly used for treatment of chronic pain. However, they are only effective in a subset of patients and have multiple side effects. Thus, studies using biomarkers for response are highly warranted. The current study prospectively examined 63 opioid-naïve patients initiating opioid use for diverse types of chronic pain at five European centers. Quantitative sensory testing, electroencephalography (EEG) recordings, and assessment of pain catastrophizing were performed prior to treatment. The co-primary outcomes were change from baseline in ratings of chronic pain and quality of life after 14 days of opioid treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28116239/characterization-of-functional-brain-activity-and-connectivity-using-eeg-and-fmri-in-patients-with-sickle-cell-disease
#20
Michelle Case, Huishi Zhang, John Mundahl, Yvonne Datta, Stephen Nelson, Kalpna Gupta, Bin He
Sickle cell disease (SCD) is a red blood cell disorder that causes many complications including life-long pain. Treatment of pain remains challenging due to a poor understanding of the mechanisms and limitations to characterize and quantify pain. In the present study, we examined simultaneously recording functional MRI (fMRI) and electroencephalogram (EEG) to better understand neural connectivity as a consequence of chronic pain in SCD patients. We performed independent component analysis and seed-based connectivity on fMRI data...
2017: NeuroImage: Clinical
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