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vaccine V114

David Greenberg, Patricia A Hoover, Timo Vesikari, Christopher Peltier, David C Hurley, Richard D McFetridge, Michael Dallas, Jonathan Hartzel, Rocio D Marchese, Beth-Ann G Coller, Jon E Stek, Chitrananda Abeygunawardana, Michael A Winters, John E MacNair, Narahari S Pujar, Luwy Musey
BACKGROUND: Pediatric use of pneumococcal conjugate vaccines (PCV) has been associated with significant decrease in disease burden. However, disease caused by non-vaccine serotypes has increased. Safety and immunogenicity of 15-valent PCV (PCV15) containing serotypes included in 13-valent PCV (PCV13) plus serotypes 22F and 33F were evaluated in infants (NCT01215188). METHODS: Infants received adjuvanted PCV15, nonadjuvanted PCV15, or PCV13 at 2, 4, 6, and 12-15 months of age...
September 20, 2018: Vaccine
Susan J Ermlich, Charles P Andrews, Steven Folkerth, Richard Rupp, David Greenberg, Richard D McFetridge, Jonathan Hartzel, Rocio D Marchese, Jon E Stek, Chitrananda Abeygunawardana, Luwy K Musey
BACKGROUND: Pneumococcal disease remains a public health priority in adults. Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV15) containing 13 serotypes included in 13-valent pneumococcal conjugate vaccine (PCV13) plus 2 additional serotypes (22F and 33F) was evaluated in adults ≥50 years old (NCT01513551). METHODS: 691 adults received one dose of PCV15, PCV13, or 23-valent pneumococcal polysaccharide vaccine (PPV23) and were followed 14 days for safety...
March 17, 2018: Vaccine
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