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https://www.readbyqxmd.com/read/28103630/orientia-tsutsugamushi-ank9-is-a-multifunctional-effector-that-utilizes-a-novel-grip-like-golgi-localization-domain-for-golgi-to-endoplasmic-reticulum-trafficking-and-interacts-with-host-copb2
#1
Andrea R Beyer, Kyle G Rodino, Lauren VieBrock, Ryan S Green, Brittney K Tegels, Lee D Oliver, Richard T Marconi, Jason A Carlyon
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that afflicts one million people annually. This obligate intracellular bacterium boasts one of the largest microbial arsenals of ankyrin repeat-containing protein (Ank) effectors, most of which target the endoplasmic reticulum (ER) by undefined mechanisms. Ank9 is the only one proven to function during infection. Here, we demonstrate that Ank9 bears a motif that mimics the GRIP domain of eukaryotic golgins and is necessary and sufficient for its Golgi localization...
January 19, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28103623/metabolic-inflexibility-with-obesity-and-the-effects-of-fenofibrate-on-skeletal-muscle-fatty-acid-oxidation
#2
Kristen E Boyle, Jacob E Friedman, Rachel C Janssen, Chantal Underkofler, Joseph A Houmard, Neda Rasouli
This study was designed to investigate mechanisms of lipid metabolic inflexibility in human obesity and the ability of fenofibrate (FENO) to increase skeletal muscle fatty acid oxidation (FAO) in primary human skeletal muscle cell cultures (HSkMC) exhibiting metabolic inflexibility. HSkMC from 10 lean and 10 obese, insulin resistant subjects were treated with excess fatty acid for 24 h (24hFA) to gauge lipid-related metabolic flexibility. Metabolically inflexible HSkMC from obese individuals were then treated with 24hFA in combination with FENO to determine effectiveness for increasing FAO...
January 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28103436/directional-charge-carrier-transport-in-oriented-benzodithiophene-covalent-organic-framework-thin-films
#3
Dana D Medina, Michiel L Petrus, Askhat N Jumabekov, Johannes T Margraf, Simon Weinberger, Julian M Rotter, Timothy Clark, Thomas Bein
Charge carrier transport in oriented COF thin films is an important factor for realizing COF-based optoelectronic devices. We describe how highly oriented electron-donating BDT-COF thin films serve as a model system for a directed charge transport study. Oriented BDT-COF films were deposited on different electrodes with excellent control over film roughness and topology, allowing for high quality electrode-COF interfaces suitable for device fabrication. Hole-only devices were constructed to study the columnar hole-mobility of the BDT-COF films...
January 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28103426/analytical-characterization-and-pharmacological-evaluation-of-the-new-psychoactive-substance-4-fluoromethylphenidate-4%C3%A2-f-mph-and-differentiation-between-the-%C3%A2-threo-and-%C3%A2-erythro-diastereomers
#4
Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Gary Hessman, Brian Murphy, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brandt
Misuse of (±)-threo-methylphenidate (methyl-2-phenyl-2-(piperidin-2-yl)acetate; Ritalin®, MPH) has long been acknowledged, but the appearance of MPH analogs in the form of 'research chemicals' has only emerged in more recent years. 4-Fluoromethylphenidate (4 F-MPH) is one of these recent examples and this study presents the identification and analytical characterization of two powdered 4 F-MPH products that were obtained from an online vendor in 2015. Interestingly, the products appeared to have originated from two distinct batches given that one product consisted of (±)-threo-4 F-MPH isomers whereas the second sample consisted of a mixture of (±)-threo and (±)-erythro 4 F-MPH...
January 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28103409/zea-mays-fe-deficiency-related-4-zmfdr4-functions-as-an-iron-transporter-in-the-plastids-of-monocots
#5
Xiu-Yue Zhang, Xi Zhang, Qi Zhang, Xiao-Xi Pan, Luo-Chen Yan, Xiao-Juan Ma, Wei-Zhong Zhao, Xiao-Ting Qi, Li-Ping Yin
Iron (Fe)-homeostasis in the plastids is closely associated with Fe transport proteins that prevent Fe from occurring in its toxic free ionic forms. However, the number of known protein families related to Fe transport in the plastids (about 5) and the function of iron in non-green plastids is limited. In the present study, we report the functional characterization of Zea mays Fe deficiency-related 4 (ZmFDR4), which was isolated from a differentially expressed clone of a cDNA library of Fe deficiency-induced maize roots...
January 19, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28103309/folate-transporters-in-placentas-from-preterm-newborns-and-their-relation-to-cord-blood-folate-and-vitamin-b12-levels
#6
Erika Castaño, Lorena Caviedes, Sandra Hirsch, Miguel Llanos, Germán Iñiguez, Ana María Ronco
Folate deficiency during pregnancy has been related to low birth weight, preterm (PT) birth and other health risks in the offspring; however, it is unknown whether prematurity is related to low folate transport through the placenta due to altered expression of specific folate transporters. We determined placental expression (mRNA and protein concentrations by RT-qPCR and WB respectively) of specific folate transporters: RFC, PCFT/HCP1 and FOLR1 in chorionic (fetal) and basal (maternal) plates of placentas of PT pregnancies (PT, 32-36 weeks, n = 51)...
2017: PloS One
https://www.readbyqxmd.com/read/28103251/active-hydrogen-bond-network-ahbn-and-applications-for-improvement-of-thermal-stability-and-ph-sensitivity-of-pullulanase-from-bacillus-naganoensis
#7
Qing-Yan Wang, Neng-Zhong Xie, Qi-Shi Du, Yan Qin, Jian-Xiu Li, Jian-Zong Meng, Ri-Bo Huang
A method, so called "active hydrogen bond network" (AHBN), is proposed for site-directed mutations of hydrolytic enzymes. In an enzyme the AHBN consists of the active residues, functional residues, and conservative water molecules, which are connected by hydrogen bonds, forming a three dimensional network. In the catalysis hydrolytic reactions of hydrolytic enzymes AHBN is responsible for the transportation of protons and water molecules, and maintaining the active and dynamic structures of enzymes. The AHBN of pullulanase BNPulA324 from Bacillus naganoensis was constructed based on a homologous model structure using Swiss Model Protein-modeling Server according to the template structure of pullulanase BAPulA (2WAN)...
2017: PloS One
https://www.readbyqxmd.com/read/28103246/joint-optimization-of-distribution-network-design-and-two-echelon-inventory-control-with-stochastic-demand-and-co2-emission-tax-charges
#8
Shuangyan Li, Xialian Li, Dezhi Zhang, Lingyun Zhou
This study develops an optimization model to integrate facility location and inventory control for a three-level distribution network consisting of a supplier, multiple distribution centers (DCs), and multiple retailers. The integrated model addressed in this study simultaneously determines three types of decisions: (1) facility location (optimal number, location, and size of DCs); (2) allocation (assignment of suppliers to located DCs and retailers to located DCs, and corresponding optimal transport mode choices); and (3) inventory control decisions on order quantities, reorder points, and amount of safety stock at each retailer and opened DC...
2017: PloS One
https://www.readbyqxmd.com/read/28103195/the-enhancement-of-nasal-drug-absorption-from-powder-formulations-by-the-addition-of-sodium-carboxymethyl-cellulose
#9
Akiko Tanaka, Tomoyuki Furubayashi, Hitomi Yamasaki, Katsuko Takano, Mayuko Kawakami, Shunsuke Kimura, Daisuke Inoue, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
For nasal drug absorption, powder formulations can be expected to provide many advantages. The first aim of this study was to examine drug absorption following nasal administration of powder formulations in rats. Pharmaceutical excipients are typically added to most powder formulations. The second aim was to investigate the change in nasal drug absorption of powder formulations in the presence of sodium carboxymethyl cellulose (CMC-Na). Model drugs used were norfloxacin (NFX), warfarin (WF), and piroxicam (PXC)...
January 4, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28103132/functional-gains-in-energy-and-cell-metabolism-after-tspo-gene-insertion
#10
Guo-Jun Liu, Ryan J Middleton, Winnie Wai-Ying Kam, David Y Chin, Claire R Hatty, Ronald H Y Chan, Richard B Banati
Recent loss-of-function studies in tissue-specific as well as global Tspo (Translocator Protein 18 kDa) knockout mice have not confirmed its long assumed indispensability for the translocation of cholesterol across the mitochondrial inter-membrane space, a rate-limiting step in steroid biosynthesis. Instead, recent studies in global Tspo knockout mice indicate that TSPO may play a more fundamental role in cellular bioenergetics, which may include the indirect down-stream regulation of transport or metabolic functions...
January 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28103121/comparison-of-helicopter-emergency-medical-services-transport-types-and-delays-on-patient-outcomes-at-two-level-i-trauma-centers
#11
Brodie Nolan, Homer Tien, Bruce Sawadsky, Sandro Rizoli, Amanda McFarlan, Andrea Phillips, Alun Ackery
BACKGROUND: Helicopter emergency medical services (HEMS) have become an engrained component of trauma systems. In Ontario, transportation for trauma patients is through one of three ways: scene call, modified scene call, or interfacility transfer. We hypothesize that differences exist between these types of transports in both patient demographics and patient outcomes. This study compares the characteristics of patients transported by each of these methods to two level 1 trauma centers and assesses for any impact on morbidity or mortality...
January 19, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28103119/iatrogenic-spinal-cord-injury-in-a-trauma-patient-with-ankylosing-spondylitis
#12
Ahmad Maarouf, Colleen M McQuown, Jennifer A Frey, Rami A Ahmed, Lisa Derrick
BACKGROUND: The recommended practice for over 30 years has been to routinely immobilize patients with unstable cervical spinal injuries using cervical spinal collars. It is shown that patients with Ankylosing spondylitis (AS) are four times more likely to suffer a spinal fracture compared to the general population and have an eleven-fold greater risk of spinal cord injury. Current protocols of spinal immobilization were responsible for secondary neurologic deterioration in some of these patients...
January 19, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28103044/when-salt-rejecting-polymers-meet-protons-an-electrochemical-impedance-spectroscopy-investigation
#13
Noga Fridman-Bishop, Viatcheslav Freger
Polymeric membranes are widely used for salt removal, but mechanism of ion permeation is still insufficiently understood. Here we analyze ion transport and scaling in polymers relevant to desalination (dense aromatic polyamide Nomex and cellulose acetate, CA) using impedance spectroscopy (EIS), focusing on the effects of the salt type, concentration and pH. The results highlight the role of proton uptake in ion permeation. For Nomex the exceptionally high affinity to proton results in a power-low dependence of conductivity on salt concentrations with an unusual exponent 1/2...
January 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28103039/single-walled-carbon-nanotubes-mimics-of-biological-ion-channels
#14
Hasti Amiri, Kenneth L Shepard, Colin Nuckolls, Raúl Hernández Sánchez
Here we report on the ion conductance through individual, small diameter single-walled carbon nanotubes. We find that they are mimics of ion channels found in natural systems. We explore the factors governing the ion selectivity and permeation through single-walled carbon nanotubes by considering an electrostatic mechanism built around a simplified version of the Gouy-Chapman theory. We find that the single-walled carbon nanotubes preferentially transported cations and that the cation permeability is size-dependent...
January 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28103016/sns2-nanowall-arrays-toward-high-performance-sodium-storage
#15
Peng Zhou, Xiao Wang, Wenhao Guan, Dan Zhang, Libin Fang, Yinzhu Jiang
Cost-effective sodium ion batteries (SIBs) are springing out as desirable alternative choice of lithium ion batteries (LIBs), in terms of application in large-scale energy storage devices. SnS2 is regarded as a potential anode material for SIBs due to its unique layered structure and high theoretical specific capacity. However, the development of SnS2 was hindered by the sluggish kinetics of diffusion process and the inevitable volume change during repeated sodiation/desodiation processes. In this work, SnS2 with a unique nanowall arrays (NWAs) structure is fabricated by one-step pulsed spray evaporation chemical vapor deposition (PSE-CVD), which could be used directly as binder-free and carbon-free anodes for SIBs...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28103012/a-bi-modal-cationic-and-water-soluble-calix-4-arene-conjugate-design-synthesis-characterization-and-transfection-of-rfp-encoded-plasmid-in-cancer-cells
#16
Kushal Samanta, Dnyanesh S Ranade, Aekta Upadhyay, Prasad Padmakar Kulkarni, Chebrolu Pulla Rao
A new bimodal fluorescent cationic calix[4]arene (L1) conjugate has been synthesized in multiple steps and well characterized by NMR and ESI-MS techniques. L1 has been investigated for its DNA binding ability by various spectroscopy techniques like, absorption, fluorescence and circular dichroism (CD). The formation of L1-DNA complex has been confirmed by the gel electrophoresis in presence of incremental concentration of L1. To visualize the packing of the plasmid (pBR322), detailed tapping mode AFM study has been performed, which revealed blob like structure of plasmid upon addition of the incremental amount of L1...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28103007/glutamate-350-plays-an-essential-role-in-conformational-gating-of-long-range-radical-transport-in-e-coli-class-ia-ribonucleotide-reductase
#17
Kanchana R Ravichandran, Ellen C Minnihan, Qinghui Lin, Kenichi Yokoyama, Alexander T Taguchi, Jimin Shao, Daniel G Nocera, JoAnne Stubbe
E. coli Ia ribonucleotide reductase is composed of two subunits that form an active α2β2 complex. The nucleoside diphosphate substrates (NDP) are reduced in α2, 35 Å from the essential diferric-tyrosyl radical (Y122•) cofactor in β2. The Y122• mediated oxidation of C439 in α2 occurs by a pathway (Y122 ↔ [W48] ↔ Y356 in β2 to Y731 ↔ Y730 ↔ C439 in α2) across the α/β interface. The absence of an α2β2 structure precludes insight into the location of Y356 and Y731 at the subunit interface...
January 19, 2017: Biochemistry
https://www.readbyqxmd.com/read/28102993/status-report-the-public-health-and-planning-101-project-strengthening-collaborations-between-the-public-health-and-planning-professions
#18
A Mahendra, T Vo, C Einstoss, J Weppler, P Gillen, L Ryan, K Haley
INTRODUCTION: Land use planning is a complex field comprised of legislation, policies, processes and tools. A growing body of evidence supports the relationship between land use planning decisions, community design and health. The built environment has been shown to be associated with physical inactivity, obesity, cardiovascular disease, respiratory disease and mental illness. Consequently, there is a growing interest within public health to work with planners on land use planning initiatives such as official plans and transportation master plans...
January 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28102989/information-and-communication-technology-ict-standards-and-guidelines-final-rule
#19
(no author information available yet)
We, the Architectural and Transportation Barriers Compliance Board (Access Board or Board), are revising and updating, in a single rulemaking, our standards for electronic and information technology developed, procured, maintained, or used by Federal agencies covered by section 508 of the Rehabilitation Act of 1973, as well as our guidelines for telecommunications equipment and customer premises equipment covered by Section 255 of the Communications Act of 1934. The revisions and updates to the section 508-based standards and section 255-based guidelines are intended to ensure that information and communication technology covered by the respective statutes is accessible to and usable by individuals with disabilities...
18, 2017: Federal Register
https://www.readbyqxmd.com/read/28102976/use-of-preventive-health-services-in-people-with-serious-mental-illness-consumer-perspectives-on-barriers-and-solutions
#20
Glen L Xiong, Ana-Maria Iosif, Nickolas H Culpepper, Robert M McCarron
Objective: This study asked 350 consumers with serious mental illness (DSM-IV) (who are using community mental health services in Sacramento County, California) for their perspective about barriers and solutions to use of preventive health services. Methods: Two questions were posed: (1) What do you think keeps you from getting preventive tests? (2) What do you think would help you complete the recommended tests? Participants were interviewed between October 2010 and December 2012...
January 5, 2017: Primary Care Companion to CNS Disorders
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