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https://www.readbyqxmd.com/read/28551861/determinants-of-clinic-absenteeism-a-novel-method-of-examining-distance-from-clinic-and-transportation
#1
Ryan W Dobbs, Neha R Malhotra, Brandon M Caldwell, Raymond Rojas, Daniel M Moreira, Michael R Abern
Delayed treatment and non-adherence are associated with inferior prostate cancer (CaP) outcomes. Missed clinic appointments (MA) are one form of non-adherence that may be preventable. We conducted a retrospective cohort study of 1341 scheduled clinic encounters for men referred to an academic urology clinic for evaluation of known or suspected CaP. Driving distance and public transit times were calculated using a Google Distance Matrix API algorithm. Zip code level data regarding socioeconomic status was obtained from the 2013 American Community Survey...
May 27, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28551824/the-role-of-the-atp2c1-gene-in-hailey-hailey-disease
#2
REVIEW
Hao Deng, Heng Xiao
Hailey-Hailey disease (HHD) is a rare autosomal dominant acantholytic dermatosis, characterized by a chronic course of repeated and exacerbated skin lesions in friction regions. The pathogenic gene of HHD was reported to be the ATPase calcium-transporting type 2C member 1 gene (ATP2C1) located on chromosome 3q21-q24. Its function is to maintain normal intracellular concentrations of Ca(2+)/Mn(2+) by transporting Ca(2+)/Mn(2+) into the Golgi apparatus. ATP2C1 gene mutations are reportedly responsible for abnormal cytosolic Ca(2+)/Mn(2+) levels and the clinical manifestations of HHD...
May 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28551820/cd147-expression-in-peritoneal-injury
#3
Harald Seeger, Joerg Latus, Daniel Kitterer, M Dominik Alscher, Dagmar Biegger, Jin Chen, Ilka Edenhofer, Rudolf P Wüthrich, Stephan Segerer
BACKGROUND: Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracellular matrix via induction of matrix metalloproteinases, cell adhesion, and regulation of immune reactions. We hypothesized that CD 147 plays a role in the peritoneal cavity...
May 27, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28551812/utilization-of-starch-enriched-brewery-rice-wine-waste-for-mixotrophic-cultivation-of-ettlia-sp-yc001-used-in-biodiesel-production
#4
Yeji Kam, Mina Sung, Hoon Cho, Chang-Min Kang, Jungmin Kim, Jong-In Han
Starch-enriched brewery waste (SBW), an unexplored feedstock, was investigated as a nutritious low-cost source for the mixotrophic cultivation of Ettlia sp. YC001 for biodiesel production. Stirring, autoclaving, and sonication were assessed for the SBW, in conjunction with pH. Stirring at 55 °C was found to be the best, in terms of the effectiveness of starch hydrolysis and yeast disintegration as well as cost. The treated solutions were found to support the mixotrophic growth of microalgae: 20 g/L of glucose medium resulted in the highest biomass production of 9...
May 27, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28551800/high-density-lipoprotein-regulation-of-mitochondrial-function
#5
C Roger White, Geeta Datta, Samantha Giordano
Lipoproteins play a key role in regulating plasma and tissue levels of cholesterol. Apolipoprotein B (apoB)-containing lipoproteins, including chylomicrons, very-low density lipoprotein (VLDL) and low-density lipoprotein (LDL), serve as carriers of triglycerides and cholesterol and deliver these metabolites to peripheral tissues. In contrast, high-density lipoprotein (HDL) mediates Reverse Cholesterol Transport (RCT), a process by which excess cholesterol is removed from the periphery and taken up by hepatocytes where it is metabolized and excreted...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551798/mitochondrial-proton-leak-plays-a-critical-role-in-pathogenesis-of-cardiovascular-diseases
#6
Jiali Cheng, Gayani Nanayakkara, Ying Shao, Ramon Cueto, Luqiao Wang, William Y Yang, Ye Tian, Hong Wang, Xiaofeng Yang
Mitochondrial proton leak is the principal mechanism that incompletely couples substrate oxygen to ATP generation. This chapter briefly addresses the recent progress made in understanding the role of proton leak in the pathogenesis of cardiovascular diseases. Majority of the proton conductance is mediated by uncoupling proteins (UCPs) located in the mitochondrial inner membrane. It is evident that the proton leak and reactive oxygen species (ROS) generated from electron transport chain (ETC) in mitochondria are linked to each other...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551793/mitochondria-in-structural-and-functional-cardiac-remodeling
#7
Natalia Torrealba, Pablo Aranguiz, Camila Alonso, Beverly A Rothermel, Sergio Lavandero
The heart must function continuously as it is responsible for both supplying oxygen and nutrients throughout the entire body, as well as for the transport of waste products to excretory organs. When facing either a physiological or pathological increase in cardiac demand, the heart undergoes structural and functional remodeling as a means of adapting to increased workload. These adaptive responses can include changes in gene expression, protein composition, and structure of sub-cellular organelles involved in energy production and metabolism...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551789/mitochondria-and-cardiac-hypertrophy
#8
Heberty di Tarso Fernandes Facundo, Robert Eli Brainard, Francisco Rodrigo de Lemos Caldas, Aline Maria Brito Lucas
Cardiac tissue responds to long-term hemodynamic load through initiation of a hypertrophic remodeling program. Importantly, if not counteracted this response will eventually lead to organ failure. Cardiac hypertrophic adaptations are complex, and involve multiple cellular events and the mechanisms underlying the development of cardiac hypertrophy are not well understood. Mitochondrial dysfunction has been indicated as a potential and important player in the development of cardiac hypertrophy. Additionally, substantial evidence shows that a significant portion of mitochondrial processes, necessary for normal cardiomyocyte physiology, are impacted by these hypertrophic changes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551786/mitochondrial-bioenergetics-during-ischemia-and-reperfusion
#9
Alicia E Consolini, María I Ragone, Patricia Bonazzola, Germán A Colareda
During ischemia and reperfusion (I/R) mitochondria suffer a deficiency to supply the cardiomyocyte with chemical energy, but also contribute to the cytosolic ionic alterations especially of Ca(2+). Their free calcium concentration ([Ca(2+)]m) mainly depends on mitochondrial entrance through the uniporter (UCam) and extrusion in exchange with Na(+) (mNCX) driven by the electrochemical gradient (ΔΨm). Cardiac energetic is frequently estimated by the oxygen consumption, which determines metabolism coupled to ATP production and to the maintaining of ΔΨm...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551782/mitochondrial-bioenergetics-and-dysfunction-in-failing-heart
#10
Freya L Sheeran, Salvatore Pepe
Energy insufficiency has been recognized as a key feature of systolic heart failure. Although mitochondria have long been known to sustain myocardial work energy supply, the capacity to therapeutically target mitochondrial bioenergetics dysfunction is hampered by a complex interplay of multiple perturbations that progressively compound causing myocardial failure and collapse. Compared to non-failing human donor hearts, activity rates of complexes I and IV, nicotinamide nucleotide transhydrogenase (NADPH-transhydrogenase, Nnt) and the Krebs cycle enzymes isocitrate dehydrogenase, malate dehydrogenase and aconitase are markedly decreased in end-stage heart failure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551638/modulation-of-melanotransferrin-and-transferrin-receptor-1-tfrc-and-cd44-based-signaling-for-tfrc-up-regulation-in-human-melanoma-cells
#11
Friedemann Laube, Dagobert Glanz
BACKGROUND: The human melanoma cell line IGR-1 was used for the detection and regulation of both melanotransferrin (MTf) and transferrin receptor 1 (TFRC, CD71). While the function in iron transport of the TFRC is well documented the functional importance of MTf is not yet fully understood. Due to the up-regulation of TFRC by hyaluronan (HA) some components and aspects of CD44 signaling were investigated. MATERIALS AND METHODS: The cell-surface proteins MTf, TFRC and ERBB2 receptor tyrosine kinase 2 (ERBB2) were detected by immunoluminescent technique using different polyclonal and monoclonal antibodies...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551637/17-allylamino-17-demethoxygeldanamycin-induced-changes-in-18-f-fluorothymidine-uptake
#12
Hang Jung Lee, DO Hyung Kim, Seung Jin Lee
The proliferation status of tumor cells can be imaged using [(18)F]fluorothymidine ([(18)F]FLT), which is trapped by cell cycle-dependent thymidine kinase 1 (TK1). Targeting of heat shock protein 90 (HSP90) disrupts multiple client proteins, leading to heterogeneous cell-cycle phenotypes. To investigate whether [(18)F]FLT uptake reflects the growth arrest caused by various mechanisms of HSP90 inhibition, we used HCT116 cells that were arrested at G0/G1 phase, and Hep3B cells at G2/M phase, by the HSP90 inhibitor 17-AAG...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551579/cadmium-exposure-exerts-neurotoxic-effects-in-peacock-blennies-salaria-pavo
#13
Azza Naïja, Patrick Kestemont, Benoit Chénais, Zohra Haouas, Ronny Blust, Ahmed Noureddine Helal, Justine Marchand
Cadmium (Cd) is considered as an important factor involved in several neurological disturbances. The aim of this study was to assess the effects of Cd in the brain of peacock blennies Salaria pavo, a species used as a bioindicator of water pollution. A sublethal contamination of 2mg CdCl2 L(-1) was performed over periods of 1, 4, 10 and 15 days. Total Cd accumulation was measured in brains and displayed low concentrations throughout the experiment. Partial-length cDNA of different ATP-binding cassette transporters (abcb1, abcc1, abcc2, abcg2 proteins) and acetylcholinesterase (ache) were characterized...
May 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28551566/silica-nanoparticles-alleviate-cadmium-toxicity-in-rice-cells-mechanisms-and-size-effects
#14
Jianghu Cui, Tongxu Liu, Fangbai Li, Jicai Yi, Chuanping Liu, Huanyun Yu
Although it was recently determined that silicon can alleviate cadmium (Cd) toxicity in rice, the effects of silicon properties and the molecular mechanisms are still unclear. Here, the effect of silica nanoparticles (SiNPs) on Cd toxicity in rice was examined using cells cultured in suspension in the presence or absence of SiNPs (19 nm, 48 nm and 202 nm). The results showed that the presence of SiNPs substantially enhanced the proportion of live cells to 95.4%, 78.6% and 66.2%, respectively, suggesting that the extent of alleviation of Cd toxicity decreased gradually with size of SiNPs...
May 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28551524/capillary-flows-across-layers-and-textural-interfaces-pathways-and-colloid-transport-considerations-in-unsaturated-layered-porous-media
#15
Frouke Hoogland, Peter Lehmann, Dani Or
Soils and other geologic porous media often display layering and associated textural contrasts that may alter unsaturated flow and transport pathways. Such natural interfaces are usually represented empirically in continuum flow models with limited mechanistic account of the effect of adjusted pathways across layers on colloid transport and on the nature of unsaturated flow. In this study we present the soil foam drainage equation (SFDE) as alternative framework to simulate unsaturated flow in layered porous media...
May 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28551510/food-transit-duration-is-associated-with-the-number-of-stage-ii-transport-cycles-when-eating-solid-food
#16
Takashi Hiraoka, Jeffrey B Palmer, Martin B Brodsky, Mitsumasa Yoda, Haruhi Inokuchi, Akio Tsubahara
OBJECTIVE: When eating solids, stage II transport (St2Tr) propels triturated food into the pharynx for bolus formation and storage before swallowing. Although the existence of St2Tr is acknowledged, the reason for its existence remains unclear. Understanding it may facilitate development of food appropriate for individuals with dysphagia. The purpose of this study was to explore how measures of duration of eating and swallowing affect the number of St2Tr cycles. DESIGN: Videofluorography was performed on 13 healthy subjects eating 6-g squares of banana, tofu, and cookies...
May 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28551491/estimating-contamination-monitor-efficiency-for-beta-radiation-by-means-of-penelope-2008-monte-carlo-simulation
#17
R Merk, J Mielcarek, J Döring, B Lange, Chr Lucks
Monte Carlo computer simulation of beta radiation transport within radioactively-contaminated food samples was studied and compared with experimental results. We used the Monte Carlo code PENELOPE-2008. The basic geometry of a hand-held contamination monitor and the geometry of beta-emitting food samples and surface sources were modeled, and the detection efficiency of the device was determined. Possibilities to improve the detection efficiency were tested by simulation.
May 19, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28551432/hydrothermal-pretreatment-of-wood-by-mild-steam-explosion-and-hot-water-extraction
#18
Joanna Wojtasz-Mucha, Merima Hasani, Hans Theliander
The aim of this work was to compare the two most common hydrothermal pre-treatments for wood - mild steam explosion and hot water extraction - both with the prospect of enabling extraction of hemicelluloses and facilitating further processing. Although both involve autohydrolysis of the lignocellulosic tissue, they are performed under different conditions: the most prominent difference is the rapid, disintegrating, discharge employed in the steam explosion opening up the structure. In this comparative study, the emphasis was placed on local composition of the pre-treated wood chips (of industrially relevant size)...
May 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28551367/a-multiscale-modelling-approach-for-the-regulation-of-the-cell-cycle-by-the-circadian-clock
#19
Raouf El Cheikh, Samuel Bernard, Nader El Khatib
We present a multiscale mathematical model for the regulation of the cell cycle by the circadian clock. Biologically, the model describes the proliferation of a population of heterogeneous cells connected to each other. The model consists of a high dimensional transport equation structured by molecular contents of the cell cycle-circadian clock coupled oscillator. We propose a computational method for resolution adapted from the concept of particle methods. We study the impact of molecular dynamics on cell proliferation and show an example where discordance of division rhythms between population and single cell levels is observed...
May 24, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28551160/copper-transporter-1-in-human-colorectal-cancer-cell-lines-effects-of-endogenous-and-modified-expression-on-oxaliplatin-cytotoxicity
#20
Haigang Cui, Anna J Zhang, Mark J McKeage, Louise M Nott, Dominic Geraghty, Nuri Guven, Johnson J Liu
Oxaliplatin-based chemotherapy is the mainstay for the treatment of advanced colorectal cancer. Copper transporter proteins have been implicated in the transport of platinum-based anticancer drugs, but their expression in human colorectal cancer cell lines and roles in controlling their sensitivity to oxaliplatin are not well studied or understood. The endogenous and modified expression of copper uptake transporter 1 (hCTR1) was studied in a panel of human colorectal cancer cell lines (DLD-1, SW620, HCT-15 and COLO205) with ~20-fold variation in oxaliplatin sensitivity...
April 25, 2017: Journal of Inorganic Biochemistry
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