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https://www.readbyqxmd.com/read/30050584/qiditangshen-granules-reduced-diabetic-kidney-injury-by-regulating-the-phosphorylation-balance-of-the-tyrosine-and-serine-residues-of-insulin-receptor-substrate-1
#1
Xue Gao, Hongfang Liu, Zhichao An, Qiying He
Background: Diabetic nephropathy (DN) is a microvascular complication induced by diabetes mellitus (DM), which can affect life quality and long-term prognosis of patients with DM. Angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) are currently recommended for treating DN proteinuria, but patients receiving ACEI/ARB are at risk of elevated serum creatinine or potassium levels. Based on the "yin-yang" theory of traditional Chinese medicine, the present study explored the effect of QiDiTangShen (QDTS) granules on DN and the phosphorylation balance of tyrosine and serine residues of IRS-1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30027695/plasma-neutrophil-gelatinase-associated-lipocalin-as-a-marker-of-tubular-damage-in-diabetic-nephropathy
#2
So Young Kim, Tae Dong Jeong, Woochang Lee, Sail Chun, Sung Sunwoo, Soon Bae Kim, Won Ki Min
BACKGROUND: An increase in neutrophil gelatinase-associated lipocalin (NGAL) indicates tubular injury. Diabetic nephropathy causes typical changes in the kidney, characterized by glomerulosclerosis and eventual tubular damage. We validated the usefulness of plasma NGAL (pNGAL) as a biomarker of tubular damage in patients with diabetic nephropathy. METHODS: We included 376 patients with diabetes mellitus (260 patients with chronic renal insufficiency who had not received hemodialysis and 116 hemodialyzed due to diabetic nephropathy) and 24 healthy controls...
November 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/30009367/the-effect-of-nitro-oleic-versus-losartan-in-diabetic-nephropathy-modulation-of-parathyroid-hormone-related-protein
#3
Asmaa Mohammed, Nermeen Sadek, Mohamed Eshra, Effat Khowailed, Laila Rashed, Basma Aboulhoda
BACKGROUND: Parathyroid hormone related protein (PTHrP) involvement in the mechanisms related to angiotensin II (Ang II)- induced renal injury has become an emerging concern. The current study was thus designed to compare the possible preventive and therapeutic effect of Ang II antagonists; losartan and nitro-oleic (NO2-OA) acid on diabetic nephropathy (DN), and evaluate their effect on PTHrP modulation as well as on the functional and histopathological parameters in the kidney of diabetic rats...
July 16, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29979643/provision-of-renal-care-for-patients-with-end-stage-kidney-disease-in-persistent-vegetative-state-in-united-arab-emirates-a-national-survey-of-renal-physicians
#4
Fayez Ebrahim Alshamsi, Ahmed Chaaban, Mona Alrukhaimi, Bassam Bernieh, Omran Bakoush
Patients with end stage kidney disease (ESKD) with severely impaired cognitive function have no survival benefit from dialysis. We therefore undertook a survey to explore the renal physicians' practices of withholding and withdrawal of dialysis treatment in vegetative state patients in the United Arab Emirates (UAE). A cross sectional survey of 29 nephrology practices in UAE exploring physicians' practices in making decisions of withholding and withdrawal of dialysis treatment during provision end-of-life care for patients in persistent vegetative state (PVS)...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29937906/retinol-binding-protein-4-versus-albuminuria-as-predictors-of-estimated-glomerular-filtration-rate-decline-in-patients-with-type-2-diabetes
#5
Aleksandra Klisic, Nebojsa Kavaric, Ana Ninic
Background: Since the increase in some tubular damage biomarkers can be observed at the early stage of diabetic nephropathy, even in the absence of albuminuria, we aimed to investigate if urinary albumin is superior than tubular damage marker, such as serum retinol-binding protein 4 (RBP4), in predicting renal function decline (defined as estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2 ) in the cohort of patients with type 2 diabetes mellitus (T2D). Materials and Methods: A total of 106 sedentary T2D patients (mean [± standard deviation] age 64...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29685824/monitoring-of-patients-with-type-2-diabetes-and-nephropathy-in-a-specialized-diabetic-nephropathy-clinic-seems-to-be-beneficial
#6
N Vallianou, T Stratigou, A Paikopoulou, T Apostolou, B Vlassopoulou, S Tsagarakis, G Ioannidis
BACKGROUND: The purpose of this study was to evaluate the outcome of DM2 patients with nephropathy when they are under surveillance of a joined clinic run by endocrinologists & nephrologists. PATIENTS AND METHODS: A cohort of 106 patients with DM2, 42-83 years of age, and eGFR < 60 ml/min/m2 were included. Age, sex, duration of diabetes, duration of attending our clinic, smoking habits, BMI, data regarding ischemic heart disease and induction of hemodialysis, urine albumin excretion (UAE) levels, eGFR (MDRD equation) and values of various biochemical parameters were recorded too...
April 13, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29466891/proenkephalin-and-risk-of-developing-chronic-kidney-disease-the-prevention-of-renal-and-vascular-end-stage-disease-study
#7
Lyanne M Kieneker, Oliver Hartmann, Andreas Bergmann, Rudolf A de Boer, Ron T Gansevoort, Michel M Joosten, Joachim Struck, Stephan J L Bakker
BACKGROUND: Proenkephalin (pro-ENK) was recently found to be associated with low estimated glomerular filtration rate (eGFR). The association of pro-ENK with urinary albumin excretion (UAE), another marker for chronic kidney disease (CKD), has not been investigated. We examined the association of pro-ENK with eGFR and UAE as markers of CKD. METHODS: We included 4375 subjects of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. CKDeGFR was defined as development of eGFR <60 ml/min/1...
July 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29422652/rage-aptamer-attenuates-deoxycorticosterone-acetate-salt-induced-renal-injury-in-mice
#8
Kensei Taguchi, Sho-Ichi Yamagishi, Miyuki Yokoro, Sakuya Ito, Goh Kodama, Yusuke Kaida, Yosuke Nakayama, Ryotaro Ando, Nana Yamada-Obara, Katsuhiko Asanuma, Takanori Matsui, Yuichiro Higashimoto, Craig R Brooks, Seiji Ueda, Seiya Okuda, Kei Fukami
The mineralocorticoid receptor (MR) and its downstream signaling play an important role in hypertensive renal injury. The interaction of advanced glycation end products (AGE) with their receptor (RAGE) is involved in the progression of renal disease. However, the pathological crosstalk between AGE-RAGE axis and MR system in kidney derangement remains unclear. We screened DNA-aptamer directed against RAGE (RAGE-apt) in vitro and examined its effects on renal injury in uninephrectomized deoxycorticosterone acetate (DOCA)/salt-induced hypertensive mice...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378039/dietary-potential-renal-acid-load-is-positively-associated-with-serum-uric-acid-and-odds-of-hyperuricemia-in-the-german-adult-population
#9
Jonas Esche, Danika Krupp, Gert B M Mensink, Thomas Remer
Background: Initial interventional data indicate that a reduction in dietary acid load (e.g., by an increased consumption of alkalizing fruit and vegetables) can increase renal uric acid excretion and decrease serum uric acid (SUA). Objective: Against this background, we examined the association between dietary potential renal acid load (PRAL) and SUA in a representative population sample. Methods: Cross-sectional analyses were performed in 6894 participants (aged 18-79 y) of the German Health Interview and Examination Survey for Adults (DEGS1)...
January 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29227974/mir302a-3p-may-modulate-renal-epithelial-mesenchymal-transition-in-diabetic-kidney-disease-by-targeting-zeb1
#10
Wen-Bin Tang, Linfeng Zheng, Renheng Yan, Jiayi Yang, Jianping Ning, Linlin Peng, Qiaoling Zhou, Liping Chen
BACKGROUND: Recent study found that microRNA (miRNA) are involved in diabetic kidney disease (DKD). The objective of this study is to determine the role of miR302a-3p in the process of renal epithelial-mesenchymal transition (EMT) in DKD. METHODS: The miRNA expression profiling of the cell line stimulated by high glucose was performed by a microarray analysis. Then real-time polymerase chain reaction (PCR) were used to determine the expression of one of the miRNAs significantly upregulated in cell line stimulated by high glucose, miR302a-3p...
2018: Nephron
https://www.readbyqxmd.com/read/29222708/correction-to-effect-of-renal-transplantation-on-cognitive-function-in-hemodialysis-patients-a-longitudinal-study
#11
Yogesh K Chhabra, Sanjay Sood, Omprakash Rathi, Sandeep Mahajan
In the original publication, the second author's affiliation was incorrectly published as "Department of Physiology, RAK College of Medical Sciences, Ras Al Khaimah, UAE". The correct affiliation should read as "Visiting Academic, Basic Medical Sciences Department, College of Medicine, University of Sharjah (UAE)".
January 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29130072/prediction-of-chronic-kidney-disease-stage-3-by-ckd273-a-urinary-proteomic-biomarker
#12
Claudia Pontillo, Zhen-Yu Zhang, Joost P Schanstra, Lotte Jacobs, Petra Zürbig, Lutgarde Thijs, Adela Ramírez-Torres, Hiddo J L Heerspink, Morten Lindhardt, Ronald Klein, Trevor Orchard, Massimo Porta, Rudolf W Bilous, Nishi Charturvedi, Peter Rossing, Antonia Vlahou, Eva Schepers, Griet Glorieux, William Mullen, Christian Delles, Peter Verhamme, Raymond Vanholder, Jan A Staessen, Harald Mischak, Joachim Jankowski
Introduction: CKD273 is a urinary biomarker, which in advanced chronic kidney disease predicts further deterioration. We investigated whether CKD273 can also predict a decline of estimated glomerular filtration rate (eGFR) to <60 ml/min per 1.73 m2 . Methods: In analyses of 2087 individuals from 6 cohorts (46.4% women; 73.5% with diabetes; mean age, 46.1 years; eGFR ≥ 60 ml/min per 1.73 m2 , 100%; urinary albumin excretion rate [UAE] ≥20 μg/min, 6.2%), we accounted for cohort, sex, age, mean arterial pressure, diabetes, and eGFR at baseline and expressed associations per 1-SD increment in urinary biomarkers...
November 2017: KI Reports
https://www.readbyqxmd.com/read/28956668/biomarkers-of-diabetic-nephropathy-a-2017-update
#13
REVIEW
Nektaria Papadopoulou-Marketou, Christina Kanaka-Gantenbein, Nikolaos Marketos, George P Chrousos, Ioannis Papassotiriou
Diabetic nephropathy (DN), also named diabetic kidney disease (DKD), is a devastating complication in patients with both type 1 and 2 diabetes mellitus (T1D and T2D) and its diagnosis has been traditionally based on the presence of micro-albuminuria (MA). The aim of this article is to update, through review of the relevant medical literature, the most promising biomarkers for early DKD detection. MA has historically been employed as an early marker of microvascular complications, indicating risk for advanced CKD...
August 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28933781/relationship-between-subtle-urinary-albumin-excretion-and-risk-of-incident-hypertension-modification-by-glomerular-filtration-rate
#14
Masanori Munakata, Tomomi Hattori, Satoshi Konno
It has been reported that an increase in urinary albumin excretion (UAE) within the normal range could be a risk factor for incident hypertension. However, it remains unclear how the subtle increases in UAE and renal function interact in the development of hypertension. We examined the modification of UAE as a risk factor for incident hypertension by glomerular filtration rate (GFR) in the Japanese population. We prospectively followed 1281 normotensive individuals from Watari town (34.3% men; mean age, 58...
December 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28878941/clinical-profiles-comorbidities-and-complications-of-type-2-diabetes-mellitus-in-patients-from-united-arab-emirates
#15
Herbert F Jelinek, Wael M Osman, Ahsan H Khandoker, Kinda Khalaf, Sungmun Lee, Wael Almahmeed, Habiba S Alsafar
OBJECTIVE: To assess clinical profiles of patients with type 2 diabetes in the United Arab Emirates (UAE), including patterns, frequencies, and risk factors of microvascular and macrovascular complications. RESEARCH DESIGN AND METHODS: Four hundred and ninety patients with type 2 diabetes were enrolled from two major hospitals in Abu Dhabi. The presence of microvascular and macrovascular complications was assessed using logistic regression, and demographic, clinical and laboratory data were collected...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28786697/the-relationship-between-the-autonomic-nervous-function-and-early-renal-dysfunction-in-elderly-patients-with-mild-to-moderate-essential-hypertension
#16
Qunwei Liu, Limin Han, Feng Chang, Guoyan Chen, Xinrui Li, Lijiao Xia
OBJECTIVE: This study investigated the relationship between autonomic nervous function and early renal dysfunction in elderly patients with mild-to-moderate essential hypertension (EH). DESIGN: A total of 223 elderly patients with mild-to-moderate EH were enrolled. Urinary albumin excretion (UAE) and urinary creatinine (UCr) were measured in all elderly patients with mild-to-moderate EH, and urinary albumin to creatinine ratio (ACR) was calculated (ACR = UAE/UCr × 0...
2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28774945/arteriolar-hyalinosis-predicts-increase-in-albuminuria-and-gfr-decline-in-normo-and-microalbuminuric-japanese-patients-with-type-2-diabetes
#17
Tatsumi Moriya, Kazuki Omura, Madoka Matsubara, Yuki Yoshida, Kei Hayama, Motoshi Ouchi
OBJECTIVE: This study investigated the association between renal histology, as assessed by morphometric analysis using light (LM) and electron (EM) microscopy, and changes in urinary albumin excretion (UAE) and glomerular filtration rate (GFR) in Japanese people with type 2 diabetes in the early stages of diabetic nephropathy. RESEARCH DESIGN AND METHODS: We performed percutaneous renal biopsies in 29 patients with type 2 diabetes (22 men, mean ± SD age 49 ± 10 years and GFR 119 ± 27 mL/min/1...
October 2017: Diabetes Care
https://www.readbyqxmd.com/read/28767702/astragaloside-iv-ameliorates-diabetic-nephropathy-by-modulating-the-mitochondrial-quality-control-network
#18
Xinhui Liu, Wenjing Wang, Gaofeng Song, Xian Wei, Youjia Zeng, Pengxun Han, Dongtao Wang, Mumin Shao, Juan Wu, Huili Sun, Guoliang Xiong, Shunmin Li
The aim of this study was to investigate the effect and possible mechanism of Astragaloside IV (AS-IV) on retarding the progression of diabetic nephropathy (DN) in a type 2 diabetic animal model, db/db mice. Eight-week-old male db/db diabetic mice and their nondiabetic littermate control db/m mice were used in the present study. AS-IV was administered to the db/db mice by adding it to standard feed at a dose of 1g/kg for 12 weeks. Renal injury was assessed by urinary albumin excretion (UAE) and Periodic acid-Schiff staining...
2017: PloS One
https://www.readbyqxmd.com/read/28744992/the-effect-of-12-weeks-carnosine-supplementation-on-renal-functional-integrity-and-oxidative-stress-in-pediatric-patients-with-diabetic-nephropathy-a-randomized-placebo-controlled-trial
#19
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Abdel Rahman El-Naggar, Mahitab Hany Hamouda, Manal El-Hamamsy
BACKGROUND AND OBJECTIVES: Oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. Carnosine is a natural radical oxygen species scavenger. We investigated the effect of carnosine as an adjuvant therapy on urinary albumin excretion (UAE), the tubular damage marker alpha 1-microglobulin (A1M), and oxidative stress in pediatric patients with type 1 diabetes and nephropathy. METHODS: This randomized placebo-controlled trial included 90 patients with diabetic nephropathy, despite oral angiotensin-converting enzyme inhibitors (ACE-Is), who were randomly assigned to receive either 12 weeks of carnosine 1 g/day (n = 45), or matching placebo (n = 45)...
May 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/28673073/primary-monosymptomatic-nocturnal-enuresis-and-associated-factors-in-a-referral-continence-clinic-of-abu-dhabi
#20
Salvatore Arena, Mario Patricolo
The aim of the present study was to investigate the prevalence of primary monosymptomatic nocturnal enuresis (PMNE) and its associated factors in a major referral centre for nocturnal enuresis in the City of Abu Dhabi. Children referred to the Pediatric Continence Clinic of Department of Pediatric and Urology Surgery at Al Noor Hospital, Abu Dhabi (UAE), between January 2014 and January 2016 for the suspected diagnosis of NE were considered. The inclusion criteria of our study were: age 5-14 years; full medical history and physical examination; urine dipstick to exclude glycosuria and proteinuria; completion of diagnostic urological work-up; final diagnosis of PMNE...
June 23, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
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