keyword
https://read.qxmd.com/read/37944829/melatonin-supplementation-enhances-pulmonary-rehabilitation-outcomes-in-copd-a-randomized-double-blind-placebo-controlled-study
#21
JOURNAL ARTICLE
Soraya Maria do Nascimento Rebouças Viana, Veralice Meireles Sales de Bruin, Renata Santos Vasconcelos, Andréa Nóbrega Cirino Nogueira, Rafael Mesquita, Pedro Felipe Carvalhedo de Bruin
Melatonin (MLT), the main product of the pineal gland, is involved in muscle tissue repair and regeneration, besides several other important physiologic functions. In COPD, MLT administration can improve lung oxidative stress and sleep quality, but its potential effects on the outcomes of pulmonary rehabilitation (PR) have not been previously investigated. A randomized controlled trial was undertaken to test the hypothesis that a combined approach of rehabilitative exercise training and MLT supplementation could maximize functional performance, health status and quality of life in patients with COPD...
December 2023: Respiratory Medicine
https://read.qxmd.com/read/37892543/the-effects-of-melatonin-supplementation-on-professional-football-player-performance-a-systematic-review
#22
REVIEW
Antonio Almendros-Ruiz, Alejandro Lopez-Moro, Javier Conde-Pipò, Alfredo Santalla, Bernardo Requena, Miguel Mariscal-Arcas
BACKGROUND: Melatonin is a hormone that has shown anti-inflammatory actions, reduced oxidative stress, and has effects on physical performance, so the aim of this study was to review the effects of melatonin supplementation on the performance of professional soccer players. METHODS: Critical and systematic review. Data were obtained by performing searches in the following bibliographic databases: Web of Science, MEDLINE (via PubMed), Embase, Cochrane Library, and Scopus...
October 21, 2023: Nutrients
https://read.qxmd.com/read/37739092/melatonin-inhibits-fibroblast-cell-functions-and-hypertrophic-scar-formation-by-enhancing-autophagy-through-the-mt2-receptor-inhibited-pi3k-akt-mtor-signaling
#23
JOURNAL ARTICLE
Yunxian Dong, Xiaoling Cao, Jinsheng Huang, Zhicheng Hu, Chufen Chen, Miao Chen, Qian Long, Zhongye Xu, Dongming Lv, Yanchao Rong, Shengkang Luo, Haibin Wang, Wuguo Deng, Bing Tang
Hypertrophic scar (HS) is a fibrotic skin condition and characterized by abnormal proliferation of myofibroblasts and accumulation of extracellular matrix. Melatonin, an endogenous hormone, can alleviate fibrosis in multiple models of diseases. This study examined the effect of melatonin on fibrosis in primary fibroblasts from human HS (HSFs) and a rabbit ear model and potential mechanisms. Melatonin treatment significantly decreased the migration and contraction capacity, collagen and α-smooth muscle actin (α-SMA) production in HSFs...
September 20, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/37721401/melatonin-attenuates-chronic-sleep-deprivation-induced-cognitive-deficits-and-hdac3-bmal1-clock-interruption
#24
JOURNAL ARTICLE
Yujie Hu, Yefan Lv, Xiaoyan Long, Guoshuai Yang, Jinxia Zhou
BACKGROUND AND AIMS: Sleep is predicted as a key modulator of cognition, but the underlying mechanisms are poorly understood. In this study, we investigated the effects of melatonin on chronic rapid eye movement sleep deprivation (CRSD)-induced cognitive impairment and circadian dysfunction in rat models. METHODS: Thirty-six Sprague-Dawley male rats were divided into three groups: CRSD with saline treatment, CRSD with chronic melatonin injection (20 mg/kg/day), and non-sleep-deprived control...
September 18, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37702245/ims-bmal1-mice-show-evident-signs-of-sarcopenia-that-are-counteracted-by-exercise-and-melatonin-therapies
#25
JOURNAL ARTICLE
José Fernández-Martínez, Yolanda Ramírez-Casas, Paula Aranda-Martínez, Alba López-Rodríguez, Ramy K A Sayed, Germaine Escames, Darío Acuña-Castroviejo
Sarcopenia is an age-related disease characterized by a reduction in muscle mass, strength, and function and, therefore, a deterioration in skeletal muscle health and frailty. Although the cause of sarcopenia is still unknown and, thus, there is no treatment, increasing evidence suggests that chronodisruption, particularly alterations in Bmal1 clock gene, can lead to those deficits culminating in sarcopenia. To gain insight into the cause and mechanism of sarcopenia and the protective effect of a therapeutic intervention with exercise and/or melatonin, the gastrocnemius muscles of male and female skeletal muscle-specific and inducible Bmal1 knockout mice (iMS-Bmal1-/- ) were examined by phenotypic tests and light and electron microscopy...
September 13, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37627494/melatonin-improves-skeletal-muscle-structure-and-oxidative-phenotype-by-regulating-mitochondrial-dynamics-and-autophagy-in-z%C3%A3-cker-diabetic-fatty-rat
#26
JOURNAL ARTICLE
Diego Salagre, Enrique Raya Álvarez, Cruz Miguel Cendan, Samira Aouichat, Ahmad Agil
Obesity-induced skeletal muscle (SKM) inflexibility is closely linked to mitochondrial dysfunction. The present study aimed to evaluate the effects of melatonin on the red vastus lateralis (RVL) muscle in obese rat models at the molecular and morphological levels. Five-week-old male Zücker diabetic fatty (ZDF) rats and their age-matched lean littermates (ZL) were orally treated either with melatonin (10 mg/kg body weight (BW)/24 h) (M-ZDF and M-ZL) or non-treated (control) (C-ZDF and C-ZL) for 12 weeks...
July 27, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37624196/subchronic-arsenite-exposure-induced-atrophy-and-erythropoietin-sensitivity-reduction-in-skeletal-muscle-were-relevant-to-declined-serum-melatonin-levels-in-middle-aged-rats
#27
JOURNAL ARTICLE
Xiong Chen, Wanying Chen, Dapeng Wang, Lu Ma, Junyan Tao, Aihua Zhang
Arsenic is a kind of widespread environmental toxicant with multiorgan-toxic effects, and arsenic exposure is associated with the occurrence and development of many chronic diseases. The influence of environmental arsenic exposure on skeletal muscle, which is a vital organ of energy and glucose metabolism, has received increasing attention. This study aimed to investigate the types of inorganic arsenic-induced skeletal muscle injury, and the potential regulatory effects of melatonin (MT) and erythropoietin (EPO) in young (3-month-old) and middle-aged (12-month-old) rats...
August 10, 2023: Toxics
https://read.qxmd.com/read/37614140/-mechanism-of-melatonin-mediated-antihyperglycemic-effect-of-transcutaneous-auricular-vagus-nerve-stimulation
#28
JOURNAL ARTICLE
Yu-Zheng-Heng Zhang, Chen Xin, Zi-Xuan Zhang, Kai-Qi Zhang, Liang Li, Pei-Jing Rong, Shao-Yuan Li
OBJECTIVE: To observe the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on plasma melatonin (MLT) content and insulin receptor expression in the liver, the skeletal muscles, and the pancreas of Zucker diabetic fatty (ZDF) rats, so as to explore the hypoglycemic mechanism of taVNS. METHODS: Thirty male ZDF rats were randomly divided into model group, taVNS group and sham-taVNS group, with 10 rats in each group; besides, 10 male Zucker lean rats of the same strain were collected for the blank control group...
August 25, 2023: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/37598085/rem-behavior-disorder-when-parkinson-s-disease-meets-morpheus
#29
REVIEW
P Dodet
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the absence of normal muscle atonia during REM sleep, resulting in excessive motor activity while dreaming. RBD can be classified as isolated which is the strongest clinical marker of prodromal synucleinopathy, or secondary, associated with other neurological diseases, mainly Parkinson's disease (PD) and dementia with Lewy bodies. The diagnosis of RBD must be systematically documented by a video polysomnography in the case of isolated RBD...
October 2023: Revue Neurologique
https://read.qxmd.com/read/37549728/downregulation-of-pdcd4-through-stat3-atf6-autophagy-mediates-mif-induced-pasmcs-proliferation-migration-and-vascular-remodeling
#30
JOURNAL ARTICLE
Limin Chai, Qingting Wang, Yan Wang, Danyang Li, Qianqian Zhang, Yuqian Chen, Jin Liu, Huan Chen, Yuanjie Qiu, Nirui Shen, Jian Wang, Xinming Xie, Manxiang Li
To address the molecular mechanisms underlying macrophage migration inhibitory factor (MIF) induced pulmonary artery smooth muscle cells (PASMCs) proliferation, migration and vascular remodeling in pulmonary hypertension (PH), primary cultured rat PASMCs and monocrotaline (MCT)-induced rats with PH were applied in the present study. The results showed that MIF increased signal transducer and activator of transcription 3 (STAT3) phosphorylation, and then stimulated activating transcription factor 6 (ATF6) activation, subsequently triggered autophagy activation, which further led to programmed cell death factor 4 (PDCD4) lysosomal degradation, and eventually promoted PASMCs proliferation/migration...
August 5, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37531568/melatonin-supplementation-promotes-muscle-fiber-hypertrophy-and-regulates-lipid-metabolism-of-skeletal-muscle-in-weaned-piglets
#31
JOURNAL ARTICLE
Wentao Chen, Yuang Tu, Peiran Cai, Liyi Wang, Yanbing Zhou, Shiqi Liu, Yuqin Huang, Shu Zhang, Xin Gu, Wuzhou Yi, Tizhong Shan
Melatonin has been reported to play crucial roles in regulating meat quality, improving reproductive properties and maintaining intestinal health in animal production, but whether it regulates skeletal muscle development in weaned piglet is rarely studied. This study was conducted to investigate the effects of melatonin on growth performance, skeletal muscle development and lipid metabolism in animals by intragastric administration of melatonin solution. Twelve 28-day-old DLY (Duroc × Landrace × Yorkshire) weaned piglets with similar body weight were randomly divided into two groups: control group and melatonin group...
August 2, 2023: Journal of Animal Science
https://read.qxmd.com/read/37408201/transcriptome-profiling-reveals-enhanced-mitochondrial-activity-as-a-cold-adaptive-strategy-to-hypothermia-in-zebrafish-muscle
#32
JOURNAL ARTICLE
Thomas Cahill, Sherine Chan, Ian M Overton, Gary Hardiman
The utilisation of synthetic torpor for interplanetary travel once seemed farfetched. However, mounting evidence points to torpor-induced protective benefits from the main hazards of space travel, namely, exposure to radiation and microgravity. To determine the radio-protective effects of an induced torpor-like state we exploited the ectothermic nature of the Danio rerio (zebrafish) in reducing their body temperatures to replicate the hypothermic states seen during natural torpor. We also administered melatonin as a sedative to reduce physical activity...
May 11, 2023: Cells
https://read.qxmd.com/read/37321183/melatonin-alters-innate-immune-function-in-infants-with-neonatal-encephalopathy
#33
JOURNAL ARTICLE
Saima Aslam, Mary O'Dea, Lynne A Kelly, Amanda O'Neill, Ellen McKenna, Tim Hurley, Aoife Branagan, David O'Driscoll, Caoimhe Normile, Shahid Saleemi, Deirdre Sweetman, Claudine Vavasseur, John Murphy, Veronica Donoghue, William Watson, Eleanor J Molloy
INTRODUCTION: Melatonin has been suggested an adjunctive therapy in neonatal encephalopathy (NE). Melatonin reduces oxidative stress and neutrophil activation; however, the immunological effects in NE have not been studied. METHODS: Infants with NE and neonatal controls were prospectively recruited. Whole blood was sampled in the first week of life. Following endotoxin and or melatonin treatment, diurnal variation was measured by RT PCR for circadian rhythm genes (brain and Muscle Arnt-Like protein [BMAL1], circadian locomotor output cycles kaput [CLOCK], Nuclear Receptor Subfamily 1 Group D Member 2 [REV Erβ], and cryptochrome circadian clock [CRY])...
2023: Neonatology
https://read.qxmd.com/read/37312741/effects-of-the-melatonin-and-vitamin-e-alpha-tocopherol-acetate-as-antioxidants-on-biochemical-blood-parameters-lipid-profile-and-muscle-vitamin-e-concentration-in-awassi-lambs-fed-a-high-energy-diet-and-normal-diet
#34
JOURNAL ARTICLE
K Ismail Mahmud, F Karadaş
Health specialists currently suggest low-cholesterol diets, suggesting that cholesterol in the form of high-density lipoprotein (HDL) reduces the risk of chronic atherosclerosis. The large volume of literature describes the biological roles of vitamin E and its application to preventing disease and improving the health and productive performances of farm animals. The present study aimed to evaluate the effects of vitamin E (Alpha-tocopherol acetate) supplementation and melatonin implants on biochemical blood, lipid profile and muscle vitamin E content of Awassi male lambs fed by a high and normal diet in Iraq...
February 2023: Archives of Razi Institute
https://read.qxmd.com/read/37288290/nocturnal-melatonin-increases-glucose-uptake-via-insulin-independent-action-in-the-goldfish-brain
#35
JOURNAL ARTICLE
Kazuki Watanabe, Masaki Nakano, Yusuke Maruyama, Jun Hirayama, Nobuo Suzuki, Atsuhiko Hattori
Melatonin, a neurohormone nocturnally produced by the pineal gland, is known to regulate the circadian rhythm. It has been recently reported that variants of melatonin receptors are associated with an increased risk of hyperglycemia and type 2 diabetes, suggesting that melatonin may be involved in the regulation of glucose homeostasis. Insulin is a key hormone that regulates circulating glucose levels and cellular metabolism after food intake in many tissues, including the brain. Although cells actively uptake glucose even during sleep and without food, little is known regarding the physiological effects of nocturnal melatonin on glucose homeostasis...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37282546/a-systematic-review-of-variations-in-circadian-rhythm-genes-and-type-2-diabetes
#36
REVIEW
Harry Stevens, Giulia Verdone, Leonie Lang, Catherine Graham, Leta Pilic, Yiannis Mavrommatis
BACKGROUND: Type 2 diabetes is a chronic disease that has severe individual and societal consequences, which is forecast to worsen in the future. A new field of investigation is variations in circadian rhythm genes, in conjunction with diet and sleep variables, associations with, and effects on, type 2 diabetes development. OBJECTIVE: This systematic review aimed to analyse all current literature regarding circadian rhythm gene variations and type 2 diabetes, and explore their interplay with diet and sleep variables on type 2 diabetes outcomes...
June 6, 2023: Nutrition and Health
https://read.qxmd.com/read/37239269/melatonin-as-a-chronobiotic-cytoprotective-agent-in-rem-sleep-behavior-disorder
#37
REVIEW
Daniel P Cardinali, Arturo Garay
Dream-enactment behavior that emerges during episodes of rapid eye movement (REM) sleep without muscle atonia is a parasomnia known as REM sleep behavior disorder (RBD). RBD constitutes a prodromal marker of α-synucleinopathies and serves as one of the best biomarkers available to predict diseases such as Parkinson disease, multiple system atrophy and dementia with Lewy bodies. Most patients showing RBD will convert to an α-synucleinopathy about 10 years after diagnosis. The diagnostic advantage of RBD relies on the prolonged prodromal time, its predictive power and the absence of disease-related treatments that could act as confounders...
May 13, 2023: Brain Sciences
https://read.qxmd.com/read/37180094/considering-rem-sleep-behavior-disorder-in-the-management-of-parkinson-s-disease
#38
REVIEW
Michela Figorilli, Mario Meloni, Giuseppe Lanza, Elisa Casaglia, Rosamaria Lecca, Francesca Lea Saibene, Patrizia Congiu, Monica Puligheddu
Rapid eye movement (REM) sleep behavior disorder (RBD) is the result of the loss of physiological inhibition of muscle tone during REM sleep, characterized by dream-enacting behavior and widely recognized as a prodromal manifestation of alpha-synucleinopathies. Indeed, patients with isolated RBD (iRBD) have an extremely high estimated risk to develop a neurodegenerative disease after a long follow up. Nevertheless, in comparison with PD patients without RBD (PDnoRBD), the occurrence of RBD in the context of PD (PDRBD) seems to identify a unique, more malignant phenotype, characterized by a more severe burden of disease in terms of both motor and non-motor symptoms and increased risk for cognitive decline...
2023: Nature and Science of Sleep
https://read.qxmd.com/read/37159853/the-effects-of-resveratrol-and-melatonin-on-cardiac-dysfunction-in-diabetic-elderly-female-rats
#39
JOURNAL ARTICLE
N Akgun-Unal, S Ozyildirim, O Unal, S B Baltaci, R Mogulkoc, A K Baltaci
We aimed to investigate the effects of melatonin and resveratrol on diabetes-related papillary muscle dysfunction and structural heart disorders. The protective effect of resveratrol and melatonin supplementation on cardiac functions was investigated in a diabetic elderly female rat model. 16-month-old rats (n=48) were allocated into 8 groups. Group1: Control, Group2: Resveratrol Control, Group3: Melatonin Control, Group4: Resveratrol and Melatonin Control, Group5: Diabetes, Group6: Diabetes Resveratrol, Group7: Diabetes Melatonin, Group8: Diabetes Resveratrol and Melatonin...
April 30, 2023: Physiological Research
https://read.qxmd.com/read/37153635/reaction-of-different-cell-types-of-the-brain-on-neurotoxin-cuprizone-and-hormone-melatonin-treatment-in-young-and-aging-mice
#40
JOURNAL ARTICLE
Irina Labunets, Anzhela Rodnichenko, Sergey Savosko, Tetyana Pivneva
INTRODUCTION: The brain myelin and neurons destruction in multiple sclerosis may be associated with the production of neuroinflammatory cells (macrophages, astrocytes, T-lymphocytes) of pro-inflammatory cytokines and free radicals. The age-associated changes of the above cells can influence on the response of nervous system cells to toxic damaging and regulatory factors of humoral/endocrine nature, in particular pineal hormone melatonin. The study aim was (1) to evaluate changes of the brain macrophages, astrocytes, T-cells, neural stem cells, neurons, and central nervous system (CNS) functioning in the neurotoxin cuprizone-treated mice of different age; and (2) to assess in such mice the effects of exogenous melatonin and possible courses of its action...
2023: Frontiers in Cellular Neuroscience
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