Saima Aslam, Mary O'Dea, Lynne A Kelly, Amanda O'Neill, Ellen McKenna, Tim Hurley, Aoife Branagan, David O'Driscoll, Caoimhe Normile, Shahid Saleemi, Deirdre Sweetman, Claudine Vavasseur, John Murphy, Veronica Donoghue, William Watson, Eleanor J Molloy
INTRODUCTION: Melatonin has been suggested an adjunctive therapy in neonatal encephalopathy (NE). Melatonin reduces oxidative stress and neutrophil activation; however, the immunological effects in NE have not been studied. METHODS: Infants with NE and neonatal controls were prospectively recruited. Whole blood was sampled in the first week of life. Following endotoxin and or melatonin treatment, diurnal variation was measured by RT PCR for circadian rhythm genes (brain and Muscle Arnt-Like protein [BMAL1], circadian locomotor output cycles kaput [CLOCK], Nuclear Receptor Subfamily 1 Group D Member 2 [REV Erβ], and cryptochrome circadian clock [CRY])...
2023: Neonatology